Protective effect of topiramate on hypoxic-ischemic brain injury in neonatal rat
Protective effect of topiramate on hypoxic-ischemic brain injury in neonatal rat作者机构：Neonatal DepartmentAffiliated Hospital of Yan'an University of Shaanxi Province
出 版 物：《Asian Pacific Journal of Tropical Medicine》 (亚太热带医药杂志（英文版）)
年 卷 期：2014年第7卷第6期
页 面：496-500页
核心收录：
学科分类：1002[医学-临床医学] 100202[医学-儿科学] 10[医学]
摘 要：Objective:To explore protective effeet of topiramate(TPM) on hypoxic—ischemic brain ***:A total of 360 neonatal rats were seleeted then randomly divided into sham operation group,ischemia and hypoxia group,conventional treatment group and degradation therapy group(n=90).After surgical treatment,sham and ischemic hypoxia group were treat with normal saline:conventional treatment group was received Tl M solution 100 mg/kg.2 times/d:degradation therapy group received TPM solution 150 mg/kg.2 times/*** 3 d treatment each dosage was reduced 50 mg/*** lowest reduced to 50 mg/*** groups received continuous treatment for 10 *** treatment for 1 d.4 d.7 d.10 d the cercbral edema,neuron-specific enolase(NSE)and γ-aminobutyric acid(GABA) levels and cognitive abilities of four groups were ***:After 1d.4d of treatment,the brain water conlenl and NSE levels in ischemia and hypoxia group,the conventional treatment group and the degradation therapy group were significantly higher than that in sham group(P.the GABA levels in the conventional treatment
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