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BIOCELL 2023年第12期47卷 2609-2615页

作者： JIE DUAN AIDONG GU WEI CHEN CHANGHAO CHEN FANGNAN SONG FAXI CHEN FANGFANG JIANG HUIWEN XING Department of Hepatobiliary Surgery The Second Hospital of NanjingNanjing Hospital Affiliated to Nanjing University of Traditional Chinese MedicineNanjing210003China

This study aims to analyze the clinical significance and mechanism of nuclear factor erythroid 2-related factor 2(NRF2)and glutathione peroxidase 4(GPX4)in primary hepatic carcinoma(phc).Methods:The expression of NRF2 and GPX4 in peripheral blood of patients with phc was determined to analyze the diagnostic value of the two combined for *** prognostic significance of NRF2 and GPX4 was evaluated by 3-year *** liver epithelial cells THLE-2 and human hepatocellular carcinoma cells HepG2 were purchased,and the expression of NRF2 and GPX4 in the cells was ***2 and GPX4 aberrant expression vectors were constructed and transfected into HepG2,and changes in cell proliferation and invasion capabilities were ***:The expression of NRF2 and GPX4 in patients with phc was higher than that in patients with LC or VH(pphc,and promotes the malignant development of phc.

关键词： Nuclear factor erythroid 2 Related factor 2 Glutathione peroxidase 4 Primary hepatic carcinoma Clinical significance Mechanism of action Pathogenesis

One-step and wash-free multiplexed immunoassay platform based on bioinspired photonic barcodes

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再生工程(英文) 2023年第3期4卷 238-244页

作者： Dagan Zhang Yuze Wang Junqi Zhao Xueqin Li Yuanyang Zhou Sen Wang Department of Andrology Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210008China Department of Clinical Laboratory The Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing210008China

Multiplex,rapid and accurate virus quantification plays a great value in biomedical ***,a novel one step,wash-free immunoassay platform based bioinspired phc barcodes for multiplexed virus quantification was *** barcodes were decorated with PDA by self-polymerization of DA,thus this nanocomposite hybridized phc barcodes facilitated the adsorption of FITC labelled antibodies and quenched itself photolumines-cent,allowing a fast responsive composite *** the presence of target analyte,the FITC-labelled detection antibody was released from the surface of PDA decorated microcarrier to specifically bind to the target ana-lyte,thus recovered the *** addition,the phc microcarrier was enabled to carry out various color barcode for different targets detection though tuning internal periodic *** on these excellent performances of the nanocomposite barcode,this method can not only capture H1N1,H5N1,SARS-CoV-2 si-multaneously with rapid,accuracy but also accomplish multiplex quantification detection with ***,our developed platform was also achieved with high-sensitivity and high-specificity through the verification of clinical samples,thus laying out a new avenue for multiplex virus detection in clinical diagnosis.

关键词： Barcode Photonic crystals Wash-free Immunoassay

Precision diagnosis of hepatocellular carcinoma

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Chinese Medical Journal 2023年第10期136卷 1155-1165页

作者： Zhenxiao Wang Hanjiao Qin Shui Liu Jiyao Sheng Xuewen Zhang Department of Hepatobiliary and Pancreatic Surgery Second Hospital of Jilin UniversityChangchunJilin 130041China Department of Radiotherapy Second Hospital of Jilin UniversityChangchunJilin 130041China

Hepatocellular carcinoma(HCC)is the most common type of primary hepatocellular carcinoma(phc).Early diagnosis of HCC remains the key to improve the *** recent years,with the promotion of the concept of precision medicine and more in-depth analysis of the biological mechanism underlying HCC,new diagnostic methods,including emerging serum markers,liquid biopsies,molecular diagnosis,and advances in imaging(novel contrast agents and radiomics),have emerged one after ***,we reviewed and analyzed scientific advances in the early diagnosis of HCC and discussed their application and *** review aimed to provide a reference for scientific research and clinical practice of HCC.

关键词： Hepatocellular carcinoma Precision medicine Serum markers Liquid biopsy Molecular diagnosis Radiomics

Factors Influencing Sexual Behavior among Female Adolescents in Onitsha, Nigeria

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Open Journal of Obstetrics and Gynecology 2014年第16期4卷 987-995页

作者： Ifeoma Bridget Udigwe Prosper Obunikem Adogu Achunam Simeon Nwabueze Echendu Dolly Adinma Chika Florence Ubajaka Chika Onwasigwe Department of Community Medicine & Primary Health Care (phc) Nnamdi Azikiwe University Teaching Hospital (NAUTH) Nnewi Nigeria Department of Community Medicine University of Nigeria Teaching Hospital (UNTH) Enugu Nigeria

Background: The sexual health indices of the adolescents are very poor. This study ascertained the factors influencing the sexual behaviour among female adolescents in Onitsha, Anambra state, Nigeria. Method: This was a cross sectional design in which a total of 800 female adolescents were selected from secondary schools in the area using multistage sampling method;and also selected from a major market (for those who were not at school) in the same geographical area using cluster sampling technique. Data were collected from the respondents about socio-demographic profile, reproductive and sexual health knowledge, attitude, behavior, sources of sexual health information. Result: The highest proportion of students who had ever had sex was found among the 16 - 17 years age group while the modal age group was 18 - 19 years for non students. Also “not living with both parents” and poor family background, were markedly associated with increased likelihood to engage in sexual activity. Poverty level was particularly high among the non-student adolescents. Furthermore, wrong knowledge of fertile period, low risk perception of HIV and premarital, and use of condoms among the respondents were all significantly associated with increased chance to engage in sex. The student adolescents got sexuality information mainly from the teachers;as opposed to their non-student counterparts who had youth organization and friends as main sources. Conclusion: Family values, poverty alleviation, change of attitude through appropriate health and sexuality education especially targeting the non-student adolescents are highly recommended. Sexual negotiation skill, accessible formal education for all should be encouraged to create the right sexual behavior among the adolescent girls.

关键词： Sexual Behavior Female Adolescent Students Non-Students Onitsha Nigeria

Pattern, Types and Predictors of Contraception among Female In-School and Out-of-School Adolescents in Onitsha, Anambra State, Nigeria

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Advances in Sexual Medicine 2014年第3期4卷 33-41页

作者： Prosper Adogu Ifeoma Udigwe Gerald Udigwe Achunam Nwabueze Chika Onwasigwe Department of Community Medicine & phc Nnamdi Azikiwe University Teaching Hospital Nnewi Nigeria Department of Community Medicine University of Nigeria Teaching Hospital Enugu Nigeria Department of Obstetrics and Gynecology Nnamdi Azikiwe University Teaching Hospital Nnewi Nigeria

Introduction: The consequences of unsafe sex are suffered mostly by adolescent girls in Nigeria despite efforts to improve accessibility to the reproductive and sexual health of this group. This study elucidates the pattern of contraceptive use, the key socio-demographic factors, sexual beliefs and practices associated with its use amongst adolescent girls in Nnewi, Nigeria. Methods: It was a descriptive cross-sectional comparative study of in-school and out-of-school female adolescents. Data were collected using questionnaires and Focus Group Discussion (FGD), then analyzed by selecting socio-demographic and other variables to assess their interaction with contraceptive use and result compared between the two groups. Data were presented in tables and charts and multivariate and chi-square analyses were performed. Result: Higher proportion of sexually active out-of-school girls than their in-school counterparts had ever used contraception—used it in their first and last sexual exposures, while condom was the commonest contraceptive employed by both groups. Age (older adolescents;F = 0.041), belief in condom use (P = 0.05), willingness to get condom for partner (P = 0.001) and regular sexual practice (P = 0.003) were the most important predictors of contraceptive use among the sexually active adolescents. Generally, the out-of-school girls are more likely to use contraceptives than their in-school counterparts. Some misconceptions about pregnancy prevention and unscientific contraceptive methods were mentioned by the subjects during the FGD. Recommendation: Access to reproductive health services needs to be improved especially among the in-school female adolescents. There is need to incorporate the right contraceptive information in the school curriculum, and the out-of-school adolescents should receive periodic dissemination of appropriate Behavior Change Communication (BCC) on the relevance of contraception.

关键词： Pattern Predictors Contraception Adolescents Onitsha Nigeria

THE EXPRESSIONS OF HBV X GENE AND ets-2, IGF-Ⅰ, c-myc AND N-ras ONCOGENES IN HUMAN HEPATOCELLULAR CARCINOMA AND TUMOR-ADJACENT TISSUES

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Chinese Journal of Cancer Research 1990年第3期2卷 15-19页

作者：连兆瑞吴孟超万大方徐国威周筱梅顾健人 Institute of Hepatobiliary Surgery Changhai Hospital The Second Military Medical University Shanghai Cancer Institute Shanghai Cancer Institutehe expressions of HBV X gene and ets-2 IGF-I c-myc and N-ras were studied in 7 pairs of human primary hepatocellular carcinoma (PHC) and tumor-adjacent tissues using RNA hybridization and im-munoblot methods. The results showed that specific 17 and 28 kD HBV X gene products (HBxAg) were existed in a portion of PHC and tumor-adjacent tissues. The 17 kD HBxAg was detected in the sera of 3 patients who also had 17 kD HBxAg in their liver tissues. Multiple expressions of oncogenes such as ets-2 c-myc and N-ras were observed in PHC and tumor-adjacent tissues that had HBxAg expressed indicating HBxAg might function as a transactivator in the course of intracellular proto-oncogene activation. It is also observed that in some tumor-adjacnet tissues the expressions of ets-2 c-myc and N-ras were higher than those in corresponding PHC. The relationship of HBxAg to the expression of est-2 IGF-Ⅱ c-myc and their possible roles in the carcinogenesis of PHC are discussed.

The expressions of HBV X gene and ets-2, IGF-I, c-myc and N-ras were studied in 7 pairs of human primary hepatocellular carcinoma (phc) and tumor-adjacent tissues, using RNA hybridization and im-munoblot methods. The results showed that specific 17 and 28 kD HBV X gene products (HBxAg) were existed in a portion of phc and tumor-adjacent tissues. The 17 kD HBxAg was detected in the sera of 3 patients who also had 17 kD HBxAg in their liver tissues. Multiple expressions of oncogenes such as ets-2, c-myc and N-ras were observed in phc and tumor-adjacent tissues that had HBxAg expressed, indicating HBxAg might function as a transactivator in the course of intracellular proto-oncogene activation. It is also observed that in some tumor-adjacnet tissues the expressions of ets-2, c-myc and N-ras were higher than those in corresponding phc. The relationship of HBxAg to the expression of est-2, IGF-Ⅱ, c-myc and their possible roles in the carcinogenesis of phc are discussed.

关键词： phc IGF c-myc AND N-ras ONCOGENES IN HUMAN HEPATOCELLULAR CARCINOMA AND TUMOR-ADJACENT TISSUES THE EXPRESSIONS OF HBV X GENE AND ets-2 HBV

Short-term efficacy assessment of transarterial chemoembolization combined with radioactive iodine therapy in primary hepatocellular carcinoma

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World Journal of Gastrointestinal Surgery 2023年第1期15卷 105-113页

作者： Lei Wang Kun Huang Yu Zhang Yi-Fan Wu Zhen-Dong Yue Zhen-Hua Fan Fu-Quan Liu Yong-Wu Li Jian Dong Department of Interventional Radiology Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China Department of Radiology Chinese Medical University Affiliated First HospitalShenyang 110001Liaoning ProvinceChina Department of Nuclear Medicine The Fifth Center of People’s Liberation Army General HospitalBeijing 100071China Department of Radiology Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China

BACKGROUND Transarterial chemoembolization(TACE)is an effective treatment for primary hepatocellular carcinoma(phc).Radioactive iodine therapy has been used in the treatment of advanced phc,especially in patients with portal vein tumor ***,data on the therapeutic effect of TACE combined with radioactive iodine therapy in phc are *** To investigate the clinical efficacy of TACE combined with radioactive iodine implantation therapy in advanced phc via perfusion computed tomography(CT).METHODS For this study,98 advanced phc patients were recruited and divided randomly into the study and control *** in the study group were treated with TACE combined radioactive iodine implantation *** in the control group were treated with only *** tumor lesion length,clinical effect,serum alpha-fetoprotein(AFP)and CT perfusion parameters were compared before and after therapy,and statistical analysis was *** There was no significant difference in tumor length and serum AFP between the study and control groups(P>0.05)before ***,the tumor length and serum AFP in the study group were lower than those in the control group 1 mo and 3 mo after *** 3 mo of treatment,the complete and partial remission rate of the study group was 93.88%,which was significantly higher than the control group(77.55%)(P0.05).After 3 mo of treatment,all perfusion CT variables were lower in the study group compared to the control group(Pphc can in

关键词： Transarterial chemoembolization Radioactive iodine Primary hepatocellular carcinoma Perfusion Computed tomography

Job Satisfaction and Mental Health among Physicians in Primary Health Care Centers in Kuwait

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Health 2019年第6期11卷 692-710页

作者： Rihab Al-Wotayan Mahmoud Annaka Maqsood Nazar Central Department of Primary Health Care Ministry of Health Kuwait Statistics and Indicators Office Central Department of PHC Ministry of Health Kuwait

Objectives: To measure the level of job satisfaction among primary health care physicians Ministry of Health (MOH) Primary Healthcare Center (phc) physicians, to evaluate the physicians’ mental health, and to assess their associated factors. Study Setting: Kuwait Ministry of Health, Primary Care Centers. Study Design: Cross-sectional study. Data Collection: The study was conducted from July to September, 2017. Of 746 questionnaires distributed to all phc physicians in the MOH, 417 questionnaires were completed. Information was collected on socio-demographic characteristics, work and health-related factors, job satisfaction (using the Warr-Cook-Wall job satisfaction scale), and mental health (using General Health Questionnaire). Principal Findings: Of participants, 40.8% were male, and 24.9% were Kuwaitis. Median overall job satisfaction was 71.4%. There were significant differences in overall job satisfaction with the physician rank (p = 0.008) and governorate (p = 0.05). The GPs were moderately satisfied with work surroundings;work freedom;recognition;degree of responsibility;salary;opportunity to use abilities;attention given to suggestions;relationship with hospital physicians, colleagues, and fellow workers;relations between management and workers;working hours;and the amount of variety in their job, but more satisfied with their immediate supervisors. Conclusions: Job satisfaction of phc physicians is critical for the improvement of health systems. This study showed that GPs (General Practitioners) were more satisfied overall than previously reported studies done in Kuwait. They were moderately satisfied with their salary and the amount of variety in work.

关键词： Physicians Job Satisfaction Primary Health Care Centers Kuwait

The Association of World Health Organisation (WHO) Safe Community Programme with Death Rate from Motorcycle Accidents in Iran

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Open Journal of Preventive Medicine 2014年第8期4卷 681-688页

作者： Alireza Moghisi Reza Mohammadi Leif Svanstrom Hossein Kazemeini Department of Public Health Science Norrbacka Karolinska Institute Stockholm Sweden phc Center Ministry of Health and Medical Education Tehran Iran

Background: Many developing countries are facing the problem of rapidly rising death rate from fatal accidents involving motorcycles. Objective: To determine the effect of participation and implementation of the World Health Organization (WHO) Safe Community Programme on death rate from fatal motorcycle accidents. Methods: Motorcycle’ fatal accident data were obtained from forensic medicine departments and hospital records in 11 cities located in three provinces in Iran during 2006-2007. Data were analyzed using chi-square and ANOVA tests. Fidelity of the data was safeguarded by using national security coding for each individual involved in the accident. Results: The highest death rate was found in the Fars province followed by Khorasan and Bushehr provinces. In Fars province, the highest mortality rate was found in Niriz city, which did not implement the Safe Community Programme and the lowest death rate was reported from Arsanjan city participating in Safe Community. Similar results were found in the Khorasan province. In Busher province, the highest death rate was found in Busher city participating in the program and the lowest in Genaveh city—not participating in the program. Among sex and age groups, males aged 19 - 39 years old had a highest death rate. Half of the death occurred at the accident scene—25% during a transfer to the hospital and 25% of death occurred at the hospital. Conclusions: The Safe Community Programme is a promising model to prevent death from fatal motorcycle accidents in urban areas in Iran.

关键词： Motorcyclists’ Death Epidemiology

Percutaneous microwave ablation and transcatheter arterial chemoembolization for serum tumor markers and prognostics of middle-late primary hepatic carcinoma

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World Journal of Gastrointestinal Surgery 2023年第12期15卷 2783-2791页

作者： Zhi-Peng Lin Da-Bei Huang Xu-Gong Zou Yuan Chen Xiao-Qun Li Jian Zhang Department of Interventional Medicine Zhongshan People’s HospitalZhongshan 528400Guangdong ProvinceChina

BACKGROUND Primary hepatic carcinoma(phc)has an insidious onset and is usually diagnosed in the middle and late *** transcatheter arterial chemoembolization(TACE)is the preferred option for treating middle-and advanced-stage phc,it has limited efficacy in killing tumor cells and poor long-term *** plus percutaneous microwave coagulation therapy(PMCT)is more effective than interventional therapy alone and can improve survival ***,there are few reports on the effects of TACE and PMCT on serum marker levels and the prognosis of patients with advanced *** To investigate the effect of PMCT+TACE on serum tumor markers and the prognosis of middle-late *** This retrospective study included 150 patients with middle-late phc admitted to Zhongshan People’s hospital between March 2018 and February *** were divided into a single group(treated with TACE,n=75)and a combined group(treated with TACE+PMCT,n=75).Before and after treatment,the clinical efficacy and serum tumor marker levels[carbohydrate antigen 19-9(CA19-9),alpha-fetoprotein(AFP),and carcinoembryonic antigen(CEA)]of both groups were *** 1-year survival rates and prognostic factors of the two groups were *** The combined group had 21 and 35 cases of complete remission(CR)and partial remission(PR),*** single group had 13 and 25 cases of CR and PR,decreased,with the decrease in the combined group being more significant(Pphc(P<0.05).CONCLUSION TACE+PMCT is effective in treating patients with mid-late *** reduces the levels of tumor markers,prolongs

关键词： Middle-late primary hepatic carcinoma Percutaneous microwave coagulation therapy Transcatheter arterial chemoembolization Effect Tumor markers Prognosis Survival