‘Invisible’ orthodontics by polymeric ‘clear’ aligners molded on 3D-printed personalized dental models

作     者：Xiaoye Yu Guanghui Li Yikan Zheng Jingming Gao Ye Fu Qunsong Wang Lei Huang Xiaogang Pan Jiandong Ding 

作者机构：State Key Laboratory of Molecular Engineering of PolymersDepartment of Macromolecular ScienceFudan UniversityShanghai 200438China Department of OrthodonticsShanghai Ninth People’s HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of Stomatology&Shanghai Research Institute of StomatologyShanghai 200011China R&D CenterEA Medical Device Technologies Co.Ltd.Wuxi 214174China 

出 版 物：《Regenerative Biomaterials》 (再生生物材料（英文版）)

年 卷 期：2022年第9卷第1期

页      面：1-12页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 0836[工学-生物工程] 

基　　金：supports from NSF of China(grants No.52130302,21961160721) National Key R&D Program of China(grant No.2016YFC1100300) 

主　　题：3D printing polymer biomaterial clear aligner orthodontics 

摘      要：The malalignment of teeth is treated classically by metal braces with alloy wires,which has an unfavorable influence on the patients appearance during the *** the development of digitization,computer simulation and three-dimensional(3D)printing technology,herein,a modern treatment was tried using clear polymeric aligners,which were fabricated by molding polyurethane films via thermoforming on the 3D-printed personalized dental *** key parameters of photocurable 3D printing of dental models and the mechanical properties of the clear aligner film material were *** precision of a 3D-printed dental model mainly relied on characteristics of photocurable resin,the resolution of light source and the exposure condition,which determined the eventual shape of the molded clear aligner and thus the orthodontic treatment *** biocompatibility of the polyurethane filmmaterial was confirmed through cytotoxicity and hemolysis tests in *** a series of 3D-printed personalized dental models and finite element analysis to predict and plan the fabrication and orthodontic processes,corresponding clear aligners were fabricated and applied in animal experiments,which proved the efficacy and biocompatibility in *** treatments of 120 orthodontic cases were finally carried out with success,which highlights the advantage of the clear aligners as an esthetic,compatible and efficient appliance.