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Malnutrition in Relation with Dietary, Geographical, and Socioeconomic Factors among Older Chinese

Biomedical and Environmental Sciences 2021年第5期34卷 337-347页

作者： ZHANG Jian SONG Peng Kun ZHAO Li Yun SUN Ye YU Kai YIN Jing PANG Shao Jie LIU Zhen MAN Qing Qing HE Li LI Cheng ARIGONI Fabrizio BOSCO Nabil DING Gang Qiang ZHAO Wen Hua National Institute of Nutrition and Health Chinese Center for Disease Control and PreventionBeijing 100050China Nestlw research Singapore Hub 138567Singapore nestle research Center China Beijing 100102China nestle research Center Lausanne 1000LausanneSwitzerland

Objective Nutrition is closely related to the health of the elderly population. This study aimed to provide a comprehensive picture of the nutrition status of elderly Chinese and its related dietary,geographical, and socioeconomic *** A total of 13,987 ≥ 60-year-old persons from the 2010–2013 Chinese National Nutrition and Health Survey were included to evaluate various aspects of malnutrition, including underweight,overweight or obesity, and micronutrient *** Overall, the prevalence of obesity, overweight, and underweight was 12.4%, 34.8%, and 5.7%,respectively, with disparities both geographically and socioeconomically. The prevalence of underweight was higher among the older old(≥ 75 years), rural residents and those with low income, with low education status, and residing in undeveloped West areas. More than 75% of the elderly do not meet the Dietary Reference Intakes for vitamins A, B1, B2, and E, folate, calcium, selenium, potassium, biotin,and choline, with the prevalence of inadequate intake increasing with age for most nutrients. At the population level, the mean intakes of numerous food groups did not meet the recommendations by the Chinese Dietary *** Obesity epidemic, inadequacy of micronutrient intake, and high prevalence of underweight and anemia in susceptible older people are the major nutrition challenges for the rapidly aging population in China.

关键词： Malnutrition Older Chinese Food intake Nutrients National survey

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Evolution of Mobility Function in Chinese Elders during the 6 Months of Nutritional Supplementation and Age-adapted Physical Activities: A Feasibility Study

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Biomedical and Environmental Sciences 2021年第11期34卷 900-904页

作者： CHANG Cui Qing KARAGOUNIS Leonidas G YU Ying Xiang YIN Jing DONATO-CAPEL Laurencel SHEVLYAKOVA Maya BEAUMONT Maurice HUANG Hong Shi OFFORD Elizabeth A HORCAJADA MarieNoelle Institute of Sports Medicine Peking University Third HospitalBeijing 100191China nestle Health Science Translation ResearchEpalingesSwitzerland University of Bern Institute of Social and Preventive Medicine(ISPM)BernCH nestle research Center Beijing 100095China nestle research LausanneSwitzerland

Knee pain and discomfort appear at the early stages of normal aging,which lead to impaired mobility and reduced quality of life(QOL).Among age-related conditions,osteoarthritis(OA)is considered the most significant cause of disability The acceleration of the aging process in China has troubled the middle-aged and elderly with a relatively high prevalence of OA,as recently reported in a meta-analysis pooling and analyzing epidemiological publications on OA in the middleaged and elderly Chinese published from 2000 to2018[1].

关键词： aging impaired acceleration

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Secretory IgA in complex with Lactobacillus rhamnosus potentiates mucosal dendritic cell-mediated Treg cell differentiation via TLR regulatory proteins, RALDH2 and secretion of IL-IO and TGF-β

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Cellular & Molecular Immunology 2017年第6期14卷 546-556页

作者： Josip Mikulic Stephanie Longet Laurent Favre Jalil Benyacoub Blaise Corthesy R&D Laboratory Division of Immunology and Allergy CHUV Centre des Laboratoires d'Epalinges 1066 Epalinges Switzerl Nutrition and Health Nestle Research Center 1000 Lausanne 26 Switzerland

The importance of secretory IgA in controlling the microbiota is well known, yet how the antibody affects the perception of the commensals by the local immune system is still poorly defined. We have previously shown that the transport of secretory IgA in complex with bacteria across intestinal micmfold cells results in an association with dendritic cells in Peyer＇s patches. However, the consequences of such an interaction on dendritic cell conditioning have not been elucidated. In this study, we analyzed the impact of the commensal Lactobacillus rhamnosus, alone or associated with secretory IgA, on the responsiveness of dendritic cells freshly recovered from mouse Peyer＇s patches, mesenteric lymph nodes, and spleen. Lactobacillus rhamnosus-conditioned mucosal dendritic cells are characterized by increased expression of Toll-like receptor regulatory proteins lincluding single immunoglobulin interleukin-1 receptor-related molecule, suppressor of cytokine signaling 1, and Toll-interacting moleculel and retinaldehyde dehydrogenase 2, low surface expression of co-stimulatory markers, high anti- versus pro-inflammatory cytokine production ratios, and induction of T regulatory cells with suppressive function. Association with secretory IgA enhanced the anti-inflammatory/regulatory Lactobacillus rhamnosus-induced conditioning of mucosal dendritic cells, particularly in Peyer＇s patches. At the systemic level, activation of splenic dendritic cells exposed to Lactobacillus rhamnosus was partially dampened upon association with secretory IgA. These data suggest that secretory IgA, through coating of commensal bacteria, contributes to the conditioning of mucosal dendritic cells toward tolerogenic profiles essential for the maintenance of intestinal homeostasis.

关键词： commensal bacteria dendritic cells secretory IgA TLR regulatory proteins T regulatory cells

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Nutrition and Arthritis

Nutrition and Arthritis

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中国畜牧兽医学会养犬学分会第十二次全国养犬学术研讨会

作者： Mark Waldron nestle research Center st.LouisMO phD

Osteoarthritis (OA) is a chronic degenerative joint disease characterized by progressive carti- lage *** may have different etiologies but similar has similar biologic,mor- phologic,and chnical *** disease processes n...

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Crohn's disease environmental factors in the developing world: A case-control study in a statewide catchment area in Brazil

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World Journal of Gastroenterology 2017年第30期23卷 5549-5556页

作者： Valéria Cristina Loureiro Salgado Ronir Raggio Luiz Neio Boechat Bianca C Schorr Isabella S Leao Tiago Nunes Cyrla Zaltman Division of Gastroenterology Department of Internal MedicineClementino Fraga Filho HospitalFederal University of Rio de Janeiro Institute for Studies in Public Health Federal University of Rio de Janeiro Multidisciplinary research Laboratory Clementino Fraga Filho University HospitalInstitute of Thoracic DiseasesFaculty of MedicineFederal University of Rio de Janeiro Gastrointestinal Physiology Institute of Nutritional ScienceNestle Research Center

To identify environmental risk factors associated with the development of Crohn’s disease (CD) in order to re-assess the hygiene hypothesis. METHODSA hospital-based, case-control study was carried out with CD patients (n = 145) and controls (n = 163) representing a socioeconomically diverse statewide catchment area in Brazil. Controls were recruited from caregivers of patients seen in different outpatient clinics at the same hospital. A multi-item survey with 94 questions regarding family history of CD, perinatal and childhood circumstances, living conditions, tobacco use and familial socioeconomic status was carried out by interviewers. RESULTSOn the univariate analysis, predictive variables for CD included being male, under age of 40, a high education level, urban dweller, smaller family size, exposure to enteric pathogens and user of treated water (P < 0.005). On the multivariate analysis, variables significantly associated with CD were male gender (OR = 2.09), under age 40 (OR = 3.10), white (OR = 2.32), from a small family in childhood (OR = 2.34) and adulthood (OR = 3.02), absence of viral infections in childhood (OR = 2.23), exposure to enteric pathogens (OR = 2.41), having had an appendectomy (OR = 2.47) and prior or current smoker (OR = 2.83/1.12). CONCLUSIONMost variables supporting the “hygiene hypothesis” are associated with the development of CD but are not independent predictors of the diagnosis.

关键词： Crohn’s disease Environment Hygiene hypothesis Risk factors

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Breast milk macronutrient composition and the associated factors in urban Chinese mothers

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Chinese Medical Journal 2014年第9期127卷 1721-1725页

作者： Yang Titi Zhang Yumei Ning Yibing You Lili Ma Defu Zheng Yingdong Yang Xiaoguang Li Wenjun Wang Junkuan Wang Peiyu Department of Nutrition & Food Hygiene School of Public Health Peking University Health Science Center Beijing 100191 China nestle research Center Beijing Beijing 100095 China National Institute for Nutrition and Food Safety Chinese CDCBeijing 100050 China nestle Nutrition Institute Beijing 100102 China

Background Infancy is a critical period of growth and physiological development,in which breast milk is the best source of *** to western countries,research on breast milk of Chinese population are ***,it is necessary to measure breast milk energy and macronutrient concentrations of healthy urban Chinese mothers at different lactation stages,to expand the database of milk composition of Chinese population,and to examine whether dietary or other maternal factors can affect the levels of macronutrients in breast *** Breast milk of full expression of one side breast from 436 urban Chinese lactating mothers at 5-11 days,12-30 days,31-60 days,61-120 days,and 121-240 days postpartum was obtained at 9：00 *** 11：00 *** energy,lactose,protein,and fat contents were measured.24-hour dietary recall was surveyed,and maternal nutrient intakes were *** Milk composition changed over the course of lactation and large individual variations were *** concentrations were 61.3 kcal/dl for total energy,7.1 g/dl for lactose,0.9 g/dl for protein,and 3.4 g/dl for fat in mature *** of lactation was a strong factor affecting milk *** evidence was found for associations between maternal current dietary intake and milk macronutrient concentration,consistently with prior *** body mass index （BMI） was positively associated with milk fat content,to a greater extent than did dietary *** other maternal characteristics were not significant for milk *** These findings suggest that milk composition is generally weakly associated with maternal factors except for stage of lactation,and is likely to be more susceptible to long-term maternal nutritional status than short-term dietary fluctuation.

关键词： lactation milk composition macronutrients dietary intake body mass index

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三年每日补充叶酸改善老年人认知功能

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英国医学杂志中文版 2008年第1期11卷 49-50页

作者： Durga J van Boxtel MP Schouten EG 徐静(译) nestle research Centre Lausanne Switzerland

设计：随机安慰剂对照试验[叶酸和颈动脉内膜厚度（Folic Acid and Carotid Intima media Thickness，FACIT）试验]。

关键词：认知功能叶酸老年人颈动脉内膜厚度 Intima 对照试验随机安慰剂

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Nutrient Intakes of Pregnant Women and their Associated Factors in Eight Cities of China： A Cross-sectional Study

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Chinese Medical Journal 2015年第13期128卷 1778-1786页

作者： Fang-Li Liu Yu-Mei Zhang Gerard Vinyes Pares Kathleen C Reidy Wen-Zhi Zhao Ai Zhao Cheng Chen Celia Y Ning Ying-Dong Zheng Pei-Yu Wang Department of Nutrition and Food Hygiene School of Public Health Peking University Health Science Center Beijing 100191 China nestle research Center Beijing 100095 China Global Meals and Drinks Nestle Infant N'utdtion Flor'ham Park N J USA Department of Epidemiology and Biostatistics School of Public Health Peking University Health Science Center Beijing 100191 China

Background： During tile last 3 decades, China has dramatic changes of the dietary pattern among its citizens, particularly in urban cities. This study aimed to determine the nutrient intake status and factors associated with nutrient intakes of urban Chinese pregnant women now-a-day. Methods： The multistage stratified random sampling method was applied in the cross-sectional study. 479 women in three trimesters of pregnancy from eight cities of China were recruited. Nutrient intakes were evaluated with one 24 h dietary recall, and compared with the Chinese Dietary Reference Intakes （DRIs） 2013 tbr available nutrients. Results： Most pregnant women had imbalanced macronutrient distribution with excessive energy derived from fat. Intakes of Vitamin A, B, calcium, magnesium, and selenium were below Chinese Recommended Nutrient Intake （RNI） and Estimated Average Requirements （EARs） in all trimesters. Most pregnant women took more tblic acid in the first trimester with a significant decrease in the second and third trimester （P 〈 0.05）. Shortfall in iron intake was tbund in the third trimester whereas some women may be at the risk of excessive iron intake. Intakes of thiamin met RNI in the first trimester but were below EAR in all trimesters. Trimester phasing was positively associated with most nutrients （P 〈 0.05）. Prepregnancy body mass index was inversely associated with energy, tht, Vitamin C, and calcium intake （P 〈 0.05）. Educational level and household income were positively associated with folic acid intake （P 〈 0.05）. Conclusions： Cunent prenatal dietary choices of urban pregnant women in China are imbalanced in the nutrient intake when compared with national DRIs 2013, particularly in intakes of energy derived from fat and micronutrients. Appropriate dietary advice to pregnant women should promote a balanced diet with emphasis on avoidance of foods of high fat content and incorporation of t＇oods that are good sources of the key micronutrients that are usually l

关键词： Dietary Assessment: Fat Nutrient Intake Physiological Status Pregnant Women

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中国12省市儿童青少年身体活动和静坐行为分析

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卫生研究 2016年第3期45卷 394-397页

作者：贾小芳王惠君王丹彤苏畅张伋姜红如欧阳一非张兵中国疾病预防控制中心营养与健康所北京100050 nestle research Center Nestec Ltd.

目的了解我国儿童青少年身体活动和静坐行为模式和水平。方法研究资料来源于2011年＂中国健康与营养调查＂,选择有完整人口统计学、身体活动和静坐行为调查数据的7～18岁儿童青少年作为研究对象。分析儿童青少年参加校外体育活动、在校... 详细信息

目的了解我国儿童青少年身体活动和静坐行为模式和水平。方法研究资料来源于2011年＂中国健康与营养调查＂,选择有完整人口统计学、身体活动和静坐行为调查数据的7～18岁儿童青少年作为研究对象。分析儿童青少年参加校外体育活动、在校体育活动、家务性劳动、往返学校交通行为身体活动和静坐行为的比例,儿童青少年身体活动和静坐行为活动量及其年龄、性别、居住地区和家庭收入差异。结果调查对象有静坐行为的比例最高（97.9%）,参加校外体育活动的比例最低（33.6%）;各年龄和性别组均呈现相似的参加身体活动和静坐行为的比例分布。参加校外体育活动或具有静坐行为的儿童青少年相应活动类型的活动量中位水平最高,分别为39.9和36.1 MET-h/week,进而体现出儿童青少年静坐行为时间过长。各种身体活动和静坐行为活动量存在年龄、性别和居住地区差异（P均〈0.05）。结论我国儿童青少年普遍缺乏身体活动,应加强以提高身体活动水平为目的的健康促进活动。

关键词：身体活动静坐行为儿童青少年

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世界最大食品公司的未来经营战略

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国际商务研究 1991年第4期 67-67,66页

作者： Hulmut Maucher 肖群 chairman of the board and chief executive officer of nestle S. A.

雀巢公司在世界六十多个国家里,拥有430家工厂200 000名员工,年销售额480亿瑞士法郎,净利润24亿瑞士法郎,现已成为世界上最大的食品公司。面对世界未来食品工业的发展趋向,它已开始着手制订公司的未来的经营战略。寻找维持日常生命的食... 详细信息

雀巢公司在世界六十多个国家里,拥有430家工厂200 000名员工,年销售额480亿瑞士法郎,净利润24亿瑞士法郎,现已成为世界上最大的食品公司。面对世界未来食品工业的发展趋向,它已开始着手制订公司的未来的经营战略。寻找维持日常生命的食物一直是人类发展过程中的中心问题。人们对饥饿的恐惧心理,能迫使民族文化、社会结构和人口发生变化;也可以导致君主统治

关键词：食品工业食品种类加工工业雀巢公司经营战略

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