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Human induced pluripotent stem cell-derived therapies for regeneration after central nervous system injury

Neural Regeneration Research 2025年第11期20卷 3063-3075页

作者： Stephen Vidman Yee Hang Ethan Ma Nolan Fullenkamp Giles W.Plant Department of Neuroscience Ohio State UniversityColumbusOHUSA

In recent years,the progression of stem cell therapies has shown great promise in advancing the nascent field of regenerative *** the non-regenerative nature of the mature central nervous system,the concept that“blank”cells could be reprogrammed and functionally integrated into host neural networks remained *** work has also demonstrated the ability of such cells to stimulate intrinsic growth programs in post-mitotic cells,such as *** embryonic stem cells demonstrated great potential in treating central nervous system pathologies,ethical and technical concerns *** barriers,along with the clear necessity for this type of treatment,ultimately prompted the advent of induced pluripotent stem *** advantage of pluripotent cells in central nervous system regeneration is multifaceted,permitting differentiation into neural stem cells,neural progenitor cells,glia,and various neuronal *** precise spatiotemporal application of extrinsic growth factors in vitro,in addition to microenvironmental signaling in vivo,influences the efficiency of this directed *** the pluri-or multipotency of these cells is appealing,it also poses the risk of unregulated differentiation and teratoma *** of the neuroectodermal lineage,such as neuronal subpopulations and glia,have been explored with varying degrees of *** the risk of cancer or teratoma formation is greatly reduced,each subpopulation varies in effectiveness and is influenced by a myriad of factors,such as the timing of the transplant,pathology type,and the ratio of accompanying progenitor ***,successful transplantation requires innovative approaches to develop delivery vectors that can mitigate cell death and support ***,host immune responses to allogeneic grafts must be thoroughly characterized and further developed to reduce the need for *** to a clinical setting wi

关键词： axon regeneration central nervous system regeneration induced pluripotent stem cells neurotrauma regenerative medicine spinal cord injury stem cell therapy

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The Effect of Reaction Conditions on the Synthesis of Thermoplastic Elastomers Containing Polyalloocimene, Polyisobutylene and Tapered Blocks

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Chinese Journal of Polymer Science 2019年第9期37卷 884-890页

作者： Jozsef Kantor Judit E. Puskas Gabor Kaszas Department of Chemical and Biomolecular Engineering The University of Akron Akron OH 44325 USA Department of Food Agricultural and Biological Engineering (1/1/2019) The Ohio State University Wooster OH 44691 USA PolyFiberMatrix LLC 2295 W. Market St. Suite D. Akron OH 44313 USA

This work investigates the effect of reaction conditions on the copolymerization of isobutylene (IB) with alloocimene (Allo) in methyl chloride (MeCl) using AlCh and ethylaluminum dichloride (EtAlCh) as coinitiators and adventitious moisture as the initiator. Both AlCh and EtAlCb produced high molecular weight (Mn > 1.0 x 10^5 g/mol) thermoplastic elastomers (TPEs) with good mechanical properties in short reaction time (< 10 min). These unique TPEs have unsaturations in the end blocks, leading to easy functionalization and/or crosslinking.

关键词： Polyisobutylene Alloocimene Triblock copolymer Carbocationic polymerization

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Extreme Weather Disruptions and Emergency Preparedness Among Older Adults in ohio: An Eight-County Assessment

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International Journal of Disaster Risk Science 2024年第2期15卷 213-225页

作者： Smitha Rao Fiona C.Doherty Anthony Traver Marisa Sheldon Emma Sakulich Holly Dabelko‑Schoeny College of Social Work The Ohio State UniversityColumbusOH 43210USA Age Friendly Innovation Center College of Social WorkThe Ohio State UniversityColumbusOH 43210USA College of Public Health The Ohio State UniversityColumbusOH 43210USA

The disproportionate risks and impacts of climate change and extreme weather on older adults are increasingly evident. While especially true in disaster-prone areas, human-caused climate change introduces an element of uncertainty even in previously identified “safe” regions such as the Midwestern United States. Using a cumulative disadvantage and vulnerability-informed framework and descriptive statistics from multiple data sources, this article provides an overview of climate impacts, vulnerabilities, and county-level characteristics, focusing on older adults living in Central ohio. A comparative multiple-case study methodology was used to triangulate regionally representative primary and secondary data sources to examine state and county-level measures of vulnerability, emergency preparedness, and disruptions caused by extreme weather among older adults across eight counties in Central ohio. Seventy-eight percent of older adults in the sample reported being prepared for emergencies per Federal Emergency Management Agency guidelines. Older adults in Union County reported the highest rates of preparedness, while those in Fayette County reported the lowest. County-level rates of disruption of life activities by extreme weather ranged widely. Among the most rural in the region, Fayette County emerged as uniquely disadvantaged, with the lowest median income, the most vulnerable across multiple social vulnerability dimensions, and the most reported disruptions to life activities from extreme weather. County profiles offer a snapshot of existing vulnerabilities, socioeconomic conditions, special needs, preparedness, and current disruptions among older adults in the region and can inform resource mobilization across community and policy contexts.

关键词： Disaster preparedness Extreme weather Midwestern United States Older adults Regional assessment Social vulnerability

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Co-delivery of mRNA and SPIONs through amino-ester nanomaterials

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Nano Research 2018年第10期11卷 5596-5603页

作者： Xiao Luo Weiyu Zhao Bin Li Xinfu Zhang Chengxiang Zhang Anna Bratas Binbin Deng David W. McComb Yizhou Dong Division of Pharmaceutics and Pharmaceutical Chemistry College of Pharmacy The Ohio State University Columbus Ohio 43210 USA Small Animal Imaging Core The Ohio State University Columbus Ohio 43210 USA Center for Electron Microscopy and Analysis Department of Materials Science and Engineering The Ohio State University Columbus Ohio 43210 USA Department of Biomedical Engineering The Ohio State University Columbus Ohio 43210 USA The Center for Clinical and Translational Science The Ohio State University Columbus Ohio 43210 USA The Comprehensive Cancer Center The Ohio State University Columbus Ohio 43210 USA Dorothy M. Davis Heart & Lung Research Institute The Ohio State University Columbus Ohio 43210 USA Department of Radiation Oncology The Ohio State University Columbus Ohio 43210 USA

Nanoparticles have been widely explored for combined therapeutic and diagnostic applications. For example, lipid-based nanoparticles have been used to encapsulate multiple types of agents and achieve multi-functions. Herein, we enabled a co-delivery of mRNA molecules and superparamagnetic iron oxide nanoparticles （SPIONs） by using an amino-ester lipid-like nanomaterial. An orthogonal experimental design was used to identify the optimal formulation. The optimal formulation, MPA-Ab-8 LLNs, not only showed high encapsulation of both mRNA and SPIONs, but also increased the r2 relaxivity of SPIONs by more than 1.5-fold in vitro. MPA-Ab-8 LLNs effectively delivered mRNA and SPIONs into cells, and consequently induced high protein expression as well as strong MRI contrast. Consistent herewith, we observed both mRNA-mediated protein expression and an evident negative contrast enhancement of MRI signal in mice. In conclusion, amino-ester nanomaterials demonstrate great potential as delivery vehicles for theranostic applications.

关键词： amino-ester nanomaterials lipid-like nanoparticles(LLNs) dual-functional superparamagnetic iron oxide nanoparticles(SPIONs) mRNA delivery magnetic resonance imaging (MRI)

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Benefits of Stochastic Optimization for Scheduling Energy Storage in Wholesale Electricity Markets

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Journal of Modern Power Systems and Clean Energy 2021年第1期9卷 181-189页

作者： Hyeong Jun Kim Ramteen Sioshansi Antonio J.Conejo the Department of Integrated Systems Engineering The Ohio State UniversityColumbusOhioUSA the Department of Electrical and Computer Engineering The Ohio State UniversityColumbus.OhioUSA

We propose a two-stage stochastic model for optimizing the operation of energy storage. The model captures two important features: uncertain real-time prices when day-ahead operational commitments are made;and the price impact of charging and discharging energy storage. We demonstrate that if energy storage has full flexibility to make real-time adjustments to its day-ahead commitment and market prices do not respond to charging and discharging decisions, there is no value in using a stochastic modeling framework, i.e., the value of stochastic solution is always zero. This is because in such a case the energy storage behaves purely as a financial arbitrageur day ahead, which can be captured using a deterministic *** show also that prices responding to its operation can make it profitable for energy storage to "waste" energy, for instance by charging and discharging simultaneously, which is normally sub-optimal. We demonstrate our model and how to calibrate the price-response functions from historical data with a practical case study.

关键词： Energy storage stochastic optimization value of stochastic solution electricity market

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Three-dimensional models: from cell culture to Patient-Derived Organoid and its application to future liposarcoma research

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Oncology research 2025年第1期33卷 1-13页

作者： Sayumi Tahara Sydney Rentsch Fernanda Costas Casal DE Faria Patricia Sarchet Roma Karna Federica Calore Raphael E Pollock Department of Surgery Division of Surgical Oncology The James Comprehensive Cancer Center The Ohio State University Wexner Medical Center Columbus OH 43210 USA. Department of Cancer Biology and Genetics The James Comprehensive Cancer Center The Ohio State University Wexner Medical Center Columbus OH 43210 USA.

Liposarcoma is one of the most common soft tissue sarcomas, however, its occurrence rate is still rare compared to other cancers. Due to its rarity, experiments are an essential approach to elucidate liposarcoma pathobiology. Conventional cell culture-based research (2D cell culture) is still playing a pivotal role, while several shortcomings have been recently under discussion. , mouse models are usually adopted for pre-clinical analyses with expectations to overcome the issues of 2D cell culture. However, they do not fully recapitulate human dedifferentiated liposarcoma (DDLPS) characteristics. Therefore, three-dimensional (3D) culture systems have been the recent research focus in the cell biology field with the expectation to overcome at the same time the disadvantages of 2D cell culture and animal models and fill in the gap between them. Given the liposarcoma rarity, we believe that 3D cell culture techniques, including 3D cell cultures/co-cultures, and Patient-Derived tumor Organoids (PDOs), represent a promising approach to facilitate liposarcoma investigation and elucidate its molecular mechanisms and effective therapy development. In this review, we first provide a general overview of 3D cell cultures compared to 2D cell cultures. We then focus on one of the recent 3D cell culture applications, Patient-Derived Organoids (PDOs), summarizing and discussing several PDO methodologies. Finally, we discuss the current and future applications of PDOs to sarcoma, particularly in the field of liposarcoma.

关键词： Cell culture Liposarcoma Patient-Derived Organoid (PDO) Spheroid Three-dimensional (3D) cell culture

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Machine Learning-Based Presymptomatic Detection of Rice Sheath Blight Using Spectral Profiles

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Plant Phenomics 2020年第1期2卷 314-323页

作者： Anna O.Conrad Wei Li Da-Young Lee Guo-Liang Wang Luis Rodriguez-Saona Pierluigi Bonello Department of Plant Pathology The Ohio State UniversityColumbusOhioUSA Department of Food Science and Technology The Ohio State UniversityColumbusOhioUSA

Early detection of plant diseases,prior to symptom development,can allow for targeted and more proactive disease *** objective of this study was to evaluate the use of near-infrared(NIR)spectroscopy combined with machine learning for early detection of rice sheath blight(ShB),caused by the fungus Rhizoctonia *** collected NIR spectra from leaves of ShBsusceptible rice(Oryza sativa L.)cultivar,Lemont,growing in a growth chamber one day following inoculation with ***,and prior to the development of any disease *** vector machine(SVM)and random forest,two machine learning algorithms,were used to build and evaluate the accuracy of supervised classification-based disease predictive *** partial least squares discriminant analysis was used to confirm the *** most accurate model comparing mockinoculated and inoculated plants was SVM-based and had an overall testing accuracy of 86.1%(N=72),while when control,mock-inoculated,and inoculated plants were compared the most accurate SVM model had an overall testing accuracy of 73.3%(N=105).These results suggest that machine learning models could be developed into tools to diagnose infected but asymptomatic plants based on spectral profiles at the early stages of disease *** testing and validation in field trials are still needed,this technique holds promise for application in the field for disease diagnosis and management.

关键词： blight forest cultivar

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High-grade pancreatic intraepithelial lesions： prevalence and implications in pancreatic neoplasia

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Hepatobiliary & Pancreatic Diseases International 2017年第2期16卷 202-208页

作者： Jean R Park Feng Li Veeral M Oza Brett C Sklaw Kevin M Cronley Michael Wellner Benjamin Swanson Somashekar G Krishna Division of Hospital Medicine The Ohio State University Wexner Medical Center Columbus Ohio USA Division of Gastroenterology Hepatology and Nutrition The Ohio State University Wexner Medical Center Columbus Ohio USA Department of Pathology The Ohio State University Wexner Medical Center Columbus Ohio USA

BACKGROUND： High-grade pancreatic intraepithelial neoplasia（Pan IN-3）, a precursor of pancreatic ductal adenocarcinoma（PDAC）, is not universally detected in resected pancreatic neoplasms. We sought to determine the prevalence and prognostic relevance of Pan IN-3 lesions in primary surgical resections of PDACs and intraductal papillary mucinous neoplasms（IPMNs）.METHODS： A retrospective review of a tertiary care center pathology database（1/2000-6/2014） was performed. Demographics, imaging, pathology, disease-recurrence, and survival data were ***： A total of 458 patients who underwent primary pancreatic resection were included. “Pan IN-3” lesions were found in 74（16.2%） patients who either had PDAC（n=67） or main duct（MD）-IPMN（n=7）. Among IPMN-MDs, Pan IN-3 lesions were exclusively found in those with pathological evidence of chronic pancreatitis. For PDACs, the median overall survival（OS） for pancreata with Pan IN-3 lesions was significantly better than those without（OS 1.12 years, interquartile range [IQR] 0.72, 2.05 years vs OS 0.86 years, IQR 0.64,1.60 years respectively; P=0.04）. Multivariate Cox regression analysis demonstrated that the presence of Pan IN-3 lesions was associated with a reduced risk of death（HR=0.43; 95% CI： 0.23-0.82; P=0.01）.CONCLUSIONS： Following primary resection of pancreatic adenocarcinoma, the lower survival observed in patients without Pan IN-3 lesions might suggest a state of complete or accelerated transformation. Further investigations are necessary to validate these findings that might impact disease prognosis and management.

关键词： pancreatic intraepithelial neoplasia intraductal papillary mucinous neoplasms pancreatic neoplasia pancreatic ductal adenocarcinoma

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No-till and conservation agriculture in the United States:An example from the David Brandt farm,Carroll,ohio

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International Soil and Water Conservation Research 2014年第1期2卷 97-107页

作者： R.Islam R.Reeder Soil Water and Bioenergy ResourcesOhio State University South CentersOH Agricultural and Biological Engineering Dept. Ohio State University

No-till(NT)farming(conservation agriculture)began in the US in the *** state of ohio has a university research location that began no-till research in 1962.A few innovative ohio farmers,including NT pioneers David Brandt and Bill Richards,were early adopters of the new conservation ***,no-till was most successful on sloping,well drained soils,then with improvements to the system,including cover crops,it became more widely adopted on all soil *** Brandt was an enthusiastic learner and teacher of no-till practices,working with chemical company representatives and Cooperative Extension Specialists to demonstrate the *** Brandt’s cooperation with ohio State University researchers continues to provide a valuable site for studying the long term changes in soil health and ecosystem *** showed that total microbial biomass as one of the soil biological health indicators significantly increased with an associated decrease in carbon(C)loss under NT compared with conventional tilled soil(CT).Under NT,there was significantly higher total C and total N compared to *** C,as a composite measure of soil health,significantly increased with *** cover crops,especially cover crop cocktail mixes,were used,NT substantially improved soil ***-term NT with cover crop cocktail mixes significantly increased the soil aggregate stability,compared with *** overall rate of C sequestration by NT suggested that the soils on the Brandt farm act as a consistent sink of atmospheric CO2 although this tends to level off after about 20 *** Brandt farm showed that crop yields are increased under long-term NT with cover crops *** suggested that starting with a cover crop when switching from CT to NT,is more likely to ensure success and to maintain economic crop *** early adopter,Bill Richards,from Circleville,ohio,also became a national leader and promoter of no-till *** served as head of the United Sta

关键词： Innovation Eco-farming Corn Soybeans Wheat Cover crops Carbon sequestration Soil organic matter Agroecosystems Carbon management index Farm bill Government policy

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Control of Directional Macromolecular Trafficking Across Specific Cellular Boundaries:A Key to Integrative Plant Biology

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Journal of Integrative Plant Biology 2007年第8期49卷 1227-1234页

作者： BiaoDing AsukaItaya Department of Plant Cellular and Molecular Biology and Plant Biotechnology Center Ohio State University ColumbusOhio 43210USA The OSU RNA GroupOhio State UniversityColumbusOhio 43210USA MolecularCellular and Developmental Biology ProgramOhio State UniversityColumbusOhio 43210USA

There is now solid evidence that cell-to-cell trafficking of certain proteins and RNAs plays a critical role in trans-cellular regulation of gene expression to coordinate cellular differentiation and development. Such trafficking also is critical for viral infection and plant defense. The mechanisms of trafficking remain poorly understood. Although some proteins may move between cells by diffusion, many proteins and RNAs move in a highly regulated fashion. Regulation is likely achieved through interactions between distinct protein or RNA motifs and cellular factors. Some motifs and factors have been identified. One of the major focuses for future studies is to identify all motifs and their cognate factors and further elucidate their roles in trafficking between specific cells. With increasing information from such studies, we should be able to develop an understanding of the mechanisms that regulate trafficking of various proteins and RNAs across all and specific cellular boundaries. On the basis of such mechanistic knowledge, we can further investigate how the trafficking machinery has evolved to regulate developmental and physiological processes in a plant, how pathogens have co-evolved to use this machinery for systemic spread in a plant, and how plants use this machinery for counterdefense.

关键词： CAPRICE GLABRA3 KNOTTED-I phloem plasmodesmata protein trafficking RNA trafficking SHORT-ROOT viral movementprotein viroid

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