检索结果-南通市图书馆

Neuromarketing: neurocode-Tracking in Combination with Eye-Tracking for Quantitative Objective Assessment of TV Commercials

引用

Journal of Behavioral and Brain Science 2015年第4期5卷 137-147页

作者： Wilfried Dimpfel c/o neurocode ag Wetzlar Germany

The term “neuromarketing” suggests a combination of marketing research and brain research. Within marketing research, objective assessment of TV commercials is performed by use of Eye-Tracking devices. Brain research has been dominated by NMRI technologies during the last years. However, information content and time resolution are much better when monitoring electric activity by spectral analysis. The current experimental approach was initiated in order to test the combination of a newly developed EEG technology (neurocode-Tracking) with commercially available Eye-Tracking. Ten male subjects were exposed to a reference recording condition (watching a fixed cross on the screen) followed by 5 TV commercials representing 5 different banks. Video films obtained from Eye-Tracking (so-called heat maps) were synchronized with the results of neurocode-Tracking in form of a second video with a time resolution of 364 ms per image. Spectral power analysis of the EEG in different brain regions allowed for assessment of single scenes for cognitive and emotional responses. Averaging of data over the whole time course gave information on mental activation, attention, visual perception, memory, pleasure and tension. Comparison of the 5 commercials to reference recording revealed the clip of the Targo-Bank having the highest values with respect to mental activation and *** experiments have proven that the combination of neurocode-Tracking with Eye-Tracking can be successfully used in advertisement research and gives valid information on individual as well as group dependent cognitive and emotional responses leading to objective assessment of TV commercials.

关键词： neurocode-Tracking Eye-Tracking Quantitative EEG TV Commercials CATEEM^(■)

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Single Dose Effects of Pascoflair^(█) on Current Source Density(CSD)of Human EEG

引用

Neuroscience & Medicine 2012年第2期3卷 130-140页

作者： Wilfried Dimpfel Klaus Koch Gabriele Weiss Justus-Liebig-University c/o neurocode ag WetzlarGermany neurocode ag WetzlarGermany Pascoe Pharmazeutische Praparate GmbH GiessenGermany

Pascoflair? 425 mg is a herbal drug based on Passiflora incarnata dry extract and is registered in different countries for the treatment of nervous restlessness and anxiety and also as an aid to sleep. The study was initiated for the quantitative assessment of the effect of this preparation on brain electric activity and cognition in human volunteers. Quantitative electroencephalographic current source density (CSD) from 16 healthy male and female human volunteers (average age 49 years) was used in a randomized, placebo-controlled crossover study. Data were taken 0.5, 1.5, 3 and 4 hours after administration of the preparations under the conditions of 6 minutes eyes open, 5 minutes d2 concentration test, mathematical calculation test and memory test respectively. During mental load, changes in spectral band power were used to analyse drug-induced effects. All variables were fed into a linear discriminant analysis (LDA) for comparison with other drug profiles. Spectral power in the delta and theta range was significantly attenuated at 3 and 4 hours after administration in comparison with the time-dependent increase normally observed due to circadian rhythm. Discriminant analysis revealed a difference to placebo for all recordings as early as 30 minutes after intake of 3 coated tablets of Pascoflair? 425 mg. Using LDA data location within the poly-dimensional space, verum was projected into the area of the effects of Gingko/Ginseng as reference drugs tested earlier under identical conditions. Psychometric performance was not disrupted. Pascoflair? 425 mg can be regarded as a well characterized plant-derived drug with anxiolytic and calming properties without negative sedative and cognition-attenuating side effects. Current results document the effecttiveness of the preparation as early as after 30 minutes. In addition, they indicate persistence of good mental performance for hours. Trial registration: the study has been registered at *** under NCT0104760

关键词： Passion Flower EEG Clinical Study Source Density Discriminant Analysis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Zynamite^(■) (Mangifera indica Leaf Extract)and Caffeine Act in a Synergistic Manner on Electrophysiological Parameters of Rat Central Nervous System

引用

Food and Nutrition Sciences 2018年第5期9卷 502-518页

作者： Wilfried Dimpfel Julia Wiebe Nigel Gericke Leonie Schombert Justus-Liebig-University Giessen c/o neurocode ag WetzlarGermany Nektium S.L. Las PalmasSpain neurocode ag WetzlarGermany

Zynamite®, a special extract from Mangifera indica, exerted stimulatory properties on the central nervous system during a pilot study. The question arose if Zynamite®?would have a similar action on the central nervous system as caffeine. Two well established animal models were used: a) quantitation of spectral power of field potentials in the freely moving rat and b) induction of long term potentiation (LTP) in the hippocampus slice preparation ex vivo after one week of daily administration. In the presence of 25 mg/kg of Zynamite®, predominantly alpha2 and beta1 spectral frequencies were attenuated in all brain areas during the first hour after administration. Exactly this pattern of frequency changes had been observed in earlier studies with i.p. administration of caffeine. Discriminant analysis confirmed this similarity by projection of Zynamite®?and 0.5 mg/kg caffeine into close neighborhood and showing identical colours, which points to a similar mechanism of action in this analysis. In addition, when Zynamite®?was combined with very low doses of caffeine synergistic effects were observed. Since alpha2 waves are under the control of dopamine, activation of this neurotransmitter system might be responsible for the stimulating property of Zynamite®. These results are corroborated by the results from the ex vivo study using the hippocampus slice in vitro to follow changes in excitability in the presence of 0.5 mg/kg of caffeine, 25 mg/kg of Zynamite®?or their combination in comparison to Placebo after daily administration for one week. Both caffeine and Zynamite®?increased LTP. LTP relates to space and time dependent memory. From these studies it is evident that both caffeine and Zynamite®?act in similar ways on brain electrical activity, and have potential to improve cognitive function. Bioactive compounds of Zynamite®?clearly pass the blood brain barrier to act on the central nervous system. Due to the demonstrat

关键词： Zynamite^(■) Mangifera indica Caffeine Rat Field Potential Hippocampus Slice Synergy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Proof of Effectiveness of PASCOFLAIR®in Subjects Suffering from Examination Anxiety Using Quantitative EEG in Combination with Eye-Tracking (EnkephaloVision). A Double-Blind, Randomized, Placebo Controlled, 2-Armed, Phase IV Study in Parallel Design

引用

Pharmacology & Pharmacy 2016年第10期7卷 424-442页

作者： Wilfried Dimpfel Gwladys N. Chiegoua Dipah Samir Suliman Justus-Liebig-University Giessen Germany neurocode ag Wetzlar Germany

The pharmaco-dynamic action of plant-derived drugs still remains a big challenge in the field of pharmacology. This applies especially for the discovering of the possible mechanism of action. With respect to the brain, surrogate parameters may be very helpful. Non-invasive pharmaco-EEG has been proven to provide valid information on drug effects in general. Fast dynamic EEG recording with epoch length of 364 ms has now been achieved in combination with Eye-Tracking in order to elucidate single scenes during cognitive and emotional challenges (EnkephaloVision). The present investigation deals with the psychophysiological characterization of the effect of a plant-derived preparation marketed in Germany under the name of PASCOFLAIR® containing 425 mg of passionflower extract in subjects suffering from examination anxiety. Forty healthy volunteer subjects (17 men and 23 woman), with ages varying between 18 and 40 years (26 ± 6.726 for men and 25 ± 5.397 for women) were included into the study when having a score higher than 60 in the PAF (PrÜfungsangstfragebogen). Spectral power analysis of pre-drug data with respect to beta waves revealed a significant correlation to the score of the PAF. Increases of delta, theta and beta waves as induced by 4 cognitive and 4 emotional challenges were attenuated in the presence of 2 tablets of PASCOFLAIR® already 45 minutes after intake in a statistically significant manner in comparison to placebo. Regarding attenuation of beta1 and beta2 spectral power, effects on glutamatergic and GABAergic neurotransmission, respectively, can be suspected according to our knowledge of frequency—transmitter relations. Accordingly, this attenuation must be interpreted as ability to counteract examination induced stress symptoms. Results confirm and extend earlier experimental data showing a calming action of PASCOFLAIR®.

关键词： EEG Source Density Spectral Power PASCOFLAIR® Psychophysiology Cognition Emotion Stress CATEEM® neurocode-Tracking Eye-Tracking Enkephalovision

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ex Vivo Characterization of the Action of Sideritis Extract Using Electrical Activity in the Rat Hippocampus Slice Preparation

引用

Pharmacology & Pharmacy 2016年第10期7卷 407-416页

作者： Wilfried Dimpfel Leonie Schombert Björn Feistel Justus-Liebig-University Giessen c/o neurocode ag Wetzlar Germany neurocode ag Wetzlar Germany Finzelberg GmbH & Co. KG Andernach Germany

A hydroethanolic extract (20% V/V) from Herba Sideritis scardica has been recognized to positively influence cognition. The present investigation aimed at the question if this extract would be able to modify intra-hippocampal communication after oral administration of 100 mg/kg daily for one week. The glutamatergic synapse between Schaffer Collaterals and pyramidal cells can be tested by electric stimulation using single pulses or theta burst stimulation. The resulting population spike is modulated by compounds acting at the central nervous system or other preparations directly or as ex vivo approach. In this case the effect of the special extract was tested in vitro the next day after repetitive in vitro administration. Conventional recording technique in the in vitro hippocampus slice revealed an increase of the population spike in the presence of single stimuli and theta burst stimuli resulting in increased long-term potentiation. This effect was tried to modulate by several glutamate receptor antagonists, among them compounds targeting at the ionic NMDA receptor (CGS19755), AMPA receptor (NBQX), Kainate receptor (UBP301) and targeting at three metabotropic glutamate receptors (mGluR I (YM298198), mGluRII ((RS)-APICA)) and mGluRIII (MSOP). Only NBQX was able to prevent the action of the Sideritis scardica extract. Since the AMPA receptor has been related to cognition in several reports in the literature, it is concluded from this result that the positive action of Sideritis scardica extract on brain function involves a modulation of AMPA receptor dependent neurotransmission.

关键词： Hippocampus Slice AMPA Receptor Sideritis scardica Greak Mountain Tea Long Term Potentiation Hippocampus

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Opposite Neurophysiological Findings Induced by Sideritis scardica and Sideritis euboa Extract in the Rat

引用

Journal of Behavioral and Brain Science 2016年第11期6卷 448-461页

作者： Wilfried Dimpfel Björn Feistel Leonie Schombert Justus-Liebig-University Giessen c/o neurocode ag Wetzlar Germany Finzelberg GmbH & Co. KG Andernach Germany neurocode ag Wetzlar Germany

Psychophysiological effects of Sideritis herba extracts depend on biologically active ingredients, which might be different for several botanical types of this plant. The present investigation aimed at the characterization of extracts from Sideritis scardica and Sideritis euboa in vivo and in vitro. Construction of electropharmacograms on the base of recording of electrical field potentials from four different brain regions was used to compare the possible pharmacological effects to a database of reference drugs with known clinical indications. Whereas Sideritis scardica produced decreases of spectral power in line with stimulatory frequency patterns as observed in the presence of Ginkgo biloba extract, administration of Sideritis euboa produced opposite effects. Electrical stimulation of the Schaffer Collaterals was used to elicit a pyramidal cell response called population spike in vitro. The amplitude of this spike was determined in the presence of single as well as theta burst stimuli. Direct exposure of brain matter to Sideritis scardica extract led to concentration dependent increases of the population spike amplitude under both stimulation patterns in the range from 12.5 to 100 mg/L. On the opposite, extract from Sideritis euboa did not change the electric response up to 50 mg/L. Higher concentrations of this extract attenuated the signal amplitude. A 1:1 blend of both gave intermediate results. The in vitro results are in line with the in vivo EEG recordings, where both extracts induced opposite changes of the electric power with respect to electric frequency patterns. The results from both models suggest a stimulatory and/or memory-enhancing action for the extract from Sideritis scardica but not for Sideritis euboa extract, where a more tranquillizing effect like that observed in the presence of Humulus cone extract may be expected.

关键词： Neurophysiology Rat Hippocampus Slice Sideritis scardica Sideritis euboa Greak Mountain Tea Electropharmacogram

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Classification of Herbal Drug Effects by Discriminant Analysis of Quantitative Human EEG Data

引用

Neuroscience & Medicine 2019年第2期10卷 101-117页

作者： Wilfried Dimpfel Justus-Liebig-University Giessen c/o neurocode ag Wetzlar Germany

Clinical indications for herbal drugs very often only rely on traditional knowledge. Single plant-derived preparations are used for many purposes and cannot be classified to belong to a single category like calming or stimulating drugs. With respect to the brain a unique possibility exists to analyze drug effects by recording the EEG. It is common knowledge that many drugs change the frequency content of electric brain activity. Quantitative analysis of the EEG by Fast Fourier Transformation reveals parameters like spectral power, which can be processed further (CATEEM®). Source density was determined from 17 channels of the quantitative EEG from 10 clinical studies recorded in a relaxed state with open eyes. Linear discriminant analysis was used to differentiate the effects of Placebo (circadian rhythm) from CNS-active herbal drugs in comparison to Valium®. Calmvalera®, L-Theanine, Lasea®, Neurapas®, Neuravena®, Neurexan®, Nutrifin Relax®, Pascoflair®(herbal calming drugs) as well as memoLoges®, Zembrin®(herbal stimulating drugs) induced different changes of the frequency content of brain electric activity. Discriminant analysis revealed that Nutrifin Relax®, Pascoflair®and Suntheanine®could not be separated well from each other indicating a similar mechanism of action. The effect of Valium®was projected at a very isolated position far away from the herbal preparations indicating a totally different mechanism of action. Zembrin®and memoLoges®grouped together with respect to the first three discriminant functions, but were different with respect to the 4th to 6th discriminant function. Lasea®as anxiolytic drug and Neurapas®as antidepressive drug were projected at isolated positions indicating their different clinical indications. The results indicate that discriminant analysis of human quantitative EEG data allows for unique pharmacological description of individual effect

关键词： Quantitative EEG Discriminant Analysis Herbal Drugs Fast Fourier Transformation Central Nervous System CATEEM

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Slow Gamma Activity of Local Field Potentials (LFP) in the Freely Moving Rat Relates to Movement

引用

Journal of Behavioral and Brain Science 2015年第10期5卷 420-429页

作者： Wilfried Dimpfel Leonie Schombert Justus-Liebig-Unversitat-Giessen Giessen Germany neurocode ag Wetzlar Germany

Quantitative assessment of local field potentials by means of Fast Fourier Transformation (FFT) results in the so-called power density spectrum. Within this spectrum particular frequency ranges are defined in order to relate these to behavior. Frequencies above 35 Hz are generally labeled as gamma oscillations, especially as low gamma (40 - 55 Hz) or high gamma (70 - 100 Hz). In order to learn more about this feature, we implanted a set of 4 bipolar concentric steel electrodes in frontal cortex, hippocampus, striatum and midbrain reticular formation of 10 rats. After recovery, field potentials were recorded and wirelessly transmitted to our computer for frequency analysis. At the same time, motion was registered during the whole experimental period of 5.75 hours. Results revealed that low gamma activity only emerged when the animal moved—at least his head. FFT of the data showed—besides other frequencies—a slow gamma activity peaking around 47 Hz pre-dominantly within the striatum, less in frontal cortex and reticular formation and nearly none in the hippocampus. Spectral analysis was performed for single epochs of 4 seconds and all 15 minutes intervals. Correlation analysis of these intervals was done to motion data. All rats showed a highly significant correlation between gamma activity and movement. We therefore conclude from these experiments that this slow gamma activity of the field potentials is not only related to movement, but possibly part of the general neuronal coding of movement.

关键词： Local Field Potential (LFP) Gamma Activity Rat Movement

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effects of Neurexan on Stress-Induced Changes of Spectral EEG Power: A Double-Blind, Randomized, Placebo-Controlled, Crossover Exploratory Trial in Human Volunteers

引用

World Journal of Neuroscience 2019年第3期9卷 100-112页

作者： Wilfried Dimpfel Justus-Liebig-University Giessen c/o NeuroCode AG Wetzlar Germany

Neurexan is a multicomponent natural medicinal product?used?for?stress-related?symptoms such as nervous restlessness and insomnia. The present study?investigated?the?efficacy?of Neurexan on stress-induced changes of brainwave frequencies?using quantitative analysis of spectral EEG power. Thirty healthy male and female volunteers were tested in a randomized, placebo controlled cross-over trial under conditions of relaxation and experimental stress-in-?duction. Recording of the EEG was performed over four hours after drug administration. Data was?analyzed using the proprietary fast dynamic EEG technology neurocode-Tracking. Quantitative EEG revealed a task dependent increase of beta2 power as a surrogate parameter of stress induced anxiety. The elevated frontotemporal beta2 power was ameliorated by intake of Neurexan during the second and third hour after administration. This indicates that Neurexan is effectively helping subjects to better cope with task-related stress situations.

关键词： Stress Anxiety qEEG Brain Map Brainwave Frequency Homeopathy Neurexan Nx4

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cerebral Bioavailability of Silexan—A Quantitative EEG Study in Healthy Volunteers

引用

Open Journal of Psychiatry 2015年第3期5卷 285-297页

作者： Wilfried Dimpfel Winfried Wedekind Angelika Dienel Justus-Liebig-University c/o neurocode ag Wetzlar Germany neurocode ag Wetzlar Germany Dr. Willmar Schwabe GmbH & Co. KG Karlsruhe Germany

Background: A quantitative EEG (qEEG) study was performed to investigate the cerebral bioavailability of Silexan. Method: Twenty-four male and female healthy volunteers between 20 and 62 years of age were eligible for participation and received 160 or 80 mg/day Silexan or placebo in randomised order according to a 3-way crossover design. Treatment phases of 14 days were separated by 14-day washout periods. qEEG recordings in conditions “eyes open”, “eyes closed”, as well as during performance of 3 different cognitive tasks, were performed at 0, 1, 2, 3, and 4 h after drug administration on the first (single-dose assessment) and last day of each treatment period (repetitive dose assessment). Result: Compared with placebo, qEEG analysis revealed a significant increase of spectral power within two hours in the alpha1 range (7.0 - 9.5 Hz), particularly in the fronto-temporal region, where it was more pronounced after administration of Silexan 160 mg/day than after the 80 mg/day dose. Changes in other frequency bands were mainly attributable to circadian rhythm. No EEG changes typically seen during the investigation of sedative drugs (general theta increase) were observed. Cognitive task performance under both doses of Silexan was not inferior compared with that in the placebo period. Conclusions: The study provides evidence that ingredients of the anxiolytic lavender oil preparation Silexan penetrate the blood-brain barrier and induce functional changes in the CNS. The types of changes observed in the qEEG are consistent with the anxiolytic clinical effect of the drug represented by increases of alpha1 spectral power. No sedative effects were observed. Silexan was well tolerated during repetitive administration of doses up to twice the marketed dose.

关键词： Silexan Clinical Trial Cerebral Bioavailability qEEG CATEEM

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：