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Metabolic reprogramming: a new option for the treatment of spinal cord injury

Neural Regeneration research 2025年第4期20卷 1042-1057页

作者： Jiangjie Chen Jinyang Chen Chao Yu Kaishun Xia Biao Yang Ronghao Wang Yi Li Kesi Shi Yuang Zhang Haibin Xu Xuesong Zhang Jingkai Wang Qixin Chen Chengzhen Liang Department of Orthopedics The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiang ProvinceChina Orthopedics research Institute of Zhejiang University Zhejiang UniversityHangzhouZhejiang ProvinceChina Key Laboratory of Motor System Disease research and Precision Therapy of Zhejiang Province HangzhouZhejiang ProvinceChina Clinical research center of Motor System Disease of Zhejiang Province HangzhouZhejiang ProvinceChina Qiandongnan Prefecture People’s Hospital KailiGuizhou ProvinceChina Department of Orthopedics Fourth Medical CenterChinese PLA General HospitalBeijingChina

Spinal cord injuries impose a notably economic burden on society,mainly because of the severe after-effects they *** the ongoing development of various therapies for spinal cord injuries,their effectiveness remains ***,a deeper understanding of metabolism has opened up a new therapeutic opportunity in the form of metabolic *** this review,we explore the metabolic changes that occur during spinal cord injuries,their consequences,and the therapeutic tools available for metabolic *** spinal cord metabolism is characterized by independent cellular metabolism and intercellular metabolic ***,spinal cord injury results in metabolic disorders that include disturbances in glucose metabolism,lipid metabolism,and mitochondrial *** metabolic disturbances lead to corresponding pathological changes,including the failure of axonal regeneration,the accumulation of scarring,and the activation of *** rescue spinal cord injury at the metabolic level,potential metabolic reprogramming approaches have emerged,including replenishing metabolic substrates,reconstituting metabolic couplings,and targeting mitochondrial therapies to alter cell *** available evidence suggests that metabolic reprogramming holds great promise as a next-generation approach for the treatment of spinal cord *** further advance the metabolic treatment of the spinal cord injury,future efforts should focus on a deeper understanding of neurometabolism,the development of more advanced metabolomics technologies,and the design of highly effective metabolic interventions.

关键词： axons glycolysis metabolic reprogramming metabolism mitochondria neural regeneration neuroprotection oxidative phosphorylation spinal cord injury therapy

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Polyphyllin I promotes cell death via suppressing UPR-mediated CHOP ubiquitination and degradation in non-small cell lung cancer

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Chinese Journal of natural Medicines 2021年第4期19卷 255-266页

作者： LIU Ming-Ming ZHU Miao-Lin DONG Rui-Fang ZHANG Chao ZHANG Hao YANG Lei KONG Ling-Yi XIA Yuan-Zheng Jiangsu Key Laboratory of Bioactive natural product research and State Key Laboratory of natural Medicines China Pharmaceutical UniversityNanjing 210009China Jiangsu Cancer Hospital Nanjing 210009China

Polyphyllin I(PPI)purified from Polyphylla rhizomes displays puissant cytotoxicity in many kinds of *** researches investigated its anti-cancer *** novel mechanisms are still worth *** study aimed to explore PPI-induced endoplasmic reticulum(ER)stress as well as the underlying mechanism in non-small cell lung cancer(NSCLC).Cell viability or colony-forming was detected by MTT or crystal violet *** cycle,apoptosis,reactive oxygen species(ROS)and mitochondrial membrane potential were assessed by flow *** and protein levels were evaluated by q RT-PCR and immunoblotting *** interaction was determined by immunoprecipitation or immunofluorescence *** overexpression or silencing was carried out by transient transfection with plasmids or small interfering *** Cancer Genome Atlas(TCGA)database was used for Gene Set Enrichment Analysis(GSEA),survival analysis,gene expression statistics or pathway enrichment *** inhibited the propagation of NSCLC cells,increased non-viable apoptotic cells,arrested cell cycle at G2/M phase,induced ROS levels but failed to decrease mitochondrial membrane *** levels of GRP78 indicates poor prognosis in NSCLC *** selectively suppressed unfolded protein response(UPR)-induced GRP78 expression,subsequently protected CHOP from GRP78-mediated ubiquitination and *** demonstrated that the natural product PPI,obtained from traditional herbal medicine,deserves for further study as a valuable candidate for lead compound in the chemotherapy of NSCLC.

关键词： Non-small cell lung cancer Polyphyllin I Endoplasmic reticulum stress C/EBP homologous protein Ubiquitination

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Variability of Soil Properties as Affected by Geological Formations in Southwestern Iran

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地学前缘 2009年第S1期16卷 244-245页

作者： Reza Soleimani Agriculture and natural research center

Parent material is the most important soil forming ***,relation between geological forma- tion and soil properties was investigated in southwestern ***,geological formations of Asmari,

关键词： soil geological formations Iran

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Rapid identification of stigmastane-type steroid saponins from Vernonia amygdalina leaf based onα-glucosidase inhibiting activity and molecular networking

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Chinese Journal of natural Medicines 2022年第11期20卷 846-853页

作者： GAO Juanjuan ZHAO Mengling SHAN Shujun LI Yongyi LUO Jun LI Yi School of Food Science and Pharmaceutical Engineering Testing&Analysis CenterNanjing Normal UniversityNanjing 210023China Jiangsu Key Laboratory of Bioactive natural product research and State Key Laboratory of natural Medicines China Pharmaceutical UniversityNanjing 210009China

Steroid saponins are secondary metabolites with multiple medicinal values that are found in large quantities in natural medicines,especially Vernonia amygdalina,a famous nature medicine for the treatment of tonsillitis,diabetes,*** current study was designed to combine molecular networking(MN)with diagnostic ions for rapid identification ofΔ^(7,9(11))stigmastane-type saponins which were theα-glucosidase inhibitory active substances in ***,theα-glucosidase inhibitory activities of fiveΔ^(7,9(11))stigmastane-type steroid saponins that were previously isolated were screened,which indicated that theΔ^(7,9(11))stigmastane-type steroid saponin was one of the active constituents responsible for ameliorating ***,a strategy was proposed to identify stigmastane-type steroid saponins and verify the plausibility of derived fragmentation pathways by applying MN,MolNetEnhancer and unsupervised substructure annotation(MS2LDA).Based on this strategy,other sevenΔ^(7,9(11))stigmastane-type steroid saponins were identified from this *** research provide scientific evidence for the antidiabetic potential of the steroid saponin-rich extract of *** leaf.

关键词： Δ^(7,9(11))Stigmastane-type steroid saponins α-Glucosidase inhibitory activity Fragmentation pathways Diagnostic ions Molecular networking

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Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

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Science China Chemistry 2025年第01期 288-296页

作者： Shuai Liu Wen-Qiang Xu Ying-Tong Di Man-Cheng Tang Ding-Kang Chen Ming-Ming Cao Yao-Wen Chang Hong-Yu Tang Chun-Mao Yuan Jun-Bo Yang Zhi-Li Zuo Han Guo Zi-Fei Xu Ying Zeng Yun-Dong Wu Xiao-Jiang Hao Key Laboratory of Phytochemistry and natural Medicines (Chinese Academy of Sciences) Kunming Institute of Botany Chinese Academy of Sciences University of Chinese Academy of Sciences Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical Oncogenomics Peking University Shenzhen Graduate School Shenzhen Bay Laboratory State Key Laboratory of Microbial Metabolism School of Life Sciences & Biotechnology Shanghai Jiao Tong University State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University Molecular Biology Experimental center Germplasm Bank of Wild Species in Southwest China Kunming Institute of Botany Chinese Academy of Sciences Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of Botany Chinese Academy of Sciences research Unit of Chemical Biology of natural Anti-Virus products Chinese Academy of Medical Sciences

In the intricate process of natural product biosynthesis, a metabolon can enhance metabolic flux by associating sequential enzymes. A fungal metabolon, comprising of flavin-dependent monooxygenase Spe F and P450 monooxygenase Spe G, is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide B. Using notoamide E as a substance, Spe F/Spe G metabolon can control the stereoselectivity of its 2,3-epoxidation, followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-m A with dienyl iminium unit. Subsequently,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol rearrangement. This provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

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The impact of Persian oak (Quercus brantii Lindl.) on soil characteristics in a declining forest

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Journal of Forestry research 2020年第6期31卷 2359-2366页

作者： Reza Soleimani Ahmad Hosseini Crop and Horticultural Science research Department Ilam Agricultural and Natural Resources Research and Education CenterAREEOIlamIran Forests and Rangelands research Department Ilam Agricultural and Natural Resources Research and Education CenterAREEOIlamIran

Root activity has an important impact on soil development but we have little knowledge of the interaction of the root zone and soil genetic *** aim of this investigation was to study the interactions between soil chemical characteristics and root zone processes in a declining Persian oak forest(Quercus brantii Lindl.).A randomized complete block design was used to investigate the long-term eff ect of Persian oak on soil horizons,and the chemical and biological properties in two soil zones(under and outside the canopy).Results indicate that the rhizosphere zone had signifi cantly higher total organic carbon(TOC)than outside the canopy soil in the upper soil *** subsurface horizons,water-extractable organic carbon values were signifi cantly higher in rhizosphere than in non-rhizospheric *** biomass carbon(MBC)values in the rhizospheric zone decreased from the fi rst to the second *** MBC/TOC ratio indicated signifi-cant diff erences between the rhizosphere and soils outside of the canopy,with the exception of the subsurface *** the subsurface horizon of the rhizosphere,there was greater respiration of organic carbon(ΣCO 2/TOC)than in outside of canopy *** addition,root processes infl uenced pH,nitrogen fractions,and availability of phosphorus,potassium,iron,zinc and *** erences in soil characteristics between rhizospheric and non-rhizospheric zones were signifi cant in surface horizons due to higher root density than in deeper soil *** fi ndings indicate that Persian oak(Quercus brantii Lindl.)roots infl uenced the main soil chemical properties,even in calcareous soils.

关键词： Declining forest Persian oak Rhizosphere Soil horizons

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Inhibiting ceramide synthase 5 expression in microglia decreases neuroinflammation after spinal cord injury

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Neural Regeneration research 2025年第10期20卷 2955-2968页

作者： Wei Zhang Yubao Lu Ruoqi Shen Yingjie Wu Chenrui Liu Xingxing Fang Liangming Zhang Bin Liu Limin Rong Department of Spine Surgery The Third Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina National Medical products Administration(NMPA)Key Laboratory for Quality research and Evaluation of Cell products GuangzhouGuangdong ProvinceChina Guangdong Provincial center for Quality Control of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina Guangdong Provincial center for Engineering and Technology research of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina

Microglia,the resident monocyte of the central nervous system,play a crucial role in the response to spinal cord ***,the precise mechanism remains *** investigate the molecular mechanisms by which microglia regulate the neuroinflammatory response to spinal cord injury,we performed single-cell RNA sequencing dataset analysis,focusing on changes in microglial *** found that the MG1 subpopulation emerged in the acute/subacute phase of spinal cord injury and expressed genes related to cell pyroptosis,sphingomyelin metabolism,and neuroinflammation at high ***,we established a mouse model of contusive injury and performed intrathecal injection of siRNA and molecular inhibitors to validate the role of ceramide synthase 5 in the neuroinflammatory responses and pyroptosis after spinal cord ***,we established a PC12-BV2 cell co-culture system and found that ceramide synthase 5 and pyroptosis-associated proteins were highly expressed to induce the apoptosis of neuron *** ceramide synthase 5 expression in a mouse model of spinal cord injury effectively reduced ***,ceramide synthase 5-induced pyroptosis was dependent on activation of the NLRP3 signaling *** ceramide synthase 5 expression in microglia in vivo reduced neuronal apoptosis and promoted recovery of neurological ***2g7 formed a“bridge”between sphingolipid metabolism and ceramide synthase 5-mediated cell death by inhibiting the NLRP3 signaling ***,these findings suggest that inhibiting ceramide synthase 5 expression in microglia after spinal cord injury effectively suppressed microglial pyroptosis mediated by NLRP3,thereby exerting neuroprotective effects.

关键词： ceramide synthase 5 gasdermin D microglia neuroinflammation NLRP3 nuclear factor kappa B Pla2g7 pyroptosis sphingomyelin metabolism spinal cord injury

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Stability and Stabilization of Sampled-Data Based LFC for Power Systems:A Data-Driven Method

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IEEE/CAA Journal of Automatica Sinica 2025年第1期 291-293页

作者： Yu-Long Fan Chuan-Ke Zhang Yong He the School of Automation China University of Geosciences the Hubei Key Laboratory of Advanced Control and Intelligent Automation for Complex Systems the Engineering research center of Intelligent Technology for Geo-Exploration Ministry of Education IEEE

Dear Editor,This letter is concerned with stability analysis and stabilization design for sampled-data based load frequency control(LFC) systems via a data-driven method. By describing the dynamic behavior of LFC systems based on a data-based representation, a stability criterion is derived to obtain the admissible maximum sampling interval(MSI) for a given controller and a design condition of the PI-type controller is further developed to meet the required MSI. Finally, the effectiveness of the proposed methods is verified by a case study.

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Biomass and carbon stocks in three types of Persian oak(Quercus brantii ***)of Zagros forests in a semi-arid area,Iran

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Journal of Arid Land 2020年第5期12卷 766-774页

作者： Ali MAHDAVI Soghra SAIDI Yaghob IRANMANESH Mostafa NADERI Faculty of Agriculture and natural Resources Ilam UniversityIlam 69315516Iran research Division of natural Resources Chaharmahal and Bakhtiari Agricultural and Natural Resources Research and Education CenterAREEOShahrekord ***Iran

Persian oak(Quercus brantii ***)is a dominant tree species of Zagros forests in a semi-arid area,western ***,the capacity of biomass and carbon stocks of these forests is not well *** selected three types of oak,i.e.,seed-originated oak,coppice oak and mixed(seed-originated and coppice)oak of Zagros forests in Dalab valley,Ilam Province,Iran to survey the capacity of biomass and carbon stocks in *** plots with an area of 1000 m2 were systematically and randomly assigned to each type of *** characteristics of trees,such as diameter at breast height(DBH),height,crown diameter and the number of sprouts in each plot were ***,aboveground biomass(AGB),belowground biomass(BGB),aboveground carbon stock(AGCS)and belowground carbon stock(BGCS)of each tree in plots were calculated using allometric *** litterfall biomass(LFB)and litterfall carbon stock(LFCS)were measured in a quadrat with 1 m×1 m in each ***-way analysis of variance and Duncan's test were performed to detect the differences in biomass and carbon stocks among three types of *** showed that AGB,BGB and BGCS were significantly different among three types of *** highest values of AGB,AGCS,BGB and BGCS in seed-originated oak were 76,043.25,14,725.55,36,737.79 and 7362.77 kg/hm2,***,the highest values of LFB and LFCS in seed-originated oak were 3298.33 and 1520.48 kg/hm2,respectively,which were significantly higher than those of the other two types of *** results imply the significant role of seed-originated oak for the regeneration of Zagros *** conservation strategy of seed-originated oak is an important step in the sustainable management of Zagros forests in Iran.

关键词： biomass carbon stock seed-originated forest coppice forest Zagros forest

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Comparison of heavy metal removal efficiencies in four activated sludge processes

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Journal of Central South University 2015年第10期22卷 3788-3794页

作者：杨军高定陈同斌雷梅郑国砥周小勇 center for Environmental Remediation Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of Sciences

The removal efficiencies of heavy metals(As, Cr, Cu, Ni, Pb and Zn) were investigated in the 17 operating municipal wastewater treatment plants(WWTPs) and compared with those in four main activated sludge processes. Significant differences of heavy metal removal efficiencies were observed among four activated sludge processes. The removal efficiency for As(75.5%) in the oxidation ditch(OD) process is significantly higher than that in the conventional activated sludge(CAS) process(38.6%) or sequencing batch reactor(SBR) process(51.4%). The mean removal efficiencies for Cu and Ni in the OD process are 90.5% and 46.7%, respectively, while low mean removal efficiencies are observed for Cu(69.9%) and Ni(16.5%), respectively, in the SBR process. The removal efficiencies for Cu and Ni in the OD process are significantly higher than those in the anaerobic-anoxic-oxic(A2-O) process. These results highlight the differences of removal efficiencies for heavy metals in different processes and should be considered when selecting a wastewater treatment process.

关键词： wastewater heavy metal removal efficiency treatment process activated sludge processes

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