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Establishing prognostic models for intrahepatic cholangiocarcinoma based on immune cells

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World Journal of Gastrointestinal Oncology 2024年第10期16卷 4092-4103页

作者： Zhuo-Ran Wang Cun-Zhen Zhang Zhan Ding Yi-Zhuo Li Jian-Hua Yin Nan Li Department of Hepatic Surgery I(Ward I)Shanghai Eastern Hepatobiliary Surgery Hospital Navy Medical UniversityShanghai 200433China Key Laboratory of Biological Defense Ministry of EducationNavy Medical UniversityShanghai 200433China Shanghai Key Laboratory of Medical Bioprotection Navy Medical UniversityShanghai 200433China Department of Epidemiology Faculty of Navy MedicineNavy Medical UniversityShanghai 200433China Department of Oncology 905 Hospital of People’s Liberation Army NavyShanghai 200050China Department of Hepatobiliary Surgery The Second Affiliated HospitalWenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina

BACKGROUND Intrahepatic cholangiocarcinoma(ICC)is a malignant liver tumor that is challenging to treat and manage and current prognostic models for the disease are inefficient or ***-associated immune cells are critical for tumor development and *** main goal of this study was to establish models based on tumor-associated immune cells for predicting the overall survival of patients undergoing surgery for *** To establish 1-year and 3-year prognostic models for ICC after surgical *** Immunohistochemical staining was performed for CD4,CD8,CD20,pan-cytokeratin(CK),and CD68 in tumors and paired adjacent tissues from 141 patients with ICC who underwent curative *** of variables was based on regression diagnostic procedures and goodness-of-fit tests(PH assumption).Clinical parameters and pathological diagnoses,combined with the distribution of immune cells in tumors and paired adjacent tissues,were utilized to establish 1-and 3-year prognostic *** This is an important application of immune cells in the tumor ***4,CD8,CD20,and CK were included in the establishment of our prognostic model by stepwise selection,whereas CD68 was not significantly associated with the prognosis of *** integrating clinical data associated with ICC,distinct prognostic models were derived for 1-and 3-year survival outcomes using variable *** 1-year prediction model yielded a C-index of 0.7695%confidence interval(95%CI):0.65-0.87 and the 3-year prediction model produced a C-index of 0.69(95%CI:0.65-0.73).Internal validation yielded a C-index of 0.761(95%CI:0.669-0.853)for the 1-year model and 0.693(95%CI:0.642-0.744)for the 3-year *** We developed Cox regression models for 1-year and 3-year survival predictions of patients with ICC who underwent resection,which has positive implications for establishing a more comprehensive prognostic model for ICC based on tumor immune microenvironment an

关键词： Intrahepatic cholangiocarcinoma Tumor immune cells Biomarkers Prognosis Prediction models

A novel cylindrical sandwich plate inspired by beetle elytra and its compressive properties

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Science China Technological Sciences 2024年第11期67卷 3465-3476页

作者： SONG YiHeng RUAN SiHan HAO Ning OKABE YoJi School of engineering The University of Tokyo School of Civil engineering Southeast University School of engineering RMIT University Institute of Industrial Science The University of Tokyo

The design and experimental analysis of a semi-cylindrical structure known as the cylindrical beetle elytron plate(CBEP) were presented. Radial compression tests and finite element simulation were performed on CBEPs under 30° and 45° inclined sliding support constraints, with a comparison made to cylindrical honeycomb plate(CHP). The study aims to investigate the superior compression performance and enhancement mechanisms of CBEPs. The results demonstrate that CBEPs exhibit a 14%–26% increase in specific load-bearing capacity and a 20% increase in specific energy absorption compared with CHPs with equal core wall thickness. Distinct “Z-shaped” tearing failures were observed, with honeycomb plates showing tearing at the center of the honeycomb walls, while beetle elytron plates exhibited tearing along the midline of the trabeculae. Three different stress patterns,including elastic-plastic development stage of arch, plastic hinge node stage, and rigid node stage, were identified and analyzed to explain the mechanical performance improvements and failure characteristics. Considering that structural damage to trabeculae mostly occurs at its junction with the skin, it is recommended to add chamfers to the junctions of CBEP. Therefore, this paper lays the groundwork for the engineering application of CBEP.

关键词： beetle elytron cylindrical beetle elytron plate compression performance failure characteristics enhancement mechanism

Cooperative control for heterogeneous multi-agent systems: progress, applications, and challenges

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Science China(Information Sciences) 2024年第5期67卷 318-320页

作者： Bing YAN Peng SHI Jonathon CHAMBERS School of Electrical and Mechanical engineering Faculty of Science Engineering and TechnologyThe University of Adelaide School of engineering College of Science and Engineering University of Leicester

Cooperative control for heterogeneous multi-agent systems(MASs) is a critical and rapidly evolving field in modern automation and robotics. Characterized by the integration of agents with diverse capabilities and func... 详细信息

关键词： Multi agent systems

Confluence of ZnO and PTFE Binder for Enhancing Performance of Thin-Film Lithium-Ion Batteries

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Energy & Environmental Materials 2024年第5期7卷 52-60页

作者： Subhashree Behera Swathi Ippili Venkatraju Jella Na-Yeong Kim Seong Cheol Jang Ji-Won Jung Soon-Gil Yoon Hyun-Suk Kim Department of Materials Science and engineering Chungnam National University School of Materials Science and engineering University of Ulsan Department of Energy and Materials engineering Dongguk University

Developing anode materials with high specific capacity and cycling stability is vital for improving thin-film lithium-ion batteries. Thin-film zinc oxide （ZnO）holds promise due to its high specific capacity, but it suffers from volume changes and structural stress during cycling, leading to poor battery performance. In this research, we ingeniously combined polytetrafluoroethylene （PTFE） with ZnO using a radio frequency （RF）magnetron co-sputtering method, ensuring a strong bond in the thin-film composite electrode. PTFE effectively reduced stress on the active material and mitigated volume change effects during Li+ion intercalation and deintercalation. The composite thin films are thoroughly characterized using advanced techniques such as X-ray diffraction, scanning electron microscopy,and X-ray photoelectron spectroscopy for investigating correlations between material properties and electrochemical behaviors. Notably, the ZnO/PTFE thin-film electrode demonstrated an impressive specific capacity of1305 mAh g-1(=7116 mAh cm-3) at a 0.5C rate and a remarkable capacity retention of 82%from the 1st to the 100th cycle, surpassing the bare ZnO thin film （50%）. This study provides valuable insights into using binders to stabilize active materials in thin-film batteries, enhancing battery performance.

关键词： li-ion batteries metal oxides anodes polytetrafluoroethylene (PTFE) thin films

Modifying effects and mechanisms of superfine stainless wires on microstructures and mechanical properties of ultra-high performance seawater sea-sand concrete

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Science China Technological Sciences 2024年第10期67卷 3205-3220页

作者： YU Feng DONG SuFen ASHOUR Ashraf DING SiQi HAN BaoGuo School of Infrastructure engineering Dalian University of Technology Faculty of engineering & Informatics University of Bradford Department of Civil and Environmental engineering The Hong Kong Polytechnic University

Ultra-high-performance seawater sea-sand concrete（UHPSSC） presents a prospective solution to address the natural resource shortage in marine infrastructure construction. To eliminate the corrosion risk of steel fibers and broaden the applicability of UHPSSC, this study investigates the mechanical properties and free chloride ion content as well as microstructures of UHPSSC reinforced with superfine stainless wires（SSWs） under natural curing. The results indicate that 1.5% SSWs can remarkably improve the flexural strength and toughness of UHPSSC by 127% and 1724%, respectively, and mitigate the long-term strength degradation of UHPSSC. The strong interfacial bond between SSW and UHPSSC improves the compactness of UHPSSC, thus reducing the growth space for Ca（OH）2crystals and swelling hydration products generated by sulfate and magnesium ions. This can be supported by the observed reduction in the Ca/Si ratio of C–S–H gels, CH crystal orientation index, and ***, through mechanisms such as pull-out, rupture, overlapping network, and internal anchor interface, SSWs effectively prevent microcrack growth and propagation, transforming single long-connected microcracks into multiple-emission microcracks centered on SSW. Additionally, the free chloride ion content of the composites at 28 and 180 d meets the ACI 318-19 standard requirements for concrete exposed to seawater. This compliance is attributed to the chloride immobilization facilitated by Friedel's salt and C–S–H gels within the interfaces around SSWs and sea-sand. Consequently, SSWs-reinforced UHPSSC exhibits considerable potential for applications in sustainable marine infrastructures, demanding long-term mechanical properties and high durability.

关键词： ultra-high performance seawater sea-sand concrete superfine stainless wire mechanical properties chloride ion content microstructure

An Icy Worlds life detection strategy based on Exo-AUV

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Science China Earth Sciences 2024年第11期67卷 3515-3535页

作者： Bin WANG Hongde QIN National Key Laboratory of Autonomous Marine Vehicle Technology Harbin Engineering University Shipbuilding engineering College Harbin Engineering University

In the solar system, Icy Worlds such as Europa and Enceladus hold great potential for extraterrestrial life and may provide humanity an answer, within this century, to the age-old question of life beyond Earth. Exo-AUV technology shows promise in life detection in the icy shell, at the ice-water interface and on the seafloor of exo-ocean. Space agencies, including NASA and DLR, are enthusiastic about deploying Exo-AUVs to explore life in these regions. However, the where and how to find life, the technologies to be utilized and the goals to be achieved are crucial aspects for future Exo-AUV life detection missions on Icy Worlds. This study delves into a hypothetical mission of life detection on Europa, discussing science goals,detectable objects, potential regions and biogenic analysis for Icy Worlds. It proposes a life detection strategy for Icy Worlds based on Exo-AUVs, presents key contextual elements for Exo-AUV operations, outlines technological requirements for hull,payloads and autonomy, introduces the current state of Exo-AUV research and addresses existing challenges. This study also suggests a roadmap for conceptual development of Exo-AUV and a Concept of Operations for Multiple Exo-AUV System(ConOps for MEAS). This system aims to assist planetary scientists and astrobiologists in exploring Icy Worlds, identifying robust biosignatures and potentially discovering extant organisms, even prebiotic chemical systems.

关键词： Icy Worlds Europa Life detection Biological potential Exo-AUV

Micro-nano-fabrication of green functional materials by multiphase microfluidics for environmental and energy applications

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Green Energy & Environment 2024年第8期9卷 1199-1219页

作者： Cheng Qi Tao Zhou Xingjiang Wu Kailang Liu Lei Li Zhou Liu Zhuo Chen Jianhong Xu Tiantian Kong Guangdong Provincial Key Laboratory of Micro/Nano Optomechatronics engineering College of Mechatronics and Control EngineeringShenzhen University The State Key Laboratory of Chemical engineering Department of Chemical EngineeringTsinghua University College of Chemistry and Environmental engineering Shenzhen University Department of Biomedical engineering School of MedicineShenzhen University

Multiphase microfluidic has emerged as a powerful platform to produce novel materials with tailor-designed functionalities, as microfluidic fabrication provides precise controls over the size, component, and structure of resultant materials. Recently, functional materials with welldefined micro-/nanostructures fabricated by microfluidics find important applications as environmental and energy materials. This review first illustrated in detail how different structures or shapes of droplet and jet templates are formed by typical configurations of microfluidic channel networks and multiphase flow systems. Subsequently, recent progresses on several representative energy and environmental applications, such as water purification, water collecting and energy storage, were overviewed. Finally, it is envisioned that integrating microfluidics and other novel materials will play increasing important role in contributing environmental remediation and energy storage in near future.

关键词： Microfluidics Multi-phase flow Droplet and microfiber Environmental remediation Energy Storage

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Localization for mixed near-field and far-field sources under impulsive noise

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Journal of Systems engineering and Electronics 2024年第2期35卷 302-315页

作者： GAO Hongyuan ZHANG Yuze DU Ya’nan CHENG Jianhua CHEN Menghan College of Information and Communication engineering Harbin Engineering UniversityHarbin 150001China College of Intelligent Systems Science and engineering Harbin Engineering UniversityHarbin 150001China

In order to solve the problem that the performance of traditional localization methods for mixed near-field sources(NFSs)and far-field sources(FFSs)degrades under impulsive noise,a robust and novel localization method is *** eliminating the impacts of impulsive noise by the weighted out-lier filter,the direction of arrivals(DOAs)of FFSs can be estimated by multiple signal classification(MUSIC)spectral peaks *** on the DOAs information of FFSs,the separation of mixed sources can be ***,the estimation of localizing parameters of NFSs can avoid two-dimension spectral peaks search by decomposing steering *** Cramer-Rao bounds(CRB)for the unbiased estimations of DOA and range under impulsive noise have been *** experiments verify that the proposed method has advantages in probability of successful estimation(PSE)and root mean square error(RMSE)compared with existing localization *** can be concluded that the proposed method is effective and reliable in the environment with low generalized signal to noise ratio(GSNR),few snapshots,and strong impulse.

关键词： source localization far-field source(NFS) near-field source(FFS) impulsive noise Cramer-Rao bound(CRB)

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Evaluating transient behaviour of large-scale photovoltaic systems during lightning events using enhanced finite difference time domain method with variable cell size approach

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High Voltage 2024年第3期9卷 636-647页

作者： Ibrahim Hetita Diaa-Eldin A.Mansour Yang Han Ping Yang Congling Wang Mohamed M.F.Darwish Matti Lehtonen Amr S.Zalhaf School of Mechanical and Electrical engineering University of Electronic Science and Technology of China(UESTC)ChengduChina Electrical Power and Machines engineering Department Faculty of EngineeringHelwan UniversityCairoEgypt Electrical Power and Machines engineering Department Faculty of EngineeringTanta UniversityTantaEgypt Department of Electrical Power engineering Faculty of EngineeringEgypt-Japan University of Science and TechnologyAlexandriaEgypt Department of Electrical engineering Faculty of Engineering at ShoubraBenha UniversityCairoEgypt Department of Electrical engineering and Automation School of Electrical EngineeringAalto UniversityEspooFinland

Photovoltaic(PV)arrays are usually installed in open areas;hence,they are vulnerable to lightning strikes that can result in cell degradation,complete damage,service disruption,and increased maintenance *** a result,it is imperative to develop an effective and efficient lightning protection system by evaluating the transient behaviour of PV arrays during lightning *** aim is to evaluate the transient analysis of large-scale PV systems when subjected to lightning strikes using the finite difference time domain(FDTD)*** overvoltages are calculated at various points within the mounting *** optimise the FDTD method's execution time and make it more suitable for less powerful hardware,a variable cell size approach is ***,larger cell dimensions are used in the earthing system and smaller cell dimensions are used in the mounting *** FDTD method is utilised to calculate the temporal variation of transient overvoltages for large-scale PV systems under different scenarios,including variations in the striking point,soil resistivity,and the presence of a metal *** results indicate that the highest transient overvoltages occur at the striking point,and these values increase with the presence of a PV metal frame as well as with higher soil ***,a comparison is performed between the overvoltage results obtained from the FDTD approach and the partial element equivalent circuit(PEEC)method at the four corner points of the mounting systems to demonstrate the superior accuracy of the FDTD ***,a laboratory experiment is conducted on a small-scale PV system to validate the simulation *** calculated overvoltages obtained from the FDTD and PEEC methods are compared with the measured values,yielding a mean absolute error of 5%and 11%for the FDTD and PEEC methods,respectively,thereby confirming the accuracy of the FDTD simulation model.

关键词： transient behaviour finite