The morphological changes in the internal organs of laboratory animals after prolonged oral administration of gold nanoparticles

作     者：Alla B.Bucharskaya Galina N.Maslyakova Svetlana S.Pakhomy Olga V.Zlobina Irina O.Bugaeva Nikita A.Navolokin Boris N.Khlebtsov Vladimir A.Bogatyrev Nikolai G.Khlebtsov Valery V.Tuchin 

作者机构：Saratov State Medical University n.a.V.I.Razumovsky 410012 SaratovRussia Institute of Biochemistry and Physiology of Plants and Microorganisms RAS 410049 SaratovRussia Research-Educational Institute of Optics and Biophotonics Saratov National Research State University 410012 SaratovRussia Institute of Precision Mechanics and Control RAS 410028 SaratovRussia Interdisciplinary Laboratory of Biophotonics Tomsk National Research State University634050 TomskRussia 

出 版 物：《Journal of Innovative Optical Health Sciences》 (创新光学健康科学杂志（英文）)

年 卷 期：2016年第9卷第4期

页      面：74-84页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by Grant No.14-13-01167 from the Russian Scientic Foundation.The morphological studies done by GNM SSP OVZ IOB and NAN were conducted by the state task of Russian ministry of Health.The work done by VVT on interpretation of experimental data was supported by Grant No.14-15-00186 of the Russian Science Foundation 

主　　题：Gold nanoparticles prolonged peroral administration morphological changes reversibility. 

摘      要：Recently gold nanoparticles(GNPs)have been actively studied as photot hermal converters,drug carriers,and imaging agents in a wide range of applications in cancer diagnosis and ther *** prolonged peroral administration of GNPs in a range of sizes was performed to investigate the morphological changes and their reversibility in the internal organs of laboratory *** this study,GNP s with average diameters of 2 nm,15 nm and 50nm were administered during 30 days,and the reversibility of morphological changes was investigated 14 days after *** the prolonged administration of GNPs,the severity of morphological changes in the liver,kidney,spleen and lymph nodes depended on the nanoparticle ***,50 nm nano-particles caused the most pronounced dystrophic and necrobiotic effects,whereas the smallest 2 nm nanoparticles caused proliferative *** importantly,the development of patho-logical processes was reversible,as evidenced by the gradual restoration of the organ structure at 14 days after the end of GNPs administration.