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Serial Interval and Reproductive Number of COVID-19 Among 116 Infector-infectee Pairs—Jingzhou City,Hubei Province,China,2020

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China CDC weekly 2020年第27期2卷 491-495页

作者： Tian Liu Li Qi Menglei Yao Keqing Tian Maowen Lin Hong Jiang Minmin Zeng Jigui Huang Department of Infectious diseases Prevention and control Jingzhou Center for Disease Control and PreventionJingzhou cityHubei ProvinceChina Chinese Field Epidemiology Training program Chinese Center for Disease Control and PreventionBeijingChina Department of Infectious diseases Prevention and control Chongqing Municipal Center for Disease Control and PreventionChongqingChina State Key Laboratory of Infectious Disease Prevention and control Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesNational Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina

What is already known about this topic?The key epidemiological parameters including serial interval,basic reproductive number(R0),and effective reproductive number(Rt)are crucial for coronavirus disease 2019(COVID-19)control and *** studies provided different estimations but were often flawed by some limitations such as insufficient sample size and selection *** is added by this report?In this study,a total of 116 infector-infectee pairs meeting strict inclusion criteria were selected for *** mean serial interval of COVID-19 was 5.81 days(standard deviation:3.24).The estimated mean with 95%confidence interval of R0 was 3.39(3.07–3.75)and 2.98(2.62–3.38)using exponential growth(EG)and maximum likelihood(ML)methods,*** Rt in the early phase of the epidemic was above 1 with the peak of 4.43 occurring on January 8,and then showing subsequent declines and approaching 1 on January *** are the implications for public health practices?This study supports previous findings that COVID-19 has high transmissibility and that implementing comprehensive measures is effective in controlling the COVID-19 outbreak.

关键词： approaching limitations measures

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A Nested-Polymerase Chain Reaction Assay to Identify and Genotype Brucella

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Biomedical and Environmental Sciences 2021年第3期34卷 227-231页

作者： TIAN Guo Zhong national Institute for communicable Disease control and Prevention Chinese Center for Disease Control and PreventionBeijing 102206China

Brucella is gram-negative,facultative,intracellular bacteria implicated in infectious zoonosis diseases,particularly among domestic animals,that are also transmittable to *** genus Brucella is classified based on the ... 详细信息

关键词： Chain Nested transmit

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Impact of national Immunization Strategies on Vaccine- Preventable diseases — China, 1950–2021

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China CDC weekly 2024年第16期6卷 339-343页

作者： Quanwei Song Yixing Li Lei Cao Lixin Hao Ning Wen Fuzhen Wang Chao Ma Guomin Zhang Hui Zheng Wenzhou Yu Zhijie An Zundong Yin Huaqing Wang national Key Laboratory of Intelligent Tracking and Forecasting for Infectious diseases(NITFID) BeijingChina national Immunization program Chinese Center for Disease Control and PreventionBeijingChina

What is already known about this topic?The incidences of vaccine-preventable diseases(VPDs)included in the Expanded program on Immunization in China have decreased significantly in recent *** is added by this report?This study summarizes the national incidences of nine VPDs and the seroprevalence of hepatitis B surface antigen(HBsAg)under different immunization strategies from 1950 through 2021 in *** sharpest decreases in VPD incidence and under-5-year HBsAg seroprevalence occurred during the latest stage of the national Immunization *** decreases in VPD incidence were most prominent among children under five years of *** are the implications for public health practice?These findings provide valuable insights for vaccine value assessment and emphasize the importance of implementing immunization strategies in targeted populations.

关键词： vaccine diseases Impact

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Synthesis, Crystal Structure and Anti-parasitic Activity of 2-(2-Methoxy-4-nitrophenylcarbamoyl)phenyl 4-Fluorobenzoate

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Chinese Journal of Structural Chemistry 2013年第6期32卷 847-852页

作者：段李平吴宁波刘丛珊陶奕张雪强张浩冰 national Institute of Parasitic diseases Chinese Center for Disease Control and Prevention Key Laboratory of Parasitology and Vector Biology at National Institute of Parasitic Diseases

The title compound 2-（2-methoxy-4-nitrophenylcarbamoyl）phenyl-4＇-fluorobenzoate （C21H15FN206, Mr = 410.35）, a fluorine-containing derivative of salicylamide, was conve- niently synthesized through two steps and crystallized in the orthorhombic space group P21/c with a = 7.6453（15）, b = 14.323（3）, c = 17.035（3） A, V= 1865.4（6） A3, Z = 4, Dc = 1.461 Mg/m^3, 2 = 0.71073 A, μ（MoKa） = 0.115 mm-1, F（000） = 848, R = 0.0705 and wR = 0.1834 for 3267 independent refections with 1 〉 2σ（I）. X-ray analysis reveals that the dihedral angles formed between the 2-methoxy-4-nitrobenzene and benzene ring, the benzene and 4-fluorobenzene, and the 2-methoxy-4-nitrobenzene and 4-fluorobenzene ring are 3.2（4）, 69.8（3） and 72.9（2）~, respectively. Bioassay shows that the title compound has anti-parasitic activity against hydatid protoscoleces.

关键词： 2-(2-methoxy-4-nitrophenyicarbamoyl)phenyl-4'-fluorobenzoate synthesis anti-parasitic crystal structure

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Thirty Years of Experience of Acute Flaccid Paralysis Surveillance for Polio — China, 1993–2022

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China CDC weekly 2024年第16期6卷 344-349页

作者： Hong Yang Ning Wen Chunxiang Fan Fuzhen Wang Yong Zhang Lei Cao Shuangli Zhu Lixin Hao Dongmei Yan Lei Wang Quanwei Song Miao Wang Yifan Song Chao Ma Zhijie An Lance ERodewald Huaqing Wang Zundong Yin national Key Laboratory of Intelligent Tracking and Forecasting for Infectious diseases(NITFID) BeijingChina national Immunization program Chinese Center for Disease Control and PreventionBeijingChina Institute for Viral Disease control and Prevention Chinese Center for Disease Control and PreventionBeijingChina

Introduction:Detecting poliovirus infections proves to be highly challenging due to their asymptomatic nature and infectious potential,highlighting the crucial importance of effective detection methods in the context of polio eradication *** many countries,including China,the primary approach for identifying polio outbreaks has been through acute flaccid paralysis(AFP)*** this study,we conducted an evaluation spanning three decades(1993–2022)to assess the effectiveness of AFP surveillance in ***:Data on all AFP cases identified since 1993 and national-level AFP surveillance system quality indicators aligned with the World Health Organization(WHO)standards were collected for *** quality indicators assess surveillance sensitivity,completeness,timeliness of detection notification,case investigation,and laboratory *** sensitivity is determined by the non-polio AFP(NPAFP)detection rate among children under 15 years of ***:Between 1993 and 2022,a total of 150,779 AFP cases were identified and *** this pool,surveillance identified 95 cases of wild poliovirus(WPV)and 24 cases due to vaccinederived *** 1995 onwards,the detection rate of NPAFP cases consistently adhered to the WHO and national standards of≥1 case per 100,000,falling between 1.38 and *** in 1997,all timeliness indicators consistently achieved the criteria of 80%,apart from the consistency in meeting standards set for the rate of positive specimens sent to the national ***:AFP surveillance has been instrumental in China’s accomplishment of maintaining a polio-free *** ongoing adherence to key performance indicators,ensuring sensitivity and prompt specimen collection,demonstrates that AFP surveillance is proficient in detecting poliovirus in *** we move into the post-eradication phase,AFP surveillance remains crucial for the sustained absence of polioviruses in the long term.

关键词： sustained prompt surveillance

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Psychoactive Substance Use and the Impact on the AIDS Epidemic Among the MSM Population:a Meta-Analysis—Worldwide,2014-2023

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China CDC weekly 2024年第42期6卷 1086-1092,I0001-I0006页

作者： Donghang Luo Jie Xu Wei Luo national Center for AIDS/STD control&Prevention Chinese Center for Diseases Control and PreventionBeijingChina

What is already known about this topic?There is a correlation between psychoactive substance use and heightened human immunodeficiency virus(HIV)susceptibility in men who have sex with men(MSM)populations,although the precise impact on transmission risk remains *** is added by this report?In MSM populations,rush poppers and amphetamines are widely used,with rates of 10.91%and 9.97%.In China,rush poppers usage is notably higher at 47.26%.For other regions and coutries,amphetamines(12.86%),rush poppers(3.62%),and GHB(3.34%)are most ***,17%of MSM use psychoactive substances,with higher HIV risk from amphetamines[Odds ratio(OR)3.06]compared to rush poppers(OR 1.51)and general substances(OR 1.76).What are the implications for public health practice?This study supports the idea that targeting specific regions and types of psychoactive substances for reduction among MSM populations can help decrease HIV transmission as well as promote prevention strategies.

关键词： prevention precise Impact

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A Large Acute Gastroenteritis Outbreak Associated with Both Campylobacter coli and Human Sapovirus—Beijing Municipality,China,2021

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China CDC weekly 2023年第52期5卷 1167-1173页

作者： Lin Zou Ying Li Guilan Zhou Zhenzhou Huang Changyan Ju Chunyan Zhao Xiang Gao Bojun Zhen Ping Zhang Xiaochen Guo Jing Zhang Yang Zhang Bo Liu Shaolei Zhou Aixia Yan Ying Kang Yanchun Wang Hongmei Ma Xiaohui Li Maojun Zhang Tongzhou District Center for Disease control and Prevention BeijingChina Shunyi District Center for Disease control and Prevention BeijingChina national Key Laboratory of Intelligent Tracking and Forecasting for Infectious diseases National Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina Nanshan District Center for Disease control and Prevention Shenzhen CityGuangdong ProvinceChina

What is already known about this topic?Campylobacter is a significant foodborne pathogen that leads to global outbreaks of acute gastroenteritis(AGE)usually affecting less than 30 *** sapovirus(HuSaV)is an enteric virus responsible for sporadic cases and outbreaks of AGE *** a study conducted in Beijing,HuSaV detection ranked second after *** is added by this report?We present a discussion of the first large-scale outbreak of AGE caused by both Campylobacter coli(***)and *** outbreak involved a total of 996 patients and exhibited two distinct peaks over a period of 17 *** case-control studies,we identified exposure to raw water from a secondary water supply system as a significant risk *** 83 patients,49 samples tested positive for ***,39 samples tested positive for HuSaV,and 27 samples tested positive for both pathogens using real-time polymerase chain reaction ***,whole-genome sequencing of 17 *** isolates obtained from 17 patients revealed that all isolates belonged to a highly clonal strain of *** are the implications for public health practice?Outbreaks of AGE resulting from multiple pathogen infections warrant increased *** report emphasizes the significance of ensuring the safety of drinking water,particularly in secondary supply systems.

关键词： Campylobacter Human enteritis

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Insufficient Physical Activity among Students Aged 6-17 Years in China,2016-2017

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Biomedical and Environmental Sciences 2024年第5期37卷 531-536页

作者： XUE Tao Tao GAO Xing Xing WANG Li Min ZHANG Xiao ZHAO Zhen Ping LI Chun NYASHA Grace Mudoti LIU Chen Yi ZHANG Mei Division of Chronic Disease and Risk Factor Surveillance National Center for Chronic and Non-communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 100050China International Education School China Medical UniversityShenyang 110122LiaoningChina

Regular physical activity of sufficient duration and intensity can provide health benefits such as improved physical fitness,which promotes bone health,prevents hypertension,improves mental health,and reduces adiposit... 详细信息

关键词： hypertension Regular benefits

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Geographic Variations in the Prevalence,Awareness,Treatment,and control of Dyslipidemia among Chinese Adults in 2018–2019:A Cross-sectional Study

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Biomedical and Environmental Sciences 2023年第4期36卷 313-323页

作者： ZHANG Mei PENG Ke ZHANG Xiao LIU Yi Shu LIU Xiao Ying HAN Gui Yuan SHI Yu HUANG Zheng Jing LI Chun ZHAO Zhen Ping WANG Li Min LI Yi Chong national Center for Chronic and non-communicable Disease control and Prevention Chinese Center for Disease Control and PreventionBeijing 100050China national Clinical Research Center for Cardiovascular diseases ShenzhenFuwai Hospital Chinese Academy of Medical SciencesShenzhen 518057GuangdongChina The George Institute for Global Health 2042New South WalesAustralia School of Medical Science Faculty of Medicine and HealthUniversity of Sydney2006New South WalesAustralia

Objective To investigate the spatial patterns of the prevalence,awareness,treatment,and control rates of dyslipidemia at the provincial level in *** A national and provincial representative cross-sectional survey was conducted among 178,558 Chinese adults in 31 provinces in China's Mainland in 2018–2019,using a multi-stage,stratified,cluster-randomized sampling ***,as households,were selected,followed by a home visit to collect *** descriptive and linear regression procedures were applied in the *** The overall prevalence of dyslipidemia was 35.6%,and wide geographic variations of prevalence,treatment,and control rates of dyslipidemia were identified among 178,558 eligible participants with a mean age of 55.1±13.8 *** highest-lowest difference regarding the provincial level prevalence rates were 19.7%vs.2.1%for high low-density lipoprotein cholesterol,16.7%vs.2.5%for high total cholesterol,35.9%vs.5.4%for high triglycerides,and 31.4%vs.10.5%for low high-density lipoprotein *** treatment rate of dyslipidemia was correlated with the socio-demographic index(Pcontrol suggest that China needs both integrated and localized public health strategies across provinces to improve lipid management.

关键词： Lipids management Dyslipidemia Public health Chinese

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Risk Assessments for Type 1 Wild Poliovirus and Type 2 Vaccine-Derived Poliovirus Importation and Transmission—China,2023

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China CDC weekly 2024年第42期6卷 1098-1104,I0007,I0008页

作者： Wei Kang Chunxiang Fan Yifan Song Zhaonan Zhang Xiaoqi Wang Miao Wang Jing Ma Mulei Chen Yuzhen Yang Yi Wen Lei Cao Lance Rodewald Fuzhen Wang Zundong Yin Ning Wen Hong Yang national Key Laboratory of Intelligent Tracking and Forecasting for Infectious diseases Chinese Center for Disease Control and PreventionBeijingChina national Immunization program Chinese Center for Disease Control and PreventionBeijingChina Education and Training of Chinese Center for Disease control and Prevention BeijingChina

Introduction:All countries face the potential threat of imported polioviruses,including both wild type and circulating vaccine-derived *** response,we conducted a province-level assessment in China to evaluate the risk of importation and transmission of type 1 wild poliovirus(WPV1)and type 2 vaccine-derived poliovirus(VDPV2).Methods:Distinct risk assessment tools for WPV1 and VDPV2 were employed,incorporating three primary indicators—population immunity,poliovirus surveillance,and importation ***1 was assessed using 13 secondary indicators,whereas VDPV2 utilized 21 secondary *** used comprehensive provincial data from the preceding five ***(S-values)were derived from the secondary indicators’criteria and ratings,and used to classify the provincial-level administrative divisions(PLADs)into three risk categories:high,medium,and *** top 10%of PLADs were designated as highrisk,with the remaining provinces equally distributed into medium-and low-risk ***:In 2023,Xizang,Qinghai,and Xinjiang PLADs faced the highest risk of WPV1 importation and transmission;Xizang,Shaanxi,and Hainan PLADs were at the greatest risk for VDPV2 importation and ***:Risk assessment for VDPV2 importation and transmission has identified a distinct set of high-risk provinces compared to those identified by WPV1 risk *** and proactive response measures tailored to the specific risks should be implemented to maintain China’s polio-free status.

关键词： immunity maintain utilized

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