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Bioactive Materials 2023年第6期24卷 438-449页

作者： Nathan Lagneau Pierre Tournier Boris Halgand François Loll Yves Maugars Jérôme Guicheux Catherine Le Visage Vianney Delplace Nantes Université OnirisCHU NantesINSERMRegenerative Medicine and SkeletonRMeSUMR 1229F-44000France

The cellular microenvironment plays a major role in the biological functions of ***,biomaterials,especially hydrogels,which can be design to mimic the cellular microenvironment,are being increasingly used for cell encapsulation,delivery,and 3D culture,with the hope of controlling cell ***,much remains to be understood about the effects of cell-material interactions,and advanced synthetic strategies need to be developed to independently control the mechanical and biochemical properties of *** address this challenge,we designed a new hyaluronic acid(HA)-based hydrogel platform using a click and bioorthogonal strain-promoted azide-alkyne cycloaddition(SPAAC)*** approach facilitates the synthesis of hydrogels that are easy to synthesize and sterilize,have minimal swelling,are stable long term,and are *** provides bioorthogonal HA gels over an uncommonly large range of stiffness(0.5-45 kPa),all forming within 1-15 *** importantly,our approach offers a versatile one-pot procedure to independently tune the hydrogel composition(e.g.,polymer and adhesive peptides).Using this platform,we investigate the independent effects of polymer type,stiffness,and adhesion on the secretory properties of human adipose-derived stromal cells(hASCs)and demonstrate that HA can enhance the secretion of immunomodulatory factors by hASCs.

关键词： Hydrogels Click and bioorthogonal chemistry Hyaluronic acid Mesenchymal stromal cells Cell-material interactions Secretome

New insights into inflammatory osteoclast precursors as therapeutic targets for rheumatoid arthritis and periodontitis

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Bone Research 2023年第2期11卷 303-315页

作者： Emilie Hascoet Frédéric Blanchard Claudine Blin-Wakkach Jérôme Guicheux Philippe Lesclous Alexandra Cloitre Nantes Université OnirisUniv AngersCHU NantesINSERMRegenerative Medicine and SkeletonRMeSUMR1229F-44000 NantesFrance UniversitéCote d'Azur CNRSLP2M NiceFrance

Rheumatoid arthritis(RA)and periodontitis are chronic inflammatory diseases leading to increased bone *** this inflammatory bone resorption is a major health *** diseases share immunopathogenic similarities and a common inflammatory *** autoimmune response or periodontal infection stimulates certain immune actors,leading in both cases to chronic inflammation that perpetuates bone ***,RA and periodontitis have a strong epidemiological association that could be explained by periodontal microbial *** dysbiosis is believed to be involved in the initiation of RA via three mechanisms.(i)The dissemination of periodontal pathogens triggers systemic inflammation.(ii)Periodontal pathogens can induce the generation of citrullinated neoepitopes,leading to the generation of anti-citrullinated peptide autoantibodies.(iii)Intracellular danger-associated molecular patterns accelerate local and systemic ***,periodontal dysbiosis could promote or sustain bone resorption in distant inflamed ***,in inflammatory conditions,the existence of osteoclasts distinct from“classical osteoclasts”has recently been *** have proinflammatory origins and *** populations of osteoclast precursors have been described in RA,such as classical monocytes,a dendritic cell subtype,and arthritis-associated osteoclastogenic *** aim of this review is to synthesize knowledge on osteoclasts and their precursors in inflammatory conditions,especially in RA and *** attention will be given to recent data related to RA that could be of potential value in periodontitis due to the immunopathogenic similarities between the two *** our understanding of these pathogenic mechanisms should lead to the identification of new therapeutic targets involved in the pathological inflammatory bone resorption associated with these diseases.

关键词： inflammatory osteoclast period

Advances in fabricating spherical alginate hydrogels with controlled particle designs by ionotropic gelation as encapsulation systems

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Particuology 2016年第1期14卷 44-60页

作者： Jun-Yee Leong Weng-Hoong Lam Kiang-Wei Ho Wan-Ping Voo Micky Fu-Xiang Lee Hui-Peng Lim Swee-Lu Lim Beng-Ti Tey Denis Poncelet alan Lagoon Selatan Bandar Sunway Selangor 46150 Malaysia Advanced Engineering Platform Monash University Malaysia Jalan Lagoon Selatan Bandar Sunway Selangor 46150 Malaysia oniris UMR CNRS 6144 GEPEA rue de la Geraudiere BP82225 Nantes 44322 France

Alginate is a biopolymer that has exceptional gelling properties, which allow easy gel formation under safe and mild conditions. Consequently, it is often used to encapsulate a variety of cargos, such as cells, enzymes, and lipids, and is typically employed as a model to study hydrogel-based encapsulation sys- tems. Since the first use of alginate in the encapsulation field in the 1970s, many methods have been developed to produce alginate hydrogel particles of different sizes, structures, and morphologies. This review provides an overview of the current progress in the fabrication of alginate hydrogels with vari- ous particle designs, including a discussion of dispersion techniques to pre-template alginate particles, gelation mechanisms, considerations in selecting suitable fabrication methods, and future directions.

关键词： Alginate lonotropic gelation Immobilization Encapsulation Hydrogel

Prediction of Thermal Conductivity and Specific Heat of Native Maize Starch and Comparison with HMT Treated Starch

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Journal of Renewable Materials 2019年第6期7卷 535-546页

作者： Aklouche Leila Monteau Jean-Yves Rezzoug Sid-Ahmed Maugard Thierry Guihard Luc Cohendoz Stephane Maache-Rezzoug Zoulikha LaSIE UMR CNRS 7356University of La RochelleAvenue Michel Crépeau17042 La RochelleFrance GEPEA UMR CNRS 6144ONIRISRue de la Géraudière44322 NantesFrance LIENSs UMR CNRS 7266 Universitéde La RochelleFrance

Specific heat(Cp)and effective thermal conductivity(λ)of native maize starch(NS)were measured by DSC and transient heat transfer method,respectively,at different moisture contents and *** dependency of temperature(T)and moisture content(W)on the two parameters were *** thermophysical properties of treated starch(TS)by four hydrothermal processes(RP-HMT,IV-HMT,DV-HMT and FV-HMT)were measured and compared to native *** treatments were performed at 3 bars(133°C)for 10 *** Cp andλmeasurements,moisture content varied for NS from 5 to 21.5%*** from 8.8 to 25%d.b.,respectively,and was fixed at 6%*** *** models were developed to specific heat and effective thermal conductivity,using a multiple regression algorithm with subsequent statistical *** proposed models for NS based on T and W predict Cp andλwith a mean absolute error of 3.5%and 1.3%,*** differences in specific heat were observed between TS and *** a temperature range of 40 to 160°C,Cp values varied from 1.964 to 2.699 for NS and 1.380 to 2.085(J.g-1.°C-1)for *** contrast,the conductivity of NS was almost identical to that of treated starch by FV-HMT,followed in an increasing order by those treated by DV-HMT,RP-HMT,and IV-HM processes.

关键词： Starch HMT treatment specific heat effective thermal conductivity

Energy Efficiency Improvement of an Industrial Crystallization Process Using Linearizing Control

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Journal of Crystallization Process and Technology 2012年第2期2卷 44-54页

作者： Cédric Damour Michel Benne Lionel Boillereaux Brigitte Grondin-Perez Jean-Pierre Chabriat GEPEA ONIRIS Nantes France. Laboratory of Energetics Electronics and Processes University of La Reunion Saint-Denis France Laboratory of Energetics Electronics and Processes University of La Reunion Saint-Denis France 2GEPEA ONIRIS Nantes France.

This paper illustrates the benefits of a multivariable linearizing control approach applied to an industrial crystallization process. This relevant approach is declined according to two different strategies: first, a setpoint tracking is proposed for the couple crystal mass/concentration, whereas a second way consists in tracking of crystal content and concentration. The controlled variables, unavailable online, are issued from an observer developed in previous works. The performance of these strategies, which application to cane sugar crystallization constitutes a real novelty, are compared with experimental data issued from a PID-controlled industrial plant. The results reveal a significant improvement of energy efficiency, leading to an economy of more than 10% of energy.

关键词： Energy Efficiency Improvement Linearizing Control Industrial Control Phase Changing Crystallization

Entomophagy and Public Health: A Review of Microbiological Hazards

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Health 2019年第10期11卷 1272-1290页

作者： Pauline Kooh Ermolaos Ververis Vincent Tesson Géraldine Boué Michel Federighi French Agency for Food Environmental and Occupational Health & Safety Risk Assessment Department Maisons-Alfort France School of Medicine National and Kapodistrian University of Athens (NKUA) Athens Greece European Food Safety Authority Parma Italy oniris UMR 1014 SECALIM INRA/Oniris Nantes France.

The world population’s constant increase and the continuous need to ensure food safety and security are among the major challenges to be faced in the next 30 years. In addition, human diet is evolving with a decreased inclusion of proteins from animal sources. In this context, consumption of insects by humans (entomophagy) could be an alternative solution to the intake of protein derived from conventional livestock, due to the lower environmental impact of insect rearing compared to traditional farming. Furthermore, various insect species have promising nutritional profiles regarding both macro and micronutrients. Nowadays, it is recognized that about 2 billion people consume insects at a worldwide scale, with more than 2000 different species to have been reported. Since the beginning of the 2000s, mass rearing of insects for human consumption has been developing all over the world. Nevertheless edible insects are foodstuffs of animal origin and are usually consumed in their entirety, including the digestive tract, meaning that they may contain biological agents with hazardous potential (e.g. bacteria, parasites, viruses, prions, yeasts, molds, mycotoxins, histamine, and antibiotic resistance genes) and they must undergo a thorough analysis. Therefore, establishing the synthesis of the current knowledge on entomophagy and the related biological hazards is the main purpose of this review.

关键词： Entomophagy Microbial Hazards Public Health Food Safety

Development of a Synthetic Medium for the in Vitro Culture of Bovine Embryos

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Journal of Agricultural Science and Technology(A) 2014年第8期4卷 679-685页

作者： Moreno D. Neira A. Dubreil L. Liegeois L. Destrumelle S. Briand-Amirat L. Bencharif D. Tainturier D. Department of Biotechnology and Pathology of Reproduction Nantes-Atlantic National College of Veterinary Medicine FoodScience and Engineering (Oniris) Nantes 44300 France Genes Diffusion SAS Douai 59501 France UMR 703. PAnTher. INRA-Nantes-Atlantic National College of Veterinary Medicine Food Science and Engineering (Oniris)Nantes 44300 France

The aim of this study was to develop a synthetic medium for the in vitro culture of bovine embryos, using various growth factors and cytokines （GF-CYK）： insulin-like growth factorl （IGF-Ⅰ）, insulin-like growth factorⅡ （IGF-Ⅱ）, basic fibroblast growth factor （bFGF）, leukemia inhibitory factor （LIF）, granulocyte-macrophage colony stimulating factor （GM-CSF） and transforming growth factor beta Ⅰ （TGF-β1）＋ hyaluronan （HA）＋ recombinant albumin （RA）. The embryos were cultured in synthetic oviduct fluid （SOF） supplemented with： treatment 1 （T1）： bovine serum albumin （BSA）＋ insulin, transferrin and selenium （ITS）（control）; or treatment 2 （T2）： GF-CYK ＋ HA ＋ RA. The blastocyst rates were not significantly different between TI and T2, at seven days post fertilization （dpf）（28.9% ± 2.4% and 31.8% ±2.2%）, and at 8 dpf （36.5% ±2.4% and 39.1% ±1.9%）, respectively （P 〉 0.05）. The total cell number （TCN） was significantly higher with T2 than that with T1 at 7 dpf（164.9 ±5.3 and 149.7 ±4.0） and 8 dpf （182.7 ±6.4 and 165.0 ±5.5）（P 〈 0.05）. The blastocyst diameter obtained with T2 was significantly greater （P 〈 0.05） than with T1 at 7 dpf （173.3 μm ±4.9 μm and 157.2μm ±4.1 μm, respectively）, however, no significant differences were observed at 8 dpf （190.3 μm 5.2 μm and 179.7 μm ± 5.3 μm, respectively）. In conclusion, the synthetic medium （T2） shows a comparable development rate to the control medium and improves the blastocyst diameter and the TCN.

关键词： Growth factors cytokines synthetic media.

Measuring organ shift and deformation for port placement in robotassisted minimally invasive surgery

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Laparoscopic, Endoscopic and Robotic Surgery 2020年第4期3卷 99-106页

作者： Mohammad R.Maddah Cedric Dumas Olivier Gauthier Marion Fusellier Caroline G.L.Cao Department of Biomedical Industrialand Human Factors EngineeringWright State UniversityDayton OHUSA IMT Atlantique NantesFrance Laboratoire des Sciences du Numerique de Nantes(LS2N) NantesFrance oniris Nantes-Atlantic College of Veterinary MedicineFood Science and EngineeringNantesFrance

Objective:Port placement is a crucial pre-operative task in robot-assisted minimally invasive *** to the insufflation process,the abdominal shape is deformed while the internal organs are shifted in *** changes need to be considered when determining the optimal port locations for the robotic ***,intra-operative medical image acquisition systems are not always *** this study,we aim to estimate the shift extent of the abdominal organs in humans by measuring the changed volume and position of the abdominal organs before and after insufflation in three ***:A 3D model of the abdomen and abdominal organs was reconstructed from 3D images of the pigs taken by an MRI scanner before and after *** shift and shape changes of the abdominal organs after insufflation were *** corresponding shift in port location for the robotic manipulators was determined based on the abdominal ***:Organ movements as a result of insufflation ranged from 6.37±0.10 cm for the spleen,to 1.64±0.22 cm for the *** a slight planar motion of the target organ(e.g.,1.33±0.06 cm,2.38±0.21 cm in X-Y plane for the left kidney)can shift the access port for the robot manipulator by about 1.6 cm on the abdominal ***:The target organs’motion due to insufflation is a critical factor in determining port locations in robot-assisted minimally invasive surgery.

关键词： Insufflation 3D abdominal model Organ shift Volume changes

Experimental investigation and numerical modeling of the hydration operation of date fruits

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International Journal of Modeling, Simulation, and Scientific Computing 2017年第2期8卷 55-71页

作者： Atef Lakoud Sebastien Curet Mnasser Hassouna Ecole Superieure des Industries Alimentaires de Tunis 58 Av.Alain Savary Tunis El Khadra1003Tunisia L’UNAM Universite ONIRISCNRSGEPEAUMR 6144 site de la GeraudiereNantesF-44322France Ecole Sup´erieure des Industries Alimentaires de Tunis 58 Av.Alain Savary Tunis El Khadra1003Tunisia

Hydration represents the main unit operation in the industrial thermal process of dry *** this work,Tunisian Deglet Nour dates were hydrated experimentally at a laboratory scale by using saturated air as it is commonly undertaken in *** study focuses on the modeling of this unit operation in order to control the moisture uptake phenomenon during processing.A physic-based simplified numerical model describing moisture transfer during hydration was implemented in COMSOL rMultiphysics soft*** model considers the real geometry of dates instead of approaching the fruits by simplified *** diffusivities of two types of Deglet Nour dry dates characterized by different maturation stages were *** showed a good agreement between experimental and numerically computed values of average moisture *** profile in dates flesh was computed numerically using estimated moisture dif*** numerical model proposed in this work could be therefore employed as a predictive tool to simulate and optimize the hydration operation of dates.

关键词： Moisture diffusivity convective coefficient moisture profile.

Comparison of Different Regularized and Shrinkage Regression Methods to Predict Daily Tropospheric Ozone Concentration in the Grand Casablanca Area

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Advances in Pure Mathematics 2018年第10期8卷 793-812页

作者： Halima Oufdou Lise Bellanger Amal Bergam Angélina El Ghaziri Kenza Khomsi El Mostafa Qannari Laboratory MAE2D University of Abdelmalek Essaadi Larache Morocco Laboratory of Mathematics Jean Leray UMR CNRS 6629 University of Nantes Nantes France Maison des Sciences de l’Homme Ange Guépin USR 3491 University of Nantes Nantes France National Meteorological Office Casablanca Morocco StatSC ONIRIS INRA Nantes France

Tropospheric ozone (O3) is one of the pollutants that have a significant impact on human health. It can increase the rate of asthma crises, cause permanent lung infections and death. Predicting its concentration levels is therefore important for planning atmospheric protection strategies. The aim of this study is to predict the daily mean O3 concentration one day ahead in the Grand Casablanca area of Morocco using primary pollutants and meteorological variables. Since the available explanatory variables are multicollinear, multiple linear regressions are likely to lead to unstable models. To counteract the multicollinearity problem, we compared several alternative regression methods: 1) Continuum Regression;2) Ridge & Lasso Regressions;3) Principal component regression (PCR);4) Partial least Square regression & sparse PLS and;5) Biased Power Regression. The aim is to set up a good prediction model of the daily ozone in the Grand Casablanca area. These models are fitted on a training data set (from the years 2013 and 2014), tested on a data set (from 2015) and validated on yet another data set data (from 2015). The Lasso model showed a better performance for the prediction of ozone concentrations compared to multiple linear regression and its other alternative methods.

关键词： Multiple Linear Regression Multicollinearity Penalized Regression Statistical Forecasting Tropospheric Ozone