检索结果-南通市图书馆

World Journal of Clinical Cases 2022年第26期10卷 9219-9227页

作者： Xin-Peng Xu Wei Wang Song Wan Chun-Feng Xiao Universal Scientific Education and research Network Beijing 100088China Beijing Anding Hospital Capital Medical UniversityBeijing 100088China

This paper reviews the underlying evidence for various aspects of the convergence mechanism of mindfulness intervention in attention deficit hyperactivity disorder(ADHD).There may be compatibility among various ADHD remission models and the therapeutic mechanism of mindfulness intervention in ADHD may be mainly via the convergence ***,neuroimaging-based analysis of the mechanisms of mindfulness intervention in treating ADHD is *** in the efficacy of various subtypes of mindfulness intervention,and corresponding specific imaging changes need further *** research may focus on the neuroimaging features of specific mindfulness intervention subtypes.

关键词： Attention deficit hyperactivity disorder Mindfulness Psychological intervention Mechanism

Reduced temporal activation during a verbal fluency test in clinical high risk of psychosis: a functional near-infrared spectroscopy-based study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

General Psychiatry 2022年第2期35卷 101-108页

作者： Yanyan Wei Xiaochen Tang Tingyu Zhang Wenjun Su Lihua Xu Huiru Cui Zhenying Qian Tianhong Zhang Jijun Wang EEG and neuroimaging Department Shanghai Mental Heath Center Shanghai Jiao Tong University School of MedicineShanghaiChina The Seventh Affiliated Hospital Sun Yat-sen University ShenzhenChina Shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina CAS Center for Excellence in Brain Science and Intelligence Technology(CEBSIT) Chinese Academy of ScienceShanghaiChina Institute of Psychology and Behavioral Science ShanghaiJiao Tong UniversityShanghaiChina

Background Clinical high risk(CHR)of psychosis is a state in which positive symptoms cause the subjects distress but do not approach a severity level that fulfils the criteria for a psychotic *** exhibits cognitive deficits;however,the underlying neurobiological mechanisms remain *** study aimed to investigate whether brain activation measured by the levels of oxygenated hemoglobin(oxy-Hb)in CHR subjects could be correlated with cognitive *** Fifty-eight CHR individuals who fulfilled the criteria for attenuated positive syndrome as specified in the Structured Interview for Prodromal Syndrome(SIPS)and the Scale of Prodromal Syndrome(SOPS)and 58 age-and sex-matched healthy participants were included in the *** subjects completed the Measurement and Treatment research to Improve Cognition in Schizophrenia(MATRICS)Consensus Cognitive Battery(MCCB)that includes tests measuring attention,verbal memory,verbal fluency,executive function,and general *** near-infrared spectroscopy(fNIRS)was used to measure the level of oxy-Hb in the dorsolateral prefrontal and frontotemporal *** We observed significantly decreased oxy-Hb levels in channel 32(located in the right superior temporal gyrus,rSTG)within the CHR individuals compared with that in the healthy controls(HCs)(t=−3.44,Bonferroni-corrected p=0.002),indicating lower brain activity.A significant positive correlation was observed between task-relatedβvalues and working memory in the CHR group(r=0.35,p=0.008).Conclusions The brain activation of rSTG is abnormal among subjects at clinicial high risk for *** abnormality is probably associated with the neural mechanisms of deficits in the working memory during the early stage of psychosis.

关键词： distress activation verbal

A Systematic Characterization of Structural Brain Changes in Schizophrenia

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2020年第10期36卷 1107-1122页

作者： Wasana Ediri Arachchi Yanmin Peng Xi Zhang Wen Qin Chuanjun Zhuo Chunshui Yu Meng Liang School of Medical Imaging and Tianjin Key Laboratory of Functional Imaging Tianjin Medical UniversityTianjin 300203China Department of Radiography and Radiotherapy Faculty of Allied Health SciencesGeneral Sir John Kotelawala Defence UniversityRatmalana 10390Sri Lanka Department of Radiology and Tianjin Key Laboratory of Functional Imaging Tianjin Medical University General HospitalTianjin 300052China Department of Psychiatric-neuroimaging-Genetics and Comorbidity Laboratory Tianjin Mental Health CenterTianjin Anding HospitalTianjin 300222China CAS Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghai 200031China

A systematic characterization of the similarities and differences among different methods for detecting structural brain abnormalities in schizophrenia,such as voxel-based morphometry(VBM),tensor-based morphometry(TBM),and projection-based thickness(PBT),is important for understanding the brain pathology in schizophrenia and for developing effective biomarkers for a diagnosis of ***,such studies are still ***,we performed VBM,TBM,and PBT analyses on T1-weighted brain MR images acquired from 116 patients with schizophrenia and 116 healthy *** found that,although all methods detected wide-spread structural changes,different methods captured different information-only 10.35%of the grey matter changes in cortex were detected by all three methods,and VBM only detected 11.36%of the white matter changes detected by ***,pattern classification between patients and controls revealed that combining different measures improved the classification accuracy(81.9%),indicating that fusion of different structural measures serves as a better neuroimaging marker for the objective diagnosis of schizophrenia.

关键词： Voxel-based morphometry Tensor-based morphometry Deformation-based morphometry Cortical thickness Multivariate pattern analysis Structural MRI Schizophrenia

维普期刊数据库

多发性硬化病人区域性颈髓萎缩和功能障碍:基于体素的分析

在线全文

学校读者我要写书评

暂无评论

国际医学放射学杂志 2013年第3期 267-267页

作者： P.Valsasina M.A.Rocca M.A.Horsfield M.Absinta R.Messina D.Caputo 施益洁 neuroimaging research unit Institute of Experimental NeurologySan Raffaele Scientific InstituteVita-Salute San Raffaele University

目的①对相对大组的多发性硬化(MS)病人应用活化表面法来绘制不同层面的脊髓萎缩的区域分布图。②比较复发-缓解型和继发进展型多发性硬化病人的脊髓萎缩的解剖位置。③估计脊髓萎缩和功能障碍间的联系。材料与方法本研究经当地伦理委... 详细信息

目的①对相对大组的多发性硬化(MS)病人应用活化表面法来绘制不同层面的脊髓萎缩的区域分布图。②比较复发-缓解型和继发进展型多发性硬化病人的脊髓萎缩的解剖位置。③估计脊髓萎缩和功能障碍间的联系。材料与方法本研究经当地伦理委员会审批通过,受试者签署书面知情同意。分别对45例复发-缓解型MS病人,26例继发进展型MS病人和67名年龄匹配的健康对照进行颈髓的高分辨率MR扫描。用活化表面法将颈髓表面从C1到C7分段,对被评估脊髓中心线垂直的脊髓断面进行影像重建。将这些展开的颈髓断面像联合录入一个共同标准的空间内,再将平滑后的颈髓二元掩码作为输入图像用于空间统计。最后用软件进行基于体素的组间比较,并分析区域性颈髓萎缩与临床和常规MR成像变量的关系。结果与对照组相比,复发缓解型MS病人显示脊髓后束局限性簇状分布的萎缩灶。相反的,继发进展型MS病人则显示弥漫性脊髓萎缩性改变,主要位于脊髓的后束和侧束。MS病人的颈髓萎缩程度与病人临床功能障碍及疾病病程相关。在较小程度上,与脑损伤的常规MR成像方法也是有关的。并未发现颈髓萎缩与局灶性脊髓病变之间的相关联系。结论对颈髓破坏的区域分布进行体素评估是可行的,这或许能促进对MS病人不可逆临床功能障碍的发生发展机制的理解。

关键词：颈髓病人 MS 功能障碍体素区域性

偏头痛病人的大脑皮质异常:基于皮质表面的分析

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

国际医学放射学杂志 2013年第5期 473-473页

作者： R.Messina M.A.Rocca B.Colombo P.Valsasina M.A.Horsfield M.Copetti 谢菲 neuroimaging research unit Institute of Experimental NeurologySan Raffaele Scientific InstituteVita-Salute San Raffaele University

摘要目的本研究期望通过观察大脑痛觉处理区的脑皮质厚度、表面积的减少及偏头痛发病机制相关区的脑皮质厚度、表面积增大的现象,探索偏头痛病人脑皮质厚度、表面积异常的形式,并评估其临床及影像学表现的相关性。材料与方法本研究获得... 详细信息

摘要目的本研究期望通过观察大脑痛觉处理区的脑皮质厚度、表面积的减少及偏头痛发病机制相关区的脑皮质厚度、表面积增大的现象,探索偏头痛病人脑皮质厚度、表面积异常的形式,并评估其临床及影像学表现的相关性。材料与方法本研究获得伦理委员会批准,每位参与者均签署了知情同意书。偏头痛组63例,对照组纳入健康志愿者18例。每例均接受MRI检查,均采集T2WI和三维T1WI,用以评估大脑皮质厚度和表面积。采用一般线性模型,行vertex-byvertex统计学分析(P<0.01)对偏头痛组与对照组、有无先兆表现及有无脑白质高信号表现等进行组间比较,评估偏头痛

关键词：皮质厚度表面积偏头痛病大脑皮质

Brain structure underlying the empathizing–systemizing difference in children with autism spectrum disorder

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World Journal of Pediatrics 2023年第8期19卷 782-792页

作者： Ning Pan Li-Zi Lin Xin Wang Lei Shi Xiao-Yu Xu Yu-Ying Jin Si Tan Xiao-Jing Song Jin Jing Xiu-Hong Li Department of Maternal and Child Health School of Public HealthSun Yat-Sen UniversityNo.74 Zhongshan Road 2Yuexiu DistrictGuangzhou510080China Guangdong Provincial Engineering Technology research Center of Environmental Pollution and Health Risk Assessment Department of Occupational and Environmental HealthSchool of Public HealthSun Yat-Sen UniversityGuangzhou510080China Key Laboratory of Brain Cognition and Education ScienceMinistry of EducationGuangzhouChina Institute for Brain research and Rehabilitation and Guangdong Key Laboratory of Mental Health and Cognitive ScienceSouth China Normal UniversityGuangzhou510631China JNU-HKUST Joint Laboratory for Neuroscience and Innovative Drug research College of PharmacyJinan UniversityGuangzhou510632China Chinese Institute for Brain research Beijing102206China

Background Behavioral research has shown that children with autism spectrum disorder(ASD)have a higher empathizing–systemizing difference(D score)than normal ***,there is no research about the neuroanatomical mechanisms of the empathizing–systemizing difference in children with *** Participants comprised 41 children with ASD and 39 typically developing(TD)children aged 6‒12 ***–systemizing difference was estimated using the D score from the Chinese version of Children’s Empathy Quotient and Systemizing *** quantified brain morphometry,including global and regional brain volumes and surface-based cortical measures(cortical thickness,surface area,and gyrification)via structural magnetic resonance *** We found that the D score was significantly negatively associated with amygdala gray matter volume[β=−0.16;95%confidence interval(CI):−0.30,−0.02;P value=0.030]in children with *** was a significantly negative association between D score and gyrification in the left lateral occipital cortex(LOC)in children with ASD(B=−0.10;SE=0.03;cluster-wise P value=0.006)and a significantly positive association between D score and gyrification in the right fusiform in TD children(B=0.10;SE=0.03;cluster-wise P value=0.022).Moderation analyses demonstrated significant interactions between D score and diagnosed group in amygdala gray matter volume(β=0.19;95%CI 0.04,0.35;P value=0.013)and left LOC gyrification(β=0.11;95%CI 0.05,0.17;P value=0.001)but not in right fusiform gyrification(β=0.08;95%CI−0.02,0.17;P value=0.105).Conclusions Neuroanatomical variation in amygdala volume and gyrification of LOC could be potential biomarkers for the empathizing–systemizing difference in children with ASD but not in TD ***-scale neuroimaging studies are necessary to test the replicability of our findings.

关键词： Autism spectrum disorder Empathy Structural magnetic resonance imaging Systemizing

In vivo tracking of tau pathology using positron emission tomography (PET) molecular imaging in small animals

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Translational Neurodegeneration 2014年第1期3卷 34-39页

作者： Eduardo Rigon Zimmer Antoine Leuzy Venkat Bhat Serge Gauthier Pedro Rosa-Neto Translational neuroimaging Laboratory(TNL) McGill Center for Studies in AgingDouglas Mental Health University InstituteMcGill University6875 La Salle Blv-FBC room 3149MontrealQCH4H 1R3Canada Montreal Neurological Institute(MNI) MontrealCanada Department of Biochemistry Federal University of Rio Grande do Sul(UFRGS)Porto AlegreBrazil Department of Psychiatry McGill UniversityMontrealBrazil

Hyperphosphorylation of the tau protein leading to the formation of neurofibrillary tangles(NFTs)is a common feature in a wide range of neurodegenerative diseases known as tauopathies,which include Alzheimer’s disease(AD)and the frontotemporal dementias(FTDs).Although heavily investigated,the mechanisms underlying the pathogenesis and progression of tauopathies have yet to be fully *** this context,several rodent models have been developed that successfully recapitulate the behavioral and neurochemical features of tau pathology,aiming to achieve a better understanding of the link between tau and *** date,behavioral and biochemical parameters assessed using these models have been conducted using a combination of memory tasks and invasive methods such as cerebrospinal fluid(CSF)sampling or post-mortem ***,several novel positron emission tomography(PET)radiopharmaceuticals targeting tau tangles have been developed,allowing for non-invasive in vivo quantification of tau *** with tau transgenic models and micro-PET,these tracers hold the promise of advancing the development of theoretical models and advancing our understanding of the natural history of AD and non-AD *** this review,we briefly describe some of the most important insights for understanding the biological basis of tau pathology,and shed light on the opportunity for improved modeling of tau pathology using a combination of tau-radiopharmaceuticals and animal models.

关键词： Positron emission tomography Tau molecular agents Tau rodent models Tauopathies

Preoperative 3T high field blood oxygen level dependent functional magnetic resonance imaging for glioma involving sensory cortical areas

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2010年第8期123卷 1006-1010页

作者： LI Shao-wu WANG Jiang-fei JIANG Tao LI Shou-wei ZHANG Wen-bo LI Zi-xiao ZHANG Zhong DAI Jian-ping WANG Zhong-cheng neuroimaging Center Beijing Neurosurgical Institute Capital Medical University Beijing 100050 China Department of Neurosurgery Beijing Tiantan Hospital Capital Medical University Beijing 100050 China Department of Neurosurgery No. 1 Hospital of Harbin Medical University Harbin Heilongjiang 150001 China Minnesota Epilepsy Group Saint Paul Minnesota 55102 USA

Background Localization of sensory cortical areas during the operation is essential to preserve the sensory function. Intraoperative direct electrostimulation under awake anesthesia is the golden standard but time-consuming. We applied 3T high field blood oxygen level-dependent （BOLD） functional magnetic resonance imaging （fMRI） to identify the relationship between glioma and cortical sensory areas preoperatively and to guide intraoperative direct electrostimulation for quick and precise localization. Methods Five glioma patients with sensory cortex involvement by or next to the lesion had preoperative BOLD fMRI to determine the spatial relationship of cortical sensory areas to the tumours. Bilateral hand opposite movement was performed by these patients for fMRI. Precentral and postcentral gyri were identified by electrical stimulation during the operation. Karnofsky Performance Status scores of the patients＇ pre- and postoperative and the role of BOLD fMRI were evaluated. Results The cortical sensory areas were all activated in five glioma patients involving postcentral gyrus areas by BOLD fMRI with bilateral hand opposite movement. The detected activation areas corresponded with the results from cortical electrical stimulation. Conclusions The relationship between cortical sensory areas and tumour can be accurately shown by BOLD fMRI before operation. And the information used to make the tumour resection could obtain good clinical results.

关键词： functional magnetic resonance imaging somatosensory area awake anesthesia cortical stimulation

维普期刊数据库

Magnetic resonance spectroscopy findings of brain olfactory areas in patients with COVID-19-related anosmia:A preliminary comparative study

在线全文

学校读者我要写书评

暂无评论

World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第2期10卷 105-112页

作者： Shadman Nemati Mohammad Haghani Dogahe Alia Saberi Naghi Ramezani Pejman Kiani Tofigh Yaghubi Kalurazi Ehsan Kazemnejad Leili Sara Seddighi Abbas Monsef Department of Otolaryngology and Head and Neck Surgery School of MedicineOtorhinolaryngology Research CenterGuilan University of Medical SciencesRashtIran Guilan Road Trauma research Center Guilan University of Medical SciencesRashtGuilanIran Department of Neurology Neuroscience Research CenterPoursina HospitalGuilan University of Medical SciencesRashtIran Department of Radiology Pars International HospitalGuilan ProvinceIran Department of Neuroscience and Addiction Studies School of Advanced Technologies in MedicineTehranIran Department of Infectious Diseases Razi Clinical Research Development UnitRazi HospitalGuilan University of Medical SciencesRashtIran Center of Magnetic Resonance research Department of Radiation OncologyUniversity of Minnesota Medical SchoolMinneapolisMinnesotaUSA

Objectives:2019 novel coronavirus disease(COVID-19)infection is commonly associated with olfactory dysfunctions,but the basic pathogenesis of these complications remains *** study seeks to evaluate the value of magnetic resonance spectroscopy(MRS)in determining the molecular neurometabolite alterations within the main brain olfactory areas in patients with COVID-19-related ***:In a cross-sectional study,seven patients with persistent COVID-19-related anosmia(mean age:29.57 years)and seven healthy volunteers(mean age:27.28 years)underwent MRS in which N-acetyl-aspartate(NAA),choline(Cho),creatine(Cr),and their ratios were measured in the anterior cingulate cortex,dorsolateral prefrontal cortex,orbitofrontal cortex(OFC),insular cortex,and ventromedial prefrontal *** were analyzed using TARQUIN software(version 4.3.10),and the results were compared with an independent sample t-test and nonparametric Mann-Whitney test based on the normality of the MRS data ***:The mean duration of anosmia before imaging was 8.5 months in COVID-19-related anosmia *** analysis elucidated a significant association between MRS findings within OFC and COVID-19-related anosmia(P_(disease)<0.01),and NAA was among the most important neurometabolites(P_(interaction)=0.006).Reduced levels of NAA(P<0.001),Cr(P<0.001)and^(NAA)/Cho ratio(P=0.007)within OFC characterize COVID-19-related ***:This study emphasizes that MRS can be illuminating in COVID-19-related anosmia and indicates a possible association between central nervous system impairment and persistent COVID-19-related anosmia.

关键词： anosmia COVID-19 magnetic resonance spectroscopy neuroimaging olfaction

维普期刊数据库

提示多发性硬化的临床孤立性综合征:灰质和白质的动态变化——2年的MRI随访研究

在线全文

学校读者我要写书评

暂无评论

国际医学放射学杂志 2016年第3期 305-305页

作者： M.A.Rocca P.Preziosa S.Mesaros E.Pagani J.Dackovic T.Stosic-Opincal 翁艺菲 neuroimaging research unit Institute of Experimental NeurologyDivision of NeuroscienceSan Raffaele Scientific InstituteVita-Salute San Raffaele University

摘要目的研究临床孤立综合征(CIS)的病人局域脑灰质和白质萎缩,白质微结构组织损伤和改变模式,能在疾病发生后2年内提示多发性硬化。材料与方法研究经过伦理委员会批准,并征得病人知情同意后进行。在疾病发生2个月内对37例CIS病人进行... 详细信息

摘要目的研究临床孤立综合征(CIS)的病人局域脑灰质和白质萎缩,白质微结构组织损伤和改变模式,能在疾病发生后2年内提示多发性硬化。材料与方法研究经过伦理委员会批准,并征得病人知情同意后进行。在疾病发生2个月内对37例CIS病人进行神经病学评估、常规MRI检查及扩散张量成像,并在之后的第3、12及24个月进行随访。同

关键词：多发性硬化白质髓质脑灰质 MRI