Omics for deciphering oral microecology
作者机构：State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral DiseasesWest China Hospital of StomatologySichuan UniversityChengduChina
出 版 物：《International Journal of Oral Science》 (国际口腔科学杂志（英文版）)
年 卷 期：2024年第16卷第2期
页 面：197-207页
核心收录：
基 金：supported by the National Natural Science Foundation of China(32070120,81991500,81991501) the Natural Science Foundation of Sichuan Province(2023NSFSC0558)
摘 要：The human oral microbiome harbors one of the most diverse microbial communities in the human body,playing critical roles in oral and systemic *** technological innovations are propelling the characterization and manipulation of oral ***-throughput sequencing enables comprehensive taxonomic and functional profiling of oral *** long-read platforms improve genome assembly from complex ***-cell genomics provides insights into uncultured *** imaging modalities including fluorescence,mass spectrometry,and Raman spectroscopy have enabled the visualization of the spatial organization and interactions of oral microbes with increasing *** techniques link phylogenetic identity with *** spectrometry imaging reveals metabolic niches and activities while Raman spectroscopy generates rapid biomolecular fingerprints for *** facilitates the isolation and cultivation of novel fastidious oral taxa using high-throughput *** integration of these technologies holds the promise of transforming our understanding of oral microbiome assembly,gene expression,metabolites,microenvironments,virulence mechanisms,and microbe-host interfaces in the context of health and ***,significant knowledge gaps persist regarding community origins,developmental trajectories,homeostasis versus dysbiosis triggers,functional biomarkers,and strategies to deliberately reshape the oral microbiome for therapeutic *** convergence of sequencing,imaging,cultureomics,synthetic systems,and biomimetic models will provide unprecedented insights into the oral microbiome and offer opportunities to predict,prevent,diagnose,and treat associated oral diseases.
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