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Predictors of 30-day readmission following pancreatic surgery:A retrospective review

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Hepatobiliary & Pancreatic Diseases International 2018年第3期17卷 269-274页

作者： Leo I.Amodu Jamil Alexis Aron Soleiman Meredith Akerman Poppy Addison Toni Iurcotta Horacio L.Rodriguez Rilo Department of Surgery Hofstra-Northwell School of Medicine Pancreas Disease Center Northwell Health Department of Biostatistics Feinstein Institute for Medical Research

Background： Pancreatectomies have been identified as procedures with an increased risk of *** surgical patients, readmissions within 30 days of discharge are usually procedure-related. We sought to determine predictors of 30-day readmission following pancreatic resections in a large healthcare ***： We retrospectively collected information from the records of 383 patients who underwent pancreaticresections from 2004–2013. To find the predictors of readmission in the 30 days after discharge,we performed a univariate screen of possible variables using the Fisher’s exact test for categorical variables and the Mann–Whitney U test for continuous variables. Multivariate analysis was used to determinethe independent factors.

关键词： Pancreatic Predictors Readmission Resection Risk30-day

Advanced imaging in surveillance of Barrett’s esophagus: Is the juice worth the squeeze?

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World Journal of Gastroenterology 2019年第25期25卷 3108-3115页

作者： Sara A Cerrone Arvind J Trindade Division of Gastroenterology Long Island Jewish Medical CenterZucker School of Medicine at Hofstra/NorthwellNorthwell Health System

Esophageal cancer is on the *** known precursor lesion is Barrett’s esophagus(BE).Patients with dysplasia are at higher risk of developing esophageal *** the gold standard for surveillance endoscopy involves taking targeted biopsies of abnormal areas as well as random biopsies every 1-2 cm of the length of the Barrett’*** studies have shown that this surveillance can miss dysplasia and *** imaging technologies have been developed that may help detect dysplasia in *** opinion review discusses advanced imaging in BE surveillance endoscopy and its utility in clinical practice.

关键词： Barrett’s esophagus Advanced imaging Chromoendoscopy Endomicroscopy

Altered leukocyte gene expression after traumatic spinal cord injury:clinical implications

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Neural Regeneration Research 2018年第9期13卷 1524-1529页

作者： Paige E.Herman Ona Bloom The Feinstein Institute for Medical Research Northwell Health Departments of Physical Medicine and Rehabilitation Molecular MedicineDonald and Barbara Zucker School of Medicine at Hofstra Northwell

In addition to changes in motor and sensory function, individuals with spinal cord injury （SCI） experience immunological changes. These changes are clinically significant, as infections are the leading cause of death for this population. Along with increased infections, inflammation is commonly observed in persons with SCI, where it may promote many common medical consequences. These include elevated risk of cardio- vascular disease, impaired wound healing, diabetes and neuropathic pain. It has also been proposed that chronic inflammation dampens neurological recovery. In order to identify therapeutic strategies to im- prove immune function, we need a greater understanding of the molecular changes that occur in immune cells after SCI. The purpose of this mini-review is to discuss two recent studies that used functional genom- ics to investigate gene expression in circulating leukocytes isolated from persons with SCI. In the future, the molecular pathways that are altered after SCI may be targeted to improve immunological function, as well as overall health and functional recovery, after SCI.

关键词： traumatic spinal cord injury inflammation immune cells functional genomics gene expression autoimmunity microarray chronic spinal cord injury

Splenic arteriovenous fistula leading to non-cirrhotic portal hypertension:a case report

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Gastroenterology Report 2023年第1期11卷 545-547页

作者： Ahmad Abou Yassine Hassan Al Moussawi Malek Kreidieh Loai Dahabra Mustafa Al-Roubaie Sanjaya Satapathy Department of Internal Medicine Staten Island University HospitalNorthwell HealthStaten IslandNYUSA Division of Gastroenterology Department of Internal MedicineStaten Island University HospitalNorthwell HealthStaten IslandNYUSA Department of Radiology North Shore University HospitalNorthwell HealthManhassetNYUSA Department of Gastroenterology North Shore University HospitalNorthwell HealthManhassetNYUSA

Introduction Non-cirrhotic portal hypertension(NCPH)is a rare disease characterized by portal hypertension in the absence of cirrhosis or other causes of liver disease and splanchnic venous *** case is a rare presenta... 详细信息

关键词： hypertension fistula arteriovenous

Outcomes following operative vs. non-operative management of blunt traumatic pancreatic injuries: a retrospective multi-institutional study

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Burns & Trauma 2016年第4期4卷 316-322页

作者： Poppy Addison Toni Iurcotta Leo I.Amodu Geoffrey Crandall Meredith Akerman Daniel Galvin Annemarie Glazer Nathan Christopherson Jose Prince Matthew Bank Christopher Sorrentino Joaquin Cagliani Jeffrey Nicastro Gene Coppa Ernesto P.Molmenti Horacio L.Rodriguez Rilo Department of Surgery Hofstra-Northwell School of MedicineHempsteadNYUSA Pancreas Disease Center Northwell HealthManhassetNYUSA Department of Surgery Hofstra-Northwell School of MedicineHempsteadNYUSA Department of Biostatistics Feinstein Institute for Medical ResearchManhassetNYUSA Pancreas Disease Center Northwell HealthManhassetNYUSA Department of Surgery Hofstra-Northwell School of MedicineHempsteadNYUSA Pancreas Disease Center Northwell HealthManhassetNYUSA northwell health 900 Northern BoulevardSuite 150Great NeckNY 11020USA

Background:Traumatic pancreatic injuries are rare,and guidelines specifying management are controversial and difficult to apply in the acute clinical *** to sparse data on these injuries,we carried out a retrospective review to determine outcomes following surgical or non-surgical management of traumatic pancreatic *** hypothesize a higher morbidity and mortality rate in patients treated surgically when compared to patients treated ***:We performed a retrospective review of data from four trauma centers in New York from 1990–2014,comparing patients who had blunt traumatic pancreatic injuries who were managed operatively to those managed *** compared continuous variables using the Mann-Whitney U test and categorical variables using the chi-square and Fisher’s exact *** analysis was performed to determine the possible confounding factors associated with mortality in both treatment ***:Twenty nine patients were managed operatively and 32 *** was a significant difference between the operative and non-operative groups in median age(37.0 vs.16.2 years,P=0.016),grade of pancreatic injury(grade I;30.8 vs.85.2%,P value for all comparisons<0.0001),median injury severity score(ISS)(16.0 vs.4.0,P=0.002),blood transfusion(55.2 vs.15.6%,P=0.0012),other abdominal injuries(79.3 vs.38.7%,P=0.0014),pelvic fractures(17.2 vs.0.00%,P=0.020),intensive care unit(ICU)admission(86.2 vs.50.0%,P=0.003),median length of stay(LOS)(16.0 vs.4.0 days,P<0.0001),and mortality(27.6 vs.3.1%,P=0.010).Conclusions:Patients with traumatic pancreatic injuries treated operatively were more severely injured and suffered greater complications than those treated *** greater morbidity and mortality associated with these patients warrants further study to determine optimal triage strategies and which subset of patients is likely to benefit from surgery.

关键词： Injury Management Non-operative Operative Pancreas Trauma

Presentation, patterns and predictive value of baseline liver tests on outcomes in COVID-19 patients without chronic liver disease

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World Journal of Gastroenterology 2021年第42期27卷 7350-7361页

作者： David Bernstein Nitzan Roth Angela Kim Marica Epstein David Hirschwerk Charlotte L Kvasnovsky Sanjaya K Satapathy Department of Medicine/Hepatology Northwell HealthZucker School of Medicine at Hofstra/NorthwellManhassetNY 11030United States Division of Infectious Diseases Department of Medicine Northwell HealthZucker School of Medicine at Hofstra/NorthwellManhassetNY 11030United States Cohen Children's Medical Center Zucker School of Medicine at Hofstra/NorthwellNew Hyde ParkNY 11042United States

BACKGROUND Coronavirus disease 2019(COVID-19)infection is known to cause abnormal hepatic *** long term consequences of such elevations are *** To assessed the prevalence and prognostic value of initial liver enzymes in a large cohort of COVID-19 *** We reviewed electronic medical records of 10614 COVID-19 patients without known chronic liver disease who were admitted to our health system from March 1,2020,to April 30,*** analyzed baseline demographics and liver *** primary outcome was in-hospital mortality,and the secondary outcome was a composite of in-hospital mortality or need for mechanical *** Subjects with abnormal liver tests had increased risks of mortality and composite outcome when compared to patients with normal measurements on unadjusted analysis and after adjustment for demographic *** In our diverse patient population,liver enzyme abnormalities are associated with increased mortality and the need for mechanical ventilation in subjects without chronic liver *** patients are at the greatest risk for poor outcomes.

关键词： COVID-19 Liver enzymes Outcomes Predictors

Review of inflammatory bowel disease and COVID-19

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World Journal of Gastroenterology 2020年第37期26卷 5534-5542页

作者： Keith Sultan Anjali Mone Laura Durbin Samreen Khuwaja Arun Swaminath Division of Gastroenterology Northwell HealthNorth Shore University Hospital and Long Island Jewish Medical CenterGreat NeckNY 10021United States Department of Gastroenterology Northwell HealthLenox Hill HospitalNew YorkNY 10075United States Department of Medicine Northwell HealthLenox Hill HospitalNew YorkNY 10075United States Department of Medicine Northwell HealthLong Island Jewish Forest Hills HospitalQueensNY 11375United States Division of Gastroenterology Northwell HealthLenox Hill HospitalNew YorkNY 10075United States

The first cases of a novel corona virus infection were reported in Wuhan China in December of 2019,followed by the declaration of an international pandemic by the World health Organization in March *** reports of the virus,now known as severe acute respiratory syndrome coronavirus 2,and its clinical disease coronavirus disease 2019(COVID-19),has shown higher rates of morbidity and mortality in the elderly and those with pre-existing medical *** particular concern is the safety of those with compromised immune *** Bowel disease(IBD)is itself caused by a disordered immune response,with the most effective medical therapies being immune suppressing or *** such,the risk of COVID-19,virus related outcomes,and appropriate management of IBD patients during the global pandemic is of immediate concern to gastroenterologists *** has been a rapid accumulation of clinical data and expert opinion on the *** review will highlight the latest source information on clinical observation/outcomes of the IBD population and provide a concise summary of the most up to date perspectives on IBD management in the age of COVID-19.

关键词： Inflammatory bowel disease COVID-19 SARS-CoV-2 Corona virus Pandemic

Characterization of inflammation and insulin resistance in high-fat diet-induced male C57BL/6J mouse model of obesity

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Animal Models and Experimental Medicine 2019年第4期2卷 252-258页

作者： Dimiter Avtanski Valentin A.Pavlov Kevin J.Tracey Leonid Poretsky Lenox Hill Hospital Friedman Diabetes InstituteNorthwell HealthNew YorkNYUSA The Feinstein Institutes for Medical Research Northwell HealthManhassetNYUSA Donald and Barbara Zucker School of Medicine at Hofstra/northwell HempsteadNYUSA

Background: Animal models of diet-induced obesity(DIO) are commonly used in medical research for mimicking human diseases. There is no universal animal model, and careful evaluation of variety of factors needs to be considered when designing new experiments. Here, we investigated the effect of 9 weeks high-fat diet(HFD) intervention, providing 60% energy from fat, on parameters of inflammation and insulin resistance in male C57 BL/6 J ***: Six weeks old mice were initiated on regular diet(RD) or HFD providing 60 kcal energy from fat for 9 weeks. Fasting blood glucose levels were measured by glucometer, and fasting plasma levels of insulin and proinflammatory cytokines by Luminex assay. Insulin sensitivity was evaluated by using QUICKI and HOMA2 ***: HFD mice showed ~ 40% higher body weight and ~ 20% larger abdominal circumference, due to an increase in the white adipose tissue mass. Liver examination revealed increased size and higher hepatic lipid accumulation in livers from HFD mice compared to their RD counterparts. Animals from the HFD group were characterized with significantly higher presence of crown-like structures(CLS) in WAT and higher plasma levels of proinflammatory cytokines(TNF-α, IL-6, leptin, MCP-1, PAI-1, and resistin). HFD-fed mice also demonstrated impaired insulin sensitivity(lower QUICKI, higher HOMA-insulin resistance(HOMA-IR), and lower HOMA-percent sensitivity(HOMA-%S)) index ***: Male C57 BL/6 J mice on 9 weeks HFD providing 60 kcal energy from fat display impaired insulin sensitivity and chronic inflammation, thus making this DIO mouse model appropriate for studies of early stages of obesity-related pathology.

关键词： diet high‐fat insulin resistance mouse model

Management of Barrett’s esophagus with dysplasia refractory to radiofrequency ablation

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World Journal of Gastroenterology 2020年第17期26卷 2030-2039页

作者： Kara L Raphael Arvind J Trindade Division of Gastroenterology Long Island Jewish Medical CenterZucker School of Medicine at Hofstra/NorthwellNorthwell Health SystemNew Hyde ParkNY 11040United States

Radiofrequency ablation(RFA)is very effective for eradication of flat Barrett’s mucosa in dysplastic Barrett’s esophagus after endoscopic resection of raised ***,in a minority of the time,RFA may be ineffective at eradication of the Barrett’s *** complete eradication of intestinal metaplasia can be challenging in these *** review article focuses on the management of patients with dysplastic Barrett’s esophagus refractory to RFA *** strategies discussed in this review include optimizing the RFA procedure,optimizing acid suppression(with medical,endoscopic,and surgical management),cryotherapy,hybrid argon plasma coagulation,and EndoRotor resection.

关键词： Low-grade dysplasia High-grade dysplasia Radiofrequency ablation Cryotherapy EndoRotor Hybrid argon plasma coagulation Argon plasma coagulation