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Asian pacific Journal of Reproduction 2024年第2期13卷 60-67页

作者： Yasmin Sabina Sa’diah Agung Dewanto Lukman A Chandra department of Obstetrics and Gynecology Faculty of MedicinePublic Health and NursingUniversitas Gadjah MadaYogyakartaIndonesia department of Pharmacology and therapy Faculty of MedicinePublic Health and NursingUniversitas Gadjah MadaYogyakartaIndonesia

Objective:To conduct a systematic examination and meta-analysis of the most reliable data from experimental studies evaluating the efficacy of autologous platelet-rich plasma(PRP)on low ovarian ***:A comprehensive search was performed utilizing pertinent search terms across electronic databases,including PubMed,Cochrane,and Google *** included studies that assigned infertile women with low ovarian reserve in experimental *** reserve parameters were measured before and after PRP injection into *** data of each study was retrieved and subsequently ***:Of 301 articles collected and reviewed,six studies were finally included in the *** PRP injection,infertile women showed a non-significant increase in anti-Mullerian hormone(AMH)level(MD=0.10;95%CI-0.04,0.23),a significant increase in antral follicular count(AFC)(MD=1.88;95%CI 0.47,3.29),and a non-significant reduction in follicle-stimulating hormone(FSH)level(MD=-0.22;95%CI-8.32,7.87).Conclusions:Autologous PRP may increase AFC,but not *** it is found beneficial in enhancing ovarian reserve(AFC),further research with strong evidence is still required.

关键词： Platelet-rich plasma Low ovarian reserve Ovarian rejuvenation

Independent and Combined Associations of Sleep Duration, Bedtime, and Polygenic Risk Score with the Risk of Hearing Loss among Middle-Aged and Old Chinese: The Dongfeng–Tongji Cohort Study

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Research 2024年第1期2023卷 721-733页

作者： Miao Liu Haiqing Zhang Zhichao Wang Tingting Mo Xuefeng Lai Yaling He Minghui Jiang Meian He Weijia Kong Tangchun Wu Xiaomin Zhang department of occupational and Environmental Health Ministry of Education Key Laboratory of Environment and Healthand State Key Laboratory of Environmental Health(Incubating)School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiChina department of Otorhinolaryngology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiChina department of Epidemiology and Biostatistics School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiChina

Evidence available on the independent and combined associations of sleep duration,bedtime,and genetic predisposition with hearing loss was *** present study included 15,827 participants from the Dongfeng–Tongji cohort *** risk was characterized by polygenic risk score(PRS)based on 37 genetic loci related to hearing *** conducted multivariate logistic regression models to assess the odds ratio(OR)for hearing loss with sleep duration and bedtime,as well as the joint association and interaction with *** showed that hearing loss was independently associated with sleeping≥9 h/night compared to the recommended 7 to9:00 *** 10:00 *** to those with bedtime>10:00 *** 11:00 p.m.,with estimated ORs of 1.25,1.27,and 1.16,respectively.

关键词： Middle hearing fen

Long noncoding RNAs HAND2-AS1 ultrasound microbubbles suppress hepatocellular carcinoma progression by regulating the miR-873-5p/tissue inhibitor of matrix metalloproteinase-2 axis

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1547-1563页

作者： Qiang Zou Hao-Wen Wang Xi-Liang Di Yuan Li Hui Gao department of Interventional therapy Tianjin Medical University Cancer Institute and HospitalTianjin 300060China National Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and TherapyTianjin’s Clinical Research Center for CancerTianjin 300060China College of Animal Science and Technology Northeast Agricultural UniversityHarbin 150030Heilongjiang ProvinceChina department of Hematology and Oncology Linyi People’s HospitalLinyi 251500Shandong ProvinceChina department of Comprehensive Oncology Baotou Cancer HospitalBaotou 014030Inner Mongolia Autonomous RegionChina

BACKGROUND Increasing data indicated that long noncoding RNAs(lncRNAs)were directly or indirectly involved in the occurrence and development of tumors,including hepatocellular carcinoma(HCC).Recent studies had found that the expression of lncRNA HAND2-AS1 was downregulated in HCC tissues,but its role in HCC progression is *** targeted microbubble destruction mediated gene transfection is a new method to overexpress *** To study the role of ultrasound microbubbles(UTMBs)mediated HAND2-AS1 in the progression of HCC,in order to provide a new reference for the treatment of *** In vitro,we transfected HAND2-AS1 siRNA into HepG2 cells by UTMBs,and detected cell proliferation,apoptosis,invasion and epithelial-mesenchymal transition(EMT)by cell counting kit-8 assay,flow cytometry,Transwell invasion assay and Western blotting,*** addition,we transfected miR-837-5p mimic into UTMBs treated cells and observed the changes of cell ***,the UTMBs treated HepG2 cells were transfected together with miR-837-5p mimic and tissue inhibitor of matrix metalloproteinase-2(TIMP2)overexpression vector,and we detected cell proliferation,apoptosis,invasion and *** vivo,we established a mouse model of subcutaneous transplantation of HepG2 cells and observed the effect of HAND2-AS1 silencing on tumor formation *** We found that UTMBs carrying HAND2-AS1 restricted cell proliferation,invasion,and EMT,encouraged apoptosis,and HAND2-AS1 silencing eliminated the effect of ***,miR-873-5p targets the gene HAND2-AS1,which also targets the 3’UTR of *** miR-873-5p mimic counteracted the impact of ***,miR-873-5p mimic solely or in combination with pcDNA-TIMP2 had been transformed into HepG2 cells exposed to *** discovered that TIMP2 reversed the effect of miR-873-5p mimic caused by the blocked signalling cascade for matrix metalloproteinase(MMP)2/*** vivo results showed that HAND2-AS1 silencing sig

关键词： Hepatocellular carcinoma Ultrasound microbubbles Long noncoding RNA HAND2-AS1 miR-873-5p Tissue inhibitor of matrix metalloproteinase-2

Associations of heavy metal mixtures with blood pressure among *** in NHANES 2017-2018 by four statistical models

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Chinese Medical Journal 2024年第5期137卷 628-630页

作者： Luli Wu Shixuan Zhang Junrou Zhang Ye Xin Piye Niu Jie Li department of occupational and Environmental Health School of Public HealthCapital Medical UniversityBeijing 100069China Beijing Key Laboratory of Environmental Toxicology School of Public HealthCapital Medical UniversityBeijing 100069China department of Nutrition Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China

To the Editor:Hypertension is one of the leading risk factors for cardiovascular disease and affects approximately 30%of the adult population.^([1,2])Environmental heavy metal pollution is an important public health *** metals may increase the risk of hypertension or other cardiovascular diseases,even beyond the influence of conventional behavioral risk factors.^([3])Meanwhile certain essential trace elements,such as selenium,zinc,and iron,are involved in various enzyme reactions directly related to blood pressure regulation and are beneficial to the human body within a specific range.^([4])The analysis of health outcomes specific to metal mixtures is challenging by nonlinear relationships and interactions between toxic metals and essential trace elements.^([5])The development of innovative statistical methods for analyzing mixtures has greatly facilitated the exploration of the health effects of multiple pollutant exposures,such as Bayesian kernel machine regression(BKMR)and quantile g-computation(QG-C).

关键词： cardiovascular diseases mixtures

Comparing the effects of dual-task training and single-task training on walking,balance and cognitive functions in individuals with Parkinson’s disease:A systematic review

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Chinese Medical Journal 2024年第13期137卷 1535-1543页

作者： Xiaoying Lin Yanming Zhang Xiaowei Zhang Xi Chen Jianhua Liu Lei Yang Marco Yiu Chung Pang department of Rehabilitation Medicine the First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi 710061China department of Rehabilitation Medicine The Second People’s Hospital of KunmingKunmingYunnan 650051China department of Rehabilitation Medicine Xuanwu HospitalCapital Medical UniversityBeijing 100000China department of Physical therapy China Rehabilitation Research CenterBeijing 100000China department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHong Kong 999077China

Background:This systematic review aimed to examine whether dual-task(DT)training was superior to single-task(ST)training in improving DT walking,balance and cognitive functions for individuals with Parkinson’s disease(PD).Methods:Literature search was performed in the following electronic databases:PubMed,the Cochrane Library,Web of Science,and Metstr covering inception to May 10,*** in order to facilitate comparison across trials,we calculated the effect size(Hedges’g)of gait,balance,cognitive,and other parameters under both ST and DT conditions,using the mean change score and standard deviation(SD)of change score of the experimental and control *** controlled trials that examined the effects of DT motor and cognitive training in individuals with Parkinson’s disease were included for this systematic ***:A total of 214 participants recruited from six articles(actually five trials)were involved in this *** terms of walking ability,only double support time and stride time variability showed significant between-group difference(Hedges’g=0.34,0.18,respectively).Compared to ST training group,DT training group had a more improvement effect in laboratory balance measurement(Hedges’g=0.18,1.25),but no significant improvement in clinical balance *** significant between-group differences were observed,thus its training effect on cognitive function was ***:The DT training failed to achieve promising results better than ST training in improving DT walking and balance functions for individuals with *** firm conclusion cannot be drawn at present,due to the limited number of eligible *** sample size and high-quality studies are needed to investigate the effectiveness of DT training in individuals with PD.

关键词： Parkinson’s disease Dual-task training Mobility Cognition Systematic review

Double contrast-enhanced ultrasonography improves diagnostic accuracy of T staging compared with multi-detector computed tomography in gastric cancer patients

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World Journal of Gastroenterology 2024年第23期30卷 3005-3015页

作者： Yan-Fen Xu Hui-Yun Ma Gui-Ling Huang Yu-Ting Zhang Xue-Yan Wang Ming-Jie Wei Xiao-Qing Pei department of Ultrasound State Key Laboratory of Oncology in South ChinaGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapyGuangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou 510060Guangdong ProvinceChina department of Radiology State Key Laboratory of Oncology in South ChinaGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapyGuangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou 510060Guangdong ProvinceChina department of Medical Ultrasound State Key Laboratory of Oncology in South ChinaGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapyGuangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou 510060Guangdong ProvinceChina

BACKGROUND Gastric cancer(GC)is the most common malignant tumor and ranks third for cancer-related deaths among the *** disease poses a serious public health problem in China,ranking fifth for incidence and third for *** of the invasive depth of the tumor is vital to treatment *** To evaluate the diagnostic performance of double contrast-enhanced ultrasonography(DCEUS)for preoperative T staging in patients with GC by comparing with multi-detector computed tomography(MDCT).METHODS This single prospective study enrolled patients with GC confirmed by preoperative gastroscopy from July 2021 to March *** underwent DCEUS,including ultrasonography(US)and intravenous contrast-enhanced ultrasonography(CEUS),and MDCT examinations for the assessment of preoperative T *** of GC were identified on DCEUS and criteria developed to evaluate T staging according to the 8th edition of AJCC cancer staging *** diagnostic performance of DCEUS was evaluated by comparing it with that of MDCT and surgical-pathological findings were considered as the gold *** A total of 229 patients with GC(80 T1,33 T2,59 T3 and 57 T4)were *** accuracies were 86.9%for DCEUS and 61.1%for MDCT(P<0.001).DCEUS was superior to MDCT for T1(92.5%vs 70.0%,P<0.001),T2(72.7%vs 51.5%,P=0.041),T3(86.4%vs 45.8%,P<0.001)and T4(87.7%vs 70.2%,P=0.022)staging of *** DCEUS improved the diagnostic accuracy of preoperative T staging in patients with GC compared with MDCT,and constitutes a promising imaging modality for preoperative evaluation of GC to aid individualized treatment decision-making.

关键词： Double contrast-enhanced ultrasonography Multi-detector computed tomography Gastric cancer T staging

Two Photosensitive Dermatitis Outbreaks Caused by Cordierites frondosus—Chuxiong Yi Autonomous Prefecture,Yunnan Province,China,2023

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China CDC weekly 2024年第24期6卷 580-584页

作者： Jiaju Zhong Hongshun Zhang Chengmin Yu Jipin Li Yizhe Zhang Jiaqi Liang Chengye Sun Qunmei Yao National Institute of occupational Health and Poison Control Chinese Center for Disease Control and PreventionBeijingChina department of Emergency Medicine The People’s Hospital of Chuxiong Yi Autonomous PrefectureChuxiong CityYunnan ProvinceChina

Summary What is already known about this topic?Cordierites frondosus(***)is a species of toxic mushroom known to induce symptoms of photosensitive *** is added by this report?In the months of May and June 2023,a total of four patients in Chuxiong Yi Autonomous Prefecture,Yunnan Province,were affected by *** poisoning,occurring over two distinct *** condition of two patients deteriorated after they were re-exposed to sunlight on the seventh day following the initial poisoning.

关键词： Prefecture poisoning breaks

Analysis of The Effect of Bundled Nursing Intervention on Lung Cancer Patients with a High Risk of PICC-Related Thrombosis

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Journal of Clinical and Nursing Research 2024年第4期8卷 231-236页

作者： Jia Meng Jianglin Zang Tianyu Gao Boyang Wu Xiaoyang Guo Wei Liu Radiation therapy department Affiliated Hospital of Hebei UniversityBaoding 071000China

Objective: To explore the effect of bundled nursing intervention on lung cancer patients with a high risk of PICC-related thrombosis. Methods: Eighty-six PICC patients were selected and randomly divided into a control group and an observation group of 43 patients each. The control group received general nursing care and the observation group received bundled nursing intervention based on the control group. The occurrence of venous thrombosis, quality of life score, Zung self-rating depression scale (SDS) score, self-rating anxiety (SAS) score, and nursing satisfaction after treatment were compared between the two groups. Results: The incidence rate of PICC-related venous thrombosis in the observation group (2/4.652%) was lower than that of the control group (13/30.231%) after nursing intervention (P < 0.05). After the intervention, the quality-of-life scores of the observation group were higher than those of the control group (P < 0.001). After the intervention, the SDS and SAS scores of the observation group were lower than those of the control group (P < 0.001). The nursing satisfaction rate of the observation group (41/ 4.652%) was higher than that of the control group (35/18.604%) (P < 0.05). The difference is statistically significant. Conclusion: In the care of lung cancer patients with a high risk of PICC-related thrombosis, bundled nursing care achieved better results.

关键词： Care bundle Lung cancer PICC Thrombosis

Identification of a novel MYO1D variant associated with laterality defects,congenital heart diseases,and sperm defects in humans

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Frontiers of Medicine 2024年第3期18卷 558-564页

作者： Zhuangzhuang Yuan Xin Zhu Xiaohui Xie Chenyu Wang Heng Gu Junlin Yang Liangliang Fan Rong Xiang Yifeng Yang Zhiping Tan department of Cardiovascular Surgery The Second Xiangya Hospital of Central South UniversityChangsha410011China Clinical Center for Gene Diagnosis and therapy The Second Xiangya Hospital of Central South UniversityChangsha410011China department of Cell Biology School of Life SciencesCentral South UniversityChangsha410013China department of Gynecology and Obstetrics Xiangya Hospital of Central South UniversityChangsha410008China

The establishment of left–right asymmetry is a fundamental process in animal *** with this process leads to a range of disorders collectively known as laterality defects,which manifest as abnormal arrangements of visceral *** patients with laterality defects,congenital heart diseases(CHD)are *** multiple model organisms,extant research has established that myosin-Id(MYO1D)deficiency causes laterality *** study investigated over a hundred cases and identified a novel biallelic variant of MYO1D(NM_015194:c.1531G>A;p.D511N)in a consanguineous family with complex CHD and laterality *** examination of the proband revealed asthenoteratozoospermia and shortened ***,the effects of the D511N variant and another known MYO1D variant(NM_015194:c.2293C>T;p.P765S)were *** assessment showed that both enhance the interaction withβ-actin and ***,this study revealed the genetic heterogeneity of this rare disease and found that MYO1D variants are correlated with laterality defects and CHD in ***,this research established a connection between sperm defects and MYO1D *** offers guidance for exploring infertility and reproductive health *** findings provide a critical basis for advancing personalized medicine and genetic counseling.

关键词： MYO1D laterality defect congenital heart disease sperm defect β-actin SPAG6

There is more to the knee joint than just the quadriceps:A systematic review with meta-analysis and evidence gap map of hamstring strength,flexibility,and morphology in individuals with gradual-onset knee disorders

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Journal of Sport and Health Science 2024年第4期13卷 521-536页

作者： Helder S.Lopes Marina C.Waiteman Liliam B.Priore Neal R.Glaviano David M.Bazett-Jones Ronaldo V.Briani Fabio M.Azevedo School of Science and Technology Physical Therapy DepartmentSao Paulo State University(UNESP)Presidente Prudente 19060-900Brazil department of Kinesiology College of AgricultureHealth and Natural ResourcesUniversity of ConnecticutStorrsCT 06269USA School of Exercise and Rehabilitation Sciences College of Health and Human ServicesUniversity of ToledoToledoOH 43606USA

Background:Impairments in hamstring strength,flexibility,and morphology have been associated with altered knee biomechanics,pain,and *** the presence of these impairments in individuals with gradual-onset knee disorders is important and may indicate targets for assessment and *** systematic review aimed to synthesize the literature to determine the presence of impairments in hamstring strength,flexibility,and morphology in individuals with gradual-onset knee ***:Five databases(MEDLINE,Embase,CINAHL,SPORTDiscus,and Web of Science)were searched from inception to September *** studies comparing hamstring outcomes(e.g.,strength,flexibility,and/or morphology)between individuals with gradual-onset knee disorders and their unaffected limbs or pain-free controls were ***-analyses for each knee disorder were ***-level certainty was assessed using the Grading of Recommendations Assessment,Development,and Evaluation,and evidence gap maps were ***:Seventy-nine studies across 4 different gradual-onset knee disorders(i.e.,knee osteoarthritis(OA),patellofemoral pain(PFP),chondromalacia patellae,and patellar tendinopathy)were *** with knee OA presented with reduced hamstring strength compared to pain-free controls during isometric(standard mean difference(SMD)=-0.76,95%confidence interval(95%CI):-1.32 to-0.21)and concentric contractions(SMD=-0.97,95%CI:-1.49 to-0.45).Individuals with PFP presented with reduced hamstring strength compared to painfree controls during isometric(SMD=-0.48,95%CI:-0.82 to-0.14),concentric(SMD=-1.07,95%CI:-2.08 to-0.06),and eccentric contractions(SMD=-0.59,95%CI:-0.97 to-0.21).No differences were observed in individuals with patellar *** with PFP presented with reduced hamstring flexibility when compared to pain-free controls(SMD=-0.76,95%CI:-1.15 to-0.36).Evidence gap maps identified insufficient evidence for chondromalacia patel

关键词： Chondromalacia patellae Knee flexors Knee osteoarthritis Patellar tendinopathy Patellofemoral pain