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Protein Disulfide Isomerase A2 Is Correlated with Immune Infiltrates and Is a Novel Prognostic Biomarker in Glioma Patients

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Current Medical Science 2023年第6期43卷 1107-1115页

作者： Zhi-gang MA Ying-xue LIU Ning ZOU Zhe HUANG Ming WANG Tao LI Jie ZHOU Li-gang CHEN department of neurosurgery The Affiliated Hospital of Southwest Medical UniversityLuzhou646000China Sichuan Clinical Medical Research Center for neurosurgery Luzhou646000China School of Clinical Medicine Southwest Medical UniversityLuzhou646000China department of Laboratory People’s Hospital of Deyang CityDeyang618000China Laboratory of Mitochondria and Metabolism Department of AnesthesiologyNational Clinical Research Center for GeriatricsWest China Hospital of Sichuan UniversityChengdu610041China neurological Diseases and Brain Function Laboratory The Affiliated Hospital of Southwest Medical UniversityLuzhou646000China Academician(Expert)Workstation of Sichuan Province The Affiliated Hospital of Southwest Medical UniversityLuzhou646000China

Objective Protein disulfide isomerase A2(PDIA2),a member of the protein disulfide isomerase family,plays a key role in the folding of nascent proteins in the endoplasmic reticulum by forming disulfide bonds,together with enzymes such as thiol isomerase,oxidase,and *** study investigated the clinical significance and potential functions of PDIA2 in *** The expression of PDIA2 in gliomas was explored using The Cancer Genome Atlas and Gene Expression Omnibus *** analyzed the clinical characteristics of glioma patients and the prognostic and diagnostic value of PDIA2 ***-Meier and Cox regression analyses were used to examine the effect of PDIA2 expression on overall survival,progression-free interval,and disease-specific ***,we performed Gene Set Enrichment Analysis and immune infiltration analysis to investigate the functions of ***2 mRNA and protein expression was evaluated in cell lines and glioma *** PDIA2 was expressed at low levels in glioma ***-Meier survival analysis showed that glioma patients with low PDIA2 levels had a worse prognosis than those with high PDIA2 *** operating characteristic curve analysis indicated the diagnostic and prognostic ability of PDIA2(area under the curve=0.918).Pathways associated with PD1,PI3K/AKT,cancer immunotherapy via PD1 blockade,Fceri-mediated NF-kB activation,FOXM1,and DNA repair were enriched in glioma patients with low levels of ***2 expression levels were negatively correlated with immune cell infiltrate *** PDIA2 levels are significantly downregulated in ***2 expression may be a potential biomarker for the diagnosis and prognosis of glioma patients.

关键词： glioma protein disulfide isomerase A2 bioinformatics diagnosis prognosis

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Microsurgical efficacy in 326 children with tethered cord syndrome: a retrospective analysis

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Neural Regeneration Research 2019年第1期14卷 149-155页

作者： Ai-Jia Shang Chang-Hao Yang Cheng Cheng Ben-Zhang Tao Yuan-Zheng Zhang Hai-Hao Gao Shao-Cong Bai department of neurosurgery PLA General Hospital department of neurosurgery Yanan University Affiliated Hospital

Tethered cord syndrome is a progressive disease with a typically insidious onset in infants and children, and which can lead to persistent progress of neurological deficits and a high rate of disability without timely intervention. The purpose of this study was to investigate the curative effect of microsurgery in children with different types of tethered cord syndrome. In this study, we analyzed 326 patients with tethered cord syndrome, aged from 2 months to 14 years old, who were followed for 3–36 months after microscopic surgery. Based on clinical manifestations and imaging findings, these patients were classified into five types: tight filum terminale(53 cases), lipomyelomeningocele(55 cases), lipomatous malformation(124 cases), postoperative adhesions(56 cases), and split cord malformation(38 cases). All patients underwent microsurgery. Curative effects were measured before and 3 months after surgery by Spina Bifida neurological Scale based on sensory and motor functions, reflexes, and bladder and bowel function. The results showed that Spina Bifida neurological Scale scores improved in all five types after surgery. Overall effective rates in these patients were 75%. Effective rates were 91% in tight filum terminale, 84% in lipomyelomeningocele, 65% in lipomatous malformation, 75% in postoperative adhesion, and 79% in split cord malformation. Binary logistic regression analysis revealed that types of tethered cord syndrome(lipoma-type or not) and symptom duration before surgery were independent influencing factors of surgical outcome. These results show that therapeutic effect is markedly different in patients with different types of tethered cord syndrome. Suitable clinical classification for tethered cord syndrome will be helpful in predicting prognosis and guiding treatment.

关键词：症候群绳索孩子功效神经病调查结果回归分析持续时间

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microRNA-455-5p alleviates neuroinflammation in cerebral ischemia/reperfusion injury

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Neural Regeneration Research 2022年第8期17卷 1769-1775页

作者： Jian-Song Zhang Pin-Pin Hou Shuai Shao Anatol Manaenko Zhi-Peng Xiao Yan Chen Bing Zhao Feng Jia Xiao-Hua Zhang Qi-Yong Mei Qin Hu Central Laboratory Renji HospitalShanghai Jiao Tong University School of MedicineShanghaiChina department of neurosurgery Renji HospitalShanghai Jiao Tong University School of MedicineShanghaiChina department of Neurology The First Affiliated Hospital of Chongqing Medical UniversityChongqingChina department of Medical Genetics Shanghai Jiao Tong University School of MedicineShanghaiChina department of neurosurgery Changzheng Hospitalthe Second Military Medical UniversityShanghaiChina

Neuroinflammation is a major pathophysiological factor that results in the development of brain injury after cerebral ischemia/*** of microRNA(miR)-455-5p after ischemic stroke has been considered a potential biomarker and therapeutic target for neuronal injury after ***,the role of miR-455-5p in the post-ischemia/reperfusion inflammatory response and the underlying mechanism have not been *** this study,mouse models of cerebral ischemia/reperfusion injury were established by transient occlusion of the middle cerebral artery for 1 hour followed by ***-455-5p,antagomir-455-5p,and their negative controls were injected intracerebroventricularly 2 hours before or 0 and 1 hour after middle cerebral artery occlusion(MCAO).The results showed that cerebral ischemia/reperfusion decreased miR-455-5p expression in the brain tissue and the peripheral ***-455-5p pretreatment increased miR-455-5p expression in the brain tissue,reduced the cerebral infarct volume,and improved neurological ***,primary cultured microglia were exposed to oxygen-glucose deprivation for 3 hours followed by 21 hours of reoxygenation to mimic cerebral ischemia/***-455-5p reduced C-C chemokine receptor type 5 mRNA and protein levels,inhibited microglia activation,and reduced the production of the inflammatory factors tumor necrosis factor-αand interleukin-1β.These results suggest that miR-455-5p is a potential biomarker and therapeutic target for the treatment of cerebral ischemia/reperfusion injury and that it alleviates cerebral ischemia/reperfusion injury by inhibiting C-C chemokine receptor type 5 expression and reducing the neuroinflammatory response.

关键词： agomiR-455-5p biomarker blood-brain barrier C-C chemokine receptor type 5 ischemia/reperfusion injury ischemic stroke microglia microRNA-455-5p neuroinflammation pretreatment

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从脑血管疾病到脑心共患病:一个新时代的挑战

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Science Bulletin 2022年第18期67卷 1830-1832页

作者：刘清源赵继宗王硕 department of neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China China National Clinical Research Center for neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China

Cerebrovascular and cardiological diseases are regarded as the leading cause of mortality among the Chinese population[1,2].Notably,there is a special condition characterized by the coexistence of cerebrovascular and cardiological diseases,also defned as neuro-co-cardiological *** the Chinese population ages,the prevalence of neuro-cardiological diseases will rise.

关键词： diseases 脑血管疾病 mortality

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Neutrophil-derived interleukin-17A participates in neuroinflammation induced by traumatic brain injury

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Neural Regeneration Research 2023年第5期18卷 1046-1051页

作者： Xiao-Jian Xu Qian-Qian Ge Meng-Shi Yang Yuan Zhuang Bin Zhang Jin-Qian Dong Fei Niu Hao Li Bai-Yun Liu Beijing Key Laboratory of Central Nervous System Injury Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Beijing Key Laboratory of Central Nervous System Injury and department of neurosurgery Beijing Neurosurgical Institute and Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Nerve Injury and Repair Center of Beijing Institute for Brain Disorders BeijingChina China National Clinical Research Center for neurological Diseases BeijingChina

After brain injury, infiltration and abnormal activation of neutrophils damages brain tissue and worsens inflammation, but the mediators that connect activated neutrophils with neuroinflammation have not yet been fully clarified. To identify regulators of neutrophil-mediated neuroinflammation after traumatic brain injury, a mouse model of traumatic brain injury was established by controlled cortical impact. At 7 days post-injury(sub-acute phase), genome-wide transcriptomic data showed that interleukin 17 A-associated signaling pathways were markedly upregulated, suggesting that interleukin 17 A may be involved in neuroinflammation. Double immunofluorescence staining showed that interleukin 17 A was largely secreted by neutrophils rather than by glial cells and neurons. Furthermore, nuclear factor-kappaB and Stat3, both of which are important effectors in interleukin 17 A-mediated proinflammatory responses, were significantly activated. Collectively, our findings suggest that neutrophil-derived interleukin 17 A participates in neutrophil-mediated neuroinflammation during the subacute phase of traumatic brain injury. Therefore, interleukin 17 A may be a promising therapeutic target for traumatic brain injury.

关键词： immune infiltration innate immunity interleukin-17A neurodegenerative disease neuroinflammation neutrophils secondary brain injury transcription factor transcriptome traumatic brain injury

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Genome-wide interrogation of transfer RNA-derived small RNAs in a mouse model of traumatic brain injury

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Neural Regeneration Research 2022年第2期17卷 386-394页

作者： Xiao-Jian Xu Meng-Shi Yang Bin Zhang Qian-Qian Ge Fei Niu Jin-Qian Dong Yuan Zhuang Bai-Yun Liu Beijing Key Laboratory of Central Nervous System Injury Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Beijing Key Laboratory of Central Nervous System Injury and department of neurosurgery Beijing Neurosurgical Institute and Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Nerve Injury and Repair Center of Beijing Institute for Brain Disorders BeijingChina China National Clinical Research Center for neurological Diseases BeijingChina

Transfer RNA(t RNA)-derived small RNAs(ts RNAs) are a recently established family of regulatory small non-coding RNAs that modulate diverse biological processes. Growing evidence indicates that ts RNAs are involved in neurological disorders and play a role in the pathogenesis of neurodegenerative disease. However, whether ts RNAs are involved in traumatic brain injury-induced secondary injury remains poorly understood. In this study, a mouse controlled cortical impact model of traumatic brain injury was established, and integrated ts RNA and messenger RNA(m RNA) transcriptome sequencing were used. The results revealed that 103 ts RNAs were differentially expressed in the mouse model of traumatic brain injury at 72 hours, of which 56 ts RNAs were upregulated and 47 ts RNAs were downregulated. Based on micro RNA-like seed matching and Pearson correlation analysis, 57 differentially expressed ts RNA-m RNA interaction pairs were identified, including 29 ts RNAs and 26 m RNAs. Moreover, Gene Ontology annotation of target genes revealed that the significantly enriched terms were primarily associated with inflammation and synaptic function. Collectively, our findings suggest that ts RNAs may be associated with traumatic brain injury-induced secondary brain injury, and are thus a potential therapeutic target for traumatic brain injury. The study was approved by the Beijing Neurosurgical Institute Animal Care and Use Committee(approval No. 20190411) on April 11, 2019.

关键词： gene set enrichment analysis inflammation integrated analysis neurodegenerative disease next-generation sequencing secondary injury synaptic function transfer RNA-derived small RNAs transfer RNAs traumatic brain injury

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A novel technique for sacropelvic fixation using image-guided sacroiliac screws:a case series and biomechanical study

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The Journal of Biomedical Research 2019年第3期33卷 208-216页

作者： Kee D.Kim Huy Duong Aditya Muzumdar Mir Hussain Mark Moldavsky Bandon Bucklen department of neurological Surgery University of California Davis department of neurosurgery Kaiser Permanente Medical Group Musculoskeletal Education and Research Center(MERC) Globus Medical Inc

In this study, we sought to assess the safety and accuracy of sacropelvic fixation performed with image-guided sacroiliac screw placement using postoperative computed tomography and X-rays. The sacroiliac screws were placed with navigation in five patients. Intact specimens were mounted onto a six-degrees-of-freedom spine motion simulator. Long lumbosacral constructs using bilateral sacroiliac screws and bilateral S1 pedicle and iliac screws were tested in seven cadaveric spines. Nine sacroiliac screws were well-placed under an image guidance system(IGS);one was placed poorly without IGS with no symptoms. Both fixation techniques significantly reduced range of motion(P<0.05) at L5-S1. The research concluded that rigid lumbosacral fixation can be achieved with sacroiliac screws,and image guidance improves its safety and accuracy. This new technique of image-guided sacroiliac screw insertion should prove useful in many types of fusion to the sacrum, particularly for patients with poor bone quality,complicated anatomy, infection, previous failed fusion and iliac harvesting.

关键词： lumbosacral fixation sacropelvic fixation sacroiliac screw computer-assisted surgery image-guided surgery

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Pulmonary complications and respiratory management in neurocritical care:a narrative review

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Chinese Medical Journal 2022年第7期135卷 779-789页

作者： Junxian Wen Jia Chen Jianbo Chang Junji Wei department of neurosurgery Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeDongcheng DistrictBeijing 100730China

Neurocritical care(NCC)is not only generally guided by principles of general intensive care,but also directed by specific goals and *** review summarizes the common pulmonary diseases and pathophysiology affecting NCC patients and the progress made in strategies of respiratory support in *** review highlights the possible interactions and pathways that have been revealed between neurological injuries and respiratory diseases,including the catecholamine pathway,systemic inflammatory reactions,adrenergic hypersensitivity,and dopaminergic *** complications of neurocritical patients include pneumonia,neurological pulmonary edema,and respiratory *** aspects of respiratory management include prioritizing the protection of the brain,and the goal of respiratory management is to avoid inappropriate blood gas composition levels and intracranial *** with the traditional mode of protective mechanical ventilation with low tidal volume(V_(t)),high positive end-expiratory pressure(PEEP),and recruitment maneuvers,low PEEP might yield a potential benefit in closing and protecting the lung *** neuromonitoring can ensure the safety of respiratory maneuvers in clinical and scientific *** studies are required to develop guidelines for respiratory management in NCC.

关键词： Neurocritical care Pneumonia Respiratory management Multimodel neuromonitoring Tracheostomy Mechanical ventilation Positive end-expiratory pressure

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Efficacy and safety of early anticoagulation after endovascular treatment in patients with atrial fibrillation

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Stroke & Vascular Neurology 2023年第5期8卷 405-412,I0017-I0023页

作者： Yaning Xu Chengchun Liu Wei Li Ximing Nie Shuhan Huang Xiaoshu Li Ya Wu Wang-Sheng Jin Jiaojin Jiang Jun Dong Yi Yang Zhiqiang Sun Wenjun Han Yanjiang Wang Liping Liu Meng Zhang department of Neurology Army Medical Center of PLAArmy Medical UniversityChongqingChina department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for neurological Diseases BeijingChina

Background The timing for initiating anticoagulant therapy in acute ischaemic stroke(AIS)patients with atrial fibrillation who recanalised after endovascular treatment(EVT)is *** objective of this study was to evaluate the effect of early anticoagulation after successful recanalisation in AIS patients with atrial *** Patients with anterior circulation large vessel occlusion and atrial fibrillation who were successfully recanalised by EVT within 24 hours after stroke in the Registration Study for Critical Care of Acute Ischemic Stroke after Recanalization registry were *** anticoagulation was defined as the initiation of unfractionated heparin(UFH)or low-molecular-weight heparin(LMWH)within 72 hours after ***-early anticoagulation was defined if it was initiated within 24 *** primary efficacy outcome was the score on the modified Rankin Scale(mRS)at day 90,and the primary safety outcome was symptomatic intracranial haemorrhage within 90 *** Overall,257 patients were enrolled,of whom 141(54.9%)initiated anticoagulation within 72 hours after EVT,including 111 within 24 hours.A significant shift towards better mRS scores at day 90 was associated with early anticoagulation(adjusted common OR 2.08(95%CI 1.27 to 3.41)).Symptomatic intracranial haemorrhage was comparable between patients treated with early and routine anticoagulation(adjusted OR 0.20(95%CI 0.02 to 2.18)).Comparison of different early anticoagulation regimens showed that ultra-early anticoagulation was more significantly associated with favourable functional outcomes(adjusted common OR 2.03(95%CI 1.20 to 3.44))and reduced the incidence of asymptomatic intracranial haemorrhage(OR 0.37(95%CI 0.14 to 0.94)).Conclusions In AIS patients with atrial fibrillation,early anticoagulation with UFH or LMWH after successful recanalisation is associated with favourable functional outcomes without increasing the risk of symptomatic intracranial haemorrhages.

关键词： patients fibrillation routine

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TDP-43 dysregulation and neuromuscular junction disruption in amyotrophic lateral sclerosis

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Translational Neurodegeneration 2022年第1期11卷 46-69页

作者： Sarah Lépine Maria José Castellanos-Montiel Thomas Martin Durcan The Neuro’s Early Drug Discovery Unit(EDDU) Department of Neurology and NeurosurgeryMontreal Neurological Institute-HospitalMcGill University3801 University StreetMontrealQC H3A 2B4Canada Faculty of Medicine and Health Sciences McGill University3605 De La MontagneMontrealQC H3G 2M1Canada

Amyotrophic lateral sclerosis(ALS)is a disease characterized by upper and lower motor neuron(MN)loss with a signature feature of cytoplasmic aggregates containing TDP-43,which are detected in nearly all *** in the gene that encodes TDP-43(TARBDP)are known to result in both familial and sporadic *** ALS,disruption of neuro-muscular junctions(NMJs)constitutes a critical event in disease pathogenesis,leading to denervation atrophy,motor impairments and *** defects and impaired synaptic transmission at NMJs have been reported in several TDP-43 animal models and in vitro,linking TDP-43 dysregulation to the loss of NMJ integrity in *** the lens of the dying-back and dying-forward hypotheses of ALS,this review discusses the roles of TDP-43 related to synaptic function,with a focus on the potential molecular mechanisms occurring within MNs,skeletal muscles and glial cells that may contribute to NMJ disruption in ALS.

关键词： Amyotrophic lateral sclerosis Denervation Neuromuscular junction TDP-43 Dying-back Dying-forward

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