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Food Science and Human Wellness 2023年

作者： Liang Tao Zi-Lin Wang Min Yang Xin-Rui Kang Jia-He Dai Cun-Chao Zhao Tian-Yi Dai Jun Sheng Yang Tian Puer university national research and development professional center for moringa processing technology yunnan agricultural university Engineering research center of development and Utilization of Food and Drug Homologous Resources Ministry of Education yunnan agricultural university yunnan Provincial Engineering research center for Edible and Medicinal Homologous Functional Food yunnan agricultural university College of Food Science and technology yunnan agricultural university

moringa oleifera Lam. (M. oleifera Lam) is a moringa genus in the moringaceae family that is high in nutrients and has a wide range of applications. Phenolic compounds are widely found in plants and have various health benefits for the human body. With its high content and wide variety of phenolic compounds， M. oleifera Lam has been widely studied for its health benefits. The phenolic compounds in M. oleifera Lam (MOPCs) can be a potential source of functional food ingredients in pharmaceutical and industrial applications. Numerous studies have shown that MOPCs have antioxidant， anti-obesity， anti-diabetic， and antibacterial effects. Although the research on MOPCs has been gradually increasing， the extraction， isolation， identification， biological activities， and comprehensive application of MOPCs need a more systematic summary and generalization. Therefore， this paper reviews the isolation and extraction methods， structure identification， biological activities， and comprehensive applications to provide a further reference for the research and application of MOPCs.

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Hypoglycemic effect of moringa oleifera leaf extract and its mechanism prediction based on network pharmacology

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未来食品学报(英文) 2023年第4期3卷 383-391页

作者： Zishan Hong Jing Xie Huili Hu Yuying Bai Xia Hu Tingting Li Jinlian Chen Jun Sheng Yang Tian College of Food Science and technology Yunnan Agricultural UniversityKunming 650201China national research and development professional center for moringa processing technology Yunnan Agricultural UniversityKunming 650201China yunnan Provincial Engineering research center for Edible and Medicinal Homologous Functional Food Yunnan Agricultural UniversityKunming 650201China Engineering research center of development and Utilization of Food and Drug Homologous Resources Ministry of EducationYunnan Agricultural UniversityKunming 650201China Key Laboratory of Pu-er Tea Science Ministry of EducationYunnan Agricultural UniversityKunming 650201China

Diabetes mellitus(DM)is a chronic metabolic disease characterized by hyperglycemia,which poses a serious threat to human health.moringa oleifera Lam.is a medicinal and edible plant with various physiological functions.However,its main hypoglycemic components and mechanisms are still unclear.In this study,network pharmacology and bioinformatics were used to analyze the potential bioactive substances of M.oleifera leaf extract(MOLE)and its hypoglycemic mechanism.Studies have shown that MOLE has the effect of increasing glucose consumption in insulin resistant-HepG2 cells.MOLE was found to contain 975 compounds by ultrahigh performance liquid chromatography-mass spectrometry(UHPLC-MS).Network pharmacology analysis indicated that the main active component was robinetin and the identified core genes were AKT1 and GAPDH.KEGG pathway enrichment analysis showed that the hypoglycemic effect of MOLE may be closely related to the PI3K-Akt signaling pathway.This study revealed the possible active components and mechanisms of action of M.oleifera for hypoglycemia,laying the theoretical foundation for subsequent studies.

关键词： moringa oleifera leaves Ultrahigh performance liquid chromatographymass spectrometry Hypoglycemia Network pharmacology PI3K-Akt signaling pathway

Exploration of Cyclooxygenase-2 (COX-2) Inhibitory Peptides from Walnut Dreg Proteins Based on In Silico and In Vitro Assessments

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Food Science and Human Wellness 2023年

作者： Zi-Shan Hong Jing Xie Liang Tao Jing-Jing Dai Ting-Ting Li Li Zhang Yu-Ying Bai Xia Hu Jin-Lian Chen Jun Sheng Yang Tian College of Food Science and technology， yunnan agricultural university Puer university Key Laboratory of Puer Tea Science， Ministry of Education， yunnan agricultural university Engineering research center of development and Utilization of Food and Drug Homologous Resources， Ministry of Education， yunnan agricultural university yunnan Provincial Engineering research center for Edible and Medicinal Homologous Functional Food， yunnan agricultural university national research and development professional center for moringa processing technology， yunnan agricultural university

Walnut dreg protein hydrolysates (WDPHs) exhibit a variety of biological activities， however， the COX-2 inhibitory peptide of WDPHs remain unclear. This aim of this study was to rapidly screen for such peptides in WDPHs through a combination of in silico and in vitro analysis. In total， 1262 peptide sequences were observed by nano LC-MS/MS and four novel COX-2 inhibitory peptides (AGFP， FPGA， LFPD， and VGFP) were identified for the first time. Enzyme kinetic data indicated that AGFP， FPGA， and LFPD displayed mixed-type COX-2 inhibition， whereas VGFP was a non-competitive inhibitor. This is mainly because the peptides form hydrogen bonds and hydrophobic interactions with residues in the COX-2 active site. These results demonstrate that computer analysis combined with in vitro evaluation allows for rapid screening of COX-2 inhibitory peptides in walnut protein dregs.

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Portable visual and electrochemical detection of hydrogen peroxide release from living cells based on dual-functional Pt-Ni hydrogels

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Microsystems & Nanoengineering 2023年第6期9卷 185-194页

作者： Guanglei Li Yao Chen Fei Liu Wenhua Bi Chenxin Wang Danfeng Lu Dan Wen State Key Laboratory of Solidification processing School of Materials Science and EngineeringNorthwestern Polytechnical University(NPU)and Shaanxi Joint Laboratory of GrapheneXi'an 710072P.R.China Interdisciplinary research center of Biology&Catalysis School of Life SciencesNPUXi'an 710072P.R.China Faculty of Printing Packaging Engineeringand Digital Media TechnologyXi'an University of TechnologyXi'an 710048P.R.China

It is important to monitor the intra-/extracellular concentration of hydrogen peroxide(H_(2)O_(2))in biological processes.However,miniaturized devices that enable portable and accurate H_(2)O_(2)measurement are still in their infancy because of the difficulty of developing facile sensing strategies and highly integrated sensing devices.In this work,portable H_(2)O_(2)sensors based on Pt-Ni hydrogels with excellent peroxidase-like and electrocatalytic activities are demonstrated.Thus,simple and sensitive H_(2)O_(2)sensing is achieved through both colorimetric and electrochemical strategies.The as-fabricated H_(2)O_(2)sensing chips exhibit favorable performance,with low detection limits(0.030μM&0.15μM),wide linearity ranges(0.10μM-10.0 mM&0.50μM-5.0 mM),outstanding long-term stability(up to 60 days),and excellent selectivity.With the aid of an M5stack development board,portable visual and electrochemical H_(2)O_(2)sensors are successfully constructed without complicated and expensive equipment or professional operators.When applied to the detection of H_(2)O_(2)released from HeLa cells,the results obtained by the developed sensors are in good agreement with those from an ultraviolet‒visible spectrophotometer(UV‒vis)(1.97μM vs.2.08μM)and electrochemical station(1.77μM vs.1.84μM).

关键词： electrochemical peroxide ultraviolet

Chilling Injury, Physicochemical Properties, and Antioxidant Enzyme Activities of Red Pitahaya (Hylocereus polyrhizus) Fruits under Cold Storage Stress

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Phyton-International Journal of Experimental Botany 2021年第1期90卷 291-305页

作者： Kai Sheng Saichao Wei Jun Mei Jing Xie College of Food Science and technology Shanghai Ocean UniversityShanghai201306China national Experimental Teaching Demonstration center for Food Science and Engineering Shanghai Ocean university Shanghai201306China Shanghai Engineering research center of Aquatic Product processing and Preservation Shanghai201306China Shanghai professional technology Service Platform on Cold Chain Equipment Performance and Energy Saving Evaluation Shanghai201306China

Low-temperature storage is extensively used to optimize the postharvest life of various fresh fruits.However,red pitahaya(Hylocereus polyrhizus)fruits are sensitive to chilling injury(CI),which leads to the limitation of low-temperature storage.In this study,red pitahaya fruits were stored at 2,4,6,8,and 10℃,respectively,for 27 days to determine the appropriate storage temperature.During the storage of red pitahaya fruits,storage at 8℃ was more effective in suppressing decay and maintaining quality than other low temperatures.Lowtemperature(2,4,and 6℃)storage decreased weight loss(WL)and maintained higher content of titratable acidity(TA),soluble sugars(SS),and total phenolics(TP)but different degrees of CI were detected.No CI was observed at 8℃ and 10℃.Red pitahay as stored at 8 and 10℃ were associated with better color evaluation,lower electrolyte leakage(EL),respiration rate,and lipoxygenase(LOX)activity,and higher fruit firmness,superoxide dismutase(SOD)activity,and catalase(CAT)activity.However,higher storage temperature(10℃)resulted in higher metabolic activity leading to lower quality and antioxidant capacities compared with 8℃.Therefore,our results demonstrated that red pitahaya stored at 8℃ exhibited a protective effect on fruit quality and resisted CI development during storage.

关键词： Red pitahaya quality low temperature chilling injury

Effect of quercetin-containing preservatives and modified atmospheric packaging on the production of biogenic amines in Pacific white shrimp(Litopenaeus vannamei)

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Aquaculture and Fisheries 2018年第6期3卷 254-259页

作者： Yunfang Qian Shengping Yang Jing-xin Ye Jing Xie College of Food Science&technology Shanghai Ocean UniversityShanghai 201306China Shanghai Engineering research center of Aquatic Product processing and Preservation Shanghai 201306China Shanghai professional technology Service Platform on Cold Chain Equipment Performance and Energy Saving Evaluation Shanghai 201306China national Experimental Teaching Demonstration center for Food Science and Engineering(Shanghai Ocean university) Shanghai 201306China

To investigate the productions of biogenic amines(BAs)in Pacific white shrimp treated by compound preservatives(P,0.05 g/L quercetin,0.025 g/L 4-hexylresorcinol,and 0.025 g/L cinnamic acid)in combination with modified atmosphere packaging(M,80% CO_(2)/10% O_(2)/10% N_(2)),four groups of samples treated with or without preservatives and alone or in combination with modified atmosphere packaging(A,A+P,M,M+P)during storage at 4℃for 12 days were analyzed.Most BAs increased in all samples,especially,putrescine and cadaverine.MAP inhibited the increase of most BAs(except for tyramine)and psychrotrophic bacterial counts.The inhibitory effect of the compound preservatives on bacterial growth and BAs was limited in aerobically-and MAP-stored samples,but they retarded the production of tyramine,which accumulated more rapidly in MAP.Lowest total BAs and bacterial counts were found in sample M+P(78.3 mg/kg and 5.82 log cfu/g,day 12),indicating that the combined treatment of the preservatives and MAP could reduce the risk of disorders caused by BAs.

关键词： Pacific white shrimp Biogenic amines Tyramine Quercetin-containing preservatives

Malvidin-3-galactoside from blueberry suppresses the growth and metastasis potential of hepatocellular carcinoma cell Huh-7 by regulating apoptosis and metastases pathways

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Food Science and Human Wellness 2020年第2期9卷 136-145页

作者： Jie Lina Jinlong Tian Chi Shu Zhen Cheng Yunen Liu Weisheng Wang Ruihai Liu Bin Li Yuehua Wang national R&D professional center For Berry processing Shenyang Agricultural UniversityLiaoningPR China Key Laborotary of Healthy Food Nutrition and Innovative Manufacturing LiaoningPR China Emergency Medicine Department of General Hospital of Shenyang Military Command Laboratory of Rescue Center of Severe Trauma PLALiaoningPR China Shenyang Blueberry Industry co.LTD. LiaoningPR China Department of Food Science Cornell UniversityIthacaNYUSA

Malvidin-3-galactoside(Mv-3-gal)is the major anthocyanin monomer in blueberry anthocyanins.The compound is well-characterized by its anti-oncogenesis function in multiple organs including liver.In the current study,the mechanism driving the anti-hepatocellular carcinoma(HCC)function of Mv-3-gal was further explored by focusing on apoptosis and metastases pathways.HCC cell line Huh-7 was firstly administrated with Mv-3-gal of different concentrations and the effect of Mv-3-gal on cell proliferation,apoptosis,colony formation ability,metastasis potential as well as the activity of Akt/PTEN and MAPK pathways was assessed.The results showed that Mv-3-gal inhibited the cell proliferation and colony formation ability,induced cell cycle arrest and apoptosis in a dose-dependent manner.Regarding the metastasis potential,Mv-3-gal suppressed the migration and invasion potential of Huh-7 cells by regulating MMPs expression.Taken together,the findings highlighted the anti-HCC potent of Mv-3-gal,which was associated with the inhibition of Akt/PTEN,MAPK and MMP pathways.

关键词： Malvidin-3-galactoside Hepatocellular carcinoma Apoptosis MAPK signaling

Learning Human-Written Commit Messages to Document Code Changes

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Journal of Computer Science & technology 2020年第6期35卷 1258-1277页

作者： Yuan Huang Nan Jia Hao-Jie Zhou Xiang-Ping Chen Zi-Bin Zheng Ming-Dong Tang national Engineering research center of Digital Life School of Data and Computer ScienceSun Yat-sen University Guangzhou 510006China School of Information Engineering Hebei GEO UniversityShijiazhuang 050031China Guangdong Key Laboratory for Big Data Analysis and Simulation of Public Opinion School of Communication and DesignSun Yat-sen UniversityGuangzhou 510006China School of Information Science and technology Guangdong University of Foreign StudiesGuangzhou 510006China Guangdong Key Laboratory of Big Data Analysis and processing Guangzhou 510006China

Commit messages are important complementary information used in understanding code changes. To address message scarcity, some work is proposed for automatically generating commit messages. However, most of these approaches focus on generating summary of the changed software entities at the superficial level, without considering the intent behind the code changes (e.g., the existing approaches cannot generate such message:"fixing 'null' pointer exception"). Considering developers often describe the intent behind the code change when writing the messages, we propose ChangeDoc, an approach to reuse existing messages in version control systems for automatical commit message generation. Our approach includes syntax, semantic, pre-syntax, and pre-semantic similarities. For a given commit without messages, it is able to discover its most similar past commit from a large commit repository, and recommend its message as the message of the given commit. Our repository contains half a million commits that were collected from SourceForge. We evaluate our approach on the commits from 10 projects. The results show that 21.5% of the recommended messages by ChangeDoc can be directly used without modification, and 62.8% require minor modifications. In order to evaluate the quality of the commit messages recommended by ChangeDoc, we performed two empirical studies involving a total of 40 participants (10 professional developers and 30 students). The results indicate that the recommended messages are very good approximations of the ones written by developers and often include important intent information that is not included in the messages generated by other tools.

关键词： commit message recommendation code syntax similarity code semantic similarity code change comprehension