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Cellular & Molecular Immunology 2019年第2期16卷 195-197页

作者： Issaoui Hussein Ghazzaui Nour Boyer François denizot Yves Saintamand Alexis Centre national de la Recherche Scientifique UnitéMixte de Recherche 7276 Institut National de la Santéet de la Recherche Médicale U1262CBRSrue du Pr.Descottes87025 LimogesFrance INSERM U1236 UniversitéRennes 1RennesFrance

Mouse B1 B cells originate in the embryonic liver and are the major B-cell population in the peritoneal and pleural cavities.1–5 By contrast,mouse B2 B cells originate in the bone marrow and are the major B-cell population in the bone marrow,spleen,and blood.B1 and B2 B cells differ not only in their origin and locations,but also in their antigen specificity,cell surface markers,capacities for class-switch recombination(CSR)and somatic hypermutation(SHM).IgH cis-regulatory regions and,particularly,transcriptional super-enhancers are major locus regulators under both normal and pathological conditions.6,7 Important differences have been found regarding the ability of the IgH 3′regulatory region(3′RR)super-enhancer to control the B1 and B2 B-cell fate.

关键词： spleen specificity peritoneal

Influence of anthropic and eco-hydrological factors on the floristic diversity of the herbaceous vegetation around the temporary ponds in Ferlo,northern Senegal

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Journal of Plant Ecology 2022年第1期15卷 26-38页

作者： Ndiabou Faye Aly Diallo Moustapha BassimbéSagna Jean Luc Peiry Papa Saliou Sarr Aliou Guisse Département de Biologie Végétale UniversitéCheikh Anta DiopDakarSenegal IRL3189 Environment SantéSociétésCentre National de la Recherche Scientifiques(CNRS)ParisFrance IRL3189 Environnement SantéSociétésUniversitéCheikh Anta DiopDakarSenegal observatoire international Hommes Milieux-OHMi Tessekere UniversitéCheikh Anta DiopDakarSenegal observatoire international Hommes Milieux-OHMi Tessekere Centre National de la Recherche Scientifique(CNRS)ParisFrance departement d’Agroforesterie UniversitéAssane Seck de ZiguinchorZinguinchorSenegal Département de Géographie Universitéde Clermont FerrandClermont-FerrandFrance Japan International Research Center for Agricultural Sciences(JIRCAS) TsukubaIbarakiJapan

Temporary ponds play substantial roles in preserving biodiversity in the *** study investigated the influence of anthropic and eco-hydrological factors on the plant diversity around two grazed ponds and one ungrazed pond in Ferlo,northern *** phytoecological transects were established per *** each transect,homogenous herbaceous vegetation units were identified and characterized(herbaceous cover,exposure,soil texture,soil moisture and pH,average height and slope).The herbaceous flora comprised 55 species,41 genera and 22 families across the three *** of the Poaceae,particularly Eragrostis tremula and Enteropogon prieurii,mostly colonized the grazed ponds,while the ungrazed pond favored other families’species such as Achyranthes sp.,Commelina forsskaolii,Corchorus *** Shannon’s diversity index(H′)of Wendu Marodi(ungrazed pond)was slightly higher(4.9 bits)than that of Belel Lougal and Belel Sow(grazed ponds)with 4.8 and 4.5 bits,*** equitability indices were relatively high in the three ponds(0.85,0.83 and 0.78).Eco-ecological factors distinguished four species’groupings:a Tribulus terrestris grouping colonizing the constraining and over-grazed zones,a Digitaria horizontalis grouping,and Chloris barbata grouping found in the transition zones,and an Achyranthes aspera grouping in the wetlands,where woody plants were strongly present and the anthropic action *** study highlighted the importance of maintaining a landscape mosaic of ungrazed or semi-protected ponds and grazed ponds to preserve the herbaceous floristic diversity in the center of Ferlo(Senegal)and the Sahel in general.

关键词： ponds Ferlo grazing herbaceous vegetation transect

Supporting People Affected by Cancer and Their Family:population Health Intervention Research,a Scientific Lever for Public Institutions

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Psycho-Oncologie 2023年第3期17卷 105-107页

作者： Norbert Ifrah Christian Rabaud Président de l’Institut national du cancer(INCa) Boulogne-BillancourtFrance Directeur général de la santé ParisFrance

[French version]Le cancer est l’une des maladies les plus répandues dans le monde:on estimait en 2018à18,1 millions le nombre de nouveaux cas diagnostiqués(toute localisation confondue)età9,6 millions celui de décès par cancer[1].L’Europe est particulièrement concernée avec 23,4%de nouveaux cas diagnostiqués et 20,3%de décès par cancer[1].Enfin en France,on estime en 2023à433138 le nombre de nouveaux cas età157400 le nombre de décès par cancer estimés en 2018[2].

关键词： millions des Institution

Effect of alcohol consumption on liver stiffness measured by transient elastography

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World Journal of Gastroenterology 2013年第4期19卷 516-522页

作者： Edouard Bardou-Jacquet Ludivine Legros Draman Soro Marianne latournerie Anne Guillygomarc'h Caroline Le lan Pierre Brissot Dominique Guyader Romain Moirand Hepatology and Addictology department University Hospital PontchaillouF35000 RennesFrance Institut national de la santé et de la Recherche Médicale U991 Institut Fédératif de Recherche 140University of Rennes 1F35000 RennesFrance

AIM:To determine the evolution of transient elastography(TE) in patients with alcoholic liver disease according to alcohol cessation or ***:We retrospectively selected in our local database all patients who had two TE between June 2005 and November 2010 with chronic alcohol excessive consumption and excluded those with associated cause of liver *** was performed at least one week apart by senior *** examinations with less than ten successful measures or with an interquartile range above 30% were *** retrospectively reviewed file of all patients to include only patient followed up by trained addictologist and for which definite information on alcohol consumption was *** biological parameters [aspartate amino transferase(AST),alanine amino transferase and gamma-glutamyl transpeptidase(GGT)] within 4 wk of initial and final TE were *** fibrosis score according to initial and final TE were determined with available cut-off for alcoholic liver disease and hepatitis *** and final putative fibrosis score were compared according to alcohol consumption during ***:During the study period 572 patients had TE examination for alcoholic liver disease and 79 of them had at least two ***-seven patients met our criteria with a median follow-up of 32.5 *** the end of the study,13(35%) were abstinent,and 24(65%) *** patients had liver biopsy during *** decreased significantly during follow-up in 85% of abstinent patients [median(range):-4.9(-6.1,-1.9)],leading to a modification of the putative fibrosis stage in 28%-71% of patient according to different cut-off *** relapsers TE increased in 45% and decreased in 54% of *** was no statistical difference between initial and final TE in *** the overall population,using 22.6 kPa as cut-off for cirrhosis,4 patients had cirrhosis at initial TE and 3 patients had cirrhosis at final ***

关键词： Alcohol Transient elastography Cirrhosis Fibrosis Liver biopsy Liver stiffness

For antigen-specific effector or Foxp3^(+) regulatory T cell fate, cyclin-dependent kinases hold the trump card

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Cellular & Molecular Immunology 2020年第4期17卷 310-312页

作者： Srinivasa Reddy Bonam Jagadeesh Bayry Neuroimmunology&peptide therapy Biotechnology and cell signalingCNRS-University of StrasbourgIllkirch 67412 StrasbourgFrance Institut national de la santéet de la Recherche Médicale Centre de Recherche des CordeliersEquipe-Immunopathologie et Immunointervention ThérapeutiqueSorbonne UniversitéUniversitéParis DescartesSorbonne Paris CitéParis F-75006France

Forkhead box p3^(+)(Foxp3^(+))regulatory T cells(Tregs)are indispensable for immune homeostasis and for maintaining immune *** studies have confirmed that injection of a T cell population depleted of Tregs causes autoimmunity,rejection of grafts and inflammatory disorders,whereas reconstitution with Tregs inhibits these pathogenic *** the last two decades,intense efforts have been made to identify Treg subsets,Treg differentiation processes,and the molecular signatures and regulators that determine Treg lineage specificity and stability.1–6 Several lines of evidence clearly demonstrate that Foxp3^(+)Tregs do not constitute a homogeneous population,and various subsets of Tregs,such as thymic Tregs(tTregs),in vitro-generated Tregs(iTregs),and peripherally induced Tregs(pTregs),have been identified.5 In addition to Foxp3,epigenetic factors and metabolic processes play key roles in maintaining Treg identity and function,and mediate the switch between effector T cells and Tregs.

关键词： Foxp3 specificity homeostasis

Cholinesterase Activity as an Indicator of Health Risks among Kou Valley Farmers

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Journal of Biosciences and Medicines 2024年第7期12卷 71-86页

作者： Thiombiano Cherileila Hien S. Aristide Koevi Nadège Bayili Bazoma Ouattara Abdoulaye Traore Patrice Traore T. Isidore Hien Herve Centre Muraz Institut National de Sant Publique (INSP) Bobo-Dioulasso Burkina Faso Institut Suprieur des Science de la sant (INSSA) University of Nazi Boni Bobo-Dioulasso Burkina Faso Institut de Recherche en Science de la sant (IRSS) Centre National de Recherche Scientifique et Technologique (CNRST) Ouagadougou Burkina Faso

Introduction: Pesticides are currently an essential component of agricultural production techniques for controlling pests and weeds. In Burkina Faso, non-compliance with good practice in the use of pesticides poses a real health problem for the population. This study examines the health risks associated with pesticide management in rice-growing areas. Material and Methods: A field survey was conducted in Bama, involving farmers, focusing on their socio-demographic characteristics, pesticide usage, and health effects. Cholinesterase levels were measured in subsample of farmers using a portable device. Data were analysed using Microsoft Excel, calculating means and percentages for various practices. Health consultations, protection methods, and pesticide management were studied. Erythrocyte acetylcholinesterase activity was compared before and after treatment. Data were categorised into classes based on inhibition levels, and correlation analyses determined relationships between variables such as age, years of experience, and cholinesterase activity. Results: The results indicate that rice cultivation is mainly carried out by a fairly young population, with nearly 63% being under the age of 50. Common poor practices in pesticide use include improper storage and reuse of leftover pesticides. Seven types of pesticides were identified, including organophosphates such as glyphosate, which was used in 26.7% of cases. This organophosphate has resulted in class B poisoning, causing a 30% - 50% reduction in erythrocyte cholinesterase activity. The health effects of pesticide use are felt by agricultural farmers through various symptoms of poisoning. Conclusion: To reduce the occurrence of pesticide poisoning, it is essential to launch information and awareness campaigns among the population and farmers to promote safe practices in pesticide use in Bama, Burkina Faso.

关键词： Pesticides Environmental Sanitary Risk Acetylcholinesterase Farmers Bama Burkina Faso

Prevalence of Pulmonary Tuberculosis and HIV Co-Infection among Women in Bogodogo, Burkina Faso

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Journal of Biosciences and Medicines 2024年第11期12卷 233-242页

作者： Wendbenedo Yasmine Astrid Sana Tani Sagna Serge Theophile Soubeiga Kekoura Ifono laure Stella Ghoma Linguissi Alexis Sama Tegwinde Rebeca Compaore Teega-Wendé Clarisse Ouedraogo Charlemagne Dabire Pierre Zabre Dieudonné Tialla Ina Traore Diane Valea Absatou Ky Ba Henri Gautier Ouedraogo Jacques Simpore laboratoire de Biologie Molculaire et de Gentique (laBIOGENE) Universit Joseph Ki-Zerbo Ouagadougou Burkina Faso Centre national de la Recherche Scientifique et Technologique (CNRST) Institut de Recherche en Sciences de la Sant (IRSS) Ouagadougou Burkina Faso Institut national de Recherche en Sciences de la sant (IRSSA) Brazzaville Republic of the Congo Centre Hospitalier Universitaire de Bogodogo Ouagadougou Burkina Faso

Introduction: The tuberculosis (TB) and HIV co-infection is a deadly combination, each accelerating the progression of the other. TB, caused by Mycobacterium tuberculosis (M. tuberculosis), is the leading cause of deaths among people living with HIV, accounting for around 40% of all HIV-positive deaths. The aim of this study was to estimate the prevalence of the tuberculosis-HIV co-infection in women. Material and Methods: The study population consisted of all suspected patients visiting the laboratory of the Bogodogo University Hospital, from May 2023 to January 2024, to be screened for M. tuberculosis. This was a descriptive cross-sectional study. Socio-demographic data were collected during individual interviews with consenting patients. M. tuberculosis was identified using the GeneXpert device, and HIV was diagnosed using the Abbott determine diagnostic test. Results: Our study population was aged, on average, 37 ± 17.5 years. The overall tuberculosis infection rate was 65%, and 35% were married. Housewives were the most infected with 22.5%. The most infected age group was the ]20 - 40], with 32.5%. Some 37.5% of the women were anorexic and 45% had asthenia. Of the suspected cases, 47.5% were people who had contact with infected persons. TB/HIV co-infection was 5%. Conclusion: Tuberculosis is still rife in many parts of the world. It infects both men and women very quickly. HIV-tuberculosis co-infection is a reality, with HIV accelerating the progression of tuberculosis and vice versa. Raising awareness of HIV and tuberculosis should be done in tandem, as their co-infection leads to a poor vital prognosis.

关键词： Tuberculosis Prevalence Pulmonary Co-Infection HIV Women

Management and development of Newborns from Mothers Carrying HBsAg at the El Rapha Polyclinic in Libreville, Gabon

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Open Journal of Pediatrics 2021年第3期11卷 468-478页

作者： Eliane Kuissi Kamgaing Steeve Minto’o Rogombe Aude-Mariella Lembet Mikolo Raïssa Koumba Maniaga Edmée Mintsa Mi Nkama Edgar-Brice Ngoungou Maiga Aité Blaise Okissi Marcelle Djiomo Simon Ategbo Polyclinique El Rapha Libreville Gabon Département de Pédiatrie Université des Sciences de la Santé (USS) Libreville Gabon department of Biostatistics Université des Sciences de la Santé (USS) Libreville Gabon

Introduction: Hepatitis B is a significant public health problem. Infected children Objective: We aimed to assess newborns’ management and outcome from reactive HBs Ag mothers at the El Rapha Polyclinic in Libreville, Gabon. Methodology: Prospective longitudinal study, carried out over four years, including all neonates born from reactive HBsAg mothers admitted in the delivery room. The parameters studied were maternal age, gestation, marital status, pregnancy follow-up, hepatitis B vaccination status, knowledge of hepatitis B, anti-Hbc antibodies’ levels, HBeAg. For the newborn: term, birth weight, management at birth, and hepatitis B serological status at 12 months. Results: We included 45 newborns. Mothers’ mean age was 30.9 ± seven years. In 32.6% of cases, antenatal consultations were ≤4, and 9.3% were vaccinated for hepatitis B. Mothers had chronic hepatitis in 74.4% of cases. All neonates were vaccinated for hepatitis B at birth;68.9% received hepatitis B immunoglobulin. At 12 months, 77.8% had HBs antibody positive, and 6.7% were HBsAg positive. Conclusion: Hepatitis B prevalence is significant among parturients. It is essential to set up a national strategy for managing the mother-child couple in a context of positive HBsAg.

关键词： Viral Hepatitis B Newborn Management Evolution Gabon

High Prevalence of Musculoskeletal Disorders and Self-Medication among Street Vendors in Bangui, Central African Republic (CAR)

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Occupational Diseases and Environmental Medicine 2023年第4期11卷 199-212页

作者： H.D. Mossoro-Kpinde Perrin Ariel Kongbanda Augustin Balekouzou Henri Saint Calvaire Diemer Julienne Anaïs Paola demba Yabada Chloé Naïgha Liliane dengue Nzobe Gerard Grésenguet Mor Ndiaye Direction de la Médecine du Travail Ministère du Travail de l’Emploi de la Protection Sociale et de la Formation Professionnelle Bangui Central African Republic Département de santé Publique Faculté des Sciences de la Santé Université de Bangui Bangui Central African Republic Faculté des Sciences de la santé Université de Bangui Bangui Central African Republic Comité national de Lutte contre le SIDA Bangui Central African Republic Service de Médecine du Travail et de Médecine Légale Faculté de Médecine de Pharmacie et d’Odontologie Université Cheick Anta Diop Dakar Senegal

Introduction: Musculoskeletal disorders (MSDs) are a set of peri-articular conditions that result mainly in pain and functional discomfort. They represent a major occupational health problem in all areas of activity. The objective of this work was to determine the prevalence of MSDs among street vendors in the city of Bangui in the Central African Republic (CAR). Methods: A cross-sectional study was conducted from September 01 to October 31, 2021 in Bangui, the capital of CAR. The study population consisted of street vendors which were included at the entrance of 4 large markets of Bangui after giving informed consent. The sample size, calculated according to the Schwartz formula, was 384. Sociodemographic data (age, gender, level of education, marital status), professional data (the duration of sale in hours, the distance traveled per day);and health data (the health problems suffered by itinerant sellers and the means of dealing with them) were collected using a pre-established self-questionnaire. This collected data was processed using Microsoft Excel 2013 and Epi-Info version 7 software. Results: Among 384 street vendors included, women represented a quarter (24.9%). The average age was 27 years;the 25-34 age group was the most represented (50%). About two-thirds (64.8%) sold for at least 12 hours and traveled more than 10 km (69.3%) per day. The main health problems reported by street vendors were musculoskeletal disorders (95.8%). Their locations concerned the upper limbs shoulder 65.36% (251), elbow 24.22% (93). Non-ergonomic postures that stress the back and joints all day long, causing pain are risk factors for MSDs. These MSDs were treated by self-medication with non-steroidal anti-inflammatory drugs (22.0%), mainly sold on the street. Conclusion: MSDs dominated the health problems of street vendors. These problems raise the need for recognition and support for these workers to optimize their performance while preserving their health through awareness and

关键词： Street Vendors Musculoskeletal Disorders Ergonomy Self-Medication Central African Republic

Epidemiological, Clinical and Anatomopathological Aspects of Cancers in Central African Republic Children

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Open Journal of Pediatrics 2022年第5期12卷 841-849页

作者： Jess Elio Kosh Komba Palet Cyriaque Simplice Kango Carine Kiteze Nguinzanemou Marie Christine Awa Sépou Yanza Marie Colette Nganda Bangue Barbara Ouansaba Mouhamadou Ousmane Jean Chrysostome Gody Boniface Koffi Complexe Pédiatrique de Bangui Bangui République Centrafricaine Faculté des Sciences de la santé de l’Université de Bangui Bangui République Centrafricaine laboratoire national de Biologie Clinique et de santé Publique Bangui République Centrafricaine

Objectives: To determine the epidemiological, clinical and anatomopathological aspects of childhood cancer in CAR. Patients and Methods: This was a retrospective study carried out from May 2015 to May 2018, at the Center Hospitalier Universitaire Pédiatrique de Bangui (CHUPB). The study population consisted of patients aged under 15 followed in the UHOPB for malignant tumors on clinical, radiological or ultrasound suspicion of malignancy and confirmed or not by histology or biology. A questionnaire was used to collect the data which was analyzed using SPSS11.0 software. Results: During the study period, we collected 107 cases of childhood cancer. The annual hospital incidence was 1.27% in 2016;1.93% in 2017 and 1.50% in 2018 The average monthly frequency of patients followed is 35.66. The intensity of pain assessed in the 99 patients ranged from 02/10 to 09/10 with an average of 5.41/10. The mean duration of the disease was 3.3 months with extremes at 1.2 months and 36 months. A predominance of comorbidity with HIV is 41.66%. Histologically diagnosed malignant tumors are dominated by 30.4% Burkitt’s lymphoma. Conclusion: Data on cancer incidence are scarce in developing countries and for the most part are hospital statistics. In CAR, it will be important to set up a national register for collecting information.

关键词： Cancer Child Epidemiology Central African Republic