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Applications of stem cells in orthodontics and dentofacial orthopedics:Current trends and future perspectives

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World Journal of Stem Cells 2018年第6期10卷 66-77页

作者： Shiva Safari Arezoo Mahdian Saeed Reza Motamedian Department of orthodontics School of Dentistry Shahid Beheshti University of Medical Sciences

A simple overview of daily orthodontic practice involves use of brackets, wires and elastomeric modules. However, investigating the underlying effect of orthodontic forces shows various molecular and cellular changes. Also, orthodontics is in close relation with dentofacial orthopedics which involves bone regeneration. In this review current and future applications of stem cells(SCs) in orthodontics and dentofacial orthopedics have been discussed. For craniofacial anomalies, SCs have been applied to regenerate hard tissue(such as treatment of alveolar cleft) and soft tissue(such as treatment of hemifacial macrosomia). Several attempts have been done to reconstruct impaired temporomandibular joint. Also, SCs with or without bone scaffolds and growth factors have been used to regenerate bone following distraction osteogenesis of mandibular bone or maxillary expansion. Current evidence shows that SCs also have potential to be used to regenerate infrabony alveolar defects and move the teeth into regenerated areas. Future application of SCs in orthodontics could involve accelerating tooth movement, regenerating resorbed roots and expanding tooth movement limitations. However, evidence supporting these roles is weak and further studies are required to evaluate the possibility of these ideas.

关键词： Alveolar bone grafting Dentofacial deformities Distraction osteogenesis Guided tissue regeneration orthodontics Orthodontic tooth movement Orthognathic surgery Periodontitis Root resorption Stem cells

Microbiological Advances in orthodontics:An Overview and Detailed Analysis of Temporary Anchorage Devices

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Current Medical Science 2022年第6期42卷 1157-1163页

作者： Ning-rui ZHAO Yan-ning GUO Sheng-jie CUI Ya-jing TIAN Yan-heng ZHOU Xue-dong WANG Department of orthodontics Peking University School and Hospital of StomatologyBeijing100081China

Dental biofilm is the initiating factor of oral diseases,such as periodontitis and *** treatment could alter the microbiome structure balance,and increase the risk of such ***,fixed appliances can induce temporary changes in the microbiome community,and the changes that clear aligners bring are smaller by *** anchorage devices(TADs)are skeletal anchorages that are widely used in orthodontic *** affect the occurrence and development of inflammation surrounding *** present,existing researches have verified the existence of plaque biofilm on the surface of TADs,but the formation of plaque biofilm and plaque composition under different stable conditions have not been fully *** development of high-throughput sequencing,molecular biology experiments,and metabonomics have provided new research ideas to solve this *** can become an effective means to explore the microbiome surrounding TADs.

关键词： orthodontics microbiome fixed appliances temporary anchorage devices next-generation sequencing

Role of third molars in orthodontics

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World Journal of Clinical Cases 2015年第2期3卷 132-140页

作者： Konstantinia Almpani Olga-Elpis Kolokitha Forsyth Institute Department of orthodontics Faculty of DentistrySchool of Health SciencesAristotle University

The role of third molars in the oral cavity has been extensively studied over the years. Literature includes numerous diagnostic and treatment alternatives regarding the third molars. However, an issue that has not been discussed at the same level is their involvement in orthodontic therapy. The aim of this study is to present a review of the contemporary literature regarding the most broadly discussed aspects of the multifactorial role of third molars in orthodontics and which are of general dental interest too.

关键词： Crowding Extraction Eruption Third molar orthodontics Impaction

Periodontally accelerated osteogenic orthodontics with platelet-rich fibrin in an adult patient with periodontal disease:A case report and review of literature

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World Journal of Clinical Cases 2021年第6期9卷 1367-1378页

作者： Min Xu Xiao-Yu Sun Jian-Guang Xu Stomatological Hospital and College Anhui Medical UniversityHefei 230032Anhui ProvinceChina Department of orthodontics Anhui Medical UniversityHefei 230032Anhui ProvinceChina

BACKGROUND In the clinical scenario,adult patients with periodontal diseases and dental malformation,characterized by dental crowding in lower anterior teeth with the thin biotype,often require orthodontic *** case report aimed to evaluate the clinical and radiographic outcomes of periodontally accelerated osteogenic orthodontics(PAOO)combined with autologous platelet-rich fibrin(PRF)in an adult patient with class I malocclusion along with dental crowding,a thin periodontal biotype,and buccal plate *** SUMMARY A 32-year-old female complaining of dental crowding and gingival bleeding was referred to the orthodontic *** patient underwent periodontal risk assessment prior to orthodontic *** was diagnosed with a high risk of gingival recession due to dental crowding,root prominence,loss of buccal plates,and a thin gingival tissue *** treatment regimen included PAOO combined with autologous PRF for alveolar augmentation and interproximal enamel reduction for moderate dental ***,PAOO-assisted orthodontic tooth movement in this case showed enhanced periodontium *** outcomes also showed statistically significant improvements(P<0.01)in the mandibular buccal alveolar *** This case report suggests the combination of autologous PRF with PAOO to enhance bone augmentation and long-term tissue support in adult orthodontic patients with periodontal disease.

关键词： Periodontally accelerated osteogenic orthodontics Orthodontic tooth movement Platelet-rich fibrin Bone augmentation Periodontal biotype Case report

Face Adaptation in orthodontics

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Open Journal of Stomatology 2014年第7期4卷 315-331页

作者： Maen Mahfouz Department of orthodontics and Pediatric Dentistry Arab American University Jenin Palestine

Bilateral Controversy in orthodontic science is widely present in different patterns;one of the most common is the debate between early versus late orthodontic treatment. This paper is going to demonstrate two clinical cases of class III malocclusion which are treated orthodontically, one in early mixed dentition and the other in permanent dentition. The face is highly capable to adapt to the changes achieved by orthodontics provided the earlier treatment begins, the more the face adapts to our standards;the later treatment begins, the more our standards have to adapt to the face.

关键词： Face Adaptation orthodontics

MANAGEMENT OF PATIENTS WITH SEVERE BONE LOSS:BONE INDUCTION AND orthodontics

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MANAGEMENT OF PATIENTS WITH SEVERE BONE LOSS:BONE INDUCTION ...

第四军医大学口腔医院2004第七届全国口腔正畸学术会议

作者： Rabie A.B.M. Associate Professor in orthodontics Faculty of Dentistry The University of Hong KongHong Kong SAR China.

Hong Kong SAR, China.

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International Journal of Oral Science 2024年第3期16卷 398-412页

作者： Yunfan Zhang Jiale Yan Yuning Zhang Hao Liu Bing Han Weiran Li Department of orthodontics Peking University School and Hospital of Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Laboratory for Digital and Material Technology of Stomatology&Beijing Key Laboratory of Digital Stomatology&Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health&NMPA Key Laboratory for Dental MaterialsBeijingChina

Compared with teenage patients,adult patients generally show a slower rate of tooth movement and more pronounced alveolar bone loss during orthodontic treatment,indicating the maladaptation of alveolar bone homeostasis under orthodontic ***,this phenomenon is not well-elucidated to date,leading to increased treatment difficulties and unsatisfactory treatment outcomes in adult *** to provide a comprehensive knowledge and further inspire insightful understanding towards this issue,this review summarizes the current evidence and underlying *** age-related abatements in mechanosensing and mechanotransduction in adult cells and periodontal tissue may contribute to retarded and unbalanced bone metabolism,thus hindering alveolar bone reconstruction during orthodontic *** this end,periodontal surgery,physical and chemical cues are being developed to reactivate or rejuvenate the aging periodontium and restore the dynamic equilibrium of orthodontic-mediated alveolar bone *** anticipate that this review will present a general overview of the role that aging plays in orthodontic alveolar bone metabolism and shed new light on the prospective ways out of the impasse.

关键词： alveolar metabolism homeostasis

Effect of Attachment on Movement Control of the Central Incisor Using Invisible orthodontics:In-Silico Finite Element Analysis

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Journal of Shanghai Jiaotong university(Science) 2021年第3期26卷 383-390页

作者： PAN Shengruan ZOU Diyang PAN Xiaogang TSAI Tsung-Yuan School of Biomedical Engineering and Med-X Research Institute Shanghai Jiao Tong UniversityShanghai200030China Department of orthodontics Shanghai Ninth People’s HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of Stomatology&Shanghai Research Institute of StomatologyShanghai200011China

We aimed to study the influence of attachment on central incisor movement control using invisible orthodontics with different translation or rotation *** this study,cone-beam computerised tomography was used to scan one 15-year-old volunteer’s ***-dimensional models of the mandibular central incisor,removable orthodontic appliance,and a rectangular attachment were reconstructed.A non-linear finite element simulation was used to analyse the influence of attachment on the stress distribution of the periodontal ligament of the central incisor under tooth rotation,mesial translation,and labial-lingual *** mandibular central incisor correction,using rectangular attachments increased the translation by up to 9.6%,increased the maximum stress on the periodontal ligament during the mesial translation correction,and reduced unwanted labial-lingual tilt by up to 40%during the rotation of the ***,wearing an attachment during labial-lingual translation had no significant effect on the orthodontic results of the mandibular central *** the mandibular central incisor’s invisible orthodontic,the rectangular attachment appliance increased the displacement and alleviated the side effect after applying mesial translation and tooth *** labial-lingual translation,the application of a rectangular attachment had no pronounced effect on the results.

关键词： oral biomechanics removable appliances attachment finite element analysis

‘Invisible’ orthodontics by polymeric ‘clear’ aligners molded on 3D-printed personalized dental models

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Regenerative Biomaterials 2022年第1期9卷 1-12页

作者： Xiaoye Yu Guanghui Li Yikan Zheng Jingming Gao Ye Fu Qunsong Wang Lei Huang Xiaogang Pan Jiandong Ding State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular ScienceFudan UniversityShanghai 200438China Department of orthodontics Shanghai Ninth People’s HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of Stomatology&Shanghai Research Institute of StomatologyShanghai 200011China R&D Center EA Medical Device Technologies Co.Ltd.Wuxi 214174China

The malalignment of teeth is treated classically by metal braces with alloy wires,which has an unfavorable influence on the patients appearance during the *** the development of digitization,computer simulation and three-dimensional(3D)printing technology,herein,a modern treatment was tried using clear polymeric aligners,which were fabricated by molding polyurethane films via thermoforming on the 3D-printed personalized dental *** key parameters of photocurable 3D printing of dental models and the mechanical properties of the clear aligner film material were *** precision of a 3D-printed dental model mainly relied on characteristics of photocurable resin,the resolution of light source and the exposure condition,which determined the eventual shape of the molded clear aligner and thus the orthodontic treatment *** biocompatibility of the polyurethane filmmaterial was confirmed through cytotoxicity and hemolysis tests in *** a series of 3D-printed personalized dental models and finite element analysis to predict and plan the fabrication and orthodontic processes,corresponding clear aligners were fabricated and applied in animal experiments,which proved the efficacy and biocompatibility in *** treatments of 120 orthodontic cases were finally carried out with success,which highlights the advantage of the clear aligners as an esthetic,compatible and efficient appliance.

关键词： 3D printing polymer biomaterial clear aligner orthodontics