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Immunohistochemical expression of matrix metalloproteinase-9 and 13 in oral squamous cell carcinoma and their role in predicting lymph node metastasis

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World Journal of Methodology 2025年第2期15卷 108-116页

作者： Bhari Sharanesha Manjunatha Keshav T Handge Vandana Sandeep Shah Yasser Eid Al-Thobaiti Deepak Gowda Sadashivappa Pateel Department of Basic oral Medicine and Allied Dental Sciences Taif UniversityAt`Taif 26571MakkahSaudi Arabia Department of oral and maxillofacial Pathology Dr.Vasantrao Pawar Medical CollegeHospital and Research CentreNashik 423101MaharashtraIndia Department of oral Pathology and Microbiology KM Shah Dental College and HospitalSumandeep VidyapeethVadodara 391760GujaratIndia Department of oral and maxillofacial surgery and Diagnostic Sciences Faculty of DentistryTaif UniversityAl-Haweiah 26571 MakkahSaudi Arabia Department of oral Pathology and Microbiology Faculty of DentistryMAHSA UniversitySelangor 42610Malaysia

BACKGROUND One of the main characteristics of oral squamous cell carcinoma(OSCC)is that it metastasizes to cervical lymph nodes frequently with a high degree of local invasiveness.A primary feature of malignant tumors is their penetration of neighboring tissues,such as lymphatic and blood arteries,due to the tumor cells'capacity to break down the extracellular matrix(ECM).Matrix metalloproteinases(MMPs)constitute a family of proteolytic enzymes that facilitate tissue remo-deling and the degradation of the ***-9 and MMP-13 belong to the group of extracellular matrix degrading enzymes and their expression has been studied in OSCC because of their specific ***-13,a collagenase family member,is thought to play an essential role in the MMP activation cascade by breaking down the fibrillar collagens,whereas MMP-9 is thought to accelerate the growth of *** MMP-13 expression has been associated with tumor behavior and patient prognosis in a number of malignant *** authors wish to thank Jadhav KB for his valuable opinion during the preparation of the manuscript.

关键词： Matrix metalloproteinases oral squamous cell carcinoma Tumor staging Immunohistochemistry Invasion Lymph node metastasis TNM stage

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Surface-modified deproteinized human demineralized tooth matrix for bone regeneration:physicochemical characterization and osteoblast cell biocompatibility

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Regenerative Biomaterials 2024年第4期3卷 1-13页

作者： Natwara Chokwattananuwat Srisurang Suttapreyasri Department of oral and maxillofacial surgery Faculty of DentistryPrince of Songkla UniversitySongkhlaThailand

Tooth presents an intriguing option as a bone graft due to its compositional similarity to ***,the deproteinized human demineralized tooth matrix(dpDTM),developed to overcome the limited availability of autologous tooth grafts,has suboptimal pore size and surface *** study aimed to fabricate a surface-modified dpDTM using acid etching and collagen coating,followed by in vitro evaluation of physicochemical and biological *** dpDTM was modified into two protocols:Acid-modified dpDTM(A-dpDTM)and collagen-modified dpDTM(C-dpDTM).Results demonstrated that A-dpDTM and C-dpDTM had increased pore sizes and rougher surfaces compared to *** immobilization was evidenced by nitrogen presence exclusively in *** groups had a Ca/P molar ratio of 1.67 and hydroxyapatite as the sole constituent,with 65-67%*** rates significantly increased to 30%and 20%for C-dpDTM and A-dpDTM,respectively,compared to 10%for dpDTM after 120 *** collagen release of C-dpDTM on Day 30 was 45.16 mg/*** attachment and proliferation were enhanced on all scaffolds,especially C-dpDTM,which displayed the highest proliferation and differentiation *** conclusion,surface modified of dpDTM,including A-dpDTM and C-dpDTM,significantly enhances bioactivity by altering surface properties and promoting osteoblast activity,thereby demonstrating promise for bone regeneration applications.

关键词： acid-modified dpDTM biocompatibility bone graft collagen-modified dpDTM deproteinized human tooth matrix tooth-derived bone graft

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Stem cells:Sources, and regenerative therapies in dental research and practice

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World Journal of Stem Cells 2015年第7期7卷 1047-1053页

作者： Lobna Abdel Aziz Aly oral and maxillofacial surgery Faculty of DentistryFuture University

Stem cells are considered to be among the principle scientific breakthroughs of the twentieth century for the future of medicine, and considered to be an important weapon to fight against diseases, particularly those that have resisted the efforts of science for a long time. Human dental tissues have limited potentials to regenerate but the discovery of dental stem cells have developed new and surprising scenario in regenerative dentistry. Stem cell treatments are one example of thepossibility using adult cells sourced from patients' own bodies' means that it can be expected that in the near future such treatments may become routine at dental practices. The hope is that it will become possible to regenerate bone and dental tissues including the periodontal ligament, dental pulp and enamel, and that the creation of new teeth may also become feasible. In view of this possibility of achieving restoration with regenerative medicine, it can be considered that a new era of dentistry is beginning. Thus the aim of this review is to give dental professionals a brief overview of different stem cells sources and the latest findings and their implications for improving oral health and treating certain conditions of the human mouth and face.

关键词： Stem cells Regeneration Dental research

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Urine products of bone breakdown as markers of bone resorption and clinical usefulness of urinary hydroxyproline:an overview

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Chinese Medical Journal 2004年第2期17卷 291-295页

作者： Baris Simsek zgülKaracaer inci Karaca Department of oral and maxillofacial surgery faculty of dentistry University of Gazi Emek Ankara TurkeyDepartment of Oral and Maxillofacial Surgery Faculty of Dentistry University of Gazi Emek Ankara TurkeyDepartment of Prosthodontics Faculty of Dentistry University of Gazi Emek Ankara Turkey

Purpose The purpose of this study is to review the urine products of bone breakdown as markers of bone resorption and usefulness of urinary hydroxyproline.Data Related researches published in 1985 -2000 were systematically reviewed.Results Bone markers could be used for early diagnosis of bone metabolic diseases. Biochemical markers of bone resorption that reflect osteoclast activity and/or collagen degradation provide a new and potentially important clinical tool for the assessment and monitoring of bone metabolism. Assessment of bone resorption can be achieved with measurement of urinary hydroxylysine glycosides, urinary excretion of the collagen pyridinium cross-links, urinary excretion of type I collagen telopeptide breakdown products (cross-linked telopeptides) and urinary hydroxyproline.Conclusion Urinary hydroxyproline has been in use as a marker of bone resorption, but it lacks sensitivity and specificity. It is a modified aminoacid that is a metabolic product of collagen breakdown. Hydroxyproline may be released either free or with fragments of the collagen molecule attached during bone resorption, and it is also liberated by the breakdown of complement and nonskeletal collagen.

关键词： bone resorption marker biochemical markers hydroxyproline collagen breakdown hydroxylysine glycosides pyrolidine deoxypyrolidine N-tebpeptides C-telopeptides

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Investigation of basement membrane proteins in a case of granular cell ameloblastoma

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International Journal of oral Science 2012年第1期4卷 45-49页

作者： Puangwan Lapthanasupkul Sopee Poomsawat Jira Chindasombatjaroen Department of oral and maxillofacial Pathology Faculty of DentistryMahidol UniversityBangkokThailand Department of oral and maxillofacial Radiology Faculty of DentistryMahidol UniversityBangkokThailand

Granular cell ameloblastoma is a rare,benign neoplasm of the odontogenic epithelium.A case of massive granular cell ameloblastoma in a 44-year-old Thai female is *** features displayed a follicular type of ameloblastoma with an accumulation of granular cells residing within the tumor *** treatment by partial mandibulectomy,the patient showed a good prognosis without recurrence in a 2-year *** characterize the granular cells in ameloblastoma,we examined the expression of basement membrane（BM） proteins,including collagen type IV,laminins 1 and 5 and fibronectin using *** for the granular cells,the tumor cells demonstrated a similar expression of BM proteins compared to follicular and plexiform ameloblastomas in our previous study,whereas the granular cells showed strong positivity to laminins 1 and 5 and *** increased fibronectin expression in granular cells suggests a possibility of age-related transformation of granular cells in ameloblastoma.

关键词： ameloblastoma collagen type IV fibronenctin granular cell laminin 1 laminin 5

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Three-dimensional virtual operations can facilitate complicated surgical planning for the treatment of patients with jaw deformities associated with facial asymmetry: a case report

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International Journal of oral Science 2013年第3期5卷 176-182页

作者： Shingo Hara Masaharu Mitsugi Takahiro Kanno Akihiko Nomachi Takehiko Wajima Yukihiro Tatemoto Hanarabi Orthodontic Dental Clinic Department of oral and maxillofacial surgery Kochi Health Sciences Center Takamatsu oral and maxillofacial surgery Clinic Department of oral and maxillofacial surgery Shimane University Faculty of Medicine

This article describes a case we experienced in which good postsurgical facial profiles were obtained for a patient with jaw deformities associated with facial asymmetry,by implementing surgical planning with SimPlant *** this method,we conducted LF1 osteotomy,intraoral vertical ramus osteotomy（IVRO）,sagittal split ramus osteotomy（SSRO）,mandibular constriction and mandibular border *** only did we obtain a class I occlusal relationship,but the complicated surgery also improved the asymmetry of the frontal view,as well as of the profile view,of the *** virtual operation using three-dimensional computed tomography（3D-CT）could be especially useful for the treatment of patients with jaw deformities associated with facial asymmetry.

关键词： facial asymmetry mnandibular constriction transverse discrepancy of the dental arch width virtual operation

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Human periodontal ligament stem cells repair mental nerve injury

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Neural Regeneration Research 2013年第30期8卷 2827-2837页

作者： Bohan Li Hun-Jong Jung Soung-Min Kim Myung-Jin Kim Jeong Won Jahng Jong-Ho Lee Department of oral and maxillofacial surgery School of Dentistry Binzhou Medical College Department of Occupation and Environment Konkuk Postgraduate Medical School Department of oral and maxillofacial surgery School of Dentistry Seoul National University Dental Research Institute Seoul National University

Human periodontal ligament stem cells are easily accessible and can differentiate into Schwann cells. We hypothesized that human periodontal ligament stem cells can be used as an alternative source for the autologous Schwann cells in promoting the regeneration of injured peripheral nerve. To validate this hypothesis, human periodontal ligament stem cells （1 × 106） were injected into the crush-injured left mental nerve in rats. Simultaneously, autologous Schwann cells （1 × 106） and PBS were also injected as controls. Real-time reverse transcriptase polymerase chain reaction showed that at 5 days after injection, mRNA expression of low affinity nerve growth factor receptor was sig-nificantaly increased in the left trigeminal ganglion of rats with mental nerve injury. Sensory tests, histomorphometric evaluation and retrograde labeling demonstrated that at 2 and 4 weeks after in-jection, sensory function was significantly improved, the numbers of retrograde labeled sensory neurons and myelinated axons were significantly increased, and human periodontal ligament stem cells and autologous Schwann cells exhibited similar therapeutic effects. These findings suggest that transplantation of human periodontal ligament stem cells show a potential value in repair of mental nerve injury.

关键词： neural regeneration peripheral nerve injury stem cells periodontal ligament stem cells mentalnerve Schwann cells cell transplantation sensory nerve neurotrophic factor neuroregeneration

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Spindle cell lipoma of the mandibular mucogingival junction: a case report of unusual oral neoplasm

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International Journal of oral Science 2014年第3期6卷 185-187页

作者： Manal Abdulaziz Al Sheddi Ahmad Assari Hezekiah Mosadomi Department of oral Medicine and Diagnostic Sciences College of Dentistry King Saud University Department of oral and maxillofacial surgery and Diagnostic Sciences Riyadh Colleges of Dentistry and Pharmacy

Spindle cell lipoma（SCL） is a benign lipomatous neoplasm typically located in the posterior neck and back of older males. It presents as a well-circumscribed mass in the buccal mucosa, tongue, floor of the mouth or hard palate. There are only two case reports of SCL in the gingiva and alveolar ridge. Here, we report a case of SCL in the mandibular mucogingival junction of a 68-year-old male. Clinical,histopathological and immunohistochemical findings are presented. Although oral SCL is rare, it should be considered in the differential diagnosis of spindle cell neoplasms occurring in the oral cavity.

关键词： lipoma mucogingival junction oral cavity spindle cell lipoma

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CHANGES IN AIRWAY SPACE FOLLOWING MANDIBULAR SETBACK USING SAGITTAL SPLIT OSTEOTOMY AND RIGID INTERNAL FIXATION

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Chinese Medical Sciences Journal 1997年第2期12卷 96-101页

作者：毛驰 Aruga Susumu Matsuura Masaroh Seto Kanichi First Department of oral and maxillofacial surgery Tsurumi University School of DentistryYokohama 230Japan First Department of oral and maxillofacial surgery Tsurumi University School of DentistryYokohama 230Japan

The changes in airway space following mandibular setback using sagittal split osteotomy and rigid internal fixation were studied in 28 Japanese patients with mandibular prognathism. The correlation between the amount of mandibular setback and airway space changes,as well as the correlation between the amount of airway space changes and relapse of pognion point during the following-up period were also studied. Lateral cephalometric radiographs were taken immediately before and shortly after surgery as well as 5 to 12 months postoperation. The cephalometric evaluations of airway space width and area were based on stable craniofacial landmarks. The mean setback of mandible was 8.3 mm in the right side,and 8. 2 mm in the left side. The mean amount of relapse of pogonion point during the following-up period was 0. 52 mm horizontally,and 0. 92 mm vertically. A significant decrease in airway space width and area,especially in the lower part of airway space was found following mandibular setback shortly after surgery. Although there was some increase both in airway space width and area during the following-up period,they did not increase to their original values. This suggests that the narrowing of airway space following mandibular setback using sagittal split osteotomy can be permanent. No significant correlation was found between the amount of mandibular setback and airway space changes. Since the relapse of pogonion point during the following-up period was too small,there is no significant correlation between it and the amount of airway space changes.

关键词： mandibular prognathism sagittal split osteotomy airway space

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Large lingual heterotopic gastrointestinal cyst in a newborn:A case report

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World Journal of Clinical Cases 2020年第17期8卷 3808-3813页

作者： Atsushi-Doksa Lee Kazuma Harada Susumu Tanaka Yusuke Yokota Takashi Mima Akifumi Enomoto Mikihiko Kogo First Department of oral and maxillofacial surgery Graduate School of DentistryOsaka UniversitySuita 565-0871OsakaJapan Department of oral and maxillofacial surgery Faculty of MedicineKindai UniversityOsaka-Sayama 589-8511OsakaJapan Department of oral and maxillofacial surgery Daini Osaka Police HospitalOsaka 543-8922OsakaJapan

BACKGROUND Heterotopic gastrointestinal cysts have gastrointestinal epithelium in the cyst wall and rarely occur in the oral *** are found in the neonatal ***,heterotopic gastrointestinal cysts that are diagnosed as a congenital tongue cyst by routine ultrasonography are extremely *** SUMMARY A 12-day-old female presented with swelling of the anterior *** obstetrician had detected significant tongue swelling on fetal ultrasonography in the 35 th gestational *** female was born by cesarean delivery at gestational week *** soon became dyspneic,and the cyst was *** the aspiration,her breathing recovered and she started *** cyst was excised under general anesthesia on the 67 th *** examination showed that that cyst wall consisted of a lining of columnar gastrointestinal-type epithelium and pseudostratified ciliated *** patient restarted breastfeeding 3 h after *** postoperative course was *** Airway distress and feeding difficulty were successfully avoided by cyst aspiration,and surgical resection was performed with no perioperative complications.

关键词： Tongue cyst Congenital cyst Prenatal diagnosis Airway management Gastrointestinal epithelium Case report

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