Synthesis, Crystal Structure and Anti-parasitic Activity of 2-(2-Methoxy-4-nitrophenylcarbamoyl)phenyl 4-Fluorobenzoate

作     者：段李平 吴宁波 刘丛珊 陶奕 张雪强 张浩冰 

作者机构：National Institute of Parasitic Diseases Chinese Center for Disease Control and Prevention Key Laboratory of Parasitology and Vector Biology at National Institute of Parasitic Diseases 

出 版 物：《Chinese Journal of Structural Chemistry》 (结构化学（英文）)

年 卷 期：2013年第32卷第6期

页      面：847-852页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 10[医学] 

基　　金：sponsored by international collaboration on drugs and diagnostics innovation of tropical diseases in PR China (International S&T Cooperation 2010DFA33970) the Special Fund for Health Research in the Public Interest (No. 201202019) Shanghai Key Lab of Chemical Biology, the General Program of the Shanghai Committee of Science and Technology (12ZR1434900) 

主　　题：2-(2-methoxy-4-nitrophenyicarbamoyl)phenyl-4'-fluorobenzoate synthesis anti-parasitic crystal structure 

摘      要：The title compound 2-（2-methoxy-4-nitrophenylcarbamoyl）phenyl-4＇-fluorobenzoate （C21H15FN206, Mr = 410.35）, a fluorine-containing derivative of salicylamide, was conve- niently synthesized through two steps and crystallized in the orthorhombic space group P21/c with a = 7.6453（15）, b = 14.323（3）, c = 17.035（3） A, V= 1865.4（6） A3, Z = 4, Dc = 1.461 Mg/m^3, 2 = 0.71073 A, μ（MoKa） = 0.115 mm-1, F（000） = 848, R = 0.0705 and wR = 0.1834 for 3267 independent refections with 1 〉 2σ（I）. X-ray analysis reveals that the dihedral angles formed between the 2-methoxy-4-nitrobenzene and benzene ring, the benzene and 4-fluorobenzene, and the 2-methoxy-4-nitrobenzene and 4-fluorobenzene ring are 3.2（4）, 69.8（3） and 72.9（2）~, respectively. Bioassay shows that the title compound has anti-parasitic activity against hydatid protoscoleces.