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Fasting as a precursor to high-fat diet enhances mitochondrial resilience in Drosophila melanogaster

Insect Science 2024年第6期31卷 1770-1788页

作者： Florence Hunter-Manseau Simon BCormier Rebekah Strang and Nicolas Pichaud Department of Chemistry and Biochemistry Universitéde MonctonMonctonNew BrunswickCanada new brunswick centre for precision medicine MonctonNew BrunswickCanada

Changes in diet type and nutrient availability can impose significant environmental stress on organisms,potentially compromising physiological functions and reproductive *** nature,dramatic fluctuations in dietary resources are often observed and adjustments to restore cellular homeostasis are crucial to survive this type of *** this study,we exposed male Drosophila melanogaster to two modulated dietary treatments:one without a fasting period before exposure to a high-fat diet and the other with a 24-h fasting *** then investigated mitochondrial metabolism and molecular responses to these *** to a high-fat diet without a preceding fasting period resulted in disrupted mitochondrial respiration,notably at the level of complex *** the other hand,a short fasting period before the high-fat diet maintained mitochondrial ***,transcript abundance of genes associated with mitophagy,heatshock proteins,mitochondrial biogenesis,and nutrient sensing pathways increased either slightly or significantly following a fasting period and remained stable when flies were subsequently put on a high-fat diet,whereas a drastic decrease of almost all transcript abundances was observed for all these pathways when flies were exposed directly to a high-fat ***,mitochondrial enzymatic activities showed less variation after the fasting period than the treatment without a fasting ***,our study sheds light on the mechanistic protective effects of fasting prior to a high-fat diet and highlights the metabolic flexibility of Drosophila mitochondria in response to abrupt dietary changes and have implication for adaptation of species to their changing environment.

关键词： dietary modulation fasting high-fat diet metabolic flexibility mitochondrial metabolism stress response

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The variation of the estimated GPS instrumental bias and its possible connection with ionospheric variability

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Science China(Technological Sciences) 2014年第1期57卷 67-79页

作者： ZHANG DongHe SHI Hao JIN YaQi ZHANG Wei HAO YongQiang XIAO Zuo Department of Geophysics Peking University Department of Geodesy and Geomatics Engineering University of New Brunswick Fredericton 4400 New Brunswick Canada

Based on the analysis of the satellite DCB data estimated by our method and the Center for Orbit Determination in Europe(CODE)from 1999 to 2011,the features of the temporal variation of differential code biases(DCB)are ***,there are three types of variations in DCB on different time *** first one is the day-to-day variation that exhibits more obviously in solar maximum *** second one is the variation with about one year periodic variation that behaves more obviously from 1999 to *** last one is the monotonously descending tendency from 1999 to *** the basic ionospheric approximation in DCB estimation method,the features of the variability of the ionospheric morphology from 1999to 2010 are also displayed based on the ionospheric characteristic *** can be concluded that the day-to-day and annual variation of the estimated global positioning system(GPS).DCB is related to the ionospheric *** variation of DCBs on solar cycle time scale includes the real hardware DCBs and pseudo-DCBs induced by ionospheric *** doubt,these kinds of"pseudo"variations of DCB will affect the precision of ionospheric total electron content(TEC)derived from the GPS *** addition,this study is helpful for evaluating the influence of ionospheric weather on TEC derivation and is also useful for developing one estimation method of DCB with more stability and precision through introducing a more practical ionospheric model.

关键词： DCB ionospheric variability GPS instrumental bias solar cycle

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Fine and hyperfine structures of pionic helium atoms

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Chinese Physics B 2023年第2期32卷 236-241页

作者：白志达钟振祥严宗朝史庭云 State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Wuhan Institute of Physics and MathematicsInnovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhan 430071China University of Chinese Academy of Sciences Beijing 100049China Department of Physics University of New BrunswickFrederictonNew BrunswickE3B5A3Canada

The fine and hyperfine structures of pionic helium metastable states is calculated within the formalism of the Breit-Pauli Hamiltonian by using the variationally generated wave functions in Hylleraas *** results not only verify the existing values of Hori et al.[***.A 89,042515(2014)]for the fine structure of π^(4)He^(+),but also determine the hyperfine structure of π^(3)He^(+).

关键词： exotic atom pionic helium fine structure hyperfine structure

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Complex coordinate rotation method based on gradient optimization

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Chinese Physics B 2021年第2期30卷 257-261页

作者： Zhi-Da Bai Zhen-Xiang Zhong Zong-Chao Yan Ting-Yun Shi State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Wuhan Institute of Physics and MathematicsInnovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhan 430071China University of Chinese Academy of Sciences Beijing 100049China Department of Physics University of New BrunswickFrederictonNew Brunswick E3B 5A3Canada Center for Cold Atom Physics Chinese Academy of SciencesWuhan 430071China

In atomic,molecular,and nuclear physics,the method of complex coordinate rotation is a widely used theoretical tool for studying resonant ***,we propose a novel implementation of this method based on the gradient optimization(CCR-GO).The main strength of the CCR-GO method is that it does not require manual adjustment of optimization parameters in the wave function;instead,a mathematically well-defined optimization path can be *** method is proven to be very efficient in searching resonant positions and widths over a variety of few-body atomic systems,and can significantly improve the accuracy of the *** a special case,the CCR-GO method is equally capable of dealing with bound-state problems with high accuracy,which is traditionally achieved through the usual extreme conditions of energy itself.

关键词： complex coordinate rotation method resonant state metastable state gradient optimization

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Geometric Design-based Dimensional Synthesis of a Novel Metamorphic Multi-fingered Hand with Maximal Workspace

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Chinese Journal of Mechanical Engineering 2021年第3期34卷 211-225页

作者： Wei An Jun Wei Xiaoyu Lu Jian S.Dai Yanzeng Li MOE Key Laboratory for Mechanism Theory and Equipment Design International Centre for Advanced Mechanisms and RoboticsTianjin UniversityTianjinChina Advanced Kinematics and Reconfigurable Robotics Lab School of Natural and Mathematical SciencesKing’s College LondonLondonUK Rutgers The State University of New JerseyNew BrunswickNew JerseyUSA

Current research on robotic dexterous hands mainly focuses on designing new finger and palm structures,as well as developing smarter control *** the dimensional synthesis of dexterous hands with traditional rigid palms has been carried out,research on the dimensional synthesis of dexterous hands with metamorphic palms remains *** study investigated the dimensional synthesis of a palm of a novel metamorphic multi-fingered hand,and explored the geometric design for maximizing the precision manipulation *** indexes were used to value the workspace of the metamorphic hand,and the best proportions between the five links of the palm to obtain the optimal workspace of the metamorphic hand were *** on the fixed total length of the palm member,four nondimensional design parameters that determine the size of the palm were introduced;through the discretization method,the influence of the four design parameters on the workspace of the metamorphic hand with full-actuated fingers and under-actuated fingers was *** on the analysis of the metamorphic multi-fingered hand,the symmetrical structure of the palm was designed,resulting in the largest workspace of the multi-fingered hand,and proved that the metamorphic palm has a massive upgrade for the workspace of underactuated *** research contributed to the dimensional synthesis of metamorphic dexterous hands,with practical significance for the design and optimization of novel metamorphic hands.

关键词： Metamorphic hands Dimensional synthesis Maximal workspace Discretization

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High-precision spectroscopy of hydrogen molecular ions

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Chinese Physics B 2015年第5期24卷 71-86页

作者：钟振祥童昕严宗朝史庭云 State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Wuhan Institute of Physics and MathematicsChinese Academy of Sciences Center for Cold Atom Physics Chinese Academy of Sciences Department of Physics University of New Brunswick

In this paper, we overview recent advances in high-precision structure calculations of the hydrogen molecular ions （H2＋ and HD＋）, including nonrelativistic energy eigenvalues and relativistic and quantum electrodynamic corrections. In combination with high-precision measurements, it is feasible to precisely determine a molecular-based value of the proton- to-electron mass ratio. An experimental scheme is presented for measuring the rovibrational transition frequency （v,L）：（0, 0） → （6,1） in HD＋, which is currently underway at the Wuhan Institute of Physics and Mathematics.

关键词： hydrogen molecular ion rovibrational transition proton-to-electron mass ratio relativistic and QED corrections

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precision calculation of fine structure in helium and Li^+

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Chinese Physics B 2015年第3期24卷 111-117页

作者：张佩佩钟振祥严宗朝史庭云 Division of Theoretical and Interdisciplinary Research State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physicsand Center for Cold Atom PhysicsWuhan Institute of Physics and MathematicsChinese Academy of Sciences University of Chinese Academy of Sciences Department of Physics University of New Brunswick

The fine structure constant α can be extracted from high-precision spectroscopy of the 2^3 P J fine structure splittings in helium and light helium-like ions. In this work, the 2^3 P J fine structure splittings of helium and Li^＋ ion are calculated,including relativistic and QED corrections of order mα^4, mα^4（m/M）, mα^5, mα^5（m/M）, and Douglas–Kroll operators of mα^6 and mα^6（m/M）, which provide an independent verification for the previous calculations performed by Drake [Can.J. Phys. 80 1195（2002）] and by Pachucki and Yerokhin [Phys. Rev. A 79 062516（2009）; Phys. Rev. Lett. 104 070403（2010）; Can. J. Phys. 89 1139（2011）]. The results of the three groups agree with each other.

关键词： fine structure helium Li^+ ion QED theory

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Quantum computing and the security of public key cryptography

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Fundamental Research 2021年第1期1卷 85-87页

作者： Kai Li Pei-Gen Yan Qing-Yu Cai State Key Laboratory of Magnetic Resonances and Atomic and Molecular Physics Innovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhan 430071China University of Chinese Academy of Sciences Beijing 100049China Department of Physics University of New BrunswickFrederictonNew Brunswick E3B 5A3Canada

Compared with electronic computers,quantum parallelism has led to a significant increase in the computing power of quantum ***,the computing power of quantum computers will also be limited by the laws of physics,and hence there is no doubt that the com-puting power of quantum computers is not *** an algorithm,we need to consider both its space complexity and time *** not only requires quantum computers to achieve large-scale integration,but also requires the quantum coherence time to be sufficiently *** either of the above two conditions is not met,the task cannot be com-pleted.

关键词： complexity. quantum hence

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类锂离子体系自旋四重态费米接触项的精密计算

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物理学报 2022年第20期71卷 39-45页

作者：魏向杰孙邓王黎明严宗朝河南师范大学物理学院新乡453007 Department of Physics University of New BrunswickFredericton E3B 5A3Canada

费米接触项与原子超精细结构常数有密切关系,往往对原子能级的超精细劈裂起主要贡献.波函数在原点处的行为以及电子之间的关联效应是影响费米接触项计算精度的两个主要因素.对于一般的原子体系来说,费米接触项的高精度计算不是一件容易... 详细信息

费米接触项与原子超精细结构常数有密切关系,往往对原子能级的超精细劈裂起主要贡献.波函数在原点处的行为以及电子之间的关联效应是影响费米接触项计算精度的两个主要因素.对于一般的原子体系来说,费米接触项的高精度计算不是一件容易的工作.本文利用Hylleraas坐标下的Rayleigh-Ritz变分法求解了锂原子和类锂离子体系(Z=4—10)自旋四重态1s2s3s^(4)S,1s2s4s^(4)S和1s2s2p^(4)P的薛定谔方程,得到的非相对论变分能量收敛精度达到10^(-13).根据所得到的高精度变分波函数,计算了这些体系的费米接触项,并研究了原子核的有限质量对结果的影响.费米接触项的精度达到了10^(-10).本文结果可以作为其他理论方法的参考基准,同时也为相关的实验研究提供了参考数据.

关键词：类锂离子费米接触项 Hylleraas坐标变分法

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precision spectroscopy of the hydrogen molecular ion D2+

Precision spectroscopy of the hydrogen molecular ion D2+

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第六届全国计算原子与分子物理学术会议

作者： Peipei Zhang Zhenxiang Zhong Zong-Chao Yan Ting-Yun Shi Wuhan Institute of Physics and Mathematics Chinese Academy of Sciences Department of Physics University of New Brunswick

＜正＞The hydrogen molecular ion and its isotopomers are the simplest molecules of fundamental interest for both theoretical[1-3]and experimental[4]research in recent *** rovibrational transition frequencies of hydrogen molecular ions strongly depend on the nuclear-electron mass ratio,making them promising candidates for improving the nuclear-electron mass ratio directly by combining precision measurement of

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