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Junshanyinzhen tea extract prevents obesity by regulating gut microbiota and metabolic endotoxemia in high-fat diet fed rats

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Food Science and Human Wellness 2024年第4期13卷 2036-2047页

作者： Jian Ouyang Xiuping Li Changwei Liu Danmin Lu Jie Ouyang Fang Zhou Qi Liu Jianan Huang Zhonghua Liu Key Laboratory of Tea Science of Ministry of Education Hunan Agricultural UniversityChangsha 410128China national research center of engineering technology for utilization of functional ingredients from botanicals Hunan Agricultural UniversityChangsha 410128China Co-Innovation center of Education Ministry for utilization of Botanical functional ingredients Hunan Agricultural UniversityChangsha 410128China Key Laboratory for Evaluation and utilization of Gene Resources of Horticultural Crops Ministry of Agriculture and Rural AffairsHunan Agricultural UniversityChangsha 410128China

Obesity is associated with gut dysbiosis and metabolic *** tea extract(JSTE)reduced fat accumulation and body weight in obese ***,the effects and mechanism of JSTE in preventing obesity were ***,we used different doses of JSTE(75,150 and 300 mg/(kg·day))to evaluate the effect on high-fat diet(HFD)-induced rats under 8 weeks of ***,our results showed that JSTE could significantly reduce body weight gain,blood lipid levels and fat accumulation,improve fatty damage in liver tissue(P<0.05).In addition,JSTE increased the expression of intestinal tight junction proteins(P<0.05),relieved metabolic endotoxemia(P<0.05)and chronic low-grade inflammation in HFD *** of fecal samples showed that JSTE could effectively reverse the microbial diversity and the ratio of Firmicutes to Bacteroidetes to normal levels in HFD-fed *** and Erysipelotrichaceae,which are positively related to obesity,were decreased by JSTE intervention(P<0.05).while Bifidobacteriaceae,Bacteroidaceae,Akkermansia,and Clostridium,which are negatively related to obesity,were ***,these results suggested that JSTE might effectively prevent obesity by modulating gut microbiota dysbiosis,intestinal barrier dysfunction,metabolic endotoxemia and chronic low-grade infl ammation in HFD-induced rats.

关键词： Junshanyinzhen tea Obesity Gut microbiota Gut barrier function Metabolic endotoxemia

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Protective effect of Fu Brick tea on high-fat diet-induced metabolic syndrome: Relevant to protecting the intestinal barrier and regulating the gut microbiota

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Food Science and Human Wellness 2024年

作者： Wenwen Fang Fang Zhou Kuofei Wang Shuai Wen Hongzhe Zeng Hao Xu Jingyi Tang Jian-an Huang Zhonghua Liu Key Laboratory of Tea Science of Ministry of Education national research center of engineering and technology for utilization of Botanical functional ingredients Key Laboratory for Evaluation and utilization of Gene Resources of Horticultural Crops Ministry of Agriculture and Rural Affairs of China Hunan Agricultural University

This study investigated the therapeutic effects on metabolic syndrome (MetS) and the impact on the intestinal barrier and gut microbiota of Fu brick tea aqueous extracts (FTE) on metabolic syndrome (MetS) in rats fed with a high-fat diet (HFD). Here， the results showed that FTE supplement significantly reduced HFD-induced weight gain， adiposity， dyslipidemia， fasting blood glucose (PBG) increment， and non-alcoholic fatty liver disease (NAFLD). Moreover， FTE supplement resulted in a decline in lipopolysaccharide (LPS) level and attenuation of colonic inflammation and oxidative stress to protect the intestinal barrier function. FTE supplement also maintained the intestinal barrier integrity by improving histological appearance and promoting ZO-1， Occludin， and Claudin-1 protein expression levels. Meanwhile， FTE supplement alleviated the gut microbiota dysbiosis by enhancing the Firmicutes/Bacteroidetes (F/B) ratio and stimulating the colonization of probiotic bacteria such as Akkermansia， Lactobacillus， Adlercreutzia， and Bacteroides. These findings collectively suggest that Fu brick tea could alleviate MetS and Mets-associated traits with the mechanism relevant to the protection of intestinal barrier and gut microbiota regulation.

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The application of protease in aquaculture: Prospects for enhancing the aquafeed industry

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Animal Nutrition 2024年第1期16卷 105-121页

作者： Shiyou Chen Sahya Maulu Jie Wang Xiaoze Xie Xiaofang Liang Hao Wang Junjun Wang Min Xue national Aquafeed Safety Assessment center Institute of Feed Research Chinese Academy of Agricultural Sciences State Key Laboratory of Animal Nutrition College of Animal Science and Technology China Agricultural University School of Biological and Marine Sciences Faculty of Science and Engineering University of Plymouth Centre for Innovative Approach Zambia (CIAZ)

Low-fishmeal and protein-saving diets are two prominent nutritional strategies utilized to address challenges related to the scarcity and sustainability of protein sources in aquaculture. However, these diets have been associated with adverse effects on the growth performance, feed utilization, and disease resistance of aquatic animals. To mitigate these challenges, exogenous protease has been applied to enhance the quality of diets with lower protein contents or fishmeal alternatives, thereby improving the bioavailability of nutritional ingredients. Additionally, protease preparations were also used to enzymatically hydrolyze fishmeal alternatives, thus enhancing their nutritional utilization. The present review aims to consolidate recent research progress on the use of protease in aquaculture and conclude the benefits and limitations of its application, thereby providing a comprehensive understanding of the subject and identifying opportunities for future research.

关键词： Protease Low-fishmeal diet Protein-saving diets Exogenous digestive enzyme Aquafeed

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Metallaphotoredox-Catalyzed Three-Component Couplings for Practical Synthesis of Ureas and Carbamates

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Chinese Journal of Chemistry 2024年第3期42卷 264-270页

作者： Ernest Koranteng Zhen-Cao Shu Yi-Yin Liu Qian Yang Bin Shi Qiang-Xian Wu Fen Tan Liang-Qiu Lu Wen-Jing Xiao engineering research center of Photoenergy utilization for Pollution Control and Carbon Reduction Ministry of EducationCollege of ChemistryCentral China Normal University152 Luoyu RoadWuhanHubei430079 China Wuhan Youji Industries Co. LtdNo.1 2nd Chemical Rd.WuhanHubei430082 China Hubei Key Laboratory of Purification and Application of Plant Anti-cancer Active ingredients School of Chemistry and Life SciencesHubei University of EducationWuhanHubei430205 China State Key Laboratory for Oxo Synthesis and Selective Oxidation Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhouGansu730000 China School of Chemistry and Chemical engineering Henan Normal UniversityXinxiangHenan453007 China Wuhan Institute of Photochemistry and technology WuhanHubei430082 China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai200032 China

Ureas are widely used in drugs,materials and catalysts because of their diamide structure,which can form strong hydrogen ***,it is of great scientific significance to develop efficient and green methods for the synthesis of urea compounds,especially unsymmetrical ***,we have disclosed novel and highly efficient three-component coupling reactions of organic halides,sodium cyanate and amines enabled by nickel/photoredox dual catalysis for the preparation of unsymmetrical *** reaction features simple and safe operations,broad substrate scopes,and product *** allows the facile synthesis of N-aryl/vinyl ureas from readily available,user-friendly feedstocks under mild conditions(27 examples,36%—98%yields).In addition,this method is further derived to alcohols as nucleophiles to synthesize a series of carbamates(15 examples,40%—95%yields).The mechanism experiment shows that the isocyanate produced by the coupling of halide and sodium cyanate may be the key intermediate in this reaction.

关键词： Cross-coupling Nickel Photoredox catalysis Three-component reaction Ureas Carbamates

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The role of cholesterol in modifying the lipid-lowering effects of Fuzhuan brick-tea in Caenorhabditis elegans via SBP-1/SREBP

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Food Science and Human Wellness 2023年第6期12卷 2297-2305页

作者： Lianyun Pan Yan Lu Shen Dai Xiangyue Tang Ligui Xiong Zhonghua Liu Yushun Gong national research center of engineering technology for utilization of functional ingredients from botanicals Hunan Agricultural UniversityChangsha 410128China Yunnan Key Laboratory of Tea Science Tea Research Institute of Yunnan Academy of Agricultural SciencesMenghai 666200China Key Laboratory of Tea Science of Ministry of Education Hunan Agricultural UniversityChangsha410128China

Fuzhuan brick-tea(FZT)has long been consumed for its supposed weight loss and lipid-lowering benefi *** this study,we show that the regulation of fat storage in Caenorhabditis elegans from a water extract of FZT was affected by cholesterol *** found that FZT signifi cantly decreased fat storage under normal cholesterol levels or in a cholesterol-free diet,while lipid accumulation was increased for a high cholesterol ***,this mechanism may involve the conserved sterol regulatory element-binding protein(SREBP)/mediator-15(MDT-15)signaling pathway and the nuclear hormone receptor *** addition,lipid synthesis-related genes inhibited by FZT were partially affected by a cholesterol-free ***,our fi ndings suggested that the potential lipid-lowering effects of FZT may depend on the cholesterol level,which may help to improve the consumption of FZT.

关键词： Fuzhuan brick tea Cholesterol Fat storage Sterol regulatory element-binding protein

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Hypoglycemic effects of black brick tea with fungal growth in hyperglycemic mice model

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Food Science and Human Wellness 2022年第3期11卷 711-718页

作者： Wei Xu Yang Zhou Ling Lin Dongyin Yuan Yingqi Peng Li Li Wenjun Xiao Zhihua Gong Key Laboratory of Tea Science of Ministry of Education Hunan Agricultural UniversityChangsha 410128China national research center of engineering and technology for utilization of Botanical functional ingredients Hunan Agricultural UniversityChangsha 410128China Co-Innovation center of Education Ministry for utilization of Botanical functional ingredients Changsha 410128China Hunan Baojiachong Tea Farm Co.Ltd. Yiyang 413500China

Dark tea(containing Eurotium cristatum)and black tea have hypoglycemic *** black brick tea with fungal growth is obtained from black tea by adding ***,followed by steaming,pressing,fungal growth,and ***,the hypoglycemic effects of black brick tea are still ***,we used black brick tea with fungal growth and black tea as raw materials to study their hypoglycemic effects in a hyperglycemic mice *** these types of black tea could lower the content of blood glucose and increase the content of hepatic glycogen by upregulating the proteins and m RNA expression of phosphatidylinositol-4,5-bisphosphate3-kinase,glycogen synthase,protein kinase B and phosphoinositidedependent protein kinase-1 and downregulating the protein and m RNA expression of glycogen synthase kinase 3β.These regulatory steps were followed by high activities of glutathione peroxidase and superoxide dismutase and low content of *** teas can promote blood glucose transport and absorption by upregulating the protein and m RNA expression of insulin receptor substrate-1 and glucose transporter-2 and stimulate glycolysis by upregulating the protein and m RNA expression of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase *** study suggests that the black brick tea was more effective than the black tea in terms of hypoglycemic.

关键词： Black tea Black brick tea(with fungal growth) High blood glucose Hypoglycemic effect

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Theasinensin A attenuated diabetic development by restoring glucose homeostasis, improving hepatic steatosis and modulating gut microbiota in high-fat-diet/streptozotocin-induced diabetic mice

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Food Science and Human Wellness 2023年第6期12卷 2073-2086页

作者： Weiqi Xu Yujie Huang Wangting Zhou Yujia Peng Xuhui Kan Wei Dong Guijie Chen Xiaoxiong Zeng Zhonghua Liu College of Food Science and technology Nanjing Agricultural UniversityNanjing 210095China Key Laboratory of Ministry of Education for Tea Science Hunan Agricultural UniversityChangsha 410128China national research center of engineering technology for utilization of Botanical functional ingredients Changsha 410128China

Theasinensin A(TSA),a dimer of epigallocatechin gallate,has been preliminarily demonstrated to have hypoglycemia and anti-inflammatory ***,little information is available on its potential mechanisms of ***,the present study aimed to investigate the influence of TSA on glucose and lipid metabolism and gut microbiota in high-fat-diet/streptozotocin-induced diabetic *** result,TSA improved polydipsia,polyphagia and impaired glucose tolerance of diabetic mice,declined the fasting blood glucose and hepatic triglyceride level,and enhanced the expression at mRNA level of insulin receptor substrate,phosphoinositide 3-kinase,protein kinase B and glucagon-like peptide 1 receptor(GLP-1R)in the diabetic ***,TSA could restore the disorder of gut microbiota of diabetic ***-dose(100 mg/kg)TSA showed better benefi cial effects from the blood biochemical parameters,hepatic function and gut *** general,high-dose TSA significantly modulated gut microbiota by increasing the relative abundance of Akkermansia and decreasing the relative abundances of Acetatifactor,Anaerotruncus,Pseudofl avonifactor,Oscillibacter and Clostridium *** results indicated that TSA could exert an anti-diabetes effect in diabetic mice through restoring glucose homeostasis,declining hepatic steatosis,activating insulin and GLP-1 signaling pathways,and ameliorating gut microbiota dysbiosis.

关键词： Tea Theasinensin A Diabetes Glucose homeostasis Gut microbiota Hepatic steatosis

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Fermentation characteristics and probiotic activity of a purified fraction of polysaccharides from Fuzhuan brick tea

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Food Science and Human Wellness 2022年第3期11卷 727-737页

作者： Guijie Chen Ziqi Zeng Minhao Xie Yujia Peng Wangting Zhou Weiqi Xu Yi Sun Xiaoxiong Zeng Zhonghua Liu College of Food Science and technology Nanjing Agricultural UniversityNanjing 210095China Collaborative Innovation center for Modern Grain Circulation and Safety College of Food Science and EngineeringNanjing University of Finance and EconomicsNanjing 210023China Key Laboratory of Ministry of Education for Tea Science Hunan Agricultural UniversityChangsha 410128China national research center of engineering technology for utilization of Botanical functional ingredients Changsha 410128China

Polysaccharides from Fuzhuan brick tea(FBTPS),one of most important bioactive components in tea,showed various health-promoting *** previous work demonstrated that the crude FBTPS(CFBTPS)could modulate the gut ***,which purified fraction in CFBTPS contributing to the modulation of gut microbiota remains ***,the fermentation characteristics and probiotic activity of a purified fraction(FBTPS-2-1)of CFBTPS were evaluated in this *** results showed that gut microbiota could utilize FBTPS-2-1 to produce short-chain fatty acids including acetic,propionic,n-butyric and n-valeric ***-2-1 could modulate the structure and metabolic pathways of gut ***-2-1 could increase the health-promoting gut microbiota such as Prevotellaceae and Bifidobacteriaceae,and decreased the harmful bacteria such as Enterobacteriaceae and *** results of metagenomics showed that Prevotella copri and Megamonas funiformis were the dominant bacteria after fermentation of ***,FBTPS-2-1 could regulate the biosynthesis and metabolism pathways of gut ***,the enrichment of food with FBTPS-2-1 is expected as a potential strategy for promoting human health due to modulation of gut microbiota.

关键词： Fuzhuan brick tea Polysaccharide Fermentation characteristics Gut microbiota

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Cold Stress-induced Glucosyltransferase CsUGT78A15 is Involved in the Formation of Eugenol Glucoside in Camellia sinensis

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Horticultural Plant Journal 2020年第6期6卷 439-449页

作者： Mingyue Zhao Binbin Cai Jieyang Jin Na Zhang Tingting Jing Jingming Wang Yuting Pan Zixiang Zhou Yifan Zhao Yingying Feng Feng Yu Mengting Zhang Yating Li Zhonghua Liu Chuankui Song State Key Laboratory of Tea Plant Biology and utilization International Joint Laboratory on Tea Chemistry and Health EffectsAnhui Agricultural UniversityHefei 230036China Key Laboratory of Tea Science of Ministry of Education National Research Center of Engineering Technology for Utilization of Functional Ingredients from BotanicalsCollege of HorticultureHunan Agricultural UniversityChangsha 410128China

Eugenol is a natural phenolic compound known for its health-promoting properties and its ability to add a floral scent to tea *** eugenol glycosides have been identified and shown to make important contributions to fruit floral ***,the details of their biosynthesis and metabolism in tea plants are still ***,eugenol glucoside was unambiguously identified as a native metabolite in the tea plant,and its biosynthesis was shown to be induced by low temperature *** the analysis of UGTs induced by low temperature,the glycosyltransferase CsUGT78A15 was identified in tea,and its encoded protein was shown to catalyze the glucosylation of ***/Km ratios showed that eugenol was the most suitable substrate for *** donor preference analysis showed that CsUGT78A15 had a higher selectivity for glucose,followed by galactose and glucuronic *** expression of CsUGT78A15was correlatedwith the accumulation of eugenol glucoside in different tissues and genotypes of ***-regulation of CsUGT78A15 led to a decreased eugenol glucoside content under cold stress,indicating that CsUGT78A15 plays an important role in the biosynthesis of eugenol glucoside under cold *** identification of eugenol glucoside in the tea plant and the discovery of a cold stress-induced eugenol glucosyltransferase in tea provide the foundation for the improvement of tea flavor under cold stress and the biotechnological production of eugenol glucoside.

关键词： Camellia sinensis Eugenol Glucosyltransferase Cold stress

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茶多酚和乳酸菌影响肉鸡血液生化、消化酶以及肠道细胞因子表达的研究(英文)

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2015年第12期16卷 1019-1026页

作者： Hua-li LI Zong-jun LI Zhong-shan WEI Ting LIU Xiao-zuo ZOU Yong LIAO Yu LUO Hunan Provincial Key Laboratory of Food Science and Biotechnology College of Food Science and TechnologyHunan Agricultural University national research center of engineering technology for utilization of functional ingredients from botanicals Hunan Institute of Animal and Veterinary Science

目的:茶多酚和乳酸菌在动物营养上的作用已经得到广泛的验证,但是关于二者联合作用的研究鲜有报道。本文采用肉鸡作为试验模型,研究了茶多酚和乳酸菌联合灌喂对肉鸡血液生化、消化酶以及肠道细胞因子表达的影响。创新点:本研究首次采用... 详细信息

目的:茶多酚和乳酸菌在动物营养上的作用已经得到广泛的验证,但是关于二者联合作用的研究鲜有报道。本文采用肉鸡作为试验模型,研究了茶多酚和乳酸菌联合灌喂对肉鸡血液生化、消化酶以及肠道细胞因子表达的影响。创新点:本研究首次采用联合灌喂茶多酚和乳酸菌,探讨了二者联合作用对肉鸡的影响,并通过模拟生产,长期观察了茶多酚和乳酸菌对肉鸡的影响。方法:对肉仔鸡灌喂不同浓度的茶多酚和乳酸菌,在第56和84天随机屠宰取样。收集血液检查血液生化指标,并测定消化酶活性。取肠道样品提取RNA,采用反转录聚合酶链反应(RT-PCR)检测细胞因子的表达以及相关信号通路的激活。结论:长期灌喂茶多酚和乳酸菌改善了肉鸡脂质代谢、消化酶活性以及炎症反应,其机制可能是通过影响了NF-κB信号通路。

关键词：茶多酚乳酸菌核因子κB(NF-κB) 肉鸡

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