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Prevalence of Reproductive Tract Infections and Association with Human Papillomavirus Infection Among Reproductive-Age Women—Six Tertiary Hospitals,China,June 2021-December 2022

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China CDC weekly 2024年第10期6卷 189-194,I0002页

作者： Di Gao Jiayue Li Gengli Zhao Zhaohui Liu Hui Bi Dai Zhang Fengxia Xue Chen Liu Hongtao Ma Bei Lin Xu Wang Xiaosong Zhang Linhong Wang Department of Obstetrics and Gynecology Peking University First HospitalBeijingChina School of Medicine University College DublinIreland Beijing Obstetrics and Gynecology Hospital BeijingChina Tianjin Medical University General Hospital TianjinChina Northwest Women’s and Children’s Hospital Xi’an CityShaanxi ProvinceChina Third Affiliated Hospital of Zhengzhou University Zhengzhou CityHenan ProvinceChina Shengjing Hospital of China Medical University Shenyang CityLiaoning ProvinceChina national Center for Chronic and Non-communicable disease control and prevention Chinese Center for Disease Control and PreventionBeijingChina

Summary What is already known about this topic?Previous studies have indicated a possible association between reproductive tract infections(RTIs)and highrisk human papillomavirus(HPV)infection,but the evidence is still *** is added by this report?This multicenter study found significantly higher positive rates of HPV,including general HPV,highrisk HPV.

关键词： Tertiary infection Reproductive

Enhanced potency of an IgM-like nanobody targeting conserved epitope in SARS-CoV-2 spike N-terminal domain

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2726-2737页

作者： Bo Liu Honghui Liu Pu Han Xiaoyun Wang Chunmei Wang Xinxin Yan Wenwen Lei Ke Xu Jianjie Zhou Jianxun Qi Ruiwen Fan Guizhen Wu Wen-xia Tian George F.Gao Qihui Wang College of Veterinary Medicine Shanxi Agricultural University030801 JinzhongChina CAS Key Laboratory of Pathogen Microbiology and Immunology Institute of MicrobiologyChinese Academy of Sciences(CAS)100101 BeijingChina School of Life Sciences Yunnan University650504 KunmingYunnan ProvinceChina NHC Key Laboratory of Biosafety National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and Prevention(China CDC)102206 BeijingChina Savaid Medical School University of Chinese Academy of Sciences101408 BeijingChina

Almost all the neutralizing antibodies targeting the receptor-binding domain(RBD)of spike(S)protein show weakened or lost efficacy against severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)emerged or emerging variants,such as Omicron and its *** suggests that highly conserved epitopes are crucial for the development of neutralizing ***,we present one nanobody,N235,displaying broad neutralization against the SARS-CoV-2 prototype and multiple variants,including the newly emerged Omicron and its ***-electron microscopy demonstrates N235 binds a novel,conserved,cryptic epitope in the N-terminal domain(NTD)of the S protein,which interferes with the RBD in the neighboring S *** neutralization mechanism interpreted via flow cytometry and Western blot shows that N235 appears to induce the S1 subunit shedding from the trimeric S ***,a nano-IgM construct(MN235),engineered by fusing N235 with the human IgM Fc region,displays prevention via inducing S1 shedding and cross-linking virus *** to N235,MN235 exhibits varied enhancement in neutralization against pseudotyped and authentic viruses in *** intranasal administration of MN235 in low doses can effectively prevent the infection of Omicron sub-variant BA.1 and XBB in vivo,suggesting that it can be developed as a promising prophylactic antibody to cope with the ongoing and future infection.

关键词： doses prevention conserved

Development of an Integrated Disposable Device for SARSCoV-2 Nucleic Acid Extraction and Detection

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Biomedical and Environmental Sciences 2024年第6期37卷 639-646页

作者： Jing Ma Yanzhe Hao Meiling Hou Xiaoshan Zhang Jingduan Liu Haodi Meng Jiangbo Chang Xuejun Ma Jihua Liu Qingjie Ying Xianhua Wang Hongxia Li Yuxi Cao Xiaoguang Zhang national Key Laboratory of Intelligent Tracking and Forecasting for Infectious diseases National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China Beijing Runbio Biotechnology Development Co. LtdBeijing 100106China Beijing Beta Technology Co. LtdBeijing 101318China Jiangsu Qitian Gene Biotechnology Co. LtdWuxi 214135JiangsuChina

Objective To develop a highly sensitive and rapid nucleic acid detection method for the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).Methods We designed,developed,and manufactured an integrated disposable device for SARS-CoV-2 nucleic acid extraction and *** precision of the liquid transfer and temperature control was tested.A comparison between our device and a commercial kit for SARS-Cov-2 nucleic acid extraction was performed using real-time fluorescence reverse transcription polymerase chain reaction(RT-PCR).The entire process,from SARS-CoV-2 nucleic acid extraction to amplification,was *** The precision of the syringe transfer volume was 19.2±1.9μL(set value was 20),32.2±1.6(set value was 30),and 57.2±3.5(set value was 60).Temperature control in the amplification tube was measured at 60.0±0.0℃(set value was 60)and 95.1±0.2℃(set value was 95)***-Cov-2 nucleic acid extraction yield through the device was 7.10×10^(6) copies/mL,while a commercial kit yielded 2.98×10^(6) copies/*** mean time to complete the entire assay,from SARS-CoV-2 nucleic acid extraction to amplification detection,was 36 min and 45 *** detection limit for SARS-CoV-2 nucleic acid was 250 copies/*** The integrated disposable devices may be used for SARS-CoV-2 Point-of-Care test(POCT).

关键词： An integrated disposable device SARS-Cov-2 Nucleic acid detection

Molecular Characteristics of Cephalosporin-Resistant Neisseria gonorrhoeae Strains in China:A Retrospective Study

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International Journal of Dermatology and Venereology 2024年第2期7卷 78-83页

作者： Jin Zhang Xiao-Yu Zhu Jing-Wei Liu Yue-Ping Yin Shao-Chun Chen Reference Laboratory for STD control Hospital for Skin Diseases(Institute of Dermatology)Chinese Academy of Medical Sciences&Peking Union Medical CollegeNanjingJiangsu 210042China national Center for STD control Chinese Center for Disease Control and PreventionNanjingJiangsu 210042China

Objective:An increasing level of antimicrobial resistance to extended-spectrum cephalosporins has been reported,so we conducted this study to investigate the molecular characteristics of cephalosporin resistant Neisseria gonorrhoeae(NG)strains isolated from China Gonococcal Antimicrobial Resistance Surveillance Programme(China-GRSP).Methods:In total,2,038 NG isolates were collected from the China-GRSP between 2015 and *** multiantigen sequence typing(NG-MAST),multilocus sequence typing(MLST),and NG sequence typing for antimicrobial resistance(NG-STAR)were used to determine characteristics and resistant determinants of cephalosporin-resistant *** results are described as ***:Seventy-four(3.6%)cephalosporin-resistant isolates were ***_(ST7363)was the most prevalent MLST among cefixime-resistant(CFX-R)isolates,whereas MLST_(ST7365)(n=8)in was the most prevalent sequence type among ceftriaxone-resistant(CRO-R)***-R strains were mainly associated with penA-X(n=27,44.3%),penA-XIII(n=6,9.8%),penA-XVIII(n=5,8.2%),and CRO-R strains were mainly related to penA-XVIII(n=10,25.6%),penA-43(n=9,23.1%),penA-XIII(n=7,17.9%).Conclusion:The main conclusion of this study is that the predominant cephalosporin-resistant clones in China include locally emerged and imported *** CFX-R and CRO-R strains are primarily related to penA mutations,and their predominant genotypes are *** the increase in international travel,tracking high-risk-resistant clones and identifying outbreaks and their associations with epidemiological characteristics are critical to improve public health.

关键词： gonorrhea resistance cephalosporin cefixime ceftriaxone

Rapid identification of full-length genome and tracing variations of monkeypox virus in clinical specimens based on mNGS and amplicon sequencing

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Virologica Sinica 2024年第1期39卷 134-143页

作者： Changcheng Wu Ruhan A Sheng Ye Fei Ye Weibang Huo Roujian Lu Yue Tang Jianwei Yang Xuehong Meng Yun Tang Shuang Chen Li Zhao Baoying Huang Zhongxian Zhang Yuda Chen Dongfang Li Wenling Wang Ke-jia Shan Jian Lu Wenjie Tan NHC Key Laboratory of Biosafety National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing100052China Chongqing Municipal Key Laboratory for High Pathogenic Microbes Chongqing Center for Disease Control and PreventionChongqing400042China MGI BGI-ShenzhenShenzhen518083China Thermo Fisher Scientific Beijing100013China School of Public Health Baotou Medical CollegeBaotou014030China BGI PathoGenesis Pharmaceutical Technology Shenzhen518000China State Key Laboratory of Protein and Plant Gene Research Center for BioinformaticsSchool of Life SciencesPeking UniversityBeijing100871China College of Life Sciences University of Chinese Academy of SciencesBeijing100049China

The monkeypox virus(MPXV)has triggered a current outbreak *** sequencing of MPXV and rapid tracing of genetic variants will benefit disease diagnosis and *** is a significant challenge but necessary to optimize the strategy and application of rapid full-length genome identification and to track variations of MPXV in clinical specimens with low viral loads,as it is one of the DNA viruses with the largest genome and the most AT-biased,and has a significant number of tandem *** we evaluated the performance of metagenomic and amplicon sequencing techniques,and three sequencing platforms in MPXV genome sequencing based on multiple clinical specimens of five mpox cases in Chinese *** rapidly identified the full-length genome of MPXV with the assembly of accurate tandem repeats in multiple clinical *** sequencing enables cost-effective and rapid sequencing of clinical specimens to obtain high-quality MPXV ***-generation sequencing facilitates the assembly of the terminal tandem repeat regions in the monkeypox virus genome and corrects a common misassembly in published ***,several intra-host single nucleotide variations were identified in the first imported mpox *** study offers an evaluation of various strategies aimed at identifying the complete genome of MPXV in clinical *** findings of this study will significantly enhance the surveillance of MPXV.

关键词： Monkeypox virus(MPXV) Metagenomic Next generation sequencing Amplicon Third-generation sequencing

Laboratory and Semi-Field Evaluation on S-Methoprene Formulations Against Anopheles sinensis(Diptera:Culicidae)—Yuxi City,Yunnan Province,China

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China CDC weekly 2024年第6期6卷 105-108页

作者： Wenbo Hu Yijin Chen Ying Liang Tianyun Su Qiyong Liu Xuewen Li Xiaobo Liu School of Public Health Cheeloo College of MedicineShandong UniversityJinan CityShandong ProvinceChina national Key Laboratory of Intelligent Tracking and Forecasting for Infectious diseases WHO Collaborating Centre for Vector Surveillance and ManagementDepartment of Vector Biology and ControlNational Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina EcoZone International Riverside CityCAUSA Department of Environment and Health School of Public HealthCheeloo College of MedicineShandong UniversityJinan CityShandong ProvinceChina Department of Vector control School of Public HealthShandong UniversityJi’nan CityShandong ProvinceChina Xinjiang Key Laboratory of Vector-borne Infectious diseases Urumqi CityXinjiang830002

Summary What is already known about this topic?Anopheles sinensis(***)is the predominant malaria vector in *** impact of S-methoprene on the emergence process of mosquito larvae suggests its potential as a control met... 详细信息

关键词： sinensis China. predominant

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ESCRT,病毒感染的“双刃剑”

中国兽医科学 2024年第2期54卷 283-284页

作者： Xuefei Wang https://***/0009-0004-1077-6715 Sahibzada Waheed Abdullah Jin'en Wu Jianli Tang Yun Zhang Hu Dong Manyuan Bai Sumin Wei Shiqi Sun sunshiqi@*** Huichen Guo https://***/0009-0004-1077-6715 guohuichen@*** State Key Laboratory for Animal disease control prevention National Foot-and-Mouth Disease Reference Laboratory Lanzhou Veterinary Research Institute Chinese Academy of Agricultural Sciences Lanzhou Gansu China State Key Laboratory for Animal disease control prevention College of Veterinary Medicine Lanzhou University Lanzhou Gansu China

内体分选转运复合体(endosomalsortingcomplex required for transport,ESCRT)是细胞中一个复杂的系统,该系统在病毒感染中起着“双刃剑”的作用,即它们能够被不同家族病毒劫持用于自身增殖,也能被宿主细胞利用对抗病毒的侵染。在病毒... 详细信息

内体分选转运复合体(endosomalsortingcomplex required for transport,ESCRT)是细胞中一个复杂的系统,该系统在病毒感染中起着“双刃剑”的作用,即它们能够被不同家族病毒劫持用于自身增殖,也能被宿主细胞利用对抗病毒的侵染。在病毒生命周期的不同阶段,病毒可以通过多种方式利用或限制ESCRT系统介导的生理过程,或者直接调控ESCRT系统的各蛋白组分的表达增加感染宿主的能力。ESCRT是由20多种蛋白质组成的复合体。根据其成分及其功能差异可以分为若干个复合物,即ESCRT-0、ESCRT-Ⅰ、ESCRT-Ⅱ、ESCRT-Ⅲ.

关键词：病毒感染蛋白组分蛋白质组成宿主细胞复合体功能差异感染宿主双刃剑

Epidemiological survey of cystic echinococcosis in southwest China:From the Qinghai-Tibet plateau to the area of Yunnan

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World Journal of Hepatology 2024年第2期16卷 229-240页

作者： Jin-Rong Zi Dan Xiao Jia Peng Fang-Wei Wu Jian-Xiong Li Xin-Liu Yan Zheng-Qing Wang Xuan Cai Qian Xu Ben-Fu Li Ya-Ming Yang Yunnan Provincial Center of Malaria Research Yunnan Institute of Parasitic DiseasesPuer 665000Yunnan ProvinceChina Yunnan institute of Parasitic diseases Yunnan Institute of Parasitic DiseasesPuer 665000Yunnan ProvinceChina Tibet Center for disease control and prevention Tibet Center for Disease Control and PreventionLhasa 85000Tibet Autonomous RegionChina Yunnan Provincial Center of Malaria Research Yunnan Institute of Parasitic DiseasesPuer 655000Yunnan ProvinceChina

BACKGROUND Echinococcosis is prevalent in 9 provinces in Western and Northern *** epidemiological survey of echinococcosis in 2012 and 2016 showed cases of echinococcosis in Yunnan *** To understand the spatial distribution and epidemiological characteristics of echinococcosis in Yunnan for the prevention and control of echinococcosis and to reduce the risk of infection in Yunnan *** Based on the China Information System for disease control and prevention(CISDCP),echinococcosis cases reported from 36 hospitals and 34 Centers for disease control were investigated and epidemiologically analyzed from 2021 to *** exclusion criteria included suspected cases,same case only counted once and cases not from Yunnan.A total of 705 cases were investigated,of which 397 cases were suitable for statistical *** these 397 cases,epidemiological investigation was tracked in 187 *** data were inputted using double entry in the Excel database,with error correction by double-entry *** data on echinococcosis cases in Yunnan Province were analyzed by ArcGIS 10.1 software to generate a density map of echinococcosis *** statistical analyses were conducted using SPSS 17.0,including the chi-square test,linear regression test and logistic univariate and multivariate regression *** A total of 397 cases were found in 89 counties in Yunnan *** number of cases in the top three prefectures were Dali(38.1%),Diqing(10.1%),and Kunming(8.3%),and the top five counties were Jianchuan(9.1%),Shangri La(8.3%),Eryuan(7.6%),Heqing(6.9%),and Dali Districts(5.0%).There were significant differences between the different *** case reporting rate by CISDCP(33.8%)was low;the first case was reported by CISDCP in 2002,and the highest number of cases was 50(2017).Confirmed and clinical cases accounted for 62.5%and 37.5%,***,90.9%of the cases of hydatid disease were reported by the hospital system,and only 9

关键词： Echinococcosis Cases Epidemiological analysis Yunnan province

Peroxidase-like active Cu-ZIF-8 with rich copper(I)-nitrogen sites for excellent antibacterial performances toward drug-resistant bacteria

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Nano Research 2024年第8期17卷 7427-7435页

作者： Xiaoze Wang Hui Wang Jingkun Zhang Ning Han Wenjun Ma Donghai Zhang Mingshui Yao Xianliang Wang Yunfa Chen State Key Laboratory of Mesoscience and Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China University of the Chinese Academy of Sciences Beijing 100049China Laboratory of Theoretical and Computational Nanoscience CAS Key Laboratory of Nanosystem and Hierarchial FabricationCAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China China CDC Key Laboratory of Environment and Population Health National Institute of Environmental HealthChinese Center for Disease Control and PreventionBeijing 100021China

Bacterial pathogens pose a serious threat to human health,and there is an urgent need to develop highly effective antibacterial materials to eliminate the increasingly serious contamination of drug-resistant ***,a Cu-doped ZIF-8 particle with unsaturated copper exhibits high peroxidase-like activity.99.998%antibacterial efficiency against *** can be achieved for 30 min at a low concentration of 50μg·mL^(−1),as well as complete sterilization against ***(up to 8 log).99.999%antibacterial efficiency against Methicillin-resistant Staphylococcus aureus can be achieved,performing orders of magnitude higher than *** mechanism shows that the unsaturated Cu-Nx sites are enzyme-like active centers,which could promote the consumption of bacteria reducing substances by H_(2)O_(2),and the generated*OH further aggravates bacterial oxidative stress and membrane *** importantly,the oxidation activity of adsorbed oxygen species on Cu-ZIF-8 is enhanced by charge transfer and structural changes between the ligand and copper center like natural ***-doped ZIF-8 with peroxidase-like activity shows great potential in antibacterial application and the revealed catalytic mechanism is helpful for understanding the high antibacterial activity of nanoparticles with Cu-Nx sites.

关键词： Cu-doped ZIF-8 peroxidase-like reactive oxygen species(ROS) catalytic mechanism antibacterial activity