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The emerging role of nitric oxide in the synaptic dysfunction of vascular dementia

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Neural Regeneration Research 2025年第2期20卷 402-415页

作者： Xiaorong Zhang Zhiying Chen Yinyi Xiong Qin Zhou Ling-Qiang Zhu Dan Liu Department of Pathology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Jiujiang Clinical Precision Medicine Research Center JiujiangJiangxi ProvinceChina Center for Cognitive science and Transdisciplinary Studies Jiujiang UniversityJiangxi ProvinceChina Department of Neurology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Rehabilitation Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Pathophysiology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

With an increase in global aging,the number of people affected by cerebrovascular diseases is also increasing,and the incidence of vascular dementia-closely related to cerebrovascular risk-is increasing at an epidemic ***,few therapeutic options exist that can markedly improve the cognitive impairment and prognosis of vascular dementia *** in Alzheimer’s disease and other neurological disorders,synaptic dysfunction is recognized as the main reason for cognitive *** oxide is one of the ubiquitous gaseous cellular messengers involved in multiple physiological and pathological processes of the central nervous ***,nitric oxide has been implicated in regulating synaptic plasticity and plays an important role in the pathogenesis of vascular *** review introduces in detail the emerging role of nitric oxide in physiological and pathological states of vascular dementia and summarizes the diverse effects of nitric oxide on different aspects of synaptic dysfunction,neuroinflammation,oxidative stress,and blood-brain barrier dysfunction that underlie the progress of vascular ***,we propose that targeting the nitric oxide-sGC-cGMP pathway using certain specific approaches may provide a novel therapeutic strategy for vascular dementia.

关键词： endoplasmic reticulum stress endothelial nitric oxide synthase gene therapy nitric oxide NO-sGC-cGMP pathway synaptic dysfunction vascular dementia

ESTIMATED AND EXACT SYSTEM RELIABILITIES OF A MAINTAINABLE COMPUTER NETWORK

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Journal of Systems science and Systems Engineering 2011年第2期20卷 229-248页

作者： Yi-Kuei LIN Ping-Chen CHANG Department of Industrial Management National Taiwan University of Science & Technology Taipei 106 Taiwan China

This paper presents an algorithm to evaluate estimated and exact system reliabilities for a computer network in the cloud computing *** the quality of service（QOS） viewpoint,the computer network should be maintained when falling to a specific state such that it cannot afford enough capacity to satisfy ***,the transmission time should be concerned as ***,the data can be sent through several disjoint minimal paths simultaneously to shorten the transmission *** the maintenance budget B and time constraint T,we evaluate the system reliability that d units of data can be sent from the cloud to the client through multiple *** procedures are integrated in the proposed algorithm-an estimation procedure for estimated system reliability and an adjusting procedure utilizing the branch-and-bound approach for exact system ***,the estimated system reliability with lower bound and upper bound,and exact system reliability are computed by applying the recursive sum of disjoint products（RSDP） algorithm.

关键词： System reliability maintenance network flows branch-and-bound approach estimation

On-line full scan inspection of particle size and shape using digital image processing

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Particuology 2010年第3期8卷 286-292页

作者： Chih-Wei Liao Jiun-Hung Yu Yeong-Shin Tarng Department of Mechanical Engineering National Taiwan University of Science and Technology Taipei 106 Taiwan China

An on-line full scan inspection system is developed for particle size analysis. A particle image is first obtained through optical line scan technology and is then analyzed using digital image processing. The system is composed of a particle separation module, an image acquisition module, an image processing module, and an electric control module. Experiments are carried out using non-uniform 0.1 mm particles. The main advantage of this system consists of a full analysis of particles without any overlap or miss, thus improving the Area Scan Charge Coupled Device （CCD） acquisition problems. Particle size distribution, roundness, and sphericity can be obtained using the system with a deviation of repeated precision of around ±1%. The developed system is shown to be also convenient and versatile for any particle size and shape for academic and industrial users.

关键词： Particle size distribution Particle characterization Image analysis Line scan CCD Automatic inspection

Toward understanding the role of genomic repeat elements in neurodegenerative diseases

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Neural Regeneration Research 2025年第3期20卷 646-659页

作者： Zhengyu An Aidi Jiang Jingqi Chen Institute of science and technology for Brain-Inspired Intelligence Fudan UniversityShanghaiChina MOE Frontiers Center for Brain science Fudan UniversityShanghaiChina MOE Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence Fudan UniversityShanghaiChina Zhangjiang Fudan International Innovation Center ShanghaiChina

Neurodegenerative diseases cause great medical and economic burdens for both patients and society;however, the complex molecular mechanisms thereof are not yet well understood. With the development of high-coverage sequencing technology, researchers have started to notice that genomic repeat regions, previously neglected in search of disease culprits, are active contributors to multiple neurodegenerative diseases. In this review, we describe the association between repeat element variants and multiple degenerative diseases through genome-wide association studies and targeted sequencing. We discuss the identification of disease-relevant repeat element variants, further powered by the advancement of long-read sequencing technologies and their related tools, and summarize recent findings in the molecular mechanisms of repeat element variants in brain degeneration, such as those causing transcriptional silencing or RNA-mediated gain of toxic function. Furthermore, we describe how in silico predictions using innovative computational models, such as deep learning language models, could enhance and accelerate our understanding of the functional impact of repeat element variants. Finally, we discuss future directions to advance current findings for a better understanding of neurodegenerative diseases and the clinical applications of genomic repeat elements.

关键词： Alzheimer's disease ataxia deep learning long-read sequencing neurodegeneration neurodegenerative diseases Parkinson's disease repeat element structural variant

Photo‑Energized MoS_(2)/CNT Cathode for High‑Performance Li–CO_(2)Batteries in a Wide‑Temperature Range

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Nano-Micro Letters 2025年第1期17卷 160-175页

作者： Tingsong Hu Wenyi Lian Kang Hu Qiuju Li Xueliang Cui Tengyu Yao Laifa Shen Jiangsu Key Laboratory of Materials and Technologies for Energy Storage College of Materials Science and TechnologyNanjing University of Aeronautics and AstronauticsNanjing 210016People’s Republic of China

Li–CO_(2) batteries are considered promising energy storage systems in extreme environments such as Mars;however,severe performance degradation will occur at a subzero temperature owning to the sluggish reaction ***,a photo-energized strategy adopting sustainable solar energy in wide working temperature range Li–CO_(2) battery was achieved with a binder-free MoS_(2)/carbon nanotube(CNT)photo-electrode as *** unique layered structure and excellent photoelectric properties of MoS_(2) facilitate the abundant generation and rapid transfer of photo-excited carriers,which accelerate the CO_(2) reduction and Li_(2)CO_(3) decomposition upon *** illuminated battery at room temperature exhibited high discharge voltage of 2.95 V and mitigated charge voltage of 3.27 V,attaining superior energy efficiency of 90.2%and excellent cycling stability of over 120 *** at an extremely low temperature of−30℃,the battery with same electrolyte can still deliver a small polarization of 0.45 V by the photoelectric and photothermal synergistic mechanism of MoS_(2)/CNT *** work demonstrates the promising potential of the photo-energized wide working temperature range Li–CO_(2) battery in addressing the obstacle of charge overpotential and energy efficiency.

关键词： Li-CO_(2)batteries Photo-energized Wide operation-temperature Kinetics MoS_(2)

GRAPHICAL-BASED RELIABILITY EVALUATION OF MULTIPLE DISTINCT PRODUCTION LINES

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Journal of Systems science and Systems Engineering 2013年第1期22卷 73-92页

作者： Yi-Kuei LIN Ping-Chen CHANG Department of Industrial Management National Taiwan University of Science & Technology

This paper proposes a graphical-based methodology to evaluate the performance of a manufacturing system in terms of network *** focus on a manufacturing system which consists of multiple distinct production lines.A transformation technique is developed to build the manufacturing system as a manufacturing *** such a manufacturing network,the capacity of each machine is multistate due to failure,partial failure,or ***,this manufacturing network is also regarded as a multistate *** evaluate the probability that the manufacturing network can meet a given demand,where the probability is referred to as the system reliability.A simple algorithm integrating decomposition technique is proposed to generate the minimal capacity vectors that machines should provide to eventually satisfy *** system reliability is derived in terms of such capacity vectors afterwards.A practical application in the context of IC card manufacturing system is utilized to demonstrate the performance evaluation procedure.

关键词： Graphical-based methodology transformation decomposition multiple distinct production lines system reliability

Activity of Reducing Steel Slag of EAF

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Journal of Wuhan university of technology(Materials science) 2011年第1期26卷 165-171页

作者：郭金祥 Department of Construction Engineering National Taiwan University of Science and Technology

Reducing steel slag （RSS） was mainly acquired from five electric-arc furnace （EAF） steelmaking plants （among them, the products of two plants were carbon steel and those of other plants were stainless steel） for research tests. The chemical properties, compound compositions, activities and contents of main expansive compounds were tested. The results showed that the field sampled RSS had a very high crystallinity and hydraulicity with main chemical compositions close to those of Portland cement. It can be known from the study that in case of C/S ratio higher than 2.0, the main compound compositions are C2S, C3S, C2F and f-CaO. However, after the RSS was stored for six months, an obvious variation occurred with potential pre-hydration in RSS, where the SO3 content was slightly reduced and the compressive activity index was obviously higher than that at the 28th day.

关键词： strength activity index basicity EAF steelmaking reducing steel slag

Manufacturing of Porous Alumina Ceramic by Gel Casting

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稀有金属材料与工程 2011年第S3期40卷 152-155页

作者： Wu Yu-Shiang Jou Min Chueh Chih-Hao China university of science and technology national taiwan Normal university

Various quantities of non-toxic monomer (2-hydroxyethyl methacrylate, HEMA) was added to form porous alumina ceramic by gel casting process. Pure water, monomer, cross-linker (N, N'-methylene-bis-acrylamide (MBAm)), and dispersant (ammonium salt of poly (methacrylic acid), PAS) were combined to form an aqueous solution, which added alumina powder and was milled to form alumina slurry with zirconia balls for 240 minutes. An initiator (ammonium persulfate, APS) was added to the alumina slurry with a vacuum mixing system and formed in an inverted metal mold. After heat treatment, curing, stripping and drying, the alumina green body was sintered at 1200, 1300, 1400, 1500 and 1600 ℃ for 1 h. The original alumina powder and sintered porous alumina ceramic materials were analyzed for particle size, viscosity, TGA/DTA, sintering density, porosity, SEM, XRD and bending strength. The results show that the porous alumina ceramic can be prepared with porosity of 12-48 wt% and bending strength of 17-153 MPa at various monomer content of 5-25 wt% and sintering temperatures of 1200-1500 ℃.

关键词： gel casting porous alumina ceramic monomer dispersant

Low‑Temperature Oxidation Induced Phase Evolution with Gradient Magnetic Heterointerfaces for Superior Electromagnetic Wave Absorption

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Nano-Micro Letters 2025年第1期17卷 191-204页

作者： Zizhuang He Lingzi Shi Ran Sun Lianfei Ding Mukun He Jiaming Li Hua Guo Tiande Gao Panbo Liu School of Chemistry and Chemical Engineering Northwestern Polytechnical UniversityXi’an 710129People’s Republic of China School of Marine science and technology Northwestern Polytechnical UniversityXi’an 710072People’s Republic of China

Gradient magnetic heterointerfaces have injected infinite vitality in optimizing impedance matching,adjusting dielectric/magnetic resonance and promoting electromagnetic(EM)wave absorption,but still exist a significant challenging in regulating local phase ***,accordion-shaped Co/Co_(3)O_(4)@N-doped carbon nanosheets(Co/Co_(3)O_(4)@NC)with gradient magnetic heterointerfaces have been fabricated via the cooperative high-temperature carbonization and lowtemperature oxidation *** results indicate that the surface epitaxial growth of crystal Co_(3)O_(4) domains on local Co nanoparticles realizes the adjustment of magnetic-heteroatomic components,which are beneficial for optimizing impedance matching and interfacial ***,gradient magnetic heterointerfaces simultaneously realize magnetic coupling,and long-range magnetic ***,the synthesized Co/Co_(3)O_(4)@NC absorbents display the strong electromagnetic wave attenuation capability of−53.5 dB at a thickness of 3.0 mm with an effective absorption bandwidth of 5.36 GHz,both are superior to those of single magnetic domains embedded in carbon *** design concept provides us an inspiration in optimizing interfacial polarization,regulating magnetic coupling and promoting electromagnetic wave absorption.

关键词： Magnetic heterointerfaces Phase evolution Interfacial polarization Magnetic coupling Electromagnetic wave absorption