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The Application of Allyl as a Protecting Group in the Preparation Of Dinucleoside Carbonat.

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Chinese Chemical Letters 1998年第9期9卷 791-793页

作者： Ying ZHOU Liang Ren ZHANG Li He ZHANG (nat.onal lab.ratory of nat.ral and Biomimetic drugs, Beijing Medical University,Beijing 100083) natl. lab. of nat./Biomimetic drugs Beijing Medical University Beijing 100083 China

Reaction of 5'-O-p-methoxytritylthymidine with 1,1'-carbonyl-diimidazole gave the 3'-O-carbonylimidazolide, which was condensed in high yield with 3'-O-protected thymidine to give a dinucleoside carbonat.. In the synthesis of dinucleoside carbonat., allyl can be used as a good protecting group for 3'-hydroxyl of thymidine. The condition of deprotection will not affect the carbonat. bridges.

关键词： allyl PdCl2 deprotection dinucleoside carbonat. synthesis

Two New Triterpenoid Saponins from the Seeds of Aesculus chinensis

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Chinese Chemical Letters 2000年第2期11卷 139-142页

作者： Xiu Wei YANG Jing ZHAO Yu Xin CUI (nat.onal lab.ratory of nat.ral and Biomimetic drugs, Beijing Medical University, Beijing 100083) natl. lab. nat. and Biomimetic drugs Beijing Medical University Beijing 100083 China

Two new triterpenoid saponins, named isoescins IIIa (1) and IIIb (2) were isolated from the seeds of Aesculus chinensis and identified by spectroscopic analysis and chemical hydrolysis. Their structures were established as 21 beta-tigloyl-28-acetylbarringtogenol C-3 beta-O-[beta D-galactopyranosyl( 1-->2)] [beta-D-glucopyranosyl (1-->])1-beta-D-glucopyranosiduronic acid (1) and 21 beta-angeloyl-28-acetylbarringtogenol C-3 beta-O-[beta-D;galactopyranosyl (1-->2)] [beta-D-glucopyranosyl(1 -->4)]-beta-D-glucopyranosiduronic acid (2), which are geometrically isomeric.

关键词： Aesculus chinensis isoescins IIIa and IIIb

Three New Triterpenoid Saponins from the Seeds of Aesculus chinensis

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Chinese Chemical Letters 1999年第12期10卷 0-0,0-0页

作者： Xiu Wei YANG Jing ZHAO Yu Xin CUI(nat.onal lab.ratory of nat.ral and Biomimetic drugs, Beijing Medical University,Beding 100083) natl. lab. nat. and Biomimetic drugs Beijing Medical University Beijing 100083 China

Three new triterpenoid saponins, escins IVg (1), IVh (2) and VIb (3) were isolatedfrom the seeds of Aesculus chinensis along with two known saponins, escin IIIa (4) anddesacylescin I (5). Their structures were elucida... 详细信息

关键词： Aesculus chinensis Hippocastanaceae escins Ⅲ4 IVg IVh and Vib desacylescin I.

A Pair of New Geometrically Isomeric Triterpenoid Saponins fromthe Seeds of Aesculus chinensis

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Chinese Chemical Letters 1999年第11期10卷 925-928页

作者： Xiu Wei YANG Jing ZHAO Yu Xin CUI Li He ZHANG(nat.onal lab.ratory of nat.ral and Biomimetic drugs, Beijing Medical University.Beijing 100083) natl. lab. nat. and Biomimetic drugs Beijing Medical University Beijing 100083 China

Two new triterpenoid saponins were isolated from the seeds of Aesculus chinensis by preparative HPLC. On the basis of chemical evidence and spectral data, their structures were established as 21 beta-tigloyl-28-acetylprotoaescigenin 3 beta-O-[beta-D-xylopyranosyl (1 --> 2)] [beta-D-glucopyranosyl (1 --> 4)]-beta-D-glucopyranosiduronic acid (isoescin IIa, 1) and 21 beta-tigloyl-28-acetylprotoaescigenin 3 beta-O-[beta-D-xylopyranosyl (1 --> 2)] [beta-D-glucopyranosyl (1 --> 4)]-beta-D-glucopyranosiduronic acid (isoescin IIb, 2), which are a pair of geometrical isomers.

关键词： Aesculus chinensis isoescin IIa and IIb

Synthesis of Two New Chiral Blocks for the Construction of Peptide Nucleic Acid (PNA)

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Chinese Chemical Letters 1999年第3期10卷 195-198页

作者： Li Gang ZHANG Ji Mei MIN Li He ZHANG(nat.onal lab.ratory of nat.ral and Biomimetic drugs. Bet-ling Medical Unlversity.Beijing 100083) natl. lab. nat. and Biomimetic drugs Beijing Medical University Beijing 100083 China

Protected (L) and (D)-lysine were used respectively as starting materials to synthesize two new types of chiral blocks for the construction of PNA. Nucleobase was linked to alpha-NH2 of lysine via -CH2C (O)- spacer in... 详细信息

关键词： peptide nucleic acid (PNA) lysine synthesis

Three New Triterpenoid Saponins from the Seeds of Aesculus chinensis

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Chinese Chemical Letters 1999年第9期10卷 767-770页

作者： Jing ZHAO Xiu Wei YANG Yu Xin CU Xue Hui LIU(nat.onal lab.ratory of nat.ral and Biomimetic drugs, Beijing Medical University.Beijing 100083) natl. lab. nat. and Biomimetic drugs Beijing Medical University Beijing 100083 China

Three new triterpenoid saponins, escins IVc (1), IVd (2) and IVf (3) were isolated from the seeds of Aesculus chinensis. They were. determined as 22 alpha-tigloyl-28-acetylprotoaescigenin-3 beta-O- [beta-D-glucopyranosyl (1-->2)] [beta-D-glucopyranosyl (1-->4)]-beta-D-glucopyranosiduronic acid 1, 22 alpha-angeloyl-28-acetylprotoaescigenin-3 beta-O- [beta-D-glucopyranosyl (1-->2)] [beta-D-glucopyrano- syl (1-->4)]-beta-D-glucopyranosiduronic acid 2 and 28-tigloyl protoaescigenin-3 beta-O- [beta-D-gluco-pyranosyl (12)] [beta-D-glucopyranosyl (1-->4)] -beta-D-glucopyranosiduronic acid 3.

关键词： triterpenoid saponins Aesculus chinensis escins IVc IVd and IVf

A New Triterpenoid Oligoglycoside Escin IVe from the Seeds ofAesculus Chinensis

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Chinese Chemical Letters 1999年第6期10卷 473-476页

作者： Jing ZHAO Xiu Wei YANGI Yu Xin CUl Xue Hut LIU Shun He OUYANGZ(nat.onal lab.ratory of nat.ral and Biomimetic drugs, Beijing Medical University.Beijing 100083Yantai Luye Pharmaceutical Co. Ltd.. 43 Yingbin Road. Yantai. Shandong 264001) natl. lab. nat. and Biomimetic drugs Beijing Medical University Beijing 100083 China Yantai Luye Pharmaceutical Co. Ltd. Yantai Shandong 264001 43 Yingbin Road China

A new triterpenoid saponin named escin IV e was isolated from the seeds of Aesculus chinensis. Its structure was established as 28-tigloylprotoaescigenin-3 beta-O- [beta-D-glucopyranosyl (1-2)] [beta-D-glucopyranosyl ... 详细信息

关键词： Aesculus chinensis hippocastanaceae triterpenoid saponins escin IVe

Four Triterpene Oligoglycosides from the seeds of Aesculus Chinensis

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Chinese Chemical Letters 1999年第4期10卷 291-294页

作者： Jing ZHAO Xiu Wei YANG Yu Xin CUI Xue Hui LIU Shu Yan LIU Hong Ying ZHI Ji Yong CHEN Fa Bing ZHU Yun Li XUE and Dian Bo LIU (nat.onal lab.ratory of nat.ral and Biomimetic drugs, Beijing Medical University ,Beijing 1 00083)(Yantai Luye Pharmaceutical natl. lab. nat. and Biomimetic drugs Beijing Medical University Beijing 100083 China Yantai Luye Pharmaceutical Co. Ltd. Yantai Shandong 264001 43 Yingbin Road China

A pair of novel geometrically isomeric triterpenoid saponins named escins IVa and IVb, together with known escins Ia and Ib. were isolated from the seeds of Aesculus chinensis. Their structures were determined on the ... 详细信息

关键词： Aesculus chinensis hippocastanaceae escins Ia Ib IVa Ivb X-ray analysis

Structural Studies of 3-(1,2-O-Isopropylidene-α-D-xylosyl)-5-phenyl-1,2,4-oxadiazole

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Chinese Chemical Letters 1999年第2期10卷 117-120页

作者： Ming Long ZHANG Yu Xin CUI Ling Tai MA Li He Zhang Yang LU Bin ZHAO Qi Tai ZHENG (The nat.onal lab.ratory of nat.ral and Biomimetic drugs．School of Pharmaceutical Sciences， Beijing Medical University， Beijing， 100083) (Institute of Materia Me natl. lab. nat. and Biomimetic drugs School of Pharmaceutical Sciences Beijing Medical University Beijing 100083 China Institute of Materia Medica Chinese Academy of Medical Sciences Peking Union Medical College Beijing 100050 China

1、2－O－Isopropylidene－3－C－cyano－5－O－benzoyl－α－D－xylose 2 was preparedstereoselectively from 1，2－O－isopropylidene－3－oxo－5－O－benzoyl－α－D－xylose *** structure of 2was studied by two－dimensional NMR spectroscopy in conjunction with X－ray crystallography of itscorresponding 5－phenyl－1，2，4－oxadiazole isocarbonucleoside derivative 3． The absoluteconfigurations of 2 and 3，and conformation of 3 are described herein．

关键词： 5-Phenyl-1,2,4-oxadiazole isocarbonucleoside stereoselectivity NMR spectroscopy X-ray crystallography