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A novel linear microprobe array for the fabrication of neural microelectrodes

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Science China(Technological Sciences) 2015年第2期58卷 346-351页

作者： ZHAO Shan Shan PEI Wei Hua ZHAO Hui WANG Yi Jun CHEN San Yuan CHEN Yuan Fang ZHANG He GUO Dong Mei GUI Qiang CHEN Hong Da State Key Laboratory on Integrated Optoelectronics Institute of Semiconductors Chinese Academy of Sciences Institute for neural Computation University of California San Diego

A novel linear microprobe array(LMPA)has been developed by a conventional microfabrication method from *** LMPA leverages the properties of conventional microwire with additional features of naturally formed regular *** the help of periodic microprobe arrays and double-side V-grooves fabricated in advance between each pair of the two microprobes’rear ends,the number of microprobe units for assembly in one array can be flexibly chosen by cleavage fracture from the *** fabrication method was demonstrated and the prototype device was assessed by electrochemical impedance spectroscopy(EIS)and in vivo *** SNR of the spikes recorded was 6.

关键词： LMPA regular spacing cleavage fracture V-groove

Using a 3-D multicellular simulation of spinal cord injury with live cell imaging to study the neural immune barrier to nanoparticle uptake

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Nano Research 2016年第8期9卷 2384-2397页

作者： Alan P. Weightman Stuart I. Jenkins Divya M. Chari Cellular and neural Engineering Group Institute for Science and Technology in Medicine Huxley Building Keele University Keele ST55BG UK

Development of nanoparticle （NP） based therapies to promote regeneration in sites of central nervous system （CNS; i.e, brain and spinal cord） pathology relies critically on the availability of experimental models that offer biologically valid predictions of NP fate in vivo. However, there is a major lack of biological models that mimic the pathological complexity of target neural sites in vivo, particularly the responses of resident neural immune cells to NPs. Here, we have utilised a previously developed in vitro model of traumatic spinal cord injury （based on 3-D organotypic slice arrays） with dynamic time lapse imaging to reveal in real-time the acute cellular fate of NPs within injury foci. We demonstrate the utility of our model in revealing the well documented phenomenon of avid NP sequestration by the intrinsic immune cells of the CNS （the microglia）. Such immune sequestration is a known translational barrier to the use of NP-based therapeutics for neurological injury. Accordingly, we suggest that the utility of our model in mimicking microglial sequestration behaviours offers a valuable investigative tool to evaluate strategies to overcome this cellular response within a simple and biologically relevant experimental system, whilst reducing the use of live animal neurological injury models for such studies.

关键词： organotypic slice culture microglia immune barrier corticosteroid dexamethasone time lapse microscopy

GENERALIZED INVERSE GROUP OF SIGNAL AND ITS IMPLEMENTATION WITH neural NETWORKS

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Journal of Electronics(China) 1994年第1期11卷 1-10页

作者：何明一 neural Network Research Laboratory Northwestern Polytechnic University Xi'an 710072

A new concept, the generalized inverse group (GIG) of signal, is firstly proposed and its properties, leaking coefficients and implementation with neural networks are presented. Theoretical analysis and computational simulation have shown that (1) there is a group of finite length of generalized inverse signals for any given finite signal, which forms the GIG; (2) each inverse group has different leaking coefficients, thus different abnormal states; (3) each GIG can be implemented by a grouped and improved single-layer perceptron which appears with fast convergence. When used in deconvolution, the proposed GIG can form a new parallel finite length of filtering deconvolution method. On off-line processing, the computational time is reduced to O(N) from O(N2). And the less the leaking coefficient is, the more reliable the deconvolution will be.

关键词： Signal processing neural networks Generalized inverse group Deconvolution

Celebration of the 10^th Anniversary of neural Regeneration Research

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neural Regeneration Research 2017年第1期12卷 5-6页

作者： Kwok-fai so Xiao-Ming Xu neural Regeneration Research

Dear Readers,We are very excited to celebrate the 10th anniversary of neural Regeneration Research（NRR）.With this first issue of 2017,we would like to express our sincere thanks for your continued support and wish you a Happy New Year!We would also like to share with you a brief overview of the growth of the journal in the past 10 years.

关键词： NRR th Anniversary of neural Regeneration Research Celebration of the 10

32-site microelectrode modified with Pt black for neural recording fabricated with thin-film silicon membrane

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Science China(Information Sciences) 2014年第5期57卷 292-298页

作者： CHEN SanYuan PEI WeiHua ZHAO Hui GUI Qiang TANG RongYu CHEN YuanFang FANG XiaoLei HONG Bo GAO XiaoRong CHEN HongDa State Key Laboratory on Integrated Optoelectronics Institute of SemiconductorsChinese Academy of Sciences Institute of neural Engineering Department of Biomedical Engineering Tsinghua University

Multi-electrode array is an important tool in the study of neural-network,cognition,remembrance,as well as brain-computer-interface,***-like 32-site microelectrodes are developed with *** use of integrated circuit technology,the length of the electrodes,the area of the recording sites,as well as the spaces between the sites are closely ***2/SiNx/SiO2composite dielectric membrane and Pt black are introduced to improve the characteristics of the *** whole thickness of the thin-film probe was 21μ*** combining the modifying process with the micro-fabrication method,this kind of silicon based microelectrode satisfies high-density recording and the performance characterization is evaluated by test in vitro and in vivo.

关键词： microelectrode brain-computer interface thin-film Si Pt black neural recording

Physiological effects of amyloid precursor protein and its derivatives on neural stem cell biology and signaling pathways involved

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neural Regeneration Research 2019年第10期14卷 1661-1671页

作者： Raquel Coronel Charlotte Palmer Adela Bernabeu-Zornoza María Monteagudo Andreea Rosca Alberto Zambrano Isabel Liste Unidad de Regeneración neural Unidad Funcional de Investigación de Enfermedades Crónicas Instituto de Salud Carlos Ⅲ (ISCⅢ)

The pathological implication of amyloid precursor protein(APP)in Alzheimer’s disease has been widely documented due to its involvement in the generation of amyloid-β ***,the physiological functions of APP are still poorly *** is considered a multimodal protein due to its role in a wide variety of processes,both in the embryo and in the adult ***,APP seems to play a key role in the proliferation,differentiation and maturation of neural stem *** addition,APP can be processed through two canonical processing pathways,generating different functionally active fragments:soluble APP-α,soluble APP-β,amyloid-β peptide and the APP intracellular C-terminal *** fragments also appear to modulate various functions in neural stem cells,including the processes of proliferation,neurogenesis,gliogenesis or cell ***,the molecular mechanisms involved in these effects are still *** this review,we summarize the physiological functions of APP and its main proteolytic derivatives in neural stem cells,as well as the possible signaling pathways that could be implicated in these *** knowledge of these functions and signaling pathways involved in the onset or during the development of Alzheimer’s disease is essential to advance the understanding of the pathogenesis of Alzheimer’s disease,and in the search for potential therapeutic targets.

关键词： amyloid precursor protein APP soluble APP alpha soluble APP beta amyloid beta peptide APP intracellular domain neural stem cells neural progenitor cells neurogenesis signaling pathways

STABILITY ANALYSIS OF ARTIFICIAL neural NETWORKS UNDER RANDOM PERTURBATION

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Journal of Electronics(China) 1992年第4期9卷 321-326页

作者：廖桂生焦李成保铮 Institute of Electronic Eng.and Center for neural Networks Xidian UniversityXi'an 710071

Based on the theory of stochastic differential equation,the stability of a kind ofcontinuous-time generalized Hopfield neural networks with white noise perturbation is studiedin the paper,and the related stability cri... 详细信息

关键词： Hopfield neural networks Stability analysis Stochastic differential equations Wiener process

Effect of vocal respiratory training on respiratory function and respiratory neural plasticity in patients with cervical spinal cord injury:a randomized controlled trial

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neural Regeneration Research 2022年第5期17卷 1065-1071页

作者： Xiao-Ying Zhang Wei-Yong Yu Wen-Jia Teng Yi-Chuan Song De-Gang Yang Hong-Wei Liu Song-Huai Liu Xiao-Bing Li Wen-Zhu Wang Jian-Jun Li School of Rehabilitation Medicine Capital Medical UniversityBeijingChina China Rehabilitation Science Institute BeijingChina Beijing Key Laboratory of neural Injury and Rehabilitation BeijingChina Center of neural Injury and Repair Beijing Institute for Brain DisordersBeijingChina Music Therapy Center Department of PsychologyChina Rehabilitation Research CenterBeijingChina Department of Imaging China Rehabilitation Research CenterBeijingChina Department of Spinal and neural Functional Reconstruction China Rehabilitation Research CenterBeijingChina Department of Music Artificial Intelligence and Music Scientific Technology Central Conservatory of MusicBeijingChina

In previous studies,researchers have used singing to treat respiratory function in patients with spinal cord ***,few studies have examined the way in which vocal training affects respiratory neural plasticity in patients with spinal cord *** respiratory training(VRT)is a type of vocal muscle-related treatment that is often a component of music therapy(MT)and focuses on strengthening respiratory muscles and improving lung *** this randomized controlled study,we analyzed the therapeutic effects of VRT on respiratory dysfunction at 3 months after cervical spinal cord *** an initial group of 37 patients,26 completed the music therapy intervention,which comprised five 30-minute sessions per week for 12 *** intervention group(n=13)received VRT training delivered by professional certified music *** control group(n=13)received respiratory physical therapy delivered by professional physical *** with the control group,we observed a substantial increase in respiratory function in the intervention group after the 12-week ***,the nerve fiber bundles in the respiratory center in the medulla exhibited a trend towards increased diversification,with an increased number,path length,thickness,and density of nerve fiber *** findings provide strong evidence for the effect of music therapeutic VRT on neural *** study was approved by the Ethics Committee of China Rehabilitation Research Center(approval No.2020-013-1)on April 1,2020,and was registered with the Chinese Clinical Trial Registry(registration *** CTR2000037871)on September 2,2020.

关键词： cervical spinal cord injury music therapy neural plasticity respiratory center respiratory function vocal respiratory training

Volterra Feedforward neural Networks:Theory and Algorithms

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Journal of Systems Engineering and Electronics 1996年第4期7卷 1-12页

作者： Jiao Lichengl Liu Fang & Xie Qin(National Lab. for Radar Signal Processing and Center for neural Networks,Xidian University, Xian 710071, P.R.China) National Lab. for Radar Signal Processing and Center for neural Networks Xidian University Xian 710071 P.R. China

The Volterra feedforward neural network with nonlinear interconnections and related homotopy learning algorithm are proposed in the paper. It is shown that Volterra neural network and the homolopy learning algorithms are significant potentials in nonlinear approximation ability,convergent speeds and global optimization than the classical neural networks and the standard BP algorithm, and related computer simulations and theoretical analysis are given too.

关键词： Volterra neural networks Homotopy learning algorithm.