Carbon nanotubes-reinforced polylactic acid/hydroxyapatite porous scaffolds for bone tissue engineering

作     者：Weiwei Lan Mingbo Wang Zhenjun Lv Jun Li Fuying Chen Ziwei Liang Di Huang Xiaochun Wei Weiyi Chen Weiwei Lan;Mingbo Wang;Zhenjun Lv;Jun Li;Fuying Chen;Ziwei Liang;Di Huang;Xiaochun Wei;Weiyi Chen

作者机构：Research Center for Nano-Biomaterials&Regenerative MedicineDepartment of Biomedical EngineeringCollege of Biomedical EngineeringTaiyuan University of TechnologyTaiyuan 030024China Guangdong Engineering Technology Research Center of Implantable Medical PolymerShenzhen Lando Biomaterials Co.Ltd.Shenzhen 518107China Shanxi-Zheda Institute of Advanced Materials and Chemical EngineeringTaiyuan 030060China Department of OrthopaedicsThe Second Hospital of Shanxi Medical UniversityTaiyuan 030001China 

出 版 物：《Frontiers of Materials Science》 (材料学前沿（英文版）)

年 卷 期：2024年第18卷第1期

页      面：59-69页

核心收录：

学科分类：07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 0702[理学-物理学] 

基　　金：supported by the National Natural Science Foundation of China(Grant Nos.12202302,12272253,and 82103147) The support of the Fund Program for the Scientific Activities of Selected Returned Overseas Professionals in Shanxi Province(Grant No.20220006)was also acknowledged with gratitude 

主　　题：CNTs/PLA/HA scaffold TIPS method mechanical property bone tissue engineering 

摘      要：In the field of bone defect repair,critical requirements for favorable cytocompatibility and optimal mechanical properties have propelled research efforts towards the development of composite *** this study,carbon nanotubes/polylactic acid/hydroxyapatite(CNTs/PLA/HA)scaffolds with different contents(0.5,1,1.5 and 2 wt.%)of CNTs were prepared by the thermally induced phase separation(TIPS)*** results revealed that the composite scaffolds had uniform pores with high porosities over 68%and high through *** addition of CNTs significantly enhanced the mechanical properties of resulted PLA/HA,in which the 1.5 wt.%CNTs/PLA/HA composite scaffold demonstrated the optimum mechanical behaviors with the bending elastic modulus of(868.5±12.34)MPa,the tensile elastic modulus of(209.51±12.73)MPa,and the tensile strength of(3.26±0.61)***,L929 cells on the 1.5 wt.%CNTs/PLA/HA scaffold displayed good spreading performance and favorable ***,it is expected that the 1.5 wt.%CNTs/PLA/HA scaffold has potential applications in bone tissue engineering.