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Clinical Study on Autosomal Dominant Polycystic Kidney Disease among South Indians

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International Journal of Clinical Medicine 2013年第4期4卷 200-204页

作者： P. Veeramuthumari W. Isabel PG & Research Department of Zoology & Biotechnology Lady Doak College Madurai India

Autosomal dominant polycystic kidney disease (ADPKD) is a commonly inherited disorder in humans, with a frequency of 1 in 100 in the general population. ADPKD is caused by mutations in PKD1 gene (85%) located on human chromosome 16p13.3;Mutations in the PKD2 gene contribute to 15% of ADPKD incidence and is located on human chromosome 4q2-23. A total of hundred ADPKD patients and age and sex matched healthy individuals were selected for the study. The study was aimed to evaluate the prevalence of ADPKD, lipid profile and level of calcium (Ca), sodium (Na), iron (Fe) and potassium (K) in patients with ADPKD and in healthy individuals. The lipid profile was analyzed using commercially available span kit and semiautoanalyzer (Erba, Chem 5X). The Ca, Na, Fe and K concentrations were estimated by flame photometry (ELICO, CL 22D) and atomic absorption spectroscopy (ELICO, SL 173) and significant changes were noted at p 0.05. The ADPKD patients were observed to have lipid abnormalities, hyponatremia, cholesterolemia, renal osteodystrophy, cardiovascular problems and anemia. Therefore, the study reveals an association between the lipid profile and Ca, Na, Fe and K levels with ADPKD among South Indian population.

关键词： Polycystic Kidney Disease Hyponatremia Renal Osteodystrophy Anemia

Phytochemical constituents and larvicidal activity of Tragia involucrata Linn.(Euphorbiacea)leaf extracts against chikungunya vector,Aedes aegypti(Linn.)(Diptera:Culicidae)

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Journal of Coastal Life Medicine 2016年第1期4卷 53-55页

作者： Ramar Ganasekar Jeyasankar Alagarmalai pg&research department of zoology Arignar Anna Government Arts CollegeMusiri-621211Tamil NaduIndia pg&research department of zoology Government Arts College(Autonomous)Coimbatore-641018Tamil NaduIndia

Objective:To determine the phytochemical and larvicidal activity of Tragia involucrata(T.involucrata)leaf extracts against fourth instar larvae of Ae.aegypti.Methods:Phytochemical analysis of hexane leaf extract was performed and larvicidal activity was determined against Ae.aegypti at concentrations of 50,100,150,200 and 250 mg/L.Larval mortality was assessed after 24 h.Results:The hexane extracts of T.involucrata was found to be higher mortality against the larvae of Ae.aegypti with a LC_(50) value of 153.51 mg/L.Conclusions:These results suggested that the leaf extracts of T.involucrata showed potential to be used as an ideal ecofriendly approach for the control of the Ae.aegypti.

关键词： Phytochemical Larvicidal Tragia involucrata Leaf extract Aedes aegypti

Ovicidal activity of Atalantia monophylla(L)Correa against Spodoptera litura Fab.(Lepidoptera:Noctuidae)

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Asian Pacific Journal of Tropical Biomedicine 2012年第12期2卷 987-991页

作者： Kathirvelu Baskar Chellaiah Muthu Gnanaprakasam Antony Raj Selvadurai Kingsley Savarimuthu Ignacimuthu Entomology research Institute Loyola College pg and research department of Advanced zoology and Biotechnology Loyola College

Objective:To evaluate the efficacy of Atalantia monophylla(A.monophylla)leaf in different solvent crude extracts and fractions against eggs of Spodoptera litura(S.litura).Methods:Hexane,ethyl acetate and chloroform solvent extracts of A.monophylla leaf and 12 fractions from hexane extract were screened at 5.0%t,2.5%,1.0%and 0.5%for crude extracts and 1000,500,250 and 125 mg/kg for fractions against the eggs of S.litura for the ovicidal activity.LC_(50)and LC_(90)were calculated using probit analysis.Results:Hexane crude extract showed maximum ovicidal activity of 61.94%at 5.0%concentration with a correlation value of r^2=0.81,and least LC_(50)value of3.06%.Hexane extract was fractionated using silica gel column chromatography and 12 fractions were obtained.Fraction 9 was active which showed maximum ovicidal activity of 75.61%at 1000mg/kg with the LC_(50)value of 318.65 mg/kg and LC_(90)value of 1473.31 mg/kg.In linear regression analysis,significant and high correlation(r^2=0.81%)was seen between concentration and ovicidal activity of hexane crude extracts and its active frsctien.Conclusions:As per our knowledge,this is the first report for ovicidal activity of A.monophylla against S.litura,A.monophylla could be used for the management of S.litura and other insect pests.

关键词： Atalantia monophylla Crude extracts Fractions Ovicidal activity Spodoptera litura

Protection of cadmium chloride induced DNA damage by Lamiaceae plants

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Asian Pacific Journal of Tropical Biomedicine 2011年第5期1卷 391-394页

作者： Ramaraj Thirugnanasampandan Rajarajeswaran Jayakumar pg and research department of Biotechnology Kongunadu ArtsScience CollegeGN Mills department of zoology Bharathiar University

Objective:To analyze the total phenolic content,DNA protecting and radical scavenging activity of ethanolic leaf extracts of three Lamiaceae plants,i.e.Anisomelos malabarica(A.malabarica),Leucas aspera(L.aspera)and Ocimum basilicum(0.basilicum).Methods:The total polyphenols and flavonoids were analyzed in the ethanolic leaf extracts of the lamiaceae plants.To determine the DNA protecting activity,various concentrations of the plant extracts were prepared and treated on cultured Hepg2 human lung cancer cells.The pretreated cells were exposed to H_2O_2to induce DNA damage through oxidative stress.Comet assay was done and the tail length of individual comets was measured.Nitric oxide and superoxide anion scavenging activities of lamiaceae plants were analyzed.Results:Among the three plant extracts,the highest amount of total phenolic content was found in O.basilicum(189.33 mg/g),whereas A.malabarica showed high levels of flavonoids(10.66 mg/g).O.basilicum also showed high levels of DNA protecting(85%)and radical scavenging activity.Conclusions:The results of this study shows that bioactive phenols present in lamiaceae plants may prevent carcinogenesis through scavenging free radicals and inhibiting DNA damage.

关键词： Cadmium chloride DNA damage Lamiaceae plants Phenols Comet assay Antioxidant activity

Bioactivity of Pseudocalymma alliaceum(Lam.)Sandwith(Bignoniaceae)against Spodoptera litura Fabricius and Helicoverpa armigera Hübner(Lepidotera:Noctuidae)

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Journal of Coastal Life Medicine 2014年第4期2卷 302-307页

作者： Alagarmalai Jeyasankar Tamilarasu Chinnamani Entomology Lab PG&Research Department of ZoologyArignar Anna Government Arts CollegeMusiri-621211Tamil NaduIndia

Objective:To evaluate the antifeedant,larvicidal and insect growth inhibitory activities of crude extracts of Pseudocalymma alliaceum tested against fourth instar larvae of Spodoptera litura(S.litura)and Helicoverpa armigera(H.armigera).Methods:Hexane,chloroform and ethyl acetate extracts were prepared and tested for antifeedant,insecticidal and growth inhibitory activities against fourth instar larvae of S.litura and H.armigera.Results:Ethyl acetate extract showed promising antifeedant,insecticidal activity against S.litura and H.armigera.Maximum percentage of deformed larvae,pupae and adults were found on treatment with ethyl acetate extract.Percentage of successful adult emergence was deteriorated by extract treated larvae.Ethyl acetate extracts of Pseudocalymma alliaceum,showed higher percentage of antifeedant,insecticidal and growth inhibition activities.Conclusions:This is the first report on S.litura and H.armigera.Further,the active compounds isolated from the ethyl acetate extracts will be useful for controlling economically important insect pests.

关键词： Pseudocalymma alliaceum Helicoverpa armigera Spodoptera litura Antifeedant Insecticidal

Effect of periodic heat transfer on the transient thermal behavior of a convective-radiative fully wet porous moving trapezoidal fin

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Applied Mathematics and Mechanics(English Edition) 2023年第4期44卷 653-668页

作者： B.J.GIREESHA M.L.KEERTHI department of pg Studies and research in Mathematics Kuvempu UniversityShankaraghatta 577451India

A moving trapezoidal profiled convective-radiative porous longitudinal fin wetted in a single-phase fluid is considered in the current article.The periodic variation in the fin base temperature is taken into account along with the temperature sensitive thermal conductivity and convective heat transfer coefficients.The modeled problem,which is resolved into a non-linear partial differential equation(PDE),is made dimensionless and solved by employing the finite difference method(FDM).The results are displayed through graphs and discussed.The effects of amplitude,frequency of oscillation,wet nature,Peclet number,and other relevant quantities on the distribution of temperature through the fin length and with the dimensionless time are investigated.It is deciphered that the periodic heat transfer gives rise to the wavy nature of the fin thermal profile against time.The analysis is beneficial in the design of fin structures for applications like solar collectors,space/airborne applications,and refrigeration industries.

关键词： convection fully wet porous fin trapezoidal profile moving fin unsteady periodic thermal condition

Organometallic L-Alanine Cadmium Iodide Crystals for Optical Device Fabrication

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Journal of Electronic Science and Technology 2022年第4期20卷 345-355页

作者： Kathiravan Vaiyapuri Thangavel Subramani Ashok Kumar Rajamani Muthu Lakshmi Thangavel Satheesh Kumar Ganesan Selvarajan Palanisamy Kumaresavanji Malaivelusamy Crystal Growth Laboratory PG and Research Department of PhysicsGovernment Arts College(Autonomous)Karur 639005 pg and research department of Physics Thiruvalluvar Government Arts CollegeRasipuram 637401 pg and research department of Physics Jairam College of Arts and ScienceKarur 639003 pg and research department of Physics National College(Autonomous)Tiruchirappalli 620001 department of Physics Aditanar College of Arts and ScienceTiruchendur 628216

Single crystals of L-alanine cadmium iodide(LACI)were grown by the slow evaporation technique at room temperature.A single-crystal X-ray diffraction(SXRD)model was used to evaluate the crystal structure of the as-grown LACI crystal.The energy dispersive X-ray(EDX)analysis and ultraviolet-visible-near infrared(UV-vis-NIR)transmittance studies were carried out,and the results reveal the presence of elements in the title compound.From the transmittance data,the optical bandgap as a function of photon energy was estimated,and the different optical constants were calculated.A fluorescence study was performed for the LACI crystal.Thermogravimetric and differential thermal analyses have also been studied to investigate the thermal property of the LACI crystal.The efficiency of the second harmonic generation(SHG)of the title crystal was investigated.The magnetic and electrical properties were estimated by the vibrating sample magnetometer(VSM)analysis and impedance study,respectively.

关键词： Fluorescence impedance thermal analysis vibrating sample magnetometer(VSM) X-ray diffraction

Impact of Dietary Supplementation on Bioenergetics and Reproductive Performances in Amphiprion sebae

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Journal of Agricultural Science and Technology(B) 2021年第2期11卷 73-88页

作者： Sakthivel Marimuthu Manickavel Arunachalam Parthiban Chermapandi pg and research department of zoology Kamaraj CollegeTuticorinTamilnadu 628003India

Effects of varied types of live feeds and pelleted feeds on the bioenergetics and reproductive performances were studied under laboratory conditions.The highest feeding rate of 279.4 J/g live fish/day was observed in test fishes feed with Moina.Fish fed with pelleted feed exhibited the lowest feeding rate of 104.4 J/g live fish/day.But the absorption efficiency showed the opposite trend.The fish fed with pelleted feed showed the highest absorption efficiency 36%whereas the fish fed with Brachionus plicatilis exhibited the lowest absorption efficiency of 28%.The brood stock maintenance and larval growth were closely observed.The larvae grew like adult after 25th day of hatching.The mortality noticed during 2nd and 7th day of hatching was overcome by feeding the larvae with nutrient rich live feed.The sexually mature females and males were injected with 50μg of GnRHa(gonadotrophin releasing hormone analogue)encapsulated in a biodegradable copolymer of fatty acid dimer and sebacic acid p(FAD-SA)of a 25:75 molar ratio.After fifteen days all treated females commenced spawning.Similar treatment induced a two-fold increase in sperm volume in male.Conclusion of the present study indicated that the laboratory scale production of marine clown fish,Amphiprion sebae can be successfully carried out using live feed than the pellet feeds which express better feeding rate,spawning and development.

关键词： Amphiprion sebae larval rearing live feed pelleted feed survival rate

Effects of stretching/shrinking on the thermal performance of a fully wetted convective-radiative longitudinal fin of exponential profile

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Applied Mathematics and Mechanics(English Edition) 2022年第3期43卷 389-402页

作者： B.J.GIREESHA M.L.KEERTHI G.SOWMYA department of pg Studies and research in Mathematics Kuvempu UniversityShankaraghatta 577451India department of pg Mathematics The National College(Auto)Bangalore 560070India

The present investigation focuses on the thermal performance of a fully wet stretching/shrinking longitudinal fin of exponential profile coated with a mechanism like a conveyer belt.The modeled equation is non-dimensionalized and solved by applying the Runge-Kutta-Fehlberg(RKF)method.The effects of parameters such as the wet parameter,the fin shape parameter,and the stretching/shrinking parameter on the heat transfer and thermal characteristics of the fin are graphically analyzed and discussed.It is inferred that the negative effects of motion and internal heat generation on the fin heat transfer rate can be lessened by setting a shrinking mechanism on the fin surface.The current examination is inclined towards practical applications and is beneficial to the design of fins.

关键词： fully wet longitudinal fin convection exponential profile internal heat generation moving fin