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Evaluation of different formulations of IGRs against Aedes albopictus and Culex quinquefasciatus(Diptera:Culicidae)

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Asian Pacific Journal of Tropical Biomedicine 2016年第6期6卷 485-491页

作者： Gul Zamin Khan Inamullah Khan Imtiaz Ali Khan Alamzeb Muhammad Salman Kalim Ullah Entomology Division Nuclear Institute for Food and Agriculture (NIFA) Department of Entomology Faculty of Crop Protection Sciencesthe University of Agriculture Pakistan Central Cotton Committee Cotton Research Station

Objective: To test the relative efficacy of pyriproxyfen and methoprene on mortality,deformity, inhibition and emergence to adult stages of Culex quinquefasciatus and Aedes ***: Serial dilutions(0.01–0.05 mg/L) of methoprene, pyriproxyfen 0.5 water dispersible granules(WDG) and pyriproxyfen 1.0 WDG were used to assess mortality and inhibition of 3rd instar larvae of Aedes albopictus and Culex quinquefasciatus. Each concentration and control was replicated four times in completely randomized *** on larval mortality, growth inhibition, deformities and adult's emergence was recorded weekly. On the basis of best comparative performance, the efficacy of pyriproxyfen 1.0 WDG at 0.1 g/m3 was also tested in the field by collecting treated water samples monthly for 1–6 months after field application. Twenty five 3rd instar larvae of Aedes and Culex spp. of the same cohorts were used for bioassays and compared with larvae in control cups containing 1 L of untreated tap ***: Results revealed variations in fatality of different insect growth regulators(IGRs) to the 3rd instar larvae of Culex and Aedes mosquitoes. Among the IGRs, pyriproxyfen 1.0 WDG was found best that exhibited significantly high emergence inhibition against Culex and Aedes spp. Based on the results, the IGRs were classified in terms of the tested parameters in order of pyriproxyfen 1.0 WDG > pyriproxyfen 0.5WDG > methoprene. In case of field studies, pyriproxyfen 1.0 WDG, pool data of the entire target treated sites showed minimum adult emergence from water sampled of habitats treated with 0.1 g/m3 of pyriproxyfen 1.0 ***: It is thus concluded that IGRs can be utilized as environment friendly control measures for Culex and Aedes spp. of mosquitoes on small and large scale. This will reduce the use of conventional insecticides by the public health authorities and help in reducing selection pressure of insecticides.

关键词： Insect growth regulators Mortality Inhibition Deformities Insecticides Environment friendly

Synthesis and preliminary biological evaluation of a technetium-99m labeled thymidine analog

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Chinese Chemical Letters 2011年第11期22卷 1309-1312页

作者： Chun Xiong Lu Zheng Wu Wang Quan Fu Jiang Jie Tang Cheng Tan Jian Kang-Zhang Key Laboratory of nuclear Medicine Ministry of Health/Jiangsu Key Laboratory of Molecular Nuclear Medicine Jiangsu Institute of Nuclear Medicine Wuxi 214063 China School of Chemical ＆ Material Engineering Jiangnan University Wuxi 214122 China Department of food Science ＆ Technology School of Agriculture and Biology Shanghai Jiao Tong University Shanghai 200240 China

The synthesis and labeling of ^（99m）Tc-N^3-（N＇-[2-sulfanyl-ethylamino）acetyl]-2-aminoethyl-sulfanyl-1-hexanamide}thymidine （^（99m）Tc-NHT） were *** the presence of sodium glucoheptonate（GH） and ethylene diamine tetraacetic acid（EDTA）,^（99m）Tc-NHT was obtained by using bisaminoethanethiol（N_2S_2） as a bifunctional coupling *** radiochemical purity of the ^（99m）Tc-NHT was over 95%.Biodistribution of ^（99m）Tc-NHT was performed in hepatoma HepA tumor-bearing *** 2 h p.i.,the ratios of tumor-to-muscle,tumor-to-bone and tumor-to-blood were 4.41±0.32,2.45±0.24 and 1.51±0.18,respectively.

关键词： Synthesis ^(99m)Tc-NHT Biodistribution Thymidine analog Tumor imaging

Switch of phosphorylation to O-GlcNAcylation of AhR contributes to vascular oxidative stress induced by benzo[a]pyrene

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food Science and Human Wellness 2023年第6期12卷 2263-2275页

作者： Rong Wang Yun Huang Xiaoruo Gan Chenghao Fu Yuemin Li Ning Chen Hao Xi Huishan Guo Wei Zhang Yuhong Lü Yan Zhang Pin Lü Cardiovascular Medical Science Center Department of Cell BiologyKey Laboratory of Neural and Vascular Biology of Ministry of EducationHebei Medical UniversityShijiazhuang 050017China Eco-environmental Monitoring Center of Hebei Province Shijiazhuang 050031China Hebei food Safety Key Laboratory Hebei Food Inspection and Research InstituteShijiazhuang 050091China

Benzo[a]pyrene(B[a]P)is a food contaminant toxic for cardiovascular *** nuclear translocation of Arylhydrocarbon receptor(AhR)plays an important role in B[a]P-induced oxidative stress and vascular *** confi rmed that B[a]P promoted ROS production in vascular smooth muscle cells(VSMCs)in vitro and in vivo,associated with the nuclear translocation of *** is known that phosphorylation inhibits while dephosphorylation of AhR promotes nuclear translocation of ***,from the posttranslational modifi cation level,the mechanism by which B[a]P activates and regulates the nuclear translocation of AhR is ***-immunoprecipitation results showed that cytoplasmic AhR was phosphorylated before B[a]P stimulation,and switched to O-GlcNAcylation upon B[a]P 1-h stimulation in VSMCs,suggesting there may be a competitively inhibitory relationship between O-GlcNAcylation and phosphorylation of ***,siRNAs of O-linked N-acetylglucosamine transferase(OGT),O-GlcNAcase(OGA)and OGA inhibitor PUGNAc were *** blocks but siOGA and PUGNAc promote B[a]P-dependent AhR nuclear translocation and oxidative ***11 may be the competitive binding site for phosphorylation and O-GlcNAcylation of ***-mimic variant inhibits but O-GlcNAcylation of AhR promotes AhR nuclear translocation and oxidative *** fi ndings highlight a new perspective for AhR nuclear translocation regulated by the competitive modifi cation between phosphorylation and O-GlcNAcylation.

关键词： Benzo[a]pyrene Vascular smooth muscle cells Aryl hydrocarbon receptor Phosphorylation modification O-GlcNAcylation modification

Isolation and bioactivity screening of soy isoflavones from soybean glycolipids identifies daidzin as a promising anti-inflammatory agent

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Traditional Medicine Research 2024年第3期9卷 1-9页

作者： Xiao-Chuan Fang Xue-Mei He Yuan-Ru Zheng Wen Li Tang-Jia Yang Jing-Tao Yu Jun-Le Li Zi-Zhe Cai Yong Wang Lin-Zhong Yu Jun-Shan Liu Third Level Research Laboratory of State Administration of Traditional Chinese Medicine Guangdong Provincial Key Laboratory of Chinese Medicine PharmaceuticsSchool of Traditional Chinese MedicineSouthern Medical UniversityGuangzhou 510515China Guangdong Saskatchewan Oilseed Joint Laboratory Department of Food Science and EngineeringJinan UniversityGuangzhou 510632China institute of Biomedical Engineering College of Life Science and TechnologyJinan UniversityGuangzhou 510632China Department of Pharmacy Zhujiang HospitalSouthern Medical UniversityGuangzhou 510515China

Background:Soybean has long been utilized in the realm of traditional Chinese *** of its extracts,soybean glycolipids,serves as a vital by-product of soybean oil refining,but its chemical composition and pharmacological potential have yet to be fully ***:In this study,the chemical components were isolated,and the inhibitory effects of these isolates were explored in different zebrafish inflammatory models by survival rate,Histological examination assay and quantitative Real-time PCR *** cytotoxicity of daidzin in RAW264.7 cells was evaluated by cell viability assay,and the effect of daidzin on the release of inflammatory cytokines in RAW264.7 cells was detected by enzyme linked immunosorbent assay(ELISA).Western blotting,immunofluorescence assay and alpha7 nicotinic acetylcholine receptors siRNA transfection assay were used to further explore the anti-inflammatory mechanism of ***:Four compounds(verticilloside,soya-cerebroside I,soya-cerebroside II and daidzin)were firstly isolated from the soybean glycolipids,among which verticilloside and daidzin inhibited the lipopolysaccharide,CuSO4-and tail cut-stimulated zebrafish ***,daidzin exhibited anti-inflammatory activities by increasing the survival rate,alleviating the inflammatory cells infiltration,and down-regulating the expression of pro-inflammatory cytokines and nuclear factor kappa-B,NF-kappa-B inhibitor alpha,and signal transducer and activator of transcription3 in ***,daidzin decreased the secretion of IL-6 and TNF-α,inhibited the nuclear translocations of nuclear factor kappa-B p65 and p-signal transducer and activator of transcription3 as well as the NF-kappa-B inhibitor alpha phosphorylation at Ser32 in RAW 264.7 *** importantly,it elevated the expression level of alpha7 nicotinic acetylcholine receptors in both zebrafish and RAW 264.7 cells,and the inhibitory effect of daidzin was attenuated after the addition of alpha7 ni

关键词： soybean daidzin anti-inflammation zebrafish α7nAchR

Capsaicin restores sodium iodine symportermediated radioiodine uptake through bypassing canonical TSH–TSHR pathway in anaplastic thyroid carcinoma cells

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Journal of Molecular Cell Biology 2021年第11期13卷 791-807页

作者： Shichen Xu Xian Cheng Jing Wu Yunping Wang Xiaowen Wang Liying Wu Huixin Yu Jiandong Bao Li Zhang NHC Key Laboratory of nuclear Medicine Jiangsu Key Laboratory of Molecular Nuclear MedicineJiangsu Institute of Nuclear MedicineWuxi 214063China School of food Science and Technology Jiangnan UniversityWuxi 214122China Department of Radiopharmaceuticals School of PharmacyNanjing Medical UniversityNanjing 211166China School of Life Science and Technology Southeast UniversityNanjing 210096China

Anaplastic thyroid cancer(ATC)is a rare but highly lethal *** are resistant to standard therapies and are extremely difficult to *** stepwise cell dedifferentiation results in the impairment of the iodine-metabolizing machinery and the infeasibility of radioiodine treatment in ***,reinducing iodine-metabolizing gene expression to restore radioiodine avidity is considered as a promising strategy to fight against *** the present study,capsaicin(CAP),a natural potent transient receptor potential vanilloid type 1(TRPV1)agonist,was discovered to reinduce ATC cell differentiation and to increase the expression of thyroid transcription factors(TTFs including TTF-1,TTF-2,and PAX8)and iodine-metabolizing proteins,including thyroidstimulating hormone receptor(TSHR),thyroid peroxidase,and sodium iodine symporter(NIS),in two ATC cell lines,8505C and ***,CAP treatment promoted NIS glycosylation and its membrane trafficking,resulting in a significant enhancement of radioiodine uptake of ATC cells in ***,CAP-activated TRPV1 channel and subsequently triggered Ca2þinflux,cyclic adenosine monophosphate(cAMP)generation,and cAMP-responsive element-binding protein(CREB)signal ***,CREB recognized and bound to the promoter of SLC5A5 to facilitate its ***,the TRPV1 antagonist CPZ,the calcium chelator BAPTA,and the PKA inhibitor H-89 effectively alleviated the redifferentiation exerted by CAP,demonstrating that CAP might improve radioiodine avidity through the activation of the TRPV1–Ca2þ/cAMP/PKA/CREB signaling *** addition,our study indicated that CAP might trigger a novel cascade to redifferentiate ATC cells and provide unprecedented opportunities for radioiodine therapy in ATC,bypassing canonical TSH–TSHR pathway.

关键词： anaplastic thyroid carcinoma capsaicin redifferentiation sodium iodine symporter radioactive iodine therapy

Advance on monitoring of radioactivity in food in China and Japan after Fukushima nuclear accident

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Radiation Medicine and Protection 2022年第1期3卷 37-42页

作者： Shuying Kong Baolu Yang Fei Tuo Tianxiang Lu National institute for Radiological Protection Chinese Center for Disease Control and PreventionKey Laboratory of Radiological Protection and Nuclear EmergencyChina CDCBeijing 100088China

After the nuclear accident at the Fukushima Daiichi nuclear Power Plant(Fukushima nuclear accident)in 2011,Japan quickly took emergency measures to reduce radiation hazards posed by the released radioactive *** a neighboring country of Japan across the East China Sea,China has also taken some corresponding prevention and control *** has continuously strengthened the monitoring of radioactivity in food in recent *** paper discusses the revision of standards for radioactivity in food,the improvement of methods and equipment,and the updating of monitoring systems performed in China and Japan over the last ten years after the Fukushima Daiichi *** addition,this paper outlines the recent problems left over from the nuclear accident,puts forward some views on the progress of important topics,and gives some thoughts and prospects on the further improvement of the monitoring systems of radioactivity in food in China.

关键词： food monitoring Radioactivity Fukushima nuclear accident

Accurate Quantification of Pure Thiacloprid with Mass Balance and Quantitative H-NMR

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Journal of Analysis and Testing 2024年第1期8卷 1-8页

作者： Mengling Tu Wei Zhang Yunxiao Zhu Wen Ma Xiao Li Shukun Zhou Hongmei Li Xianjiang Li Key Laboratory of Chemical Metrology and Applications on Nutrition and Health for State Market Regulation Division of Metrology in ChemistryNational Institute of MetrologyBeijing 100029China State Key Laboratory of Heavy Oil Processing College of Chemical Engineering and EnvironmentChina University of PetroleumBeijing 102249China State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing 100191China

Thiacloprid is the first-generation neonicotinoid insecticide,which is widely used in modern *** materials are essential for sound measurement and traceability of results in chemical *** thiacloprid was comprehensively assessed by two orthonormal methods:mass balance(MB) and quantitative nuclear magnetic resonance spectroscopy(qNMR).From MB,its mass fraction value was 998.4 mg/g with the subtraction of structurally related impurities(99.87%),inorganic impurities(0.006 mg/g),water(0.33 mg/g),and volatile organic solvent(0 mg/g).To guarantee sufficient separation of structurally related purity,peak purity of thiacloprid was evaluated by five points of UV *** the qNMR of hydrogen,its mass fraction value was 995.7 mg/g which was traced to the internal standard(methyl sulfone).Finally,the certified value was assigned to 997 mg/g,together with an expanded uncertainty of 3 mg/g(k=2).This high-purity thiacloprid can be applied to routine monitoring in agriculture and the food fields.

关键词： Mass balance Quantitative nuclear magnetic resonance spectroscopy Reference material Thiacloprid

Association Mapping and Marker Development of Genes forStarch Lysophospholipid Synthesis in Rice

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Rice science 2016年第6期23卷 287-296页

作者： TONG Chuan LIU Lei Daniel L.E.WATERS BAO Jin-song institute of nuclear Agricultural Sciences College of Agriculture and BiotechnologyZhejiang UniversityHangzhou 310029China institute of food Science Zhejiang Academy of Agricultural SciencesHangzhou 310021China Southern Cross Plant Science Southern Cross UniversityLismoreNSW 2480Australia

Phospholipids are a major kind of lipids in rice grains and have fundamental nutritional andfunctional benefits to the plant. Their lyso forms （lysophospholipids, LPLs） often form inclusion complexeswith amylose or independently influence the physicochemical and functional properties of rice ***, the genetic basis for LPL synthesis in rice endosperm is largely unknown. Here, we performeda preliminary association test of 13 LPL compositions among 20 rice accessions, and identified 22putative main-effect quantitative trait loci responsible for all LPLs except for LPC14：0 and LPE14：0. Fivederived cleaved amplified polymorphic sequences and one insertion/deletion marker for threeLPL-synthesis-related candidate genes were developed. Association analysis revealed two markerssignificantly associated with starch LPL traits. These results provide an insight into the genetic basis ofphospholipid biosynthesis in rice and may contribute to the rice quality breeding programs usingfunctional markers.

关键词： rice starch lysophospholipid phospholipid biosynthesis grain quality QTL molecularmarker association mapping

Evaluation of the chemical profile from four germplasms sources of Pruni Semen using UHPLC-LTQ-Orbitrap-MS and multivariate analyses

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Journal of Pharmaceutical Analysis 2022年第5期12卷 733-742页

作者： Zihan Zhao Yue Liu Yushi Zhang Zeyu Geng Rina Su Lipeng Zhou Chao Han Zhanjun Wang Shuangcheng Ma Weidong Li School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing102488China institute of Forestry and Grassland Ecology Ningxia Academy of Agricultural and Forestry SciencesYinchuan750002China institute for Control of Chinese Traditional Medicine and Ethnic Medicine National Institutes for Food and Drug ControlBeijing100050China

Pruni Semen,the seed of several unique Prunus plants,is a traditional purgative herbal *** determine the authentic sources of Pruni Semen,46 samples from four species were collected and *** compounds including multiflorin A(Mul A),a notable purative compound,were isolated and identified by chemical separation and nuclear magnetic resonance ***-six communal components were identified by ultra-high performance liquid chromatography with linear ion trap-quadrupole Orbitrap mass spectrometry,and acetyl flavonoid glycosides were recognized as characteristic *** flavonoids were distributed in the seed coat and cyanogenic glycosides in the *** on this,methods for identifying Pruni Semen from different sources were established using chemical fingerprinting,quantitative analysis of the eight principal compounds,hierarchical cluster analysis,principal component analysis,and orthogonal partial least squares discriminant *** results showed that the samples were divided into two categories:one is the small seeds from Prunus humilis(Ph)and Prunus japonica(Pj),and the other is the big seeds from Prunus pedunculata(Pp)and Prunus triloba(Pt).The average content of Mul A was 3.02,6.93,0.40,and 0.29 mg/g,while the average content of amygdalin was 18.5,17.7,31.5,and 30.9 mg/g in Ph,Pj,Pp,and Pt,*** the above information suggests that small seeds might be superior sources of Pruni *** is the first comprehensive report on the identification of chemical components in Pruni Semen from different species.

关键词： Pruni semen Acetyl flavonoids Amygdalin Multivariate analyses Authentic sources