检索结果-南通市图书馆

Thermoregulation,incubator humidity,and skincare practices in appropriate for gestational age ultra-low birth weight infants:need for more evidence

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Pediatrics 2024年第7期20卷 643-652页

作者： Umesh Mishra Deanne August Karen Walker Pranav R.Jani Mark Tracy Faculty of Medicine and Health University of SydneySydneyAustralia department of Neonatology Westmead HospitalWestmeadNSWAustralia Grantley Stable neonatal Unit Royal Brisbane and Women’s HospitalBrisbaneAustralia School of Nursing Midwifery and Social WorkUniversity of QueenslandBrisbaneAustralia department of newborn care Royal Prince Alfred HospitalCamperdownAustralia

Background Although not universal,active care is being offered to infants weighing<500 g at birth,referred to as ultra-low birth weight(ULBW)infants appropriate for gestational *** infants have the greatest risk of dy... 详细信息

Background Although not universal,active care is being offered to infants weighingcare to this cohort of *** sources A comprehensive review of the literature was performed using the PubMed and Embase *** keywords included“thermoregulation or body temperature regulation”,“incubator humidity”,“skin care”,“infant,extremely low birth weight”and“ultra-low birth weight infants”.Results Evidences for thermoregulation,incubator humidity,and skincare practices are available for preterm infants weighingcare practices had a small sample size and did not include a sub-group analysis for ULBW *** practice recommendations in ULBW infants are adopted from research in very and/or extremely low birth weight *** This narrative review focuses on challenges in thermoregulation,incubator humidity,and skincare practices in ULBW infants,highlights current research gaps and suggests potential developments for informing practices for improving health outcomes in ULBW infants.

关键词： Incubator humidity neonatal intensive care unit Skincare Thermoregulation Ultra-low birth weight

Prognostic value of circulating tumor cells in esophageal cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2017年第7期23卷 1310-1318页

作者： Hai-Tao Xu Jing Miao Jian-Wei Liu Lian-Guo Zhang Qing-Guang Zhang department of Thoracic Surgery Affiliated Hospital of Binzhou Medical University department of neonatal Intensive care Unit Binzhou People’s Hospital

AIM To perform a meta-analysis of the related studies to assess whether circulating tumor cells(CTCs) can be used as a prognostic marker of esophageal *** Pub Med, Embase, Cochrane Library and references in relevant studies were searched to assess the prognostic relevance of CTCs in patients with esophageal cancer. The primary outcome assessed was overall survival(OS). The meta-analysis was performed using the random effects model, with hazard ratio(HR), risk ratio(RR) and 95% confidence intervals(95%CIs) as effect *** Nine eligible studies were included involving a total of 911 esophageal cancer patients. Overall analyses revealed that CTCs-positivity predicted disease progression(HR = 2.77, 95%CI: 1.75-4.40, P < 0.0001) and reduced OS(HR = 2.67, 95%CI: 1.99-3.58, P < 0.00001). Further subgroup analyses demonstrated that CTCs-positive patients also had poor OS in different subsets. Moreover, CTCs-positivity was also significantly associated with TNM stage(RR = 1.48, 95%CI: 1.07-2.06, P = 0.02) and T stage(RR = 1.44, 95%CI: 1.13-1.84, P = 0.003) in esophageal *** Detection of CTCs at baseline indicates poor prognosis in patients with esophageal cancer. However, this finding relies on data from observational studies and is potentially subject to selection bias. Prospective trials are warranted.

关键词： Circulating tumor cells Esophageal cancer Prognosis Meta-analysis

Magnesium sulfate and fetal neuroprotection: overview of clinical evidence

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2018年第12期13卷 2044-2049页

作者： Clément Chollat Stéphane Marret Institut National de la Santé et de la Recherche Médicale U1245 Genetics and Pathophysiology of Neurodevelopmental Disorders Team 4Neovasc Institute of Research and Innovation in Biomedicine Rouen School of Medicine Normandy University department of neonatal Intensive care Port Royal University Hospital department of neonatal Pediatrics and Intensive care and Neuropediatrics Charles-Nicolle University Hospital

Antenatal administration of magnesium sulfate is an important part of the neuroprotective strategy for preterm infants. Strong evidence from five randomized controlled trials and five meta-analyses has demonstrated that magnesium sulfate, when administered before preterm delivery, significantly reduces the risk of cerebral palsy at two years. Through secondary analyses of randomized controlled trials and other original clinical studies, this state-of-the-art review highlights the absence of serious adverse effects in both pregnant women and neonates, as well as the impact of maternal body mass index and preeclamptic status on the maternal and neonatal magnesium levels, which could influence the magnitude of the neuroprotective effect. Although antenatal magnesium sulfate is a cost-effective strategy, some practice surveys have demonstrated that the use of magnesium sulfate is not sufficient and that its use is heterogeneous, differing among different maternity wards. Since 2010, an increasing number of obstetrical societies have recommended its use to improve the neurological outcomes of preterm infants, especially the International Federation of Gynecology and Obstetrics and World Health Organization in 2015, and France in 2017. Considering the neuroprotective impact of magnesium sulfate when administered before delivery, postnatal administration should be considered, and its effects should be assessed using randomized controlled trials.

关键词： magnesium sulfate preterm birth neuroprotection cerebral palsy neurodevelopment international recommendations clinical studies meta-analysis preeclampsia cost-effectiveness

Early neonatal complications in pregnant women with gestational diabetes mellitus and the effects of glycemic control on neonatal infection

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Diabetes 2023年第9期14卷 1393-1402页

作者： Bei-Bei Wang Mei Xue department of neonatal Intensive care Unit Taizhou People’s Hospital of Jiangsu ProvinceTaizhou 225300Jiangsu ProvinceChina

BACKGROUND Gestational diabetes mellitus(GDM)has become increasingly prevalent *** control in pregnant women with GDM has a critical role in neonatal *** To analyze the early neonatal complications in GDM,and examine the effect of blood glucose control level on neonatal *** The clinical data of 236 pregnant women with GDM and 240 healthy pregnant women and newborns during from March 2020 to December 2021 the same period were retrospectively analyzed,and the early complications in newborns in the two groups were *** patients were divided into the conforming glycemic control group(CGC group)and the non-conforming glycemic control group(NCGC group)based on whether glycemic control in the pregnant women with GDM conformed to *** data,immune function,infectionrelated markers,and infection rates in neonates were compared between the two *** The incidence of neonatal complications in the 236 neonates in the GDM group was significantly higher than that in the control group(P0.05).Additionally,the NCGC group had significantly decreased peripheral blood CD3^(+),CD4^(+),CD8^(+)T cell ratios,CD4/CD8 ratios and immunoglobulin G in neonates compared with the CGC group(Pneonatal infection rate was also significantly increased in the NCGC group(Pneonatal complications increased in pregnant women with *** glycemic control decreased neonatal immune function,and increased the incidence of neonatal infections.

关键词： Gestational diabetes mellitus Early neonatal complications Glycemic control neonatal infection

Protective effect of topiramate on hypoxic-ischemic brain injury in neonatal rat

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Medicine 2014年第6期7卷 496-500页

作者： Hong Jiang Juan-Juan Lei Yi-He Zhang neonatal department Affiliated Hospital of Yan'an University of Shaanxi Province

Objective:To explore protective effeet of topiramate(TPM) on hypoxic—ischemic brain ***:A total of 360 neonatal rats were seleeted then randomly divided into sham operation group,ischemia and hypoxia group,conventional treatment group and degradation therapy group(n=90).After surgical treatment,sham and ischemic hypoxia group were treat with normal saline:conventional treatment group was received Tl'M solution 100 mg/kg.2 times/d:degradation therapy group received TPM solution 150 mg/kg.2 times/*** 3 d treatment each dosage was reduced 50 mg/*** lowest reduced to 50 mg/*** groups received continuous treatment for 10 *** treatment for 1 d.4 d.7 d.10 d the cercbral edema,neuron-specific enolase(NSE)and γ-aminobutyric acid(GABA) levels and cognitive abilities of four groups were ***:After 1d.4d of treatment,the brain water conlenl and NSE levels in ischemia and hypoxia group,the conventional treatment group and the degradation therapy group were significantly higher than that in sham group(P.the GABA levels in the conventional treatment

关键词： TPM Brain Injury NSE GABA

Effect of erythropoietin combined with hypothermia on serum tau protein levels and neurodevelopmental outcome in neonates with hypoxic-ischemic encephalopathy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2017年第10期12卷 1655-1663页

作者： Hong-yan Lv Su-jing Wu Qiu-li Wang Li-hong Yang Peng-shun Ren Bao-jun Qiao Zhi-ying Wang Jia-hong Li Xiu-ling Gu Lian-xiang Li department of Neonatology Handan Maternal and Child Health Care HospitalHandanHebei ProvinceChina department of neonatal Pathology Handan Maternal and Child Health Care HospitalHandanHebei ProvinceChina department of Children’s Rehabilitation Handan Maternal and Child Health Care HospitalHandanHebei ProvinceChina department of Neural Development and Neural Pathology Hebei University of Engineering School of MedicineHandanHebei ProvinceChina

Although hypothermia therapy is effective to treat neonatal hypoxic-ischemic encephalopathy,many neonatal patients die or suffer from severe neurological *** is considered one of the most promising neuroprotective *** hypothesized that erythropoietin combined with hypothermia will improve efficacy of neonatal hypoxic-ischemic encephalopathy *** this study,41 neonates with moderate/severe hypoxic-ischemic encephalopathy were randomly divided into a control group（hypothermia alone for 72 hours,n = 20） and erythropoietin group（hypothermia ＋ erythropoietin 200 IU/kg for 10 days,n = 21）.Our results show that compared with the control group,serum tau protein levels were lower and neonatal behavioral neurological assessment scores higher in the erythropoietin group at 8 and 12 ***,neurodevelopmental outcome was similar between the two groups at 9 months of *** findings suggest that erythropoietin combined with hypothermia reduces serum tau protein levels and improves neonatal behavioral neurology outcome but does not affect long-term neurodevelopmental outcome.

关键词： nerve regeneration erythropoietin hypothermia hypoxic-ischemic encephalopathy neonate tau protein biomarkers prognosis neuroprotection neural regeneration

Variable phenotypes and outcomes associated with the MMACHC c.482G>A mutation:follow-up in a large CblC disease cohort

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Pediatrics 2024年第8期20卷 848-858页

作者： Sheng-Nan Wu Hui-Shu E Yue Yu Shi-Ying Ling Li-Li Liang Wen-Juan Qiu Hui-Wen Zhang Rui-Xue Shuai Hai-Yan Wei Chi-Ju Yang Peng Xu Xi-Gui Chen Hui Zou Ji-Zhen Feng Ting-Ting Niu Hai-Li Hu Kai-Chuang Zhang De-Yun Lu Zhu-Wen Gong Xia Zhan Wen-Jun Ji Xue-Fan Gu Yong-Xing Chen Lian-Shu Han department of Endocrinology and Metabolism Henan Key Laboratory of Children’s Genetics and Metabolic DiseasesChildren’s Hospital Affiliated to Zhengzhou UniversityHenan Children’s HospitalZhengzhou Children’s HospitalNo.255 Gangdu StreetZhengzhouChina department of Pediatric Endocrinology and Genetics Fujian Children’s HospitalFuzhouChina The Center for Pediatric Liver Diseases Children’s HospitalFudan UniversityShanghaiChina department of Pediatric Endocrinology/Genetics Shanghai Institute for Pediatric ResearchXinhua HospitalSchool of MedicineShanghai Jiao Tong UniversityNo.1665 Kongjiang RoadShanghaiChina department of Pediatrics Second Affiliated Hospital of Naval Medical UniversityShanghaiChina Center of neonatal Disease Screening Jining Maternal and Child Health Care HospitalJiningChina Center of neonatal Disease Screening Jinan Maternal and Child Health Care HospitalJinanChina Center of neonatal Disease Screening Shijiazhuang Maternal and Child Health Care HospitalShijiazhuangChina Center of neonatal Disease Screening Shandong Maternal and Child Health Care HospitalJinanChina Center of neonatal Disease Screening Hefei Maternal and Child Health Care HospitalHefeiChina

Background The aim of this study was to characterize the variable phenotypes and outcomes associated with the methylmalonic aciduria and homocystinuria type C protein gene(MMACHC)c.482G>A mutation in 195 Chinese cases with CblC *** We carried out a national,retrospective multicenter study of 195 Chinese patients with CblC disease attributable to the MMACHC c.482G>A variant either in a homozygous or compound heterozygous *** control group consisted of 200 patients diagnosed with CblC disease who did not possess the c.482G>A *** features,including disease onset,symptoms,biochemical metabolites,gene mutation,and follow-up outcomes were reviewed and analyzed in *** median follow-up period spanned 3 years and 8 months,with a range of 1 year and 2 months to 12 years and 10 *** Among 195 patients carrying the c.482G>A variant,125(64.1%)cases were diagnosed by newborn screening(NBS),60(30.8%)cases were detected due to disease onset,and 10(5.1%)cases were identified from sibling *** hundred and seventeen(93.6%)individuals who were diagnosed by NBS,and nine patients who came from sibling diagnoses remained asymptomatic in this *** 69 symptomatic patients of the c.482G>A group,more patients presented with later onset,and the top six common clinical symptoms at disease onset were developmental delay(59.4%),lower limb weakness and poor exercise tolerance(50.7%),cognitive decline(37.7%),gait instability and abnormal posture(36.2%),seizures(26.1%),and psychiatric and behavioral disturbances(24.6%).In the 159 symptomatic patients lacking c.482G>A variants,the most frequently observed clinical manifestations at disease onset included developmental delay(81.8%),lethargy and feeding difficulty(62.9%),lower limb weakness and poor exercise tolerance(54.7%),prolonged neonatal jaundice(51.6%),vomiting(47.2%),and seizures(32.7%).Before treatment,the levels of blood propionylcarnitine,propionylcarnitine/acetylcarnitine ratio

关键词： c.482G>A CblC disease MMACHC gene newborn screening Outcome

Treating aplasia cutis congenita in a newborn with the combination of ionic silver dressing and moist exposed burn ointment: A case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2019年第17期7卷 2611-2616页

作者： Guo-Feng Lei Jun-Ping Zhang Xiao-Bing Wang Xiao-Li You Jin-Ya Gao Xiao-Mei Li Mei-Ling Chen Xiu-Qin Ning Jiang-Li Sun department of neonatal Intensive care Unit Sanmenxia Central HospitalSanmenxia 472000Henan ProvinceChina department of Intensive care Unit Sanmenxia Central HospitalSanmenxia 472000Henan ProvinceChina Reproductive endocrine center Sanmenxia Central HospitalSanmenxia 472000Henan ProvinceChina

BACKGROUND Aplasia cutis congenita (ACC) in newborns is a condition in which congenital defects or hypoplasia is present in part of the epidermis,dermis and even subcutaneous tissue (including muscle and bones).First reported by Cordon in 1767,ACC is a rare disease with a low incidence of 1/100000 to 3/***,there are 500 cases reported *** can be accompanied by other *** onset mechanism of the disease remains unknown but is thought to be correlated to factors such as genetics,narrow uterus,foetal skin and amniotic membrane adhesion,use of teratogenic drugs in early pregnancy and viral *** SUMMARY In August 2018,we treated a newborn with ACC on the left lower limbs using a combination of ionic silver dressing and moist exposed burn ointment (MEBO) and achieved a satisfactory treatment *** skin defects were observed on the external genitals and on areas from the left foot to 3/4 of the upper left *** tissue and blood vessels were observed in the regions with skin *** following treatments were ***,the wound was rinsed with 0.9% sodium chloride solution followed by disinfection with povidone-iodine *** then MEBO was applied to the wound at a thickness of approximately 1 *** applying ionic silver dressing,the wound was covered with sterile *** wound dressing was replaced every 2-3 *** the 4-mo follow-up,the treatment outcome was *** was minimal scar tissue formation,and limb function was not *** The combination of ionic silver dressing and MEBO to ACC is helpful.

关键词： Aplasia cutis congenita newborns Ionic silver dressing Moist exposed burn ointment

Aluminum exposure and toxicity in neonates:a practical guide to halt aluminum overload in the prenatal and perinatal periods

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Pediatrics 2014年第2期10卷 101-107页

作者： Daniela Fanni Rossano Ambu Clara Gerosa Sonia Nemolato Nicoletta Iacovidou Peter Van Eyken Vassilios Fanos Marco Zaffanello Gavino Faa department of Pathology University Hospital San Giovanni di DioAOU Cagliari and University of CagliariItaly National and Kapodistrian University of Athens Medical SchoolAthensGreece department of Pathology K.U.LeuvenLeuvenBelgium neonatal Intensive care Unit Puericulture Institute and Neonatal SectionAOU Cagliari and University of CagliariItaly department of Pediatrics University of VeronaItaly

Background:During the last years,human newborns have been overexposed to biologically reactive aluminum,with possible relevant consequences on their future health and on their susceptibility to a variety of ***,newborns and particularly preterm neonates are at an increased risk of aluminum toxicity because of their relative *** sources:Based on recent original publications and classical data of the literatures,we reviewed the aluminum content in mother's food during the intrauterine life as well as in breast milk and infant formula during *** also determined the possible role of aluminum in parenteral nutrition solutions,in adjuvants of vaccines and in pharmaceutical products.A special focus is placed on the relationship between aluminum overexposure and the insurgence of bone ***:Practical points of management and prevention are *** sources that infants may receive during the fi rst 6 months of life are *** the context of prevention of possible adverse effects of aluminum overload in fetal tissues during development,simple suggestions to pregnant women are ***,practical points of management and prevention are ***:Pediatricians and neonatologists must be more concerned about aluminum content in all products our newborns are exposed to,starting from monitoring aluminum concentrations in milk-and soybased formulas in which,on the basis of recent studies,there is still too much aluminum.

关键词： aluminum fetus newborn toxicity