检索结果-南通市图书馆

Accelerated intermetallic phase amorphization in a Mg-based high-entropy alloy powder

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Magnesium and Alloys 2024年第5期12卷 1792-1798页

作者： Prince Sharma Purvam Mehulkumar Gandhi Kerri-Lee Chintersingh Mirko Schoenitz Edward L.Dreizin Sz-Chian Liou Ganesh Balasubramanian Institute for Functional Materials&Devices Lehigh University center of Materials for Advanced Energetics New Jersey Institute of Technology

We describe a novel mechanism for the synthesis of a stable high-entropy alloy powder from an otherwise immiscible Mg-Ti rich metallic mixture by employing high-energy mechanical milling. The presented methodology expedites the synthesis of amorphous alloy powder by strategically injecting entropic disorder through the inclusion of multi-principal elements in the alloy composition. Predictions from first principles and materials theory corroborate the results from microscopic characterizations that reveal a transition of the amorphous phase from a precursor intermetallic structure. This transformation, characterized by the emergence of antisite disorder, lattice expansion, and the presence of nanograin boundaries, signifies a departure from the precursor intermetallic structure. Additionally, this phase transformation is accelerated by the presence of multiple principal elements that induce severe lattice distortion and a higher configurational entropy. The atomic size mismatch of the dissimilar elements present in the alloy produces a stable amorphous phase that resists reverting to an ordered lattice even on annealing.

关键词： High-entropy alloy High-energy milling Antisite disorder Amorphous Intermetallic

Di-PEGylated insulin:A long-acting insulin conjugate with superior safety in reducing hypoglycemic events

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2024年第6期14卷 2761-2772页

作者： Zhipeng Zeng Runcheng Tan Shi Chen Haolin Chen Zhijia Liu Lixin Liu Mingqiang Li Yongming Chen Laboratory of biomaterials and Translational Medicine Center for NanomedicineThe Third Affiliated HospitalSun Yat-sen UniversityGuangzhou 510630China School of Materials Science and Engineering Center of Functional BiomaterialsKey Laboratory of Polymeric Composite Materials and Functional Materials of Ministry of EducationSun Yat-sen UniversityGuangzhou 510275China

Although the discovery of insulin 100 years ago revolutionized the treatment of diabetes,its therapeutic potential is compromised by its short half-life and narrow therapeutic index.Current long-acting insulin analogs,such as insulin-polymer conjugates,are mainly used to improve pharmacokinetics by reducing renal clearance.However,these conjugates are synthesized without sacrificing the bioactivity of insulin,thus retaining the narrow therapeutic index of native insulin,and exceeding the efficacious dose still leads to hypoglycemia.Here,we report a kind of di-PEGylated insulin that can simultaneously reduce renal clearance and receptor-mediated clearance.By impairing the binding affinity to the receptor and the activation of the receptor,di-PEGylated insulin not only further prolongs the half-life of insulin compared to classical mono-PEGylated insulin but most importantly,increases its maximum tolerated dose 10-fold.The target of long-term glycemic management in vivo has been achieved through improved pharmacokinetics and a high dose.This work represents an essential step towards long-acting insulin medication with superior safety in reducing hypoglycemic events.

关键词： Diabetes Insulin Therapeutic index Hypoglycemia PEGylation Receptor-mediated clearance Half-life Diabetic nephropathy

Pylephlebitis-induced acute liver failure: A case report and review of literature

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Hepatology 2024年第1期16卷 103-108页

作者： Vera Hapshy Steven Imburgio Harshavardhan Sanekommu Brandon Nightingale Sobaan Taj Mohammad A Hossain Swapnil Patel Department of Internal Medicine Jersey Shore University Medical CenterNeptuneNJ 07753United States

BACKGROUND Pylephlebitis is an extremely rare form of septic thrombophlebitis involving the portal vein,carrying high rates of morbidity and mortality.CASE SUMMARY We present a case of a 42-year-old male with no past medical history who presented with acute onset of abdominal pain and altered mental status with laboratory tests demonstrating new-onset acute liver failure.Pylephlebitis was determined to be the underlying etiology due to subsequent workup revealing polymicrobial gram-negative anaerobic bacteremia and complete thrombosis of the main and left portal veins.To our knowledge,this is the first documented case of acute liver failure as a potential life-threatening complication of pylephlebitis.CONCLUSION Our case highlights the importance of considering pylephlebitis in the broad differential for abdominal pain,especially if there are co-existing risk factors for hypercoagulability.We also demonstrate that fulminant hepatic failure in these patients can potentially be reversible with the immediate initiation of antibiotics and anticoagulation.

关键词： Portal vein thrombosis Septic thrombophlebitis Gram negative anaerobic bacteremia Pylephlebitis Acute liver failure Case report

Clean production of lactic acid by selective carbon-carbon bond cleavage of biomass feedstock over a novel carbon-bismuth oxychloride photocatalyst

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Chemical Science and Engineering 2024年第2期18卷 69-81页

作者： Zulfiqar Ali Jiliang Ma Dongnv Jin Rui Cui Runcang Sun Liaoning Key Lab of Lignocellulose Chemistry and biomaterials Liaoning Collaborative Innovation Center for Lignocellulosic BiorefineryCollege of Light Industry and Chemical EngineeringDalian Polytechnic UniversityDalian 116034China

The use of functional materials such as carbon-bismuth oxyhalides in integrated photorefineries for the clean production of fine chemicals requires restructuring.A facile biomass-assisted solvothermal fabrication of carbon/bismuth oxychloride nanocomposites(C/BiOCl)was achieved at various temperatures.Compared with BiOCl and C/BiOCl-120,C/BiOCl-180 exhibited higher crystallinity,wider visible light absorption,and a faster migration/separation rate of photoinduced carriers.For the selective C–C bond cleavage of biomass-based feedstocks photocatalyzed by C/BiOCl-180,the xylose conversion and lactic acid yield were 100%and 92.5%,respectively.C/BiOCl-180 efficiently converted different biomass-based monosaccharides to lactic acid,and the efficiency of pentoses was higher than that of hexoses.Moreover,lactic acid synthesis was favored by all active radicals including superoxide ion(·O_(2)^(−)),holes(h^(+)),hydroxyl radical(·OH),and singlet oxygen(^(1)O_(2)),with·O_(2)^(−)playing a key role.The fabricated photocatalyst was stable,economical,and recyclable.The use of biomass-derived monosaccharides for the clean production of lactic acid via the C/BiOCl-180 photocatalyst has opened new research horizons for the investigation and application of C–C bond cleavage in biomass-based feedstocks.

关键词： carbon-carbon bond cleavage biomass reforming C/BiOCl lactic acid photocatalysis

A strategy for mechanically integrating robust hydrogeltissue hybrid to promote the anti-calcification and endothelialization of bioprosthetic heart valve

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Regenerative biomaterials 2024年第2期3卷 123-136页

作者： Haoshuang Wu Nuoya Chen Tiantian Zheng Li Li Mengyue Hu Yumei Qin Gaoyang Guo Li Yang Yunbing Wang National Engineering Research center for biomaterials Sichuan UniversityChengdu 610065China Institute of Clinical Pathology West China Hospital of Sichuan UniversityChengdu 610041China College of Polymer Science and Engineering Sichuan UniversityChengdu 610065China

Bioprosthetic heart valve(BHV)replacement has been the predo-minant treatment for severe heart valve diseases over decades.Most clinically available BHVs are crosslinked by glutaraldehyde(GLUT),while the high toxicity of residual GLUT could initiate calcification,severe thrombosis,and delayed endothelializa-tion.Here,we construed a mechanically integrating robust hydrogel-tissue hybrid to improve the performance of BHVs.In particular,recombinant humanized coilagen type Ⅲ(rhCOLⅢ),which was precisely customized with anti-coagulant and pro-endothelialization bioactivity,was first incorporated into the polyvinyl alcohol(PVA)-based hydrogel via hydrogen bond interactions.Then,tannic acid was introduced to enhance the mechanicalperfo of PVA-based hvdrogel and interfacial bonding between the hydrogel layer and bio-derived tissue due to the strong affinity for a wide range of substrates.In vitro and in vivo experimental results confirmed that the GLUT-crosslinked BHVs modified by the robust PVA-based hydrogel embedded rhCOLII and TA possessed long-term anti-coagulant,accelerated endothelialization,mild inflammatory response and anti-calcification properties.Therefore,our mechanically integrating robust hydrogel-tissue hybrid strategy showed the potential to enhance the service function and prolong the service life of the BHVs after implantation.

关键词： bioprosthetic heart valves recombinant humanized collagen typeⅢ endothelialization anti-calcification anti-coagulation

持续释放蒙脱土插层杂化复合材料中的成骨微量元素促进骨再生

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Materials 2024年第7期67卷 2067-2079页

作者：童磊刘泉滢熊丽王培磊赵明达李星梁洁樊渝江张兴栋孙勇 National Engineering Research center for biomaterials College of Biomedical EngineeringSichuan UniversityChengdu 610065China Sichuan Testing center for biomaterials and Medical Devices Sichuan UniversityChengdu 610065China

优化支架组分和结构以实现内源性成骨是骨组织工程中一项有前景的进展.本研究将蒙脱土作为一种增强相,以插层结构引入到多巴胺介导的仿生有机/无机杂化水凝胶中.通过蒙脱土-聚合物相互作用和多酚介导的多重反应改善了骨再生支架(HDC-HAp... 详细信息

优化支架组分和结构以实现内源性成骨是骨组织工程中一项有前景的进展.本研究将蒙脱土作为一种增强相,以插层结构引入到多巴胺介导的仿生有机/无机杂化水凝胶中.通过蒙脱土-聚合物相互作用和多酚介导的多重反应改善了骨再生支架(HDC-HAp-MMT)的理化特性,增强了力学性能和抗降解能力.特别是,持续性释放的有益微量元素为成骨微环境提供了关键的成骨生化信号.该水凝胶在体外促进了骨髓间充质干细胞增殖和成骨分化.同时,在异位成骨模型中,显著增强了矿物沉积(30天后机械增强6.91倍);在原位兔颅骨修复实验中,实现了相对于天然骨80.94%的骨体积分数和85.89%的骨密度.该策略可能代表了一种新型的生物活性骨再生支架的制备方法.

关键词： montmorillonite osteogenic elements hybrid com-posites bone regeneration

A stepwise-responsive editor integrated with three copper ions for the treatment of oral squamous cell carcinoma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2024年第6期17卷 5424-5434页

作者： Jinna Ren Jingying Hu Fan Dong Yan Xu Yang Peng Yuping Qian Guanmeng Zhang Min Wang Yuguang Wang Department of Prosthodontics Hospital of StomatologyJilin UniversityChangchun 130021China Department of General Dentistry II Peking University School and Hospital of Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical DevicesBeijing 100081China center of Digital Dentistry Peking University School and Hospital of Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical DevicesBeijing 100081China Department of Nursing Peking University School and Hospital of Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical DevicesBeijing 100081China The VIP Department School and Hospital of StomatologyChina Medical UniversityLiaoning Provincial Key Laboratory of Oral DiseasesShenyang 110002China

Cuprotosis,a new type of cell death,provides great opportunities for the treatment of oral squamous cell carcinoma,as nanocarriers of copper ions can induce cuprotosis and immunogenic death.Here,we studied an editor that enables production of a nanoparticle“storm”in oral squamous cell carcinoma,maximizing the toxic effect of these particles and reprogramming the tumor microenvironment;as a result,T cells and natural killer(NK)cells can infiltrate the tumor microenvironment to activate an antitumor immune response.On this basis,the editor can be combined with optical therapy to improve patient prognosis.In this study,the metal ratio was regulated in response to the nanocarrier of acid response type.Thus,in the presence of a specific copper ion content,the nanocarrier could change the permeability of the tumor cell membrane.Based on these results,the nanoparticles were cracked in an acidic environment and then released copper ions.Finally,the nanoparticles contributed to cuprotosis and immunogenic death.In addition,the editor could inhibit murine oral cancer 1(MOC1)tumors in C57BL/6 without toxicity.The rate of tumor growth inhibition was as high as approximately 80%.This strategy provides a new idea for immunotherapy.Moreover,it can improve the interaction between immunotherapy and the copper-induced death of oral squamous cell carcinoma.Above all,this study will provide a new opportunity for the effective treatment of oral squamous cell carcinoma.

关键词： cuprotosis immunogenic death photothermal therapy tumor microenvironment immunotherapy

Extrusion-base d 3D-printe d“rolle d-up”composite scaffolds with hierarchical pore structure for bone growth and repair

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2024年第4期171卷 222-234页

作者： Yufan Li Li Chen Yijing Stehle Mingyue Lin Chenxin Wang Rui Zhang Min Huang Yubao Li Qin Zou Research center for Nano biomaterials Analytical&Testing CenterSichuan UniversityChengdu 610064China Analytical&Testing center Sichuan UniversityChengdu 610064China Department of mechanical engineering Union College807 Union St.SchenectadyNY 12308USA Sichuan Institute of Atomic Energy Chengdu 610101China

Three-dimensional(3D)bioprinting,specifically direct ink writing(DIW)capable of printing biologically active substances such as growth factors or drugs under low-temperature conditions,is an emerging di-rection in bone tissue engineering.However,limited by the bio-ink mobility and the poor resolution of this printing technology,the lateral pores of current crisscross-stacked scaffolds printed through DIW tend to clog and are inimical to bone growth.Therefore,it is critical to develop DIW printed biologi-cal scaffold structure with high mechanical strength,porosity,and biocompatibility performance.Herein,patterned polylactic acid(PLA)/polycaprolactone(PCL)/nano-hydroxyapatite(n-HA)based scaffold was printed through DIW technological and rolled-up for properties characterization,cytocompatibility test,and bone repair experiment.The result not only shows that the hexagonal patterned scaffolds are me-chanically strong with porosity,but also demonstrated that the hierarchical pore structure formed during rolled-up has the potential to address the clogging problem and stimulates bone growth and repair.

关键词： Direct ink writing(DIW) Bone repair scaffold,Micro-CT Bio composites

Carbon nanotubes-reinforced polylactic acid/hydroxyapatite porous scaffolds for bone tissue engineering

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Materials Science 2024年第1期18卷 59-69页

作者： Weiwei Lan Mingbo Wang Zhenjun Lv Jun Li Fuying Chen Ziwei Liang Di Huang Xiaochun Wei Weiyi Chen Research center for Nano-biomaterials&Regenerative Medicine Department of Biomedical EngineeringCollege of Biomedical EngineeringTaiyuan University of TechnologyTaiyuan 030024China Guangdong Engineering Technology Research center of Implantable Medical Polymer Shenzhen Lando Biomaterials Co.Ltd.Shenzhen 518107China Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering Taiyuan 030060China Department of Orthopaedics The Second Hospital of Shanxi Medical UniversityTaiyuan 030001China

In the field of bone defect repair,critical requirements for favorable cytocompatibility and optimal mechanical properties have propelled research efforts towards the development of composite materials.In this study,carbon nanotubes/polylactic acid/hydroxyapatite(CNTs/PLA/HA)scaffolds with different contents(0.5,1,1.5 and 2 wt.%)of CNTs were prepared by the thermally induced phase separation(TIPS)method.The results revealed that the composite scaffolds had uniform pores with high porosities over 68%and high through performances.The addition of CNTs significantly enhanced the mechanical properties of resulted PLA/HA,in which the 1.5 wt.%CNTs/PLA/HA composite scaffold demonstrated the optimum mechanical behaviors with the bending elastic modulus of(868.5±12.34)MPa,the tensile elastic modulus of(209.51±12.73)MPa,and the tensile strength of(3.26±0.61)MPa.Furthermore,L929 cells on the 1.5 wt.%CNTs/PLA/HA scaffold displayed good spreading performance and favorable cytocompatibility.Therefore,it is expected that the 1.5 wt.%CNTs/PLA/HA scaffold has potential applications in bone tissue engineering.

关键词： CNTs/PLA/HA scaffold TIPS method mechanical property bone tissue engineering