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自动主成分分析滤过改进动态对比增强CT与MRI的信噪比

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国际医学放射学杂志 2011年第2期 179-180页

作者： D.Balvay N.Kachenoura S.Espinoza I.Thomassin-Naggara L.S.Fournier O.Clement 唐光健 INSERM U970 Paris Cardiovascular Research Center(PARCC)

目的开发一种新的自动主成分滤过技术并评价其对动态对比增强(DCE)MR与CT数据中已知低信噪比(CNR)代偿,而无明显信号损失的能力。材料与方法研究中

关键词：动态对比增强 MRI 主成分分析多元分析滤过 CT

Is aberrant CD8+ T cell activation by hypertension associated with cardiac injury in severe cases of COVID-19?

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Cellular & Molecular Immunology 2020年第6期17卷 675-676页

作者： Chao Zhang Fu-Sheng Wang Jean-Sébastien Silvestre Fernando Arenzana-Seisdedos Hong Tang Treatment and Research Center for Infectious Diseases The Fifth Medical Center of PLA General HospitalNational Clinical Research Center for Infectious DiseasesBeijingChina Inserm UMRS 970 Paris Centre de Recherche Cardiovasculaire(PARCC)75737 Paris cedex 15CedexFrance CAS Key Laboratory of Molecular Virology and Immunology COVID-19 Response TeamInstitut Pasteur of ShanghaiChinese Academy of SciencesShanghaiChina

COVID-19 global pandemic,caused by severe acute respiratory syndrome coronavirus type 2(SARS-CoV-2),1 has swept 185 countries and regions with more than 2,824,728 confirmed cases,and 197,667 death as on April 25,2020 according the Coronavirus Resource Center at Johns Hopkins *** data suggest that hypertension,diabetes,and cardiovascular diseases are the most frequent comorbidities in COVID-19 patients,and case mortality rates tended to be high in these individuals.

关键词： hypertension cases Hopkins

Atrial fibrillation： the current epidemic

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Journal of Geriatric Cardiology 2017年第3期14卷 195-203页

作者： Carlos A Morillo Amitava Banerjee Pablo Perel David Wood Xavier Jouven Department of Cardiac Sciences Division of Cardiology Libin Cardiovascular Institute University of Calgary Calgary AB Canada Population Health Research Institute Hamilton Health Sciences McMaster University Hamilton ON Canada Farr Institute of Health Informatics Research University College of London London UK Centre for Global NCDs London School of Hygiene & Tropical Medicine London UK World Heart Federation Geneva Switzerland International Centre for Circulatory Health Imperial College London London UK Department of Cardiology European Georges-Pompidou Hospital Paris France Paris Cardiovascular Research Center Paris Descartes University lnserm U970 (PARCC) Paris France

Atrial fibrillation （AF） is the most common arrhythmia diagnosed in clinical practice. The consequences of AF have been clearly estab- lished in multiple large observational cohort studies and include increased stroke and systemic embolism rates if no oral anticoagulation is prescribed, with increased morbidity and mortality. With the worldwide aging of the population characterized by a large influx of ＂baby boomers＂ with or without risk factors for developing AF, an epidemic is forecasted within the next 10 to 20 years. Although not all studies support this evidence, it is clear that AF is on the rise and a significant amount of health resources are invested in detecting and managing AF This review focuses on the worldwide burden of AF and reviews global health strategies focused on improving detection, prevention and risk stratification of AF, recently recommended by the World Heart Federation.

关键词： Aging Anticoagulation Atrial fibrillation Heart failure Hypertension Stroke

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Chromophobe renal cell carcinoma: Novel molecular insights and clinicopathologic updates

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Asian Journal of Urology 2022年第1期9卷 1-11页

作者： Reza Alaghehbandan G.Przybycin Christopher Virginie Verkarre Rohit Mehra Department of Pathology Faculty of MedicineUniversity of British ColumbiaRoyal Columbian HospitalVancouverBCCanada Robert J Tomsich Pathology and Laboratory Medicine Institute Cleveland ClinicClevelandOHUSA Department of Pathology Georges Pompidou European HospitalAP-HPParis UniversityINSERM UMR 970PARCCParisFrance Department of Pathology University of Michigan Medical SchoolAnn ArborMIUSA Michigan Center for Translational Pathology Ann ArborMIUSA Rogel Cancer Center Michigan MedicineAnn ArborMIUSA

Chromophobe renal cell carcinoma(ChRCC)is the third most common renal cell carcinoma(RCC)subtype,which predominantly occurs in sporadic *** are considered to originate from the intercalated cell of distal tubules with two main morphological variants,classic and *** ChRCCs carry a favorable clinical *** alone is limited in predicting the behavior of ChRCCs that do not have overtly aggressive morphologic findings such as necrosis and sarcomatoid *** with positive CD117 expression,classic ChRCCs generally express diffuse and uniform CK7,while eosinophilic variant demonstrates more heterogeneous CK7 expression(rare or patchy).Multiple losses of chromosomes 1,2,6,10,13,17,and 21 are considered to be the genetic hallmarks of classic and eosinophilic ChRCCs,while chromosomal gains are known to be associated with sarcomatoid ***53 and PTEN are the two most frequently mutated genes in *** major challenge in the differential diagnosis of ChRCCs includes considerations around the eosinophilic variant(of ChRCCs),where it may share overlapping features with oncocytoma or other recent emergent oncocytic *** eosinophilic ChRCCs share expression of the recently described biomarkers,LINC01187 and FOXI1,with classic ChRCCs,however,a subset of eosinophilic-like ChRCCs with lower biomarker expression have been demonstrated to harbor MTOR gene ***,the morphologic features of ChRCCs and genetic profile with combinations of chromosomal losses and gains suggest this tumor entity to represent a distinct,yet heterogeneous group of renal neoplasms.

关键词： Renal cell carcinoma Chromophobe Immunohisto-chemistry RNA in situ hybridization Next-generation sequencing Oncocytic tumors Molecular

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共赢方法论——协调社会利益关系的系统方法论

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共赢方法论——协调社会利益关系的系统方法论

经济全球化与系统工程——中国系统工程学会第16届学术年会

作者：李亚李习彬北京理工大学管理与经济学院 parcc at Maxwell School Syracuse University 国家行政学院

社会关系的本质是利益关系.为弥补传统系统方法论处理社会关系的不足,本文提出一种新的系统方法论——共赢方法论.传统系统方法论以辅助决策者为己任,主要以提高决策的科学化水平为目标,而共赢方法论既辅助决策者,也辅助利益相关者,特... 详细信息

社会关系的本质是利益关系.为弥补传统系统方法论处理社会关系的不足,本文提出一种新的系统方法论——共赢方法论.传统系统方法论以辅助决策者为己任,主要以提高决策的科学化水平为目标,而共赢方法论既辅助决策者,也辅助利益相关者,特别是支持弱势群体的民主参与,进而实现决策科学化与民主化的互补与整合,并通过创造性地探索共赢方案,最终实现所有利益相关者共赢的决策目标.首先介绍共赢方法论提出的背景,分析了共赢概念并阐述共赢目标何以能够实现的理论依据,然后重点讨论共赢方法论的基本思路,以及其在公共政策制定中运用的逻辑程序和组织模式.

关键词：共赢方法论系统方法利益冲突公共参与

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钆螯合物于小鼠母胎内的药代动力学研究

国际医学放射学杂志 2011年第2期 180-180页

作者： M.R.Mühler O.Clément L.J.Salomon D.Balvay G.Autret C.Vayssettes 唐光健 INSERM U970Paris Cardiovascular Research Center-PARCC

目的确定母源性注射0.5mmol/kg的高剂量钆后,前48h内钆特酸葡胺在小鼠母胎内的药代动力学。材料与方法所有研究均符合法国法律与国家健康研究所的实验

关键词：母胎药代动力学胎儿羊水药物动力学胞浆水小鼠小家鼠钆特酸螯合物

应用MR血氧水平依赖(BOLD)成像在体评估宫内生长受限大鼠模型的胎盘和胎儿的氧合改变

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国际医学放射学杂志 2013年第4期 393-393页

作者： S. Aimot -Macron L.J. Salomon B. Deloison R. Thiam C.A. Cuenod O. Clement 董龙春 INSERM U970 Paris Cardiovascular Research Center-PARCC56rueLeblanc75015ParisFrance

目的评价氧合过度所致的BOLD信号强度的改变是否与大鼠宫内生长受限(IUGR)有关。方法在妊娠第16天,结扎左侧子宫血管根部,建立妊娠大鼠的IUGR模型。在第19天,应用1.5TMR设备以平衡稳态自由进动(balanced-SSFP)序列对大鼠模型进行BOLDMR... 详细信息

目的评价氧合过度所致的BOLD信号强度的改变是否与大鼠宫内生长受限(IUGR)有关。方法在妊娠第16天,结扎左侧子宫血管根部,建立妊娠大鼠的IUGR模型。在第19天,应用1.5TMR设备以平衡稳态自由进动(balanced-SSFP)序列对大鼠模型进行BOLDMR成像。比较母体肝脏、对照组及生长受限胎儿胎盘单元(FPU)在氧合过度发生前后的信号强度(SI)。结果 18只大鼠中,母体氧合过度导致所有感兴趣区SI明显增加(P<0.05)。对照组中,胎盘(n=74)和胎儿(n=53)信号强度(平均值±SD)分别增加(21±15)%和(13±8.5)%。IUGR组中,信号强度增加的幅度明显较低:胎盘(n=36)为(6.5±4)%,胎儿(n=34)为(7±5.5)%;P<0.05。结论 BOLDMRI可以无创评估大鼠母体氧合过度所致的胎儿胎盘反应,并显示其在IUGR模型中的信号强度改变。这种成像技术可提供一种有用的辅助方法,用以早期诊断、评估和治疗人类IUGR。要点①宫内生长受限是围产期发病和死亡的重要原因。②BOLDMRI可以无创评估胎儿胎盘对母体氧合过度的反应。③IUGR大鼠的胎儿胎盘对母体氧合过度的反应发生改变。④功能MRI有助于评估人IUGR。

关键词：胎儿胎盘 BOLDMRI 宫内生长受限(IUGR) 胎儿胎盘氧合作用

Theranostics:纳米热疗法或可软化肿瘤,提高癌症靶向疗法的治疗效率

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现代生物医学进展 2017年第3期17卷 I0003-I0003页

作者： Iris Marangon Amanda A. K. Silva Thomas Guilbert Jelena Kolosnjaj-Tabi Carmen Marchiol Sharuja Natkhunarajah Foucault Chamming’s Cécilia Ménard-Moyon Alberto Bianco Jean-Luc Gennisson Gilles Renault Florence Gazeau Laboratoire Matière et Systèmes Complexes (MSC) CNRS-UMR 7057 Université Paris Diderot Sorbonne Paris Cité 10 rue Alice Domon et Léonie Duquet F-75205 Paris Cedex 13 France Plateforme Imagerie Institut Cochin Inserm U1016-CNRS UMR8104-Université Paris Descartes Sorbonne Paris Cité Paris 22 rue Méchain 75014 Paris France parcc Inserm U970 Paris Cardiovascular Research Center-PARCC / Université Paris-Descartes Sorbonne Paris Cité 56 rue Leblanc 75015 Paris France University of Strasbourg CNRS Immunopathology and Therapeutic Chemistry UPR 3572 67000 Strasbourg France Institut Langevin CNRS-UMR 7587 1 place Jussieu 75205 Paris France.✉ Corresponding author: Florence GAZEAU rf.toredid-sirap-vinu@uaezag.ecnerolf. Tel: +33 (0)1 57 27 62 03 Fax: +33 (0)1 57 27 62 11.Competing Interests: The authors have declared that no competing interest exists.

肿瘤的机械阻力和标准疗法的附带损伤往往会阻碍抵御癌症的效果，近日，来自法国国家健康与医学研究所等机构的研究人员通过对肿瘤加热成功软化了恶性肿瘤，这种方法称之为纳米热疗法，其能够让肿瘤对治疗制剂更加敏感，相关研究刊登于... 详细信息

肿瘤的机械阻力和标准疗法的附带损伤往往会阻碍抵御癌症的效果，近日，来自法国国家健康与医学研究所等机构的研究人员通过对肿瘤加热成功软化了恶性肿瘤，这种方法称之为纳米热疗法，其能够让肿瘤对治疗制剂更加敏感，相关研究刊登于国际杂志Theranostics上。

关键词：恶性肿瘤热疗法软化纳米癌症疗效附带损伤机械阻力

Targeted therapy for capillary-venous malformations

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Signal Transduction and Targeted Therapy 2024年第7期9卷 3024-3039页

作者： Lola Zerbib Sophia Ladraa Antoine Fraissenon Charles Bayard Marina Firpion Quitterie Venot Sanela Protic Clément Hoguin Amandine Thomas Sylvie Fraitag Jean-Paul Duong Sophie Kaltenbach Estelle Balducci Coline Lefevre Patrick Villarese Vahid Asnafi Christine Broissand Nicolas Goudin Ivan Nemazanyy Gwennhael Autret Bertrand Tavitian Christophe Legendre Nadia Arzouk Veronique Minard-Colin Caroline Chopinet Michael Dussiot Denise MAdams Tristan Mirault Laurent Guibaud Paul Isenring Guillaume Canaud UniversitéParis Cité ParisFrance INSERM U1151 Institut Necker-Enfants MaladesParisFrance Service d’Imagerie Pédiatrique Hôpital Femme-Mère-EnfantHCLBronFrance CREATIS UMR 5220 Villeurbanne 69100France Service de Radiologie Mère-Enfant Hôpital NordSaint EtienneFrance Service d’Anatomie pathologique Hôpital Necker-Enfants MaladesAP-HPParisFrance Laboratoire d’Oncohématologie Hôpital Necker-Enfants MaladesAP-HPParisFrance Pharmacie Hôpital Necker-Enfants MaladesAP-HPParisFrance Necker Bio-Image Analysis INSERM US24/CNRS UMS 3633ParisFrance Platform for Metabolic Analyses Structure Fédérative de Recherche NeckerINSERM US24/CNRS UMS 3633ParisFrance Plateforme Imageries du Vivant Universitéde ParisPARCCINSERMParisFrance Service de Néphrologie Transplantation AdultesHôpital Necker-Enfants MaladesAP-HPParisFrance Service de Transplantation Hôpital La PitiéSalpétrièreAP-HPParisFrance Department of Pediatric and Adolescent Oncology INSERM 1015Gustave RoussyUniversitéParis-SaclayVillejuifFrance Service de Physiologie&Explorations Fonctionnelles Cardiovasculaires CHU de LilleLille 59000France INSERM U1163 Laboratory of Cellular and Molecular Mechanisms of Hematological Disorders and Therapeutic ImplicationsLaboratoire d’Excellence GR-ExParisFrance Division of Oncology Comprehensive Vascular Anomalies ProgramChildren’s Hospital of PhiladelphiaPhiladelphiaPAUSA Service de Médecine Vasculaire hôpital Européen Georges-PompidouParisFrance Nephrology Research Group L’Hôtel-Dieu de Québec Research CenterDepartment of MedicineFaculty of MedicineLaval UniversityQuebecQC G1R2J6Canada Unitéde médecine translationnelle et thérapies ciblées Hôpital Necker-Enfants MaladesAP-HPParisFrance CNRS UMR8253 Institut Necker-Enfants MaladesParisFrance

Sporadic venous malformations are genetic conditions primarily caused by somatic gain-of-function mutation of PIK3CA or TEK,an endothelial transmembrane receptor signaling through *** malformations are associated with pain,bleedings,thrombosis,pulmonary embolism,esthetic deformities and,in severe cases,life-threatening *** authorized medical treatment exists for patients with venous ***,we created a genetic mouse model of PIK3CA-related capillary venous malformations that replicates patient *** showed that these malformations only partially signal through AKT *** compared the efficacy of different drugs,including rapamycin,a mTORC1 inhibitor,miransertib,an AKT inhibitor and alpelisib,a PI3Kαinhibitor at improving the lesions seen in the mouse *** demonstrated the effectiveness of alpelisib in preventing vascular malformations’occurrence,improving the already established ones,and prolonging *** these findings,we were authorized to treat 25 patients with alpelisib,including 7 children displaying PIK3CA(n=16)or TEK(n=9)-related capillary venous malformations resistant to usual therapies including sirolimus,debulking surgical procedures or percutaneous *** assessed the volume of vascular malformations using magnetic resonance imaging(MRI)for each *** demonstrated improvement in all 25 *** malformations previously considered intractable were reduced and clinical symptoms were *** showed a decrease of 33.4%and 27.8%in the median volume of PIK3CA and TEK malformations respectively,over 6 months on *** conclusion,this study supports PI3Kαinhibition as a promising therapeutic strategy in patients with PIK3CA or TEK-related capillary venous malformations.

关键词： PIK3CA malformations venous