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Local dose-dense chemotherapy for triple-negative breast cancer via minimally invasive implantation of 3D printed devices

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Asian Journal of Pharmaceutical sciences 2024年第1期19卷 69-85页

作者： Noehyun Myung Hyun-Wook Kang Department of Biomedical engineering Ulsan National Institute of Science and Technology(UNIST)Ulju-gun 44919South Korea

Dose-dense chemotherapy is the preferred first-line therapy for triple-negative breast cancer(TNBC),a highly aggressive disease with a poor *** treatment uses the same drug doses as conventional chemotherapy but with shorter dosing intervals,allowing for promising clinical outcomes with intensive ***,the frequent systemic administration used for this treatment results in systemic toxicity and low patient compliance,limiting therapeutic efficacy and clinical ***,we report local dose-dense chemotherapy to treat TNBC by implanting 3D printed devices with timeprogrammed pulsatile release *** implantable device can control the time between drug releases based on its internal microstructure design,which can be used to control dose *** device is made of biodegradable materials for clinical convenience and designed for minimally invasive implantation via a *** density variation of local chemotherapy using programmable release enhances anti-cancer effects in vitro and in *** the same dose density conditions,device-based chemotherapy shows a higher anticancer effect and less toxic response than intratumoral *** demonstrate local chemotherapy utilizing the implantable device that simulates the drug dose,number of releases,and treatment duration of the dose-dense AC(doxorubicin and cyclophosphamide)regimen preferred for TNBC *** density modulation inhibits tumor growth,metastasis,and the expression of drug resistance-related proteins,including p-glycoprotein and breast cancer resistance *** the best of our knowledge,local dose-dense chemotherapy has not been reported,and our strategy can be expected to be utilized as a novel alternative to conventional therapies and improve anti-cancer efficiency.

关键词： Dose-dense chemotherapy Triple-negative breast cancer 3D printing Pulsatile release Local drug delivery systems

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Autonomous Recommendation of Fault Detection Algorithms for Spacecraft

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Ieee/CAA Journal of Automatica Sinica 2024年第1期11卷 273-275页

作者： Wenbo Li Baoling Ning the national Key Laboratory of science and Technology on Space Intelligent Control Beijing Institute of Control EngineeringBeijing 100094China the School of Data science and Technology Heilongjiang UniversityHarbin 150001China

Dear editor, This letter deals with the problem of algorithm recommendation for online fault detection of spacecraft. By transforming the time series data into distributions and introducing a distribution-aware measure, a principal method is designed for quantifying the detectabilities of fault detection algorithms over special datasets.

关键词： fault introducing letter

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Challenges and Opportunities in Preserving Key Structural Features of 3D-Printed Metal/Covalent Organic Framework

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Nano-Micro Letters 2024年第8期16卷 362-381页

作者： Ximeng Liu Dan Zhao John Wang Department of Materials science and engineering National University of SingaporeSingapore 117574Singapore Department of Chemical and Biomolecular engineering National University of SingaporeSingapore 117585Singapore national University of Singapore(Chongqing)Research institute Chongqing 401123People’s Republic of China

Metal-organic framework(MOF)and covalent organic framework(COF)are a huge group of advanced porous materials exhibiting attractive and tunable microstructural features,such as large surface area,tunable pore size,and functional surfaces,which have significant values in various application *** emerging 3D printing technology further provides MOF and COFs(M/COFs)with higher designability of their macrostructure and demonstrates large achievements in their performance by shaping them into advanced 3D ***,the currently available 3D printing M/COFs strategy faces a major challenge of severe destruction of M/COFs’microstructural features,both during and after 3D *** is envisioned that preserving the microstructure of M/COFs in the 3D-printed monolith will bring a great improvement to the related *** this overview,the 3D-printed M/COFs are categorized into M/COF-mixed monoliths and M/COF-covered *** differences in the properties,applications,and current research states are *** up-to-date advancements in paste/scaffold composition and printing/covering methods to preserve the superior M/COF microstructure during 3D printing are further discussed for the two types of 3D-printed M/*** the analysis of the current states of 3D-printed M/COFs,the expected future research direction to achieve a highly preserved microstructure in the 3D monolith is proposed.

关键词： Metal-organic frameworks Covalent organic frameworks 3D printing Microstructure Monolith

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Color coded metadevices toward programmed terahertz switching

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Light(science & Applications) 2024年第7期13卷 1383-1392页

作者： Weibao He Xiang’ai Cheng Siyang Hu Ziheng Ren Zhongyi Yu Shun Wan Yuze Hu Tian Jiang College of Advanced Interdisciplinary Studies National University of Defense TechnologyChangshaChina. Nanhu Laser Laboratory National University of Defense TechnologyChangshaChina. Hunan Provincial Key Laboratory of High energy Laser Technology National University of Defense TechnologyChangshaChina. institute for Quantum science and Technology College of ScienceNational University of Defense TechnologyChangshaChina

Terahertz modulators play a critical role in high-speed wireless communication,non-destructive imaging,and so on,which have attracted a large amount of research ***,all-optical terahertz modulation,an ultrafast dynamical control approach,remains to be limited in terms of encoding and *** we experimentally demonstrated an optical-programmed terahertz switching realized by combining optical metasurfaces with the terahertz metasurface,resulting in 2-bit dual-channel terahertz *** terahertz metasurface,made up of semiconductor islands and artificial microstructures,enables effective all-optical programming by providing multiple frequency channels with ultrafast modulation at the nanosecond ***,optical metasurfaces covered in terahertz metasurface alter the spatial light field distribution to obtain color *** to the time-domain coupled mode theory analysis,the energy dissipation modes in terahertz metasurface can be independently controlled by color excitation,which explains the principle of 2-bit encoding *** work establishes a platform for all-optical programmed terahertz metadevices and may further advance the application of composite metasurface in terahertz manipulation.

关键词： terahertz surface excitation

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Chemical and mechanical properties of stainless, environment-friendly, and nonflammable Mg alloys (SeN alloys): A review

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Journal of Magnesium and Alloys 2024年第3期12卷 841-872页

作者： Jong Un Lee Hyun Ji Kim Sang-Cheol Jin Ye Jin Kim Young Min Kim Bong Sun You Jun Ho Bae Sung Hyuk Park Advanced Metals Division Korea Institute of Materials ScienceChangwon 51508Republic of Korea Department of Materials science and Metallurgical engineering Kyungpook National UniversityDaegu 41566Republic of Korea Missile Research institute Agency for Defense DevelopmentDaejeon 34060Republic of Korea

This review article provides overall understanding of stainless,environment-friendly,and nonflammable Mg alloys(SeN alloys)recently developed at the Korea institute of Materials *** alloys are produced by adding small amounts of Ca and Y(eachercial Mg–Al based alloys,resulting in exceptional ignition and corrosion resistances and impressive mechanical *** main advantages of SeN alloys are as follows.(1)A dense multi-oxide layer of SeN alloys comprising MgO,CaO,and Y_(2)O_(3) impedes the outward dispersion of Mg vapor and the inward penetration of O_(2) during oxidation,thereby enhancing the oxidation and ignition resistances.(2)The presence of Ca-and Y-based second-phase particles in SeN alloys can enhance their corrosion resistance because Ca-containing particles prevent the spread of corrosion,and the replacement of Al-containing particles with less noble ones containing Y(e.g.,Al–Mn–Y or Al–Y particles)retards corrosion.(3)The addition of minor amounts of Ca and Y renders excellent mechanical properties due to improved strengthening *** enhanced properties are attributed to more pronounced dynamic recrystallization and grain refining behaviors caused by the second-phase particles during extrusion.(4)Despite the presence of various types of second-phase particles,the fatigue properties of SeN9 alloys are similar to those of commercial AZ91 alloys.(5)Simultaneous introduction of Ca and Y suppresses the formation of Mg17Al12 discontinuous precipitates during aging,leading to the enhanced elongation of aged SeN alloys.(6)Adding mischmetal into the SeN9 alloy leads to a six-fold enhancement in ***,the studies conducted on SeN alloys demonstrate their excellent ignition and corrosion resistances and mechanical properties,which broaden the industrial applications of Mg alloys by addressing their inherent weaknesses.

关键词： SeN magnesium alloy Corrosion resistance Ignition resistance Mechanical properties extrudability.

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Monophase-homointerface electrodes intrinsically stabilize high-voltage all-solid-state batteries

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science China Chemistry 2024年第5期67卷 1729-1739页

作者： Xiaolin Xiong Xianguo Ma Tianshi Lv Liquan Chen Liumin Suo Beijing national Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of ScienceBeijing 100190China Center of Materials science and Optoelectronics engineering University of Chinese Academy of SciencesBeijing 100049China

The electrochemical stability and contact reliability of heterointerfaces between the solid electrolyte(Se) and electrode are critical for all-solid-state batteries(ASSBs), particularly much more challenging for high-voltage ASSBs, owing to the limited thermodynamically electrochemical window and mechanical inflexibility of Se, aggravating interfacial side reactions and contact failure. Considering all those issues originating from intrinsic heterogeneity in physicochemical features between the cathode material and Se, we are thinking about simplifying the heterointerfaces into a homointerface as a permanent cure to solve all electrochemical-mechanical interfacial failure. Herein, we propose monophase cathodes to construct thermodynamically stable all-in-one homointerfaces in ASS electrodes, removing unstable heterointerfaces by excluding Ses and intrinsically eliminating the Li chemical potential gap to avoid the formation of lithium-depleted space-charge layer and highly resistive mixed ion–electron conductor interphase. Our conception is successfully validated in the layered transition-metal oxide cathodes, which display outstanding stability no matter the MH-LiCoO_(2) cathode charging to 4.7 V or MH-Li_(1.2)Mn_(0.54)Ni_(0.13)-Co_(0.13)O_(2) cathode charging to 5.3 V. It is undeniable that our current version of above-illustrated MH-cathodes would bring out some new challenges for the practical application due to abandoning the Se. However, we believe our work also offers a brandnew direction to ultimately address the electrochemical–mechanical interfacial issues that would be promising for high-energy ASSBs with more discoveries of advanced monophase cathodes in the future.

关键词： monophase-homointerface electrode high-voltage all-solid-state batteries electrochemical-mechanical interfacial issue

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A multilayer network diffusion-based model for reviewer recommendation

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Chinese Physics B 2024年第3期33卷 700-717页

作者：黄羿炜徐舒琪蔡世民吕琳媛 institute of Fundamental and Frontier sciences University of Electronic Science and Technology of ChinaChengdu 611731China Yangtze Delta Region institute (Huzhou) University of Electronic Science and Technology of ChinaHuzhou 313001China institute of Dataspace Hefei Comprehensive National Science CenterHefei 230088China Big Data Research Center University of Electronic Science and Technology of ChinaChengdu 611731China School of Computer science and engineering University of Electronic Science and Technology of ChinaChengdu 611731China School of Cyber science and Technology University of Science and Technology of ChinaHefei 230026China

With the rapid growth of manuscript submissions,finding eligible reviewers for every submission has become a heavy *** systems are powerful tools developed in computer science and information science to deal with this ***,most existing approaches resort to text mining techniques to match manuscripts with potential reviewers,which require high-quality textual information to perform *** this paper,we propose a reviewer recommendation algorithm based on a network diffusion process on a scholar-paper multilayer network,with no requirement for textual *** network incorporates the relationship of scholar-paper pairs,the collaboration among scholars,and the bibliographic coupling among *** results show that our proposed algorithm outperforms other state-of-the-art recommendation methods that use graph random walk and matrix factorization and methods that use machine learning and natural language processing,with improvements of over 7.62%in recall,5.66%in hit rate,and 47.53%in ranking *** work sheds light on the effectiveness of multilayer network diffusion-based methods in the reviewer recommendation problem,which will help to facilitate the peer-review process and promote information retrieval research in other practical scenes.

关键词： reviewer recommendation multilayer network network diffusion model recommender systems complex networks

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enhanced memristor performance via coupling effect of oxygen vacancy and ferroelectric polarization

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Journal of Materials science & Technology 2024年第4期171卷 139-146页

作者： Zhi Yun Yue Zhi Dong Zhang Zhan Jie Wang Shenyang national Laboratory for Materials science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials science and engineering University of Science and Technology of ChinaShenyang 110016China School of Materials science and engineering Shenyang University of TechnologyShenyang 110870China

As a new type of nonvolatile memory,the resistive memristor has broad application prospects in in-formation storage and neural computing based on its excellent resistive switching(RS)*** present,it is still a great challenge to improve both ferroelectric polarization and leakage current to achieve a high RS on/offratio of ferroelectric ***,epitaxial Pb(Zr_(0.40)Ti_(0.60))O_(3)(PZT)thin films with low content Ca doping were deposited on the Nb:SrTiO_(3)substrate to prepare PCZT/NSTO het-erostructures and their RS behaviors were *** research findings show that compared with pure PZT film,the ferroelectric polarization of 1-mol%-Ca-doped PZT film is slightly improved,while the leak-age current is increased by three orders of ***,the RS on/offratio reaches 2.5×10^(5),about three orders of magnitude higher than pure PZT *** theoretical analysis reveals that the RS behavior of PCZT/NSTO heterostructures is controlled by the PCZT/NSTO interfacial barrier and the space charge-limited current *** results demonstrate that the ferroelectricity and electricity of ferroelectric thin films can be improved simultaneously by doping low-content Ca ions to increase the RS performance,which provides a good reference for the development of high-performance ferroelectric memristor devices.

关键词： Ferroelectric memristor Ca-doped PZT Ferroelectric polarization Oxygen vacancies Resistive switching

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Optimum process conditions for preparation of Cu-en/AP composite microspheres by electrostatic spray method based on ANSYS(Fluent) simulation

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火炸药学报 2024年

作者： Lei Liu TianYuan Hu MingJun Song Wei Ji national Academy of Defense Technology， Southwest University of science and Technology 201 Research institute， Sixth Research institute of China Aerospace science and Industry Corporation

This study employed ANSYS (Fluent) to set up an orthogonal experimental design for simulating the preparation of AP/Cu-en composite microspheres via the electrostatic spray method. Additionally， a controlled variable approach was used to simulate the influence of flow rate， solvent ratio， and solid mass on the experimental results. The purpose is to study the optimal process conditions for preparing Cu-en/AP composite microspheres through electrostatic spray and to reveal the effects of changes in droplet properties and flow rate during the electrostatic spray process on the experimental *** results indicate that under the following process conditions: a flow rate of 2.67e-3 kg/s， acetone to deionized water ratio of 1.5:1， and a solid mass of 200 mg， the theoretical diameter of the composite microspheres can reach the nanoscale. These microspheres exhibit high velocity within the electric field， there was no significant deviation in the motion trajectory. The particle diameter decreases with the increase of *** the process，This decreasing trend begins to moderate when the flow rate is 1e-3kg/s. When increasing the solvent ratio (higher acetone content)，at the begging，the particle diameter is reduced， followed by an increase. An increase in solid mass also leads to reduced in particle diameter. At a solid mass of approximately 220 mg， the particle diameter starts to increase linearly. It will be explained in detail in this paper.

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Self-supported VO_(2)on polydopamine-derived pyroprotein-based fibers for ultrastable and flexible aqueous zinc-ion batteries

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Carbon energy 2024年第7期6卷 1-13页

作者： Jeong Seok Yeon Sul Ki Park Shinik Kim Santosh VMohite Won Il Kim Gun Jang Hyun-Seok Jang Jiyoung Bae Sang Moon Lee Won GHong Byung Hoon Kim Yeonho Kim Ho Seok Park School of Chemical engineering College of EngineeringSungkyunkwan UniversityGyeonggi-doRepublic of Korea Department of engineering University of CambridgeCambridgeUK Department of Applied Chemistry Konkuk UniversityChungjuRepublic of Korea Department of Chemistry Ulsan National Institute of Science and Technology(UNIST)College of Natural SciencesUlsanRepublic of Korea Department of Physics Incheon National UniversityIncheonRepublic of Korea Intelligent Sensor Convergence Research Center Incheon National UniversityIncheonRepublic of Korea institute of Basic science Incheon National UniversityIncheonRepublic of Korea Division of Material Analysis and Research Korea Basic Science InstituteDaejeonRepublic of Korea

A conventional electrode composite for rechargeable zinc-ion batteries(ZIBs)includes a binder for strong adhesion between the electrode material and the current ***,the introduction of a binder leads to electrochemical inactivity and low electrical conductivity,resulting in the decay of the capacity and a low rate *** present a binder-and conducting agent-free VO_(2)composite electrode using in situ polymerization of dopamine on a flexible current collector of pyroprotein-based *** as-fabricated composite electrode was used as a substrate for the direct growth of VO_(2)as a self-supported form on polydopamine-derived pyroprotein-based fibers(pp-fibers@VO_(2)(B)).It has a high conductivity and flexible nature as a current collector and moderate binding without conventional binders and conducting agents for the VO_(2)(B)*** addition,their electrochemical mechanism was *** energy storage is induced by Zn^(2+)/H^(+)coinsertion during discharging,which can be confirmed by the lattice expansion,the formation of by-products including Zn_(x)(OTf)_(y)(OH)_(2x−y)·nH_(2)O,and the reduction of V^(4+)to V^(3+).Furthermore,the assembled Zn//pp-fibers@VO_(2)(B)pouch cells have excellent flexibility and stable electrochemical performance under various bending states,showing application possibilities for portable and wearable power sources.

关键词： aqueous battery binder free conducting agent‐free flexible electrode zinc‐ion battery

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