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Epidemiological characteristics of centenarian deaths in China during 2013-2020:A trend and subnational analysis

Chinese Medical Journal 2024年第13期137卷 1544-1552页

作者： Fan Mao Weiwei Zhang Peng Yin Lijun Wang Jinling You Jiangmei Liu Yunning Liu Maigeng Zhou national Center for Chronic and non-communicable Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijing 100050China

Background:Studies that comprehensively address the characteristics of centenarian deaths are *** present study aimed to depict the characteristics of centenarian deaths in China and their changing ***:Data on centenarian deaths between 2013 and 2020 were obtained from the national mortality surveillance system of China,including date,place of death(PoD),and underlying cause of death(CoD).Descriptive analyses were performed to understand the epidemiological characteristics,and a joinpoint regression model was adopted to examine the changing trends in the proportions of different PoDs,CoDs among centenarians,and centenarian deaths accounting for all deaths and deaths among people aged 65 years and ***:There were 46,938 registered centenarian deaths between 2013 and 2020 that included 34,311 females(73.10%)and 12,627 males(26.90%).January(12.05%),February(9.99%),and December(9.74%)were the top three months with the highest number of *** proportions of deaths that occurred in homes,hospitals,and nursing homes were 81.71%,13.63%,and 2.68%,*** proportion of deaths in nursing homes increased by 9.60%(95%confidence intervals[CIs],6.4-12.9%)from 2014 to *** disease(35.72%)was the leading cause of death,followed by respiratory diseases(17.63%),cerebrovascular disease(15.60%),and old age(11.22%).The proportion of respiratory diseases decreased by 4.8%(95%CI,-8.8 to-0.7%),and the proportion of deaths from old age decreased by 2.3%(95%CI,-4.4 to-0.1%)per *** had the highest proportions of deaths in hospitals(39.38%)and nursing homes(14.68%).Sichuan had the highest proportion of deaths attributed to respiratory diseases(32.30%),while Jiangsu(26.58%)and Zhejiang(23.61%)had the highest proportions of deaths from old ***:Unlike other countries,centenarian deaths in China are characterized by a higher proportion of home and heart disease deaths,and this death pattern differs across provinces.

关键词： Centenarians Death Aging Cardiovascular diseases Respiratory tract diseases Place of death Cause of death

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Prevalence of hypertension and its associations with body composition across Chinese and American children and adolescents

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World Journal of Pediatrics 2024年第4期20卷 392-403页

作者： Li-Wang Gao Yi-Wen Huang Hong Cheng Xi Wang Hong-Bo Dong Pei Xiao Yin-Kun Yan Xin-Ying Shan Xiao-Yuan Zhao Jie Mi Center for non-communicable Disease Management Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthNo.56 Nanlishi RoadXicheng DistrictBeijing100045China Department of Epidemiology Capital Institute of PediatricsNo.2 Yabao RoadChaoyang DistrictBeijing100020China Key Laboratory of Major diseases in Children Ministry of EducationBeijingChina

Background The age of onset of hypertension(HTN)is decreasing,and obesity is a significant risk *** prevalence and racial disparities in pediatric HTN and the association between body composition and blood pressure are insufficiently *** study aimed to evaluate the prevalence of HTN in Chinese and American children and adolescents and to assess the relationship between various body composition indices and *** Seven thousand,five hundred and seventy-three Chinese and 6239 American children and adolescents aged 8–18 years from the 2013–2015 China Child and Adolescent Cardiovascular Health study and the 2011–2018 national Health and Nutrition Examination Surveys were *** pressure and body composition(fat and muscle)were measured by trained *** crude prevalence and age-standardized prevalence rate(ASPR)of primary HTN and its subtypes[isolated systolic hypertension(ISH)and isolated diastolic hypertension(IDH)]were calculated based on 2017 American Academy of Pediatrics ***-adjusted linear regression coefficients and odds ratios(ORs)were calculated to assess the associations of body composition indicators with HTN,ISH and *** The ASPR of HTN was 18.5%in China(CN)and 4.6%in the United States(US),whereas the obesity prevalence was 7.4%and 18.6%,and the population attributable risk of HTN caused by overweight and obesity was higher in the US than in *** fat mass,muscle mass and body fat percentage mass were associated with a higher risk of HTN in both *** percent of muscle body mass had a protective effect on HTN and ISH in both countries[HTN(CN:OR=0.83,95%CI=0.78–0.88;US:OR=0.72,95%CI=0.64–0.81);ISH(CN:OR=0.87,95%CI=0.80–0.94;US:OR=0.71,95%CI=0.62–0.81)],and the protective effect was more common among children and adolescents with high levels of physical *** The burden of HTN in Chinese children and adolescents was substantial and much greater than that in the US,and th

关键词： Body composition Children and adolescents China Child and Adolescent Cardiovascular Health Hypertension national Health and Nutrition Examination Surveys

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Assessment of disability weights at the provincial and city levels based on 93,254 respondents in Fujian,China:Findings from the Fujian disability weight measurement study

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Chinese Medical Journal 2024年第11期137卷 1375-1377页

作者： Shaofen Huang Xiuquan Lin Peng Yin Yanrong Yin Maigeng Zhou Jinlei Qi Chuanhua Yu Tiehui Chen Wenling Zhong Institute for Endemic and Chronic and non-communicable diseases Fujian Provincial Center for Disease Control and PreventionFuzhouFujian 350012China Department of Epidemiology and Health Statistics The School of Public HealthFujian Medical UniversityFuzhouFujian 350122China national Center for Chronic and non-communicable Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijing 100050China Department of Epidemiology and Biostatistics School of Public HealthWuhan UniversityWuhanHubei 430071China

To the Editor:Disability weights(DWs)are essential factors to quantify health losses relating to non-fatal outcomes for estimates of disability-adjusted life years(DALYs).Although national and subnational sets of DWs were published recently in the Chinese mainland,[1]data from only 4925 participants who responded to population health equivalence(PHE)questions used to anchor the 0-1 DWs scale did not include participants from Fujian ***,it remains unknown whether people living in different cities share the same *** study provided an alternative approach using non-parametric regression to locate the DWs scale,as used in European surveys,[2]aimed at measuring DWs at the provincial and subprovincial levels in Fujian.

关键词： weights mainland Fujian

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Emergence of Erythromycin-Resistant and Pertactin-and Filamentous Hemagglutinin-Deficient Bordetella pertussis Strains—Beijing,China,2022-2023

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China CDC weekly 2024年第20期6卷 437-441页

作者： Guilan Zhou Ying Li Hairui Wang Yuanyuan Wang Yuan Gao Juan Xu Fengshuang Wang Tao Peng Maojun Zhang Zhujun Shao national Key Laboratory of Intelligent Tracking and Forecasting for Infectious diseases National Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina Shunyi District Center for Disease Control and Prevention BeijingChina

Summary What is already known about this topic?Pertussis has reemerged as a significant public health threat,primarily due to variations in Bordetella pertussis strains,antimicrobial resistance,and vaccine *** is added by this report?All isolated strains were identified as ptxA1/ptxC2/ptxP3/prn150/fim2-1/fim3-1/fhaB1/tcfA2 type and exhibited resistance to erythromycin.

关键词： vaccine pertussis primarily

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Prevalence and Influencing Factor Analysis of Typhoid/Paratyphoid Fever—China,2011-2020

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China CDC weekly 2024年第21期6卷 493-498页

作者： Shumei Huang Meiying Yan Biao Kan School of Public Health Shandong UniversityJinan CityShandong ProvinceChina national Key Laboratory of Intelligent Tracking and Forecasting for Infectious diseases National Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina

Introduction:Over the last 12 years,there has been a consistent decline in the cases of typhoid/paratyphoid fever in *** the epidemiological patterns of these diseases in various provincial-level administrative divisions(PLADs)and examining potential influencing factors can provide crucial information for implementing successful control ***:In this study,we analyzed the cases and incidence rates of typhoid/paratyphoid fever reported in various PLADs of China from 2011 to 2022,along with exploring potential influencing *** initially studied spatial shifts in the incidence rates through centroid shift *** variations in typhoid/paratyphoid fever onset were examined using *** autocorrelation analysis was utilized to understand the spatial correlations among different *** assess potential factors,we utilized a generalized estimating equations model that integrated spatial lag effects and sequence comparison ***:The study identified significant geographical clustering of typhoid/paratyphoid fever cases in southwestern China.A decrease in incidence rates in the west resulted in a movement of the disease center towards the *** incidence occurred during warmer seasons,highlighting the seasonal pattern of the *** such as meteorological conditions and socioeconomic status were probable influencers of typhoid/paratyphoid ***:The geographical and temporal spread of typhoid/paratyphoid fever can be impacted by meteorological and socioeconomic *** economic conditions,particularly in regions with high disease prevalence,could aid in the prevention and management of these fevers.

关键词： prevention utilized meteorological

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Notch signaling pathway in cancer:from mechanistic insights to targeted therapies

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2527-2563页

作者： Qingmiao Shi Chen Xue Yifan Zeng Xin Yuan Qingfei Chu Shuwen Jiang Jinzhi Wang Yaqi Zhang Danhua Zhu Lanjuan Li State Key Laboratory for Diagnosis and Treatment of Infectious diseases National Clinical Research Center for Infectious DiseasesNational Medical Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

Notch signaling,renowned for its role in regulating cell fate,organ development,and tissue homeostasis across metazoans,is highly conserved throughout *** Notch receptor and its ligands are transmembrane proteins containing epidermal growth factor-like repeat sequences,typically necessitating receptor-ligand interaction to initiate classical Notch signaling *** evidence indicates that the Notch signaling pathway serves as both an oncogenic factor and a tumor suppressor in various cancer *** of this pathway promotes epithelial-mesenchymal transition and angiogenesis in malignancies,closely linked to cancer proliferation,invasion,and ***,the Notch signaling pathway contributes to maintaining stem-like properties in cancer cells,thereby enhancing cancer *** regulatory role of the Notch signaling pathway in cancer metabolic reprogramming and the tumor microenvironment suggests its pivotal involvement in balancing oncogenic and tumor suppressive ***,the Notch signaling pathway is implicated in conferring chemoresistance to tumor ***,a comprehensive understanding of these biological processes is crucial for developing innovative therapeutic strategies targeting Notch *** review focuses on the research progress of the Notch signaling pathway in cancers,providing in-depth insights into the potential mechanisms of Notch signaling regulation in the occurrence and progression of ***,the review summarizes pharmaceutical clinical trials targeting Notch signaling for cancer therapy,aiming to offer new insights into therapeutic strategies for human malignancies.

关键词： Notch invasion involvement

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Transcriptomic and cellular decoding of scaffolds-induced suture mesenchyme regeneration

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International Journal of Oral Science 2024年第2期16卷 306-321页

作者： Jiayi Wu Feifei Li Peng Yu Changhao Yu Chuyi Han Yitian Wang Fanyuan Yu Ling Ye State Key Laboratory of Oral diseases&national Center for Stomatology&national Clinical Research Center for Oral diseases&West China Hospital of Stomatology Sichuan UniversityChengduChina State Key Laboratory of Oral diseases&national Center for Stomatology&national Clinical Research Center for Oral diseases&Department of Cariology and Endodontics West China Hospital of StomatologySichuan UniversityChengduChina State Key Laboratory of Oral diseases&national Center for Stomatology&national Clinical Research Center for Oral diseases&Department of Pediatric Dentistry West China Hospital of StomatologySichuan UniversityChengduChina

Precise orchestration of cell fate determination underlies the success of scaffold-based skeletal *** extensive studies on mineralized parenchymal tissue rebuilding,regenerating and maintaining undifferentiated mesenchyme within calvarial bone remain very challenging with limited advances *** knowledge has evidenced the indispensability of rebuilding suture mesenchymal stem cell niches to avoid severe brain or even systematic *** to date,the absence of promising therapeutic biomaterials/scaffolds *** reason lies in the shortage of fundamental knowledge and methodological evidence to understand the cellular fate regulations of *** address these issues,in this study,we systematically investigated the cellular fate determinations and transcriptomic mechanisms by distinct types of commonly used calvarial *** data elucidated the natural processes without scaffold transplantation and demonstrated how different scaffolds altered in vivo cellular responses.A feasible scaffold,polylactic acid electrospinning membrane(PLA),was next identified to precisely control mesenchymal ingrowth and self-renewal to rebuild non-osteogenic suture-like tissue at the defect center,meanwhile supporting proper osteointegration with defect bony ***,transcriptome analysis and cellular mechanisms underlying the well-orchestrated cell fate determination of PLA were *** study for the first time cellularly decoded the fate regulations of scaffolds in suture-bony composite defect healing,offering clinicians potential choices for regenerating such complicated injuries.

关键词： injuries healing suture

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Magnesium promotes vascularization and osseointegration in diabetic states

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International Journal of Oral Science 2024年第1期16卷 122-133页

作者： Linfeng Liu Feiyu Wang Wei Song Danting Zhang Weimin Lin Qi Yin Qian Wang Hanwen Li Quan Yuan Shiwen Zhang State Key Laboratory of Oral diseases&national Center for Stomatology&national Clinical Research Center for Oral diseases&West China Hospital of Stomatology Sichuan UniversityChengduChina State Key Laboratory of Oral diseases&national Center for Stomatology&national Clinical Research Center for Oral diseases&Department of Oral Implantology West China Hospital of StomatologySichuan UniversityChengduChina

Diabetes has long been considered a risk factor in implant therapy and impaired wound healing in soft and hard oral *** has been proved to promote bone healing under normal ***,we elucidate the mechanism by which Mg^(2+)promotes angiogenesis and osseointegration in diabetic *** generated a diabetic mice model and demonstrated thealveolar bone healing was compromised,with significantly decreased *** then developed Mg-coating implants with hydrothermal *** implants successfully improved the vascularization and osseointegration in diabetic ***,Mg^(2+)promoted the degradation of Kelch-like ECH-associated protein 1 (Keap1) and the nucleation of nuclear factor erythroid 2-related factor 2 (Nrf2) by up-regulating the expression of sestrin 2 (SESN2) in endothelial cells,thus reducing theelevated levels of oxidative stress in mitochondria and relieving endothelial cell dysfunction under ***,our data suggested that Mg^(2+)promoted angiogenesis and osseointegration in diabetic mice by regulating endothelial mitochondria metabolism.

关键词： healing diabetic impaired

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Emerging roles of exosomes in oral diseases progression

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International Journal of Oral Science 2024年第1期16卷 36-51页

作者： Jiayi Wang Junjun Jing Chenchen Zhou Yi Fan State Key Laboratory of Oral diseases&national Center for Stomatology&national Clinical Research Center for Oral diseases&Department of Cariology and Endodontics West China Hospital of StomatologySichuan UniversityChengduChina State Key Laboratory of Oral diseases&national Center for Stomatology&national Clinical Research Center for Oral diseases&West China Hospital of Stomatology Sichuan UniversityChengduChina State Key Laboratory of Oral diseases&national Center for Stomatology&national Clinical Research Center for Oral diseases&Department of Pediatric Dentistry West China Hospital of StomatologySichuan UniversityChengduChina

Oral diseases, such as periodontitis, salivary gland diseases, and oral cancers, significantly challenge health conditions due to their detrimental effects on patient's digestive functions, pronunciation, and esthetic demands. Delayed diagnosis and non-targeted treatment profoundly influence patients' prognosis and quality of life. The exploration of innovative approaches for early detection and precise treatment represents a promising frontier in oral medicine.

关键词： diseases diagnosis salivary

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Omics for deciphering oral microecology

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International Journal of Oral Science 2024年第2期16卷 197-207页

作者： Yongwang Lin Xiaoyue Liang Zhengyi Li Tao Gong Biao Ren Yuqing Li Xian Peng State Key Laboratory of Oral diseases&national Center for Stomatology&national Clinical Research Center for Oral diseases West China Hospital of StomatologySichuan UniversityChengduChina

The human oral microbiome harbors one of the most diverse microbial communities in the human body,playing critical roles in oral and systemic *** technological innovations are propelling the characterization and manipulation of oral ***-throughput sequencing enables comprehensive taxonomic and functional profiling of oral *** long-read platforms improve genome assembly from complex ***-cell genomics provides insights into uncultured *** imaging modalities including fluorescence,mass spectrometry,and Raman spectroscopy have enabled the visualization of the spatial organization and interactions of oral microbes with increasing *** techniques link phylogenetic identity with *** spectrometry imaging reveals metabolic niches and activities while Raman spectroscopy generates rapid biomolecular fingerprints for *** facilitates the isolation and cultivation of novel fastidious oral taxa using high-throughput *** integration of these technologies holds the promise of transforming our understanding of oral microbiome assembly,gene expression,metabolites,microenvironments,virulence mechanisms,and microbe-host interfaces in the context of health and ***,significant knowledge gaps persist regarding community origins,developmental trajectories,homeostasis versus dysbiosis triggers,functional biomarkers,and strategies to deliberately reshape the oral microbiome for therapeutic *** convergence of sequencing,imaging,cultureomics,synthetic systems,and biomimetic models will provide unprecedented insights into the oral microbiome and offer opportunities to predict,prevent,diagnose,and treat associated oral diseases.

关键词： insight holds oral

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