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Coverage of the Combined DTaP-IPV/Hib Vaccine Among Children Aged 2-18 Months—9 PLADs,China,2019-2021

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China CDC weekly 2024年第19期6卷 418-423,I0001页

作者： Li Li Hui Liang Yifan Song Zhaonan Zhang Jing An Ning Li Huifeng Sun Ying Bao Leijin Mao Lin Ding Jie Yan Zhiguo Wang Lei Cao Jiakai Ye Wenzhou Yu national Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases BeijingChina national Immunization program Chinese Center for Disease Control and PreventionBeijingChina Zhejiang Center for Disease control and prevention Hangzhou CityZhejiang ProvinceChina Gansu Center for Disease control and prevention Lanzhou CityGansu ProvinceChina Hubei Center for Disease control and prevention Wuhan CityHubei ProvinceChina Shandong Center for Disease control and prevention Jinan CityShandong ProvinceChina Sichuan Center for Disease control and prevention Chengdu CitySichuan ProvinceChina Anhui Center for Disease control and prevention Hefei CityAnhui ProvinceChina Guizhou Center for Disease control and prevention Guiyang CityGuizhou ProvinceChina Hunan Center for Disease control and prevention Changsha CityHunan ProvinceChina Jiangsu Center for Disease control and prevention Nanjing CityJiangsu ProvinceChina

Summary What is already known on this topic?In China,there is limited data available on the use and coverage of the non-program,combined diphtheria,tetanus toxoid,acellular pertussis adsorbed,inactivated poliovirus and haemophilus influenzae type b(DTaPIPV/Hib)pentavalent vaccine,and its role as a substitute for the separately administered standalone program vaccines.

关键词： vaccine Hib DTaP

Comparison of Statistical Signal Detection Methods in Adverse Events Following Immunization — China, 2011–2015

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China CDC weekly 2024年第16期6卷 350-356,I0001页

作者： Lanfang Xia Keli Li Yan Li Zhijie An Quanwei Song Lei Wang Zundong Yin Huaqing Wang national Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases(NITFID) BeijingChina national Immunization program Chinese Center for Disease Control and PreventionBeijingChina

Introduction:The current study aims to assess the performance of data mining techniques in detecting safety signals for adverse events following immunization(AEFI)using routinely obtained data in *** different methods for detecting vaccine safety signals were ***:The AEFI data from 2011 to 2015 was collected for our *** analyzed the data using four different methods to detect signals:the proportional reporting ratio(PRR),reporting odds ratio(ROR),Bayesian confidence propagation neural network(BCPNN),and multi-item gamma Poisson shrinker(MGPS).Each method was evaluated at 1–3 thresholds for *** assess the performance of these methods,we used the published signal rates as gold standards to determine the sensitivity and ***:The number of identified signals varied from 602 for PRR1(with a threshold of 1)to 127 for *** considering the common reactions as the reference standard,the sensitivity ranged from 0.9%for MGPS1/2 to 38.2%for PRR1/2,and the specificity ranged from 85.2%for PRR1 and ROR1 to 96.7%for *** considering the rare reactions as the reference standard,PRR1,PRR2,ROR1,ROR2,and BCPNN exhibited the highest sensitivity(73.3%),while MGPS1 exhibited the highest specificity(96.9%).Discussion:For common reactions,the sensitivities were modest and the specificities were *** rare reactions,both the sensitivities and specificities were *** study provides valuable insights into the selection of signal detection methods and thresholds for AEFI data in China.

关键词： specificity routine vaccine

A Scoping Review of Real-World Study in Vaccine Evaluation

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China CDC weekly 2024年第16期6卷 357-362页

作者： Lei Wang Hong Yang Lanfang Xia Quanwei Song Na Liu Guomin Zhang Fuzhen Wang Huaqing Wang national Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases(NITFID) BeijingChina national Immunization program Chinese Center for Disease Control and PreventionBeijingChina

Real-world study(RWS)gained prominence starting with a significant investigation on ramipril’s impact on hypertension in 1993(1).A key advancement for the Food and Drug Administration(FDA)occurred with the enactment of the 21st Century Cures Act in 2016,emphasizing RWS(2).The FDA’s Real-world Evidence program establishes real-world data(RWD)as“data relating to patient health status and/or the delivery of health care routinely collected from a variety of sources”,while real-world evidence(RWE)is“clinical evidence about the usage and potential benefits or risks of a medical product derived from analysis of RWD”(3).The proliferation of big data,electronic medical records(EMR),electronic health records(EHR),and medical claims data offers vast information resources facilitating *** access to RWD allows for worldwide monitoring of the impacts of various public health initiatives like vaccination *** randomized clinical trials(RCTs)traditionally gauge vaccine efficacy and shortterm safety,RWS can assess vaccine performance and safety across larger,more diverse populations and are adept at identifying rare events not easily discernible in RCTs due to their infrequency.

关键词： routine gained traditionally

COVID-19 Outbreak Caused by Contaminated Packaging of Imported Cold-Chain Products—Liaoning Province,China,July 2020

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China CDC weekly 2021年第21期3卷 441-447页

作者： Huilai Ma1 Jianqun Zhang Ji Wang Ying Qin Cao Chen Yang Song Liang Wang Jun Meng Lingling Mao Fengqin Li Ning Li Jian Cai Yong Zhang Dayan Wang Yunting Xia Hong Wang Shaofeng Jiang Xiang Zhao Peihua Niu Wenjie Tan Tao Ma Yecheng Yao Naiying Mao Zhen Zhu Tianjiao Ji Qian Yang Baoying Huang Li Zhao Jianxing Yu Li Bai Shuangli Zhu Dongyan Wang Yan Zhang Yingwei Sun Mingchun Luan Yanhai Wang Haibo Sun Shihong Yang Zhijian Bo Xiang Ren Zhongjie Li George Fu Gao Wei Yao Wenqing Yao Zijian Feng Wenbo Xu Chinese Center for Disease control and prevention BeijingChina Dalian Center for Disease control and prevention DalianLiaoningChina national Institute for Viral Disease control and prevention Chinese Center for Disease Control and PreventionBeijingChina Chengdu Center for Disease control and prevention ChengduSichuanChina Liaoning Center for Disease control and prevention ShenyangLiaoningChina China national Center for Food Safety Risk Assessment BeijingChina Zhejiang Center for Disease control and prevention HangzhouZhejiangChina national Center for Rural Water Supply Technical Guidance Chinese Center for Disease Control and PreventionBeijingChina national Institute of Occupational Health and Poison control Chinese Center for Disease Control and PreventionBeijingChina Nanjing Center for Disease control and prevention NanjingJiangsuChina national Institute for Nutrition and Health Chinese Center for Disease Control and PreventionBeijingChina

Summary What is known about this topic?Few major outbreaks of coronavirus disease 2019(COVID-19)have occurred in China after major nonpharmaceutical interventions and vaccines have been deployed and ***,sporadic outbreaks that had high possibility to be linked to cold chain products were reported in several cities of China..What is added by this report?In July 2020,a COVID-19 outbreak occurred in Dalian,*** investigations of this outbreak strongly suggested that the infection source was from COVID-19 virus-contaminated packaging of frozen seafood during inbound unloading personnel *** are the implications for public health practice?Virus contaminated paper surfaces could maintain infectivity for at least 17–24 days at-25℃.Exposure to COVID-19 virus-contaminated surfaces is a potential route for introducing the virus to a susceptible *** with no domestic transmission of COVID-19 should consider introducing prevention strategies for both inbound travellers and imported *** measures to prevent the introduction of the virus via cold-chain goods can be implemented.

关键词： introducing prevention maintain

Progress Towards the 90-90-90 Targets for controlling HIV --China, 2018

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China CDC weekly 2019年第1期1卷 4-7页

作者： Yan Zhao Mengjie Han Ye Ma Dongmin Li national Center for AIDS/STD control and prevention Chinese Center for Disease Control and PreventionBeijingChina.

What is already known about this topic?Since the Joint United Nations programme on HIV and AIDS(UNAIDS)announced the 90-90-90 targets to control the global HIV epidemic in 2014,many countries have undertaken innovative measures to achieve this *** national Center for AIDS/STD control and prevention(NCAIDS)of China CDC convenes experts annually to evaluate the national progress towards these *** most recent progress of 90-90-90 targets in China has not been previously *** is added by this report?At the end of 2018,the percentage of living with HIV(PLWH)who had received a confirmed HIV diagnosis in China was 68.9%(61.5%-78.3%).The antiretroviral treatment coverage of diagnosed PLWH was 83.4%,and among patients on treatment for at least 12 months,94.2%achieved viral *** provides most recent progress of 90-90-90 target in *** are the implications for public health practice?China has made significant strides in curbing the HIV epidemic,but analysis on progress for the first 90 target for HIV testing remains out of *** testing strategies may need to be developed to ensure that more PLWH can be identified.

关键词： diagnosis testing annually

Emergence of Multidrug-Resistant Proteus mirabilis Harboring both blaNDM-1 and cfr genes

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Biomedical and Environmental Sciences 2024年第10期37卷 1208-1212页

作者： Meiqing Sun Xiuhong Yang Beibei Miao Jingyi Zhang Shuang Meng Zhe Feng Juan Li national Key Laboratory of Intelligent Tracking and Forecasting for Infectious Disease National Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China Wuqing District Centre for Disease control and prevention Tianjin 301700China Baoshan Disease control and prevention Baoshan 678000YunnanChina

Proteus mirabilis is abundant in soil and water,and although it is part of the normal human intestinal flora(along with Klebsiella species and Escherichia coli),it is known to cause serious infections in humans,with a fatality rate of 20%-50%[1].Proteus mirabilis is intrinsically resistant to tetracycline,tigecycline,and *** widespread and irregular use of antimicrobial agents,*** antimicrobial resistance has *** acquire antimicrobial resistance(AMR)by capturing plasmids,transposons,or other mobile elements harboring antimicrobial resistance *** mechanism allows the rapid selection and transmission of numerous AMR genes in clinical,veterinary,food production,transportation,and environmental settings.

关键词： lis Proteus ant

Coverage of 13-Valent Pneumococcal Conjugate Vaccine Among Children 0–15 Months of Age—9 Provinces,China,2019–2021

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China CDC weekly 2023年第17期5卷 379-384页

作者： Lijun Liu Zhaonan Zhang Xixi Zhang Changsha Xu Yifan Song Li Li Jiakai Ye Zhiguo Wang Hui Liang Weiyan Zhang Ling Lin Ning Li Shujun Zhang Qianli Ma Wen Du Yongzhuo Jiao Lingsheng Cao Qi Qi Lei Cao Wenzhou Yu Sichuan Center for Disease control and prevention Chengdu CitySichuan ProvinceChina national Immunization program Chinese Center for Disease Control and PreventionBeijingChina Suqian Center for Disease control and prevention Suqian CityJiangsu ProvinceChina Jiangsu Center for Disease control and prevention Nanjing CityJiangsu ProvinceChina Zhejiang Center for Disease control and prevention Hangzhou CityZhejiang ProvinceChina Shandong Center for Disease control and prevention Jinan CityShandong ProvinceChina Anhui Center for Disease control and prevention Hefei CityAnhui ProvinceChina Hubei Center for Disease control and prevention Wuhan CityHubei ProvinceChina Hunan Center for Disease control and prevention Changsha CityHunan ProvinceChina Guizhou Center for Disease control and prevention Guiyang CityGuizhou ProvinceChina Gansu Center for Disease control and prevention Lanzhou CityGansu ProvinceChina

Summary What is already known on this topic?Limited data exist regarding the coverage of the 13-valent pneumococcal conjugate vaccine(PCV13)in China.A lack of official statistics,coupled with an insufficient body of published literature,hinders the accurate depiction of the current *** is added by this report?This study investigated the utilization of PCV13 and estimated its coverage in nine provinces across eastern,central,and western China between 2019 and *** an annual increase in PCV13 usage during this period,the overall coverage remained suboptimal.

关键词： spite coverage hinder

Impact of Influenza and Pneumococcal Polysaccharide Vaccination on Economic Burden from Acute Exacerbations of Chronic Obstructive Pulmonary Disease-Hebei Province,China,November 2018 to November 2020

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China CDC weekly 2023年第20期5卷 452-458,I0003页

作者： Yan Li Pingshu Zhang Zhijie An Ying Ma Yamin Wang Liye Wang Yunqiu Liu Xiaodong Yuan Keli Li Zundong Yin Huaqing Wang national Immunization program Chinese Center for Disease Control and PreventionBeijingChina Kailuan General Hospital Tangshan CityHebei ProvinceChina

Summary What is already known on this topic?Chronic obstructive pulmonary disease(COPD)exacerbations increase household economic burden,but there is limited evidence from prospective cohort studies in China about the impact of vaccination on economic *** is added by this report?This study demonstrated the economic burden of COPD exacerbations,pneumonia,and hospitalization in COPD patients in China is *** vaccine and 23-valent pneumococcal polysaccharide vaccine(PPSV23),separately or together,were significantly associated with decreased economic *** are the implications for public health practice?Our study supports evidence on recommendations that COPD patients in China are offered both influenza vaccine and PPSV23.

关键词： Impact burden Hebei

Serial Interval and Reproductive Number of COVID-19 Among 116 Infector-infectee Pairs—Jingzhou City,Hubei Province,China,2020

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China CDC weekly 2020年第27期2卷 491-495页

作者： Tian Liu Li Qi Menglei Yao Keqing Tian Maowen Lin Hong Jiang Minmin Zeng Jigui Huang Department of Infectious Diseases prevention and control Jingzhou Center for Disease Control and PreventionJingzhou cityHubei ProvinceChina Chinese Field Epidemiology Training program Chinese Center for Disease Control and PreventionBeijingChina Department of Infectious Diseases prevention and control Chongqing Municipal Center for Disease Control and PreventionChongqingChina State Key Laboratory of Infectious Disease prevention and control Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesNational Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina

What is already known about this topic?The key epidemiological parameters including serial interval,basic reproductive number(R0),and effective reproductive number(Rt)are crucial for coronavirus disease 2019(COVID-19)control and *** studies provided different estimations but were often flawed by some limitations such as insufficient sample size and selection *** is added by this report?In this study,a total of 116 infector-infectee pairs meeting strict inclusion criteria were selected for *** mean serial interval of COVID-19 was 5.81 days(standard deviation:3.24).The estimated mean with 95%confidence interval of R0 was 3.39(3.07–3.75)and 2.98(2.62–3.38)using exponential growth(EG)and maximum likelihood(ML)methods,*** Rt in the early phase of the epidemic was above 1 with the peak of 4.43 occurring on January 8,and then showing subsequent declines and approaching 1 on January *** are the implications for public health practices?This study supports previous findings that COVID-19 has high transmissibility and that implementing comprehensive measures is effective in controlling the COVID-19 outbreak.

关键词： approaching limitations measures