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Recent progress in the applications of presynaptic dopaminergic positron emission tomography imaging in parkinsonism

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Neural Regeneration research 2025年第1期20卷 93-106页

作者： Yujie Yang Xinyi Li Jiaying Lu Jingjie Ge Mingjia Chen Ruixin Yao Mei Tian Jian Wang Fengtao Liu Chuantao Zuo Key Laboratory of Arrhythmias Ministry of EducationDepartment of Medical GeneticsShanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina Department of Neurology National Research Center for Aging and MedicineNational Center for Neurological Disordersand State Key Laboratory of Medical NeurobiologyHuashan HospitalFudan UniversityShanghaiChina Department of Nuclear Medicine&PET center National Center for Neurological Disordersand National Clinical Research Center for Aging and MedicineHuashan HospitalFudan UniversityShanghaiChina International Human Phenome Institutes(Shanghai) ShanghaiChina Human Phenome Institute Fudan UniversityShanghaiChina

Nowadays,presynaptic dopaminergic positron emission tomography,which assesses deficiencies in dopamine synthesis,storage,and transport,is widely utilized for early diagnosis and differential diagnosis of *** review provides a comprehensive summary of the latest developments in the application of presynaptic dopaminergic positron emission tomography imaging in disorders that manifest *** conducted a thorough literature search using reputable databases such as PubMed and Web of *** criteria involved identifying peer-reviewed articles published within the last 5 years,with emphasis on their relevance to clinical *** findings from these studies highlight that presynaptic dopaminergic positron emission tomography has demonstrated potential not only in diagnosing and differentiating various Parkinsonian conditions but also in assessing disease severity and predicting ***,when employed in conjunction with other imaging modalities and advanced analytical methods,presynaptic dopaminergic positron emission tomography has been validated as a reliable in vivo *** validation extends to screening and exploring potential neuropathological mechanisms associated with dopaminergic *** summary,the insights gained from interpreting these studies are crucial for enhancing the effectiveness of preclinical investigations and clinical trials,ultimately advancing toward the goals of neuroregeneration in parkinsonian disorders.

关键词： aromatic amino acid decarboxylase brain imaging dopamine transporter Parkinson’s disease parkinsonism positron emission tomography presynaptic dopaminergic function vesicle monoamine transporter type 2

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Effect of different treatments on electrokinetic remediation of Zn, Pb and Cd from a contaminated calcareous soil

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Chinese Journal of Chemical Engineering 2021年第10期34卷 255-265页

作者： Hossein Beyrami national salinity research center Agricultural ResearchEducation and Extension OrganizationYazdIran

Electrokinetic remediation is a promising method to decontamination of the heavy metals from *** this paper,the remediation of a contaminated calcareous soil with Zn,Cd and Pb sampled from around Zanjan province of Iran,was investigated using electrokinetic *** this paper,the soil contain a high concentration of Zn(1400 mg·kg^(-1)),Cd(15 mg·kg^(-1))and Pb(250 mg·kg^(-1)).Electrokinetic decontamination consists of two series of experiments as follows:(1)the effect of five treatments including the use of distilled water,acetic acid and EDTA electrolyte solutions,and approaching anodes systems,and the circulation flow of electrolyte at two different voltage gradient(i.e.1.33 and 2.66 V·cm^(-1)),and(2)the effect of moisture content(saturated,FC and 0.7 FC,FC indicated soil moisture at "Field Capacity")with a voltage gradient of 1.33 V·cm^(-1).After applying electric current for 5 days,the results of experiments indicated that the removal efficiency of heavy metals can be increased by raising the voltage *** this matter,the highest remediation can be observed among different treatments in EDTA(Ethylene diamine tetra acetic acid)treatment(40.11%,43.10%and 24.7%for Zn,Cd and Pb,respectively).Moreover,the heavy metals removal at the saturated moisture was at the highest level so that 32.62%cadmium,31.33%zinc and 18.82%lead being removed after 120 h of electric current *** decreasing moisture to 0.7 FC,the removal percentage for the three heavy metals obtained 20.97%,18.44%and 12.25%,***,Cd had the highest removal,and Zn and Pb were next among the three heavy metals in question.

关键词： Decontamination Soil moisture Voltage gradient Cadmium Lead Zinc

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Mechanism of inflammatory response and therapeutic effects of stem cells in ischemic stroke:current evidence and future perspectives

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Neural Regeneration research 2025年第1期20卷 67-81页

作者： Yubo Wang Tingli Yuan Tianjie Lyu Ling Zhang Meng Wang Zhiying He Yongjun Wang Zixiao Li Vascular Neurology Department of NeurologyBeijing Tiantan HospitalCapital Medical UniversityBeijingChina China national Clinical research center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Shanghai Engineering research center of Stem Cells Translational Medicine ShanghaiChina national center for Healthcare Quality Management in Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Institute for Regenerative Medicine Shanghai East HospitalSchool of Life Sciences and TechnologyTongji UniversityShanghaiChina Chinese Institute for Brain research BeijingChina research Unit of Artificial Intelligence in Cerebrovascular Disease Chinese Academy of Medical SciencesBeijingChina Beijing Engineering research center of Digital Healthcare for Neurological Diseases BeijingChina

Ischemic stroke is a leading cause of death and disability worldwide,with an increasing trend and tendency for onset at a younger ***,in particular,bears a high burden of stroke *** recent years,the inflammatory response after stroke has become a research hotspot:understanding the role of inflammatory response in tissue damage and repair following ischemic stroke is an important direction for its *** review summarizes several major cells involved in the inflammatory response following ischemic stroke,including microglia,neutrophils,monocytes,lymphocytes,and ***,we have also highlighted the recent progress in various treatments for ischemic stroke,particularly in the field of stem cell ***,understanding the complex interactions between inflammation and ischemic stroke can provide valuable insights for developing treatment strategies and improving patient *** cell therapy may potentially become an important component of ischemic stroke treatment.

关键词： cell therapy immune cell inflammatory ischemic stroke stem cell

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New glucocerebrosidase antibodies can advance research in the field of neurodegenerative disorders

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Neural Regeneration research 2025年第4期20卷 1085-1086页

作者： Charis Ma Krystyna Rytel Yu Chen Ellen Sidransky Medical Genetics Branch National Human Genome Research InstituteNational Institutes of HealthBethesdaMDUSA

In medical research,there are times when the introduction of a new tool can launch scientific discovery in new *** antibody development may be considered mundane,in the field of glucocerebrosidase(GCase)research,the dearth of validated antibodies for different applications has impeded progress in studies of disease pathogenesis and therapeutic *** recent introduction of new,rigorously evaluated antibodies can now propel research into the link between glucocerebrosidase and Parkinson’s disease(PD)as well as aspects of the pathobiology of Gaucher disease(Jong et al.,2024).

关键词： antibodies cerebro

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Tailoring Light–Matter Interactions in Overcoupled Resonator for Biomolecule Recognition and Detection

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Nano-Micro Letters 2025年第1期17卷 262-280页

作者： Dongxiao Li Hong Zhou Zhihao Ren Cheng Xu Chengkuo Lee Department of Electrical and Computer Engineering National University of SingaporeSingapore 117583Singapore center for Intelligent Sensors and MEMS(CISM) National University of SingaporeSingapore 117608Singapore

Plasmonic nanoantennas provide unique opportunities for precise control of light–matter coupling in surface-enhanced infrared absorption(SEIRA)spectroscopy,but most of the resonant systems realized so far suffer from the obstacles of low sensitivity,narrow bandwidth,and asymmetric Fano resonance ***,we demonstrated an overcoupled resonator with a high plasmon-molecule coupling coefficient(μ)(OC-Hμresonator)by precisely controlling the radiation loss channel,the resonator-oscillator coupling channel,and the frequency detuning *** observed a strong dependence of the sensing performance on the coupling state,and demonstrated that OC-Hμresonator has excellent sensing properties of ultra-sensitive(7.25%nm^(−1)),ultra-broadband(3–10μm),and immune asymmetric Fano *** characteristics represent a breakthrough in SEIRA technology and lay the foundation for specific recognition of biomolecules,trace detection,and protein secondary structure analysis using a single array(array size is 100×100μm^(2)).In addition,with the assistance of machine learning,mixture classification,concentration prediction and spectral reconstruction were achieved with the highest accuracy of 100%.Finally,we demonstrated the potential of OC-Hμresonator for SARS-CoV-2 *** findings will promote the wider application of SEIRA technology,while providing new ideas for other enhanced spectroscopy technologies,quantum photonics and studying light–matter interactions.

关键词： Plasmonic nanoantennas Light-matter interaction Surface-enhanced infrared absorption Overcoupled Biosensing

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Interconnections between diabetic corneal neuropathy and diabetic retinopathy:diagnostic and therapeutic implications

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Neural Regeneration research 2025年第8期20卷 2169-2180页

作者： Mingyi Yu Faith Teo En Ning Chang Liu Yu-Chi Liu Tissue Engineering and Stem Cell Group Singapore Eye Research InstituteSingapore Yong Loo Lin School of Medicine National University of SingaporeSingapore Department of Cornea and External Eye Disease Singapore National Eye CenterSingapore Ophthalmology and Visual Sciences Academic Clinical Program Duke-NUS Medical SchoolSingapore

Diabetic corneal neuropathy and diabetic retinopathy are ocular complications occurring in the context of diabetes *** corneal neuropathy refers to the progressive damage of corneal *** retinopathy has traditionally been considered as damage to the retinal ***,growing evidence suggests that diabetic retinopathy is a complex neurovascular disorder resulting from dysfunction of the neurovascular unit,which includes both the retinal vascular structures and neural *** retinopathy is one of the leading causes of blindness and is frequently screened for as part of diabetic ocular ***,diabetic corneal neuropathy is commonly overlooked and underdiagnosed,leading to severe ocular surface *** studies have found that these two conditions tend to occur together,and they share similarities in their pathogenesis pathways,being triggered by a status of chronic *** review aims to discuss the interconnection between diabetic corneal neuropathy and diabetic retinopathy,whether diabetic corneal neuropathy precedes diabetic retinopathy,as well as the relation between the stage of diabetic retinopathy and the severity of corneal *** also endeavor to explore the relevance of a corneal screening in diabetic eyes and the possibility of using corneal nerve measurements to monitor the progression of diabetic retinopathy.

关键词： cornea corneal nerves diabetes diabetic corneal neuropathy diabetic retinopathy retina

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A New Transplanting Approach to Enhance Salt Tolerance of Tree Saplings

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Pedosphere 2004年第1期14卷 77-84页

作者： S.M.MEHDI G.HASSAN A.H.SHAH M.SARFRAZ M.SADIQ Soil salinity research Institute (SSRI) Pindi Bhattian (Pakistan).Soil Salinity Research Institute (SSRI) Pindi Bhattian (Pakistan).International Waterlogging and Salinity Research Institute Lahore (Pakistan)Soil Salinity Research Institute (SSRI) Pindi Bhattian (Pakistan).Soil Salinity Research Institute (SSRI) Pindi Bhattian (Pakistan).

A field investigation was conducted to determine the survival and growth rate of eucalyptus (Eucalyptus camaldulensis Dehn.) and guava (Psidium guajava L.) saplings planted in salt-affected soils. The field used was highly saline-sodic in nature with a wide variation in electrical conductivity of the saturated soil extract (ECe), pHs, sodium adsorption ratio (SAR) and gypsum requirement (GR). A randomized complete block design was utilized with three treatments, i.e. T1 = plastic container bags totally removed, T2 = only the plastic container bag's base removed and T3 = plastic container bags un-removed. There were 34 and 8 plants in each block for eucalyptus and guava, correspondingly. The survival rates of eucalyptus and guava saplings were greater than 90%. In addition, gain in eucalyptus height was significantly higher in the T1 treatment where the bags were totally removed while for guava height the treatments were not *** gain in girth was not significant for both eucalyptus and guava saplings. With eucalyptus the taproot length was greater than the lateral roots while for guava the lateral roots were longer than the *** was a decrease in the salinity-sodicity of the soils for the upper 30 cm depth under both types of vegetation, indicating that the salts had leached down to the B-horizon.

关键词： eucalyptus guava salinity-sodicity salt tolerance transplanting

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Mechanism of Salt Tolerance in Rice

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Pedosphere 2003年第3期13卷 233-238页

作者： N.HUSSAIN A.ALI G.SARWAR F.MUJEEB M.TAHIR Soil salinity research Institute Pindi BhattianPunjab(Pakistan)National Agriculture Research CenterIslamabad(Pakistan)Soil Salinity Research InstitutePindi BhattianPunjab(Pakistan)Soil Salinity Research InstitutePindi BhattianPunjab(Pakistan)UNDP-AusAIT-Govt.of PakistanBiosaline Community ProjectPindi Bhattian(Pakistan)

Shaheen Basma ti was evolved as a salt tolerant fine rice va riety by the Soil salinity research Institute,Pindi Bhattian, Pakistan. Water culture studies were conducted to investigate the physiological mechanismexercised by this variety in particular and rice plant in general to face the saline environment. Performanceof this rice variety and the concentration and uptake of ions were studied under stress of three salinity levels(30, 60 and 90 mmol L-1) created with NaCl. Recorded data indicated that shoot dry matter was notsignificantly affected by all the three levels of salinity. However, NaCl levels of 60 and 90 mmol L-1 affectedthe root dry matter significantly. Sodium concentration and uptake was enhanced significantly in root andshoot at the first level of salinity (30 mmol L-1) but thereafter the differences were non-significant, indicatingthe preferential absorption of this cation. The K concentration decreased significantly in shoots at all thelevels. The impact was less pronounced in roots as far as K absorption was concerned. The effect on Ca andMg concentrations was not significant. The values of K:Na, Ca:Na and (Ca+Mg):Na ratios in shoot and rootwere comparatively low under stress conditions, indicating that selective ion absorption may be the principalsalt tolerance mechanism of variety Shaheen Basmati when grown in a saline medium.

关键词： dry matter rice variety salinity salt tolerance mechanism selective ionabsorption

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Small extracellular vesicles derived from human induced pluripotent stem cell-differentiated neural progenitor cells mitigate retinal ganglion cell degeneration in a mouse model of optic nerve injury

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Neural Regeneration research 2025年第2期20卷 587-597页

作者： Tong Li Hui-Min Xing Hai-Dong Qian Qiao Gao Sheng-Lan Xu Hua Ma Zai-Long Chi State Key Laboratory of Ophthalmology Optometry and Visual ScienceEye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina national Clinical research center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina

Several studies have found that transplantation of neural progenitor cells(NPCs)promotes the survival of injured ***,a poor integration rate and high risk of tumorigenicity after cell transplantation limits their clinical *** extracellular vesicles(sEVs)contain bioactive molecules for neuronal protection and *** studies have shown that stem/progenitor cell-derived sEVs can promote neuronal survival and recovery of neurological function in neurodegenerative eye diseases and other eye *** this study,we intravitreally transplanted sEVs derived from human induced pluripotent stem cells(hiPSCs)and hiPSCs-differentiated NPCs(hiPSC-NPC)in a mouse model of optic nerve *** results show that these intravitreally injected sEVs were ingested by retinal cells,especially those localized in the ganglion cell *** with hiPSC-NPC-derived sEVs mitigated optic nerve crush-induced retinal ganglion cell degeneration,and regulated the retinal microenvironment by inhibiting excessive activation of *** analysis further revealed that hiPSC-NPC derived sEVs transported neuroprotective and anti-inflammatory miRNA cargos to target cells,which had protective effects on RGCs after optic nerve *** findings suggest that sEVs derived from hiPSC-NPC are a promising cell-free therapeutic strategy for optic neuropathy.

关键词： exosome miRNA neural progenitor cell neurodegeneration neuroinflammation neuroprotection optic nerve crush optic neuropathy retinal ganglion cell small extracellular vesicles

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The interaction between KIF21A and KANK1 regulates dendritic morphology and synapse plasticity in neurons

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Neural Regeneration research 2025年第1期20卷 209-223页

作者： Shi-Yan Sun Lingyun Nie Jing Zhang Xue Fang Hongmei Luo Chuanhai Fu Zhiyi Wei Ai-Hui Tang Hefei national research center for Physical Sciences at the Microscale CAS Key Laboratory of Brain Function and DiseaseMinistry of Education Key Laboratory for Membrane-less Organelles and Cellular DynamicsDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina CAS center for Excellence in Molecular Cell Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Neurobiology School of Life SciencesSouthern University of Science and TechnologyShenzhenGuangdong ProvinceChina Brain research center Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina

Morphological alterations in dendritic spines have been linked to changes in functional communication between neurons that affect learning and ***-4 KIF21A helps organize the microtubule-actin network at the cell cortex by interacting with KANK1;however,whether KIF21A modulates dendritic structure and function in neurons remains *** this study,we found that KIF21A was distributed in a subset of dendritic spines,and that these KIF21A-positive spines were larger and more structurally plastic than KIF21A-negative ***,the interaction between KIF21A and KANK1 was found to be critical for dendritic spine morphogenesis and synaptic *** of either KIF21A or KANK1 inhibited dendritic spine morphogenesis and dendritic branching,and these deficits were fully rescued by coexpressing full-length KIF21A or KANK1,but not by proteins with mutations disrupting direct binding between KIF21A and KANK1 or binding between KANK1 and *** down KIF21A in the hippocampus of rats inhibited the amplitudes of long-term potentiation induced by high-frequency stimulation and negatively impacted the animals’cognitive *** together,our findings demonstrate the function of KIF21A in modulating spine morphology and provide insight into its role in synaptic function.

关键词： actin cytoskeleton dendrite KANK1 KIF21A microtubule spine morphology spine synaptic plasticity talin1

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