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Elucidating regulatory processes of intense physical activity by multi-omics analysis

Military Medical research 2024年第4期 479-499页

作者： Ernesto S.Nakayasu Marina A.Gritsenko Young-Mo Kim Jennifer E.Kyle Kelly G.Stratton Carrie D.Nicora Nathalie Munoz Kathleen M. Navarro Daniel Claborne Yuqian Gao Karl K.Weitz Vanessa L. Paurus Kent J. Bloodsworth Kelsey A. Allen Lisa M. Bramer Fernando Montes Kathleen A. Clark Grant Tietje Justin Teeguarden Kristin E.Burnum-Johnson Biological Sciences division Pacific Northwest National Laboratory Environmental and Molecular Sciences division Pacific Northwest National Laboratory Centers for Disease Control and Prevention National Institute for Occupational Safety and Health Western States Division Computational Analytics division Pacific Northwest National Laboratory national Security Directorate Pacific Northwest National Laboratory Los Angeles County Fire Department Centers for Disease Control and Prevention National Institute for Occupational Safety and Health Respiratory Health Division Environmental and Molecular Toxicology Oregon State University

Background: Physiological and biochemical processes across tissues of the body are regulated in response to the high demands of intense physical activity in several occupations, such as firefighting, law enforcement, military, and sports. A better understanding of such processes can ultimately help improve human performance and prevent illnesses in the work ***: To study regulatory processes in intense physical activity simulating real-life conditions, we performed a multi-omics analysis of 3 biofluids(blood plasma, urine, and saliva) collected from 11 wildland firefighters before and after a 45 min, intense exercise regimen. Omics profiles post-vs. pre-exercise were compared by Student's t-test followed by pathway analysis and comparison between the different omics ***: Our multi-omics analysis identified and quantified 3835 proteins, 730 lipids and 182 metabolites combining the 3 different types of samples. The blood plasma analysis revealed signatures of tissue damage and acute repair response accompanied by enhanced carbon metabolism to meet energy demands. The urine analysis showed a strong, concomitant regulation of 6 out of 8 identified proteins from the renin-angiotensin system supporting increased excretion of catabolites, reabsorption of nutrients and maintenance of fluid balance. In saliva, we observed a decrease in 3 pro-inflammatory cytokines and an increase in 8 antimicrobial peptides. A systematic literature review identified 6 papers that support an altered susceptibility to respiratory ***: This study shows simultaneous regulatory signatures in biofluids indicative of homeostatic maintenance during intense physical activity with possible effects on increased infection susceptibility, suggesting that caution against respiratory diseases could benefit workers on highly physical demanding jobs.

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2.32W anti-misaligned Er:LuAG single-longitudinal-mode laser in the double corner-cube-retroreflector resonator and MOPA system

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Chinese Optics Letters 2024年第2期22卷 114-119页

作者：范佳玮鞠有伦姜辰晨袁越闫东杨星帮段小明戴通宇姚宝权吴佳泽 national Key Laboratory of Tunable Laser Technology Harbin Institute of TechnologyHarbin 150001China Department of Physics and Chemistry PLA Army Academy of Special OperationsGuangzhou 510507China Zhengzhou research institute of Harbin institute of Technology Zhengzhou 450000China

We demonstrate a high power,Er:Lu AG single-longitudinal-mode laser in an anti-misaligned *** on the Faraday effect,a 1.61 W single-longitudinal-mode(SLM)laser is obtained with the double corner-cube-retroreflector(CCR)structure,and the tunable wavelength is 1649.2-1650.3 ***,we investigate the anti-misalignment characteristics when the CCR moves and rotates along the optical ***,by utilizing the Er:Lu AG amplifier,the maximum 2.32 W single-longitudinal-mode laser at 1649.6 nm is *** beam quality factors M^(2) of the 2.32 W Er:Lu AG single-longitudinal-mode laser are 1.23 and 1.25 along the horizontal(x)and vertical(y)directions,respectively.

关键词： Er:Lu AG single-longitudinal-mode laser Faraday effect MOPA system double corner-cube-retroreflector resonator

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Importance of dietary supplementation of soluble and insoluble fibers to sows subjected to high ambient temperatures during late gestation and effects on lactation performance

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Animal Nutrition 2024年第1期16卷 73-83页

作者： Seung Min Oh Abdolreza Hosseindoust Sang Hun Ha Jun Young Mun Joseph Moturi Habeeb Tajudeen Yo Han Choi Su Hyup Lee Jin Soo Kim Gyeongbuk Livestock research institute Department of Animal Industry Convergence Kangwon National University Swine division National Institute of Animal Science Rural Development Administration Department of Swine Science Korea National University of Agriculture and Fisheries

Heat stress adversely affects sows' performance, which can be improved by applying proper nutritional strategies. This study was conducted to investigate the interactive effects of dietary fiber levels and sources on sows' reproductive performance, metabolic response during gestation, and the carry-over influence on litter performance in the lactation period during heat stress(average room temperature of 27.1°C). Fifty-four multiparous sows(Landrace × Yorkshire; initial body weight of 236.3 ± 16 kg; 2, 3and 4 parities) at d 90 of gestation were assigned to a 2 × 3 factorial arrangement(9 sows/treatment),involving 2 dietary fiber levels(4.5% and 6% crude fiber) and 3 dietary fiber sources(wheat bran [WB],palm kernel meal [PK], and beet pulp [BP]). Sows fed the BP diet had highest(P < 0.01) feed intake and constipation index and lowest(P < 0.01) farrowing duration. Piglet weight(P = 0.041) and litter weight(P < 0.01) at weaning were higher in sows in the BP treatment compared to PK treatment. Sows in the BP treatment showed the greatest(P < 0.01) digestibility of crude protein and neutral detergent fiber. The fecal concentration of acetate was the lowest(P < 0.01) in the PK treatment. Total short-chain fatty acid production was increased in the WB and BP treatments compared with the PK. Sows in the BP treatment showed the lowest(P = 0.036) hair cortisol. The blood insulin concentration of sows was higher(P = 0.026) in the high fiber(6%) treatment compared with the low fiber(4.5%) treatment at 90 min and120 min after the meal. The concentration of phthalic acid, succinic acid, phenylethylamine, hydrocinnamic acid, iron, linoleic acid, glycerol, ketone, and formamide were increased(P < 0.05) in the BP treatment compared with the WB. The BP treatment with high soluble fiber content improved the constipation index, farrowing duration, and litter performance, while high insoluble fibers increased sows comfort and reduced stress factors including respiratory rate and rectal

关键词： Soluble fiber Insoluble fiber Beet pulp Wheat bran Palm kernel Metabolites

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Wharton’s jelly mesenchymal stem cells: Future regenerative medicine for clinical applications in mitigation of radiation injury

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World Journal of Stem Cells 2024年第7期16卷 742-759页

作者： Prashasti Sharma Dharmendra Kumar Maurya Life Sciences Homi Bhabha National InstituteMumbai 400094MaharashtraIndia Radiation Biology&health Sciences division Bhabha Atomic Research CentreMumbai 400085MaharashtraIndia

Wharton’s jelly mesenchymal stem cells(WJ-MSCs)are gaining significant attention in regenerative medicine for their potential to treat degenerative diseases and mitigate radiation ***-MSCs are more naïve and have a better safety profile,making them suitable for both autologous and allogeneic *** review highlights the regenerative potential of WJ-MSCs and their clinical applications in mitigating various types of radiation *** this review,we will also describe why WJ-MSCs will become one of the most probable stem cells for future regenerative medicine along with a balanced view on their strengths and ***,the most updated literature related to both preclinical and clinical usage of WJ-MSCs for their potential application in the regeneration of tissues and organs will also be compiled.

关键词： Stem cells Wharton’s jelly mesenchymal stem cells Radiotherapy Xerostomia Lung fibrosis

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Thermal stability improvement and microstructure optimization of high cobalt content Nd-Fe-B magnets via terbium grain boundary diffusion

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Journal of Rare Earths 2024年第8期42卷 1531-1538,I0004页

作者： Jiyuan Xu Ruiyang Meng Jing Liu Jiateng Zhang Rui Han Yikun Fang Shengzhi Dong Wei Li division of Functional Materials research Central Iron and Steel Research InstituteBeijing100081China

The substitution of Fe by Co in the 2:14:1 phase is an effective method to increase the Curie temperature and enhance the thermal stability of the Nd-Fe-B ***,the accumulation of Co ele ment at the grain boundaries(GBs) changes the GBs from nonmagnetic to ferromagnetic and causes the thinlayer GBs to become rare,In this paper,the method of diffusing Tb element was chosen to improve the microstructure and temperature stability of high-Co *** original sintered Nd_(28.5)Dy_(3)-CO_(x)e_(bal)M_(0.6)B_(i)(x=0,6 wt%,12 wt%;M = Cu,Al,Zr) magnets with different Co contents were diffused with Tb by grain boundary diffusion(GBD).After GBD,high-Co magnets exhibit more continuously distributed thin-layer GBs,and their thermal stability is significantly *** high-Co magnets(x=6 wt%),the absolute value of the temperature coefficient of coercivity decreases from 0.603%/K to0.508%/K in the temperature range of 293-413 K,that of remanence decreases from 0.099%/K to 0.091%/K,and the coercivity increases from 18.44 to 25.04 *** electron microscopy(TEM)characterization reveals that there are both the 1:2 phase and the amorphous phase in the high-Co magnet before and after GBD,EDS elemental analysis shows that Tb element is more likely to preferentially replace the rare earth elements in the 2:14:1 main phase than in the 1:2 phase and the amorphous *** concentration of Tb at the edge of the main phase is much higher than that in the 1:2phase and amorphous phase,which is beneficial to the improvement of the *** preferential replacement of Tb elements at the edge of the 2:14:1 phase and thin-layer GBs with a more continuous distribution are synergistically responsible for improving the thermal stability of high-Co *** study indicates that GBD is an effective method to improve the microstructure and thermal stability of high-Co magnets.

关键词： Nd-Fe-B magnets Coercivity Grain boundary diffusion Thermal stability Micro structure Rare earths

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Study of Type-B QPOs Observed in Black Hole X-Ray Binary Swift J1728.9-3613

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research in Astronomy and Astrophysics 2024年第3期24卷 1-9页

作者： Raj Kumar Astrophysical Sciences division Bhabha Atomic Research CentreMumbai 400085India Homi Bhabha national institute Mumbai 400094India

We report the detection of type-B quasi-periodic oscillation(QPO)of the black hole X-ray binary Swift J1728.9-3613 observed by NICER during the 2019 outburst.A type-B QPO was observed for the first two days and it disappeared as flux increased,but again appeared at∼7.70 Hz when flux was dramatically *** source was found in the soft intermediate state during these *** further studied the energy dependence of the *** found that QPO was observed only for a higher energy range implying that the origin of QPO is possibly due to the corona emitting higher energy photons by the inverse Compton *** variation of spectral parameters can be explained with the disk truncation *** fractional rms was found to be monotonically increased with *** phase lag spectrum followed the“U-shaped”*** rms and phase lag spectrum are modeled and explained with the single-component Comptonization model vkompthdk.

关键词： X-rays binaries-accretion-accretion disks-X-rays individual (Swift J1728.9-3613)

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Theoretical analysis and engineering application of controllable shock wave technology for enhancing coalbed methane in soft and low‑permeability coal seams

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International Journal of Coal Science & Technology 2024年第2期11卷 123-142页

作者： Guodong Qiao Zegong Liu Yongmin Zhang Changping Yi Kui Gao Shigui Fu Youzhi Zhao School of safety Science and Engineering Anhui University of Science and TechnologyHuainan 232001AnhuiChina institute of Energy Hefei Comprehensive National Science CenterHefei 230031AnhuiChina School of Electrical Engineering Xi’an Jiaotong UniversityXi’an 710049ShanxiChina division of mining and Geotechnical Engineering LuleåUniversity of TechnologyLuleåSweden

Coalbed methane(CBM)is a significant factor in triggering coal and gas outburst disaster,while also serving as a clean *** the increasing depth of mining operations,coal seams that exhibit high levels of gas content and low permeability have become increasingly *** controllable shockwave(CSW)technology has proven effective in enhancing CBM in laboratory settings,there is a lack of reports on its field applications in soft and low-permeability coal *** study establishes the governing equations for stress waves induced by *** numerical inversion was employed to analyse the dynamic response of the coal seam during CSW ***,quantitative calculations were performed for the crushed zone,fracture zone,and effective CSW influence range,which guided the selection of field test *** results of the field test unveiled a substantial improvement in the gas permeability coefficient,the average rate of pure methane flowrate,and the mean gas flowrate within a 10 m radius of the antireflection *** enhancements were notable,showing increases of 3 times,13.72 times,and 11.48 times,***,the field test performed on the CSW antireflection gas extraction hole cluster demonstrated a noticeable improvement in CBM *** antireflection,the maximum peak gas concentration and maximum peak pure methane flow reached 71.2%and 2.59 m^(3)/min,*** findings will offer valuable guidance for the application of CSW antireflection technology in soft and low-permeability coal seams.

关键词： CSW antireflection in coal seams CBM extraction enhancement Soft and low-permeability coal seams Field test

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Weight change and all-cause and cause-specific mortality:A 25-year follow-up study

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Chinese Medical Journal 2024年第10期137卷 1169-1178页

作者： Huan Yang Jianbing Wang Xiaokun Wang Wanyi Sun Chenyunhao Tong Jinhu Fan Youlin Qiao Christian *** Department of Cancer Epidemiology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Public health Zhejiang University School of MedicineNational Clinical Research Center for Children’s HealthHangzhouZhejiang 310058China Metabolic Epidemiology Branch Division of Cancer Epidemiology and GeneticsNational Cancer InstituteRockvilleMD 20850USA

Background:Whether the dynamic weight change is an independent risk factor for mortality remains *** study aimed to examine the association between weight change and risk of all-cause and cause-specific mortality based on the Linxian Nutrition Intervention Trial(NIT)***:Body weight of 21,028 healthy residents of Linxian,Henan province,aged 40-69 years was measured two times from 1986 to *** events were prospectively collected up to *** maintenance group(weight change<2 kg)or stable normal weight group was treated as the *** proportional hazard model was performed to calculate hazard ratios(HRs)and 95%confidence intervals(95%CIs)to estimate the risk of ***:A total of 21,028 subjects were included in the final *** with the weight maintenance group,subjects with weight loss≥2 kg had an increased risk of death from all-cause(HR_(All-cause)=1.14,95%CI:1.09-1.19,P<0.001),cancer(HR_(Cancer)=1.12,95%CI:1.03-1.21,P=0.009),and heart disease(HR_(Heart diseases)=1.21,95%CI:1.11-1.31,P<0.001),whereas subjects with weight gain≥5 kg had 11%(HR_(Cancer)=0.89,95%CI:0.79-0.99,P=0.033)lower risk of cancer mortality and 23%higher risk of stroke mortality(HR_(Stroke)=1.23,95%CI:1.12-1.34,P<0.001).For the change of weight status,both going from overweight to normal weight and becoming underweight within 5 years could increase the risk of total death(HR_(Overweight to normal)=1.18,95%CI:1.09-1.27;HR_(Becoming underweight)=1.35,95%CI:1.25-1.46)and cancer death(HR_(Overweight to normal)=1.20,95%CI:1.04-1.39;HR_(Becoming underweight)=1.44,95%CI:1.24-1.67),while stable overweight could increase the risk of total death(HR_(Stable overweight)=1.11,95%CI:1.05-1.17)and death from stroke(HR_(Stable overweight)=1.44,95%CI:1.33-1.56).Interaction effects were observed between age and weight change on cancer mortality,as well as between baseline BMI and weight change on all-cause,heart disease,and stroke mortality(all P_(

关键词： Weight change All-cause mortality Cancer Stroke Heart diseases Body mass index

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Overexpression of wild-type HRAS drives non-alcoholic steatohepatitis to hepatocellular carcinoma in mice

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Zoological research 2024年第3期45卷 551-566页

作者： Chen Ling Su-Su Liu Yu-Ya Wang Gui-Tao Huo Yan-Wei Yang Nan Xu Hong Wang Yong Wu Yu-Fa Miao Rui Fu Yu-Wei Zhao Chang-Fa Fan College of Life Sciences Northwest UniversityProvincial Key Laboratory of Biotechnology of Shaanxi ProvinceXi’anShaanxi 710069China division of Animal Model research Institute for Laboratory Animal ResourcesNational Institutes for Food and Drug Control(NIFDC)Beijing 102629China national Center for safety Evaluation of Drugs National Institutes for Food and Drug Control(NIFDC)Beijing 100176China division of HIV/AIDS and Sexually Transmitted Virus Vaccines Institute for Biological Products ControlNational Institutes for Food and Drug Control(NIFDC)Beijing 102629China division of Laboratory Animal Monitoring Institute for Laboratory Animal ResourcesNational Institutes for Food and Drug Control(NIFDC)Beijing 102629China

Hepatocellular carcinoma(HCC),a prevalent solid carcinoma of significant concern,is an aggressive and often fatal disease with increasing global incidence rates and poor therapeutic *** etiology and pathological progression of non-alcoholic steatohepatitis(NASH)-related HCC is multifactorial and ***,no single animal model can accurately mimic the full NASH-related HCC pathological progression,posing considerable challenges to transition and mechanistic ***,a novel conditional inducible wild-type human HRAS overexpressed mouse model(HRAS-HCC)was established,demonstrating 100%morbidity and mortality within approximately one month under normal dietary and lifestyle *** symptoms of HCC such as ascites,thrombus,internal hemorrhage,jaundice,and lung metastasis were successfully replicated in ***-depth pathological features of NASH-related HCC were demonstrated by pathological staining,biochemical analyses,and typical marker gene *** murine anti-PD-1 and sorafenib treatment effectively prolonged mouse survival,further confirming the accuracy and reliability of the *** on protein-protein interaction(PPI)network and RNA sequencing analyses,we speculated that overexpression of HRAS may initiate the THBS1-COL4A3 axis to induce NASH with severe fibrosis,with subsequent progression to ***,our study successfully duplicated natural sequential progression in a single murine model over a very short period,providing an accurate and reliable preclinical tool for therapeutic evaluations targeting the NASH to HCC continuum.

关键词： HRAS THBS1 HCC driver factor NASH Fibrosis Cirrhosis HCC Treatment evaluation

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Rice ONAC016 promotes leaf senescence through abscisic acid signaling pathway involving OsNAP

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The Crop Journal 2024年第3期12卷 709-720页

作者： Eunji Gi Sung-Hwan Cho Suk-Hwan Kim Kiyoon Kang Nam-Chon Paek Department of Agriculture Forestry and BioresourcesPlant Genomics and Breeding InstituteResearch Institute of Agriculture and Life SciencesSeoul National UniversitySeoul 08826Republic of Korea division of Life Sciences Incheon National UniversityIncheon 22012Republic of Korea

Senescence-induced NAC(senNAC)TFs play a crucial role in senescence during the final stage of leaf *** this study,we identified a rice senNAC,ONAC016,which functions as a positive regulator of leaf *** expression of ONAC016 increased rapidly in rice leaves during the progression of dark-induced and natural *** onac016-1 knockout mutant showed a delayed leaf yellowing phenotype,whereas the overexpression of ONAC016 accelerated leaf ***,ONAC016 expression was upregulated by abscisic acid(ABA),and thus detached leaves of the onac016-1 mutant remained green much longer under ABA *** RT-PCR analysis showed that ONAC016 upregulates the genes associated with chlorophyll degradation,senescence,and ABA *** one-hybrid and dual-luciferase assays revealed that ONAC016 binds directly to the promoter regions of OsNAP,a key gene involved in chlorophyll degradation and ABA-induced *** together,these results suggest that ONAC016 plays an important role in promoting leaf senescence through the ABA signaling pathway involving OsNAP.

关键词： Rice ONAC016 OsNAP Leaf senescence Abscisic acid signaling

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