The Application of Allyl as a Protecting Group in the Preparation Of Dinucleoside Carbonate

作     者：Ying ZHOU Liang Ren ZHANG Li He ZHANG (National Laboratory of Natural and Biomimetic Drugs, Beijing Medical University,Beijing 100083) 

作者机构：Natl. Lab. of Nat./Biomimetic Drugs Beijing Medical University Beijing 100083 China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：1998年第9卷第9期

页      面：791-793页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

主　　题：allyl PdCl2 deprotection dinucleoside carbonate synthesis 

摘      要：Reaction of 5 -O-p-methoxytritylthymidine with 1,1 -carbonyl-diimidazole gave the 3 -O-carbonylimidazolide, which was condensed in high yield with 3 -O-protected thymidine to give a dinucleoside carbonate. In the synthesis of dinucleoside carbonate, allyl can be used as a good protecting group for 3 -hydroxyl of thymidine. The condition of deprotection will not affect the carbonate bridges.