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Supramolecular Biomaterials for Cancer Immunotherapy

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Research 2024年第2期2023卷 491-509页

作者： Huan Liang Qingqing Lu Jie Yang guocan Yu College of Science Nanjing Forestry UniversityNanjing 210037P.R.China Key Laboratory of Bioorganic phosphorus chemistry&Chemical Biology Department of ChemistryTsinghua UniversityBeijing 100084P.R.China

Cancer immunotherapy has achieved tremendous successful clinical results and obtained historic victories in tumor ***,great limitations associated with feeble immune responses and serious adverse effects still cannot be neglected due to the complicated multifactorial etiology and pathologic microenvironment in *** rapid development of nanomedical science and material science has facilitated the advanced progress of engineering biomaterials to tackle critical *** supramolecular biomaterials with flexible and modular structures have exhibited unparalleled advantages of high cargo-loading efficiency,excellent biocompatibility,and diversiform immunomodulatory activity,thereby providing a powerful weapon for cancer *** past decades,supramolecular biomaterials were extensively explored as versatile delivery platforms for immunotherapeutic agents or designed to interact with the key moleculars in immune system in a precise and controllable *** this review,we focused on the crucial role of supramolecular biomaterials in the modulation of pivotal steps during tumor immunotherapy,including antigen delivery and presentation,T lymphocyte activation,tumor-associated macrophage elimination and repolarization,and myeloid-derived suppressor cell *** on extensive research,we explored the current limitations and development prospects of supramolecular biomaterials in cancer immunotherapy.

关键词： biomaterials limitations thereby

Nanozyme catalysis in a crowded environment:The impact of diffusion and surface shielding

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Nano Research 2024年第7期17卷 5795-5800页

作者： Vasily g.panferov Juewen Liu department of chemistry Waterloo Institute for NanotechnologyWaterlooOntario N2L 3G1Canada

Nanozymes are widely used in various applications as nanosized catalysts for replacing *** accurate estimation of the catalytic activity of nanozymes in real conditions is *** this article,for the first time,we systematically studied the effect of macromolecular molecules co-existing in the real system on the oxidoreductase(peroxidase,oxidase,and catalase)-mimicking nanozymes made of a gold nanoparticle core and a platinum shell,prussian Blue,Mn2O3 and CoO *** were made with horseradish *** distinguished two main mechanisms of the negative impact of macromolecules on nanozyme catalysis—slowed diffusion and surface shielding of *** the first mechanism is typical for enzymes,the second one is specific only for *** the mechanisms is essential for developing approaches to reduce the unavoidable impact of macromolecules for various analytical and biomedical applications.

关键词： molecular crowding biosensors nanoparticles

Recent Advances in 0D Ni/Co-based Hollow Electrocatalysts for Electrochemical Water Splitting

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Chemical Research in Chinese Universities 2024年第3期40卷 437-450页

作者： gE Wenjing CHEN Xiaocui MA Ruizhao ZHENg Siyuan SHANg Ningzhao ZHAO Xiaoxian department of chemistry College of ScienceHebei Agricultural UniversityBaoding 071001P.R.China

Electrochemical water splitting using renewable energy sources has been recognized as a sustainable way to produce hydrogen energy due to the characteristics of low-carbon and no ***,the slow hydrogen/oxygen evolution reactions(HER/OER)seriously hinder the practical application of large-scale water *** this paper,the 0D Ni/Co-based hollow material is discussed in detail because of adjustable morphology,low mass density and abundant active sites,which provides an effective solution for improving the HER/OER reaction *** synthesis methods of hollow materials,such as hard template,soft template and self-template are ***,catalysts with different structural designs of hollow structures are reviewed,including hollow single-shelled structure,hollow core-shelled structure,hollow double-shelled structure and hollow multi-shelled structure(HoMS)***,the research progress of the 0D Ni/Co-based HoMS electrocatalysts in recent years and their prominent performances in water splitting are ***,the challenges and development prospects of designing Ni/Co-based HoMS catalysts in water splitting in the future are discussed.

关键词： Electrochemical watersplitting Morphological regulation Hollow structure Hollow multi-shelled structure(HoMS)

Nuclearity and Finite-Representability in the System of Completely Integral Mapping Spaces

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Acta Mathematica Sinica,English Series 2024年第5期40卷 1197-1214页

作者： Zhe DONg Ji Cheng TAO Ya Fei ZHAO department of Mathematics Zhejiang UniversityHangzhou 310027P.R.China department of Mathematics China Jiliang UniversityHangzhou 310018P.R.China department of Mathematics Zhejiang International Studies UniversityHangzhou 310023P.R.China

In this paper,we investigate local properties in the system of completely integral mapping *** introduce notions of injectivity,local reflexivity,exactness,nuclearity,finite-represent ability and WEp in the system of completely integral mapping *** we obtain that any finite-dimensional operator space is injective in the system of completely integral mapping *** we prove that C is the unique nuclear operator space and the unique exact operator space in this *** also show that C is the unique operator space which is finitely representable in{T_(n)}n∈Nin this *** corollaries,Kirchberg’s conjecture and QWEp conjecture in the system of completely integral mapping spaces are false.

关键词： Completely integral mapping space injectivity exactness nuclearity finite-representability WEp

Nanomaterial Assisted Exosome Analysis Using Mass Spectrometry

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Chemical Research in Chinese Universities 2024年第2期40卷 237-254页

作者： ZHANg Yi ZHOU Bokai LI Qiuning JIN Mingshi BAI Yu Beijing National Laboratory for Molecular Sciences Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of EducationCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing100871P.R.China department of chemistry Yanbian UniversityYanji133002P.R.China

Exosomes,extracellular vesicles(EVs)that play crucial roles in biological processes,have emerged as attractive targets for noninvasive disease diagnosis and *** spectrometry(MS)offers high sensitivity,high throughput,and excellent qualification and quantification capacity,which is the ideal approach for exosome ***’unique physiochemical properties,controllable morphology,and large surface area make them promising in biological sample pretreatment and *** contributed diverse functions to the exosome MS analysis,encompassing substrates for exosome isolation and cargos enrichment,matrices for laser desorption/ionization(LDI),read-out signals and supporters for signal amplification strategies,*** this review,recent progress in the applications of nanomaterial in the exosome MS analysis was summarized and a comprehensive discussion on the challenges and perspectives was proposed for the development of an advancing analysis approach of exosomes for the accurate diagnosis and monitoring of diseases.

关键词： Exosome Nanomaterial Enrichment Matrix Mass spectrometry

Formadinium Cation Doping Stabilized Ultra-deep-blue Lead Halide perovskite Nanocrystal Light-emitting Diodes

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Chemical Research in Chinese Universities 2024年第3期40卷 556-560页

作者： pui Kei KO Jonathan E.HALpERT department of chemistry The Hong Kong University of Science and TechnologyKowloonHong Kong 999077P.R.China

The halide migration effect in mixed-halide lead-based perovskite is a serious problem hindering the development of its display *** this study,we have successfully addressed this issue by reporting formadinium(FA)doped mixed-halide perovskite nanocrystals(NCs)with ultra-deep-blue emission of 450 nm,narrow bandwidth of 16 nm,and a high photoluminescence quantum yield(pLQY)of 66%.The perovskite nanocrystal light-emitting diodes(NC-LEDs)using this nanocrystal as an active layer achieved a maximum external quantum efficiency(EQE)of 0.32%,30-fold improved compared to that of pristine and stable electroluminescence(EL)spectra at 450 nm under a 4.9–8.0 V *** findings demonstrate the potential of our approach in developing stable and efficient deep blue perovskite NC-LEDs.

关键词： Halide perovskite Light-emitting diode Deep-blue

Thermochemical co-conversion of biomass-plastic waste to biochar:a review

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green Chemical Engineering 2024年第1期5卷 31-49页

作者： Adewale george Adeniyi Kingsley O.Iwuozor Ebuka Chizitere Emenike Oluwaseun J.Ajala Samuel Ogunniyi Kabir B.Muritala department of Chemical Engineering Faculty of Engineering and TechnologyUniversity of IlorinIlorinP.M.B.1515Nigeria department of Chemical Engineering Landmark UniversityOmu-AranKwara StateP.M.B.1001Nigeria department of pure and Industrial chemistry Nnamdi Azikiwe UniversityAwkaP.M.B.5025Nigeria department of chemistry Federal University of TechnologyBosso CampusMinnaNiger StateP.M.B.65Nigeria

Biomass and plastics are two of the most common municipal solid wastes globally that have continuously placed a burden on the *** is therefore important that they are properly *** coconversion offers a valuable opportunity to recycle biomass and plastics simultaneously into biochar,which reduces the time and cost of recycling them individually while producing a material with a wide range of *** study is a review of published literature that discusses the thermochemical co-processing of biomass and plastic wastes into *** was observed that co-pyrolysis and co-hydrothermal carbonization are the most commonly utilized technologies for this *** characteristics of different biomass and plastics that have been thermochemically converted into biochar were *** properties of the resulting biochar are affected by the feedstock composition,pre-treatment and blending ratio,the reactor’s configuration,reaction temperature,and the presence of a *** studies found that treating the feedstocks separately resulted in a lower yield of biochar than processing them *** biochar created by this procedure has been used as a soil additive and as an adsorbent for water *** perspectives and suggestions,such as the necessity for some technical advancement,biochar’s economic benefits,improved government participation,and raised social awareness,were also *** factors have the potential to propel this field of study to great horizons.

关键词： Biomass Co-pyrolysis plastic Thermochemical process Valorization

Strategy for Detecting Systemic Treatment Sensitivity of primary Liver Cancer Based on a Novel Infrared-emissive Organic Nanoparticle

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Chemical Research in Chinese Universities 2024年第1期40卷 145-152页

作者： WU Jun LI Yongzhi QIN Hanjiao gAO Ying YANg Bing SHENg Jiyao ZHANg Xuewen department of Hepatobiliary and pancreatic Surgery the Second Hospital of Jilin UniversityChangchun130022P.R.China department of Radiation Oncology the Second Hospital of Jilin UniversityChangchun130022P.R.China State Key Laboratory of Supramolecular Structure and Materials Institute of Theoretical ChemistryCollege of ChemistryJilin UniversityChangchun130012P.R.China

In this study,we synthesized an organic material with near-infrared emission capabilities:4-(2-(4-(9-(4-(diphenylamino)phenyl)naphtho[2,3-c][1,2,5]thiadiazol-4-yl)phenyl)-1H-phenol-1-ylidene)malononitrile(TpA).Furthermore,TpA-p.g.000 fluorescent nanoparticles were prepared via coating the shells with ***-p.g.000 exhibited strong near-infrared emission near 700 nm,with a photoluminescence quantum yield of 15.09%,indicating a high emission *** biology experiments have confirmed its low toxicity and excellent *** cholesterol and phospholipid levels in liver cancer cell membranes with low sensitivity or high drug resistance lead to increased rigidity,reduced membrane fluidity,reduced endocytic efficiency,and reduced ***,the uptake of TpA-p.g.000 nanoparticles into cells and the near-infrared fluorescence intensity can be used to evaluate the sensitivity of systemic liver cancer treatment in a simple and efficient manner.

关键词： Nanoparticle Near-infrared Fluorescence Systemic treatment sensitivity Cell membrane fluidity

Targeting gut microbiota in osteoporosis:impact of the microbial based functional food ingredients

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Food Science and Human Wellness 2024年第1期13卷 1-15页

作者： pauline Duffuler Khushwant S.Bhullar Jianping Wu department of Agricultural Food&Nutritional Science University of AlbertaEdmonton T6G 2P5Canada

Osteoporosis is the most common bone disorder,characterized by low bone mineral density and microarchitectural deterioration of the bone tissue,which increases the susceptibility to *** the past decade,emerging research findings reported the implication of gut microbiota on bone health and osteoporosis *** patients or individuals with a lower bone mineral density exhibit an alteration of the gut microbiota at several taxonomic *** reports demonstrate that gut microbiota regulates bone metabolism through the modulation of the gut function(mineral availability and absorption,gut integrity),the immune system,and the endocrine ***,based on the vital role of gut microbiota on bone health,it has emerged as a novel therapeutic target for the prevention of bone loss and the treatment of ***-based functional food ingredients,such as probiotics,prebiotics,synbiotics,and fermented foods,have been developed to alter the gut microbiota composition and function and thus,to provide benefits to the host bone *** promising initial results,microbial-based therapies are still under ***,additional animal studies and clinical trials are needed to understand the interactions between gut microbiota and bone metabolism before further applications.

关键词： Dysbiosis Bone health probiotic prebiotic Fermented food Synbiotic