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Characterization of cerebral blood flow dynamics with multiscale entropy

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Journal of Innovative Optical health Sciences 2017年第5期10卷 85-93页

作者： Alexey N.Pavlov Arkady S.Abdurashitov Olga N.Pavlova Maria V.Ulanova Anastasia A.Bodrova Natalia A.Shushunova Alexander P.Khorovodov Oxana V.Semyachkina-Glushkovskaya Yuri Gagarin state Technical university.of saratov 77 Politechnicheskaya Street Saratov 410054Russia saratov national research state university.83 Astrakhanskaya Street Saratov 410012Russia

Based on the laser speckle contrast imaging(LSCI)and the multiscale entropy(MSE),we study in this work the blood flow dynamics at the levels of cerebral veins and the surrounding network of microcerebral *** discuss how the phenylephrine-related acute peripheral bypertension is refected in the cerebral circulation and show that the observed changes are scale dependent,and they are signifcantly more pronounced in microcerebral vessels,while the macrocerebral dynamics does not demonstrate authentic inter-group *** also consider the permeability of blood-brain barrier(BBB)and study its opening caused by sound *** show that alterations associated with the BBB opening can be revealed by the analysis of blood flow at the level of macrocerebral vessels.

关键词： Cerebral blood flow laser speckle contrast imaging arterial pressure complexity

Plasmonic nanoparticles and nucleic acids hybrids for targeted gene delivery,bioimaging,and molecular recognition

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Journal of Innovative Optical health Sciences 2021年第4期4卷 3-30页

作者： Timofey Pylaev Elena Avdeeva Nikolai Khlebtsov Institute of Biochemistry and Physiology of Plants and Microorganisms Russian Academy of Sciences Saratov 410049Russia Razumovsky saratov state Medical university Saratov 410012Russia Federal Center of Agriculture research of the South-East Region Saratov 410010Russia saratov national research state university Saratov 410012Russia

Promising biomedical applications of hybrid materials composed of gold nanoparticles and nucleic acids have attracted strong interest from the nanobiotechnological *** particular interest is owing to the robust and easy-to-make synthetic approaches,to the versatile optical and catalytic properties of gold nanoparticles combined with the molecular recognition and programmable properties of nucleic *** significant progress is made in the develop-ment of DNA-gold nanostructures and their applications,such as molecular recognition,cell and tissue bioimaging,targeted delivery of therapeutic agents,*** review is focused on the critical discussion of the recent applications of the gold nanoparticles-nucleic acids *** effect of particle size,surface,charge and thermal properties on the interactions with functional nucleic acids is *** each of the above topics,the basic principles,recent advances,and current challenges are *** is placed on the systematization of data over the theranostic systems on the basis of the gold nanoparticles-nucleic acids ***,we start our discussion with observation of the recent data on interaction of various gold nano-particles with nucleic *** we describe existing gene delivery systems,nucleic acids detection,and bioimaging ***,we describe the phenomenon of the polymerase chain reaction improvement by gold nanoparticle additives and its potential underlying ***,we provide a short summary of reported data and outline the challenges and perspectives.

关键词： gold nanoparticles delivery DNA detection bioimaging

Tumor cell death visualization of renal cell carcinoma under the combined effect of the Gratiola officinalis extract and cyclophosphamide using fluorescent staining methods

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Journal of Innovative Optical health Sciences 2021年第5期4卷 46-52页

作者： Artyom Mylnikov Nikita Navolokin Dmitry Mudrak Natalya Polukonova Alla Bucharskaya Galina Maslyakova saratov state Medical university named after V.I.Razumovsky 112 Bolshaya Kazachia Street Saratov 410012Russia national research saratov state university 83 Astrakhanskaya Street Saratov 410012Russia national research Tomsk state university 36 Lenin Avenue Tomsk 634050Russia

Objective of the study:We used fluorescence imaging methods of apoptosis and necrosis in human renal carcinoma A498 tumor cells in vitro to reveal the indicated forms of cell death under the combined effect of flavonoid-containing extract of Gratiola officinalis and cytostatic(cyclo-phosphamide).Materials and methods:The dyes were propidium iodide and acridine orange,which were used in the"alive and dead"*** test helped us to identify the total number of dead cells in the forms of necrosis and apoptosis and the number of cells in which apoptosis had started,it was characterized by the appearance of apoptotic bodies or nucleus ***:We found the most pronounced cytotoxic activity at the ratio of extract of Gratiola officinalis and cyclophosphamide concentrations of 1∶*** number of living cells decreased when exposed to the ratio of extract and cytostatic concentrations of 2∶*** the ratio of concentration of the extract relative to the cytostatic increased to 3∶1,the cytostatic activity of the extract began to appear,the total number of tumor cells *** number of cells with nucleus pyknosis and the number of cells with apoptosis signs significantly increased at a 3∶1 ratio of extract and cytostatic concentrations,which confirms the presence of pro-apoptotic activity of the studied *** trend indicates the dependence of a certain form of cell death(apoptosis,necrosis)on the ratio of extract and cytostatic doses,and it also demon-strates the cytostatic and cytotoxic effects of this ***:Fluorescence methods of investigation in the"alive and dead"test allowed us to visualize the forms of cell death of human kidney carcinoma A498 by combined exposure to the fiavonoid-containing extract of Gratiola officinalis and cytostatic(cyclophosphamide)24 h after *** found that the combination with a concentration ratio of the extract and cyclophosphamide of 3:1 has the greatest effectiveness due to stimulation of t

关键词： A498 cell line Gratiola officinalis extract antitumor activity cytostatic activity flavonoids fluorescent methods kidney cancer

The morphological changes in the internal organs of laboratory animals after prolonged oral administration of gold nanoparticles

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Journal of Innovative Optical health Sciences 2016年第4期9卷 74-84页

作者： Alla B.Bucharskaya Galina N.Maslyakova Svetlana S.Pakhomy Olga V.Zlobina Irina O.Bugaeva Nikita A.Navolokin Boris N.Khlebtsov Vladimir A.Bogatyrev Nikolai G.Khlebtsov Valery V.Tuchin saratov state Medical university.n.a.V.I.Razumovsky 410012 saratov Russia Institute of Biochemistry and Physiology of Plants and Microorganisms RAS 410049 saratov Russia research-Educational Institute of Optics and Biophotonics saratov national research state university.410012 saratov Russia Institute of Precision Mechanics and Control RAS 410028 saratov Russia Interdisciplinary Laboratory of Biophotonics Tomsk national research state university 634050 TomskRussia

Recently gold nanoparticles(GNPs)have been actively studied as photot hermal converters,drug carriers,and imaging agents in a wide range of applications in cancer diagnosis and ther *** prolonged peroral administration of GNPs in a range of sizes was performed to investigate the morphological changes and their reversibility in the internal organs of laboratory *** this study,GNP's with average diameters of 2 nm,15 nm and 50nm were administered during 30 days,and the reversibility of morphological changes was investigated 14 days after *** the prolonged administration of GNPs,the severity of morphological changes in the liver,kidney,spleen and lymph nodes depended on the nanoparticle ***,50 nm nano-particles caused the most pronounced dystrophic and necrobiotic effects,whereas the smallest 2 nm nanoparticles caused proliferative *** importantly,the development of patho-logical processes was reversible,as evidenced by the gradual restoration of the organ structure at 14 days after the end of GNPs administration.

关键词： Gold nanoparticles prolonged peroral administration morphological changes reversibility.

The Objective Assessment of Event-Related Potentials:An Influence of Chronic Pain on ERP Parameters

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Neuroscience Bulletin 2023年第7期39卷 1105-1116页

作者： Maksim Zhuravlev Mikhail Novikov Ruzanna Parsamyan Anton Selskii Anastasiya Runnova Coordinating Center for Fundamental research National Medical Research Center for Therapy and Preventive MedicineMoscow 101000Russia Institute of Physics Saratov State UniversitySaratov 410012Russia Department of Fundamental research in Neurocardiology Institute of Cardiological ResearchSaratov State Medical UniversitySaratov 410012Russia

The article presents an original method for the automatic assessment of the quality of event-related potentials(ERPs),based on the calculation of the coefficientε,which describes the compliance of recorded ERPs with some statistically significant *** method was used to analyze the neuropsychological EEG monitoring of patients suffering from *** frequency of migraine attacks was correlated with the spatial distribution of the coefficientsε,calculated for EEG *** than 15 migraine attacks per month was accompanied by an increase in calculated values in the occipital *** with infrequent migraines exhibited maximum quality in the frontal *** automatic analysis of spatial maps of the coefficientεdemonstrated a statistically significant difference between the two analyzed groups with different means of migraine attack numbers per month.

关键词： Event-related potential Chronic migraine ERP quality Automatic evaluation

Laser speckle imaging and wavelet analysis of cerebral blood flow associated with the opening of the blood–brain barrier by sound

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Chinese Optics Letters 2017年第9期15卷 2-6页

作者： O.Semyachkina-Glushkovskaya A.Abdurashitov A.Pavlov A.Shirokov N.Navolokin O.Pavlova A.Gekalyuk M.Ulanova N.Shushunova A.Bodrova E.Saranceva A.Khorovodov I.Agranovich V.Fedorova M.Sagatova A.E.Shareef C.Zhang D.Zhu V.Tuchin saratov national research state university Saratov 410012Russia Yuri Gagarin state Technical university.of saratov Saratov 410054Russia Institute of Biochemistry and Physiology of Plants and Microorganisms Russian Academy of SciencesSaratov 410049Russia saratov state Medical university Saratov 410012Russia Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for Optoelectronics(WNLO)Huazhong University of Science and Technology(HUST)Wuhan 430074China Key Laboratory for Biomedical Photonics HUSTMinistry of EducationWuhan 430074China national research Tomsk state university Tomsk 634050Russia Institute of Precision Mechanics and Control Russian Academy of SciencesSaratov 410028Russia

The cerebral blood flow（CBF） alterations related to sound-induced opening of the blood–brain barrier（BBB） in adult mice are studied using laser speckle contrast imaging（LSCI） and wavelet analysis of vascular *** results clearly show that the opening of the BBB is accompanied by the changes of venous but not microvessel circulation in the brain. The elevation of the BBB permeability is associated with the decrease of venous CBF and the increase of its complexity. These data suggest that the cerebral veins rather than microvessels are sensitive components of the CBF related to the opening BBB.

关键词： BBB Laser speckle imaging and wavelet analysis of cerebral blood flow associated with the opening of the blood brain barrier by sound

Oxygen functionalization-assisted anionic exchange toward unique construction of flower-like transition metal chalcogenide embedded carbon fabric for ultra-long life flexible energy storage and conversion

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Carbon Energy 2024年第1期6卷 72-93页

作者： Roshan M.Bhattarai Kisan Chhetri Nghia Le Debendra Acharya Shirjana Saud Mai Cao hoang Phuong Lan Nguyen Sang Jae Kim Young Sun Mok Department of Chemical Engineering Jeju National UniversityJejuRepublic of Korea Department of Nano Convergence Engineering Jeonbuk National UniversityJeonjuRepublic of Korea Regional Leading research Center(RLRC)for Nanocarbon-based Energy Materials and Application Technology Jeonbuk National UniversityJeonjuRepublic of Korea Department of Chemistry Mississippi State UniversityStarkvilleMississippiUSA Nanomaterials and System Laboratory Department of Mechatronics EngineeringJeju National UniversityJejuRepublic of Korea

The metal-organic framework(MOF)derived Ni–Co–C–N composite alloys(NiCCZ)were“embedded”inside the carbon cloth(CC)strands as opposed to the popular idea of growing them upward to realize ultrastable energy storage and conversion *** NiCCZ was then oxygen functionalized,facilitating the next step of stoichiometric sulfur anion diffusion during hydrothermal sulfurization,generating a flower-like metal hydroxysulfide structure(NiCCZOS)with strong partial implantation inside *** obtained NiCCZOS shows an excellent capacity when tested as a supercapacitor electrode in a three-electrode ***,when paired with the biomass-derived nitrogen-rich activated carbon,the asymmetric supercapacitor device shows almost 100%capacity retention even after 45,000 charge–discharge cycles with remarkable energy density(59.4 Wh kg^(-1)/263.8μWh cm^(–2))owing to a uniquely designed ***,the same electrode performed as an excellent bifunctional water-splitting electrocatalyst with an overpotential of 271 mV for oxygen evolution reaction(OER)and 168.4 mV for hydrogen evolution reaction(hER)at 10 mA cm−2 current density along with 30 h of unhinged chronopotentiometric stability performance for both hER and ***,a unique metal chalcogenide composite electrode/substrate configuration has been proposed as a highly stable electrode material for flexible energy storage and conversion applications.

关键词： carbon cloth energy conversion energy storage flexible metal embedding ultra-stable

An overview and experimental analysis of WO3/TiO2 composite with enhanced electrochromic properties for smart windows application

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Tungsten 2024年第4期6卷 732-747页

作者： Ayesha Khan Mayur A.Gaikwad Jin hyeok Kim Anamika Kadam The Institute of Science Dr.Homi Bhabha State University Optoelectronics Convergence research Center and Department of Materials Science and Engineering Chonnam National University

Internationally,standards for electrochromic（EC） requirements in smart window applications have been established,with ongoing global initiatives aimed at elevating them to highly advanced *** paper covers a comprehensive investigation of the structural,optical,morphological,and electrochemical properties of WO3/TiO2composite ***,an experimental analysis of WO3/TiO2was envisaged by a two-step ***,WO3thin films were hydrothermally deposited onto indium-doped tin oxide-coated glass substrates using an aqueous solution of Na2WO4·2h2O at a ph value of ***,a layer of TiO2was electrodeposited onto the WO3thin films.X-ray diffraction analysis confirmed the successful formation of WO3/TiO2composite films,with the WO3phase exhibiting a hexagonal tunnel *** electron microscopy revealed the formation of porous nanorods（NRs） of WO3,uniformly coated with TiO2,resulting in a porous morphology of the WO./*** EC performance of the WO3/TiO2films was thoroughly assessed through cyclic voltammetry and chronoamperometry measurements over a potential window ranging from-2.0 to+1.2 V（versus Ag/AgCl） in a 0.5 mol·L-1LiClO4-PC *** WO3/TiO2composite films exhibited cathodic electrochromism,characterized by a reversible color change from dark blue to *** improved EC performance in comparison to pure WO3films is attributed to enhanced double ion/electron insertion and extraction ***,the WO3/TiO2composite films demonstrated excellent optical modulation properties,with a significant modulation at 633 nm（46.87%）.The coloration efficiency reached a high value of 193.25 cm2·C-1,indicating their potential for practical EC ***,the WO3/TiO2composite films displayed exceptional EC stability,with no significant degradation observed over 2500 cyclic voltammetry *** superior EC performance can be attributed to the synergistic effect between the hexagonal WO3NRs

关键词： Electrochromism Smart window Stability WO3/TiO2

Glycerol effects on optical,weight and geometrical properties of skin tissue

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Journal of Innovative Optical health Sciences 2021年第5期4卷 64-74页

作者： Vadim D.Genin Elina A.Genina Valery V.Tuchin Alexey N.Bashkatov saratov state university.national research university. 83Astrakhanskaya Str.Saratov 410012Russia Tomsk state university.national research university. 36Lenina Av.Tomsk 634050Russia Institute of Precise Mechanics and Control of RAS 24Rabochaya Str.Saratov 410028Russia

Complex study of glycerol effects on the skin tissue was *** change in optical,weight and geometrical parameters of the rat skin under the action of the glycerol solutions was studied ex *** mechanisms of the skin optical clearing under the action of glycerol solutions of different concentrations were *** results can be helpful for refinement of models developed to evaluate the effective diffusion coefficients of glycerol in tissues.

关键词： Glycerol solutions skin optical clearing collimated transmittance dehydration