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PREPARATION AND CELL COMPATIBILITY OF FUNCTIONALIZED BIODEGRADABLE POLY(DL-LACTIDE-co-RS-β-MALIC ACID)

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Chinese Journal of Polymer Science 2008年第2期26卷 177-186页

作者：何斌顾忠伟 engineering research Center of biomaterials Sichuan UniversityNational Engineering Research Center for Biomaterials

In order to create a functionalized biodegradable polymer for vascular tissue engineering application,poly(DL- lactide-co-RS-β-malic acid)(PDLLMAc)was *** was obtained after hydrogenolysis of poly(DL- lactide-co-RS-β-benzyl malolactonate)(PDLLMA),which was from the ring-opening polymerization of DL-lactide(DLLA) and RS-β-benzyl malolactonate(MA)using stannous octoate as *** copolymers were characterized by ~1H-NMR, FTIR,GPC and *** tensile strength and water uptake of the copoly...

关键词： Biodegradable Functionalization Poly(DL-lactide-co-RS-β-malic acid) Tissue engineering.

A NOVEL METHOD TO PREPARE CROSSLINKED POLYETHYLENEIMINE HOLLOW NANOSPHERES

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Chinese Journal of Polymer Science 2007年第5期25卷 431-435页

作者：何斌顾忠伟 engineering research Center of biomaterials Sichuan University National Engineering Research Center for Biomaterials

A novel method to prepare crosslinked polyethyleneimine （CPEI） hollow nanospheres was reported. Uniform silica nanospheres were used as templates, 3-aminopropyl trimethoxysilane （APS） was immobilized on the surface of silica nanospheres as couple agent. Aziridine was initiated ring-opening polymerization with the amino groups in APS to form polyethyleneimine （PEI） shell layer. 1,4-Butanediol diacrylate was utilized to crosslink PEI polymeric shell. The silica nanospheres in core were etched by hydrofluoric acid to obtain hollow CPEI nanospheres. The hollow nanospheres were characterized by X-ray photoelectron spectroscopy （XPS）, transmission electron microscopy （TEM）, and thermogravimetric analysis （TGA）.

关键词： Hollow nanospheres Polyethyleneimine Template Crosslink.

NOVEL pH-SENSITIVE DRUG DELIVERY SYSTEM BASED ON NATURAL POLYSACCHARIDE FOR DOXORUBICIN RELEASE

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Chinese Journal of Polymer Science 2008年第3期26卷 369-374页

作者：樊渝江 national engineering research Center for biomaterials Engineering Research Center of BiomaterialsSichuan UniversityChengdu 610064China

A novel pH-sensitive nanoparticle drug delivery system (DDS) derived fl om natural polysaccharide pullulan for doxorubicin (DOX) release was *** was functionalized by successive carboxymethylization and amidation to introduce hydrazide *** was then grafted onto pullulan backbone through the pH-sensitive hydrazone bond to form a pullulan/DOX *** conjugate self-assembled to form nano-sized particles in aqueous solution as a result of the hydrophobic interaction of the ***...

关键词： Natural polysaccharide pH-sensitive Nanoparticle drug delivery system Doxorubicin

COMPARISON OF DRUG DELIVERY PROPERTIES OF PEG-b-PDHPC MICELLES WITH DIFFERENT COMPOSITIONS

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Chinese Journal of Polymer Science 2012年第3期30卷 387-396页

作者：顾忠伟 national engineering research Center for biomaterials Sichuan University

An anti-tumor drug doxorubicin was encapsulated in micelles of poly（ethylene glycol）-b-poly（2,2-dihydroxyl- methyl propylene carbonate）（PEG-b-PDHPC） diblock copolymers. The morphololgy of both blank miceiles and drug loaded micelles was characterized by TEM. The in vitro drug release profiles of micelles were investigated, The cytotoxicity of the micelles was evaluated by incubating with Hela tumor cells and 3T3 fibroblasts. The drug loaded micelles were co-cultured with HepG2 cells to evaluate the in vitr9 anti-tumor efficacies. The results showed that the mean sizes of both micelles with different copolymer compositions increased after being loaded with drugs. The drug release rate of PEG45-b-PDHPC34 micelles was faster than that of mPEGt14-b-PDHPC26 micelles. Both of the two block copolymers were non-toxic. The confocal laser scanning microscopy a：ad flow cytometry results showed that both the drug loaded micelles could be internalized efficiently in HepG2 cells. The PEG45-b-PDHPC34 micelles exhibited higher anti-tumor activity comparing to mPEGxla-b-PDHPC26 micelles.

关键词： Drug delivery Micelles Doxorubicin Biodegradable.

INCLUSION COMPLEX FORMATION BETWEENα-CYCLODEXTRIN AND BIODEGRADABLE COMBLIKE COPOLYMERS WITH POLY(α,β-MALIC ACID) BACKBONES AND mPEG SIDE CHAINS

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Chinese Journal of Polymer Science 2009年第5期27卷 729-737页

作者：何斌顾忠伟 national engineering research Center for biomaterials(Sichuan University)

Inclusion complexes(ICs) composed ofα-cyclodextrins(α-CD) and biodegradable comblike copolymers with poly(α,β-malic acid)(PMA) backbones and methylated poly(ethylene glycol)(mPEG) side chains were prepared by the host-guest *** series of ICs with mPEG750 and mPEG2000 were *** stoichiometry(EG/CD) of all the ICs in mPEG2000 series was 3.1,no matter what the graft degree *** in mPEG750 series,the stoichiometry(EG/CD) was very different:it increased with the amount of mPEG ***...

关键词： Inclusion complexes α-Cyclodextrins Comblike copolymer.

Biodegradable polymeric nanoparticles based on amphiphilic principle:construction and application in drug delivery

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Science China Chemistry 2014年第4期57卷 461-475页

作者： ZHANG ShiYong WU Yao HE Bin LUO Kui GU ZhongWei national engineering research Center for biomaterials Sichuan University

The use of nanotechnology in drug-delivery systems(DDS) is attractive for advanced diagnosis and treatment of cancer diseases. Biodegradable polymeric nanoparticles, for example, have promising applications as advanced drug carriers in cancer treatment. In this review, we discuss the development of drug-delivery systems based on an amphiphilic principle mainly conducted by our group for anti-cancer drug delivery. We first briefly address the synthetic chemistry for amphiphilic biodegradable polymers. In the second part, we summarize progress in the application of self-assembled polymer micelles using amphiphilic biodegradable copolymers as anti-tumor drug carriers.

关键词： biodegradable polymer miceUe amphiphilicity drug-delivery system cancer

Passive activity enhances residual control ability in patients with complete spinal cord injury

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Neural Regeneration research 2025年第8期20卷 2337-2347页

作者： Yanqing Xiao Mingming Gao Zejia He Jia Zheng Hongming Bai Jia-Sheng Rao Guiyun Song Wei Song Xiaoguang Li Beijing Key Laboratory for biomaterials and Neural Regeneration Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijingChina Department of Rehabilitation Evaluation China Rehabilitation Research CenterBeijingChina Cardiac Center Beijing Children’s HospitalCapital Medical UniversityBeijingChina The State Key Laboratory of Virtual Reality Technology and Systems Beihang UniversityBeijingChina Department of Rehabilitation engineering China Rehabilitation Science InstituteBeijingChina

Patients with complete spinal cord injury retain the potential for volitional muscle activity in muscles located below the spinal injury ***,because of prolonged inactivity,initial attempts to activate these muscles may not effectively engage any of the remaining neurons in the descending pathway.A previous study unexpectedly found that a brief clinical round of passive activity significantly increased volitional muscle activation,as measured by surface *** this study,we further explored the effect of passive activity on surface electromyographic signals during volitional control tasks among individuals with complete spinal cord *** patients with chronic complete thoracic spinal cord injury were *** electromyography data from eight major leg muscles were acquired and compared before and after the passive activity *** results indicated that the passive activity led to an increased number of activated volitional muscles and an increased frequency of *** the cumulative root mean square of surface electromyography amplitude for volitional control of movement showed a slight increase after passive activity,the difference was not statistically *** findings suggest that brief passive activity may enhance the ability to initiate volitional muscle activity during surface electromyography tasks and underscore the potential of passive activity for improving residual motor control among patients with motor complete spinal cord injury.

关键词： complete spinal cord injury cycle training epidural electrical stimulation motor training passive activity physiological state spinal cord circuit surface electromyography volitional control task

Bioactive titanium metal surfaces with antimicrobial properties prepared by anodic oxidation treatment

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Science China(Technological Sciences) 2009年第8期52卷 2269-2274页

作者： YUE ChongXia YANG BangCheng ZHANG XingDong engineering research Center for biomaterials Sichuan UniversityChengdu 610064China national engineering research Center in biomaterials Chengdu 610064China

In order to endow titanium metals with bioactivity and antimicrobial properties, titanium plates were subjected to anodic oxidation treatment in NaCl solutions in this study. The treated titanium metals could induce apatite formation in the fast calcification solution, and osteoblasts on the treated titanium surfaces proliferated well as those on the untreated titanium metal surfaces. The treated metals could inhibit S. aureus growth in the microbial culture experiments. It was assumed that Ti-OH groups and Ti-Cl groups formed on the treated titanium surface were responsible for the bioactivity and antimicrobial properties of the metals. The anodic oxidation treatment was an effective way to prepare bioactive titanium surfaces with antimicrobial properties.

关键词： titanium anodic oxidation bioactivity antimicrobial property

Recent progress in functional modification and crosslinking of bioprosthetic heart valves

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Regenerative biomaterials 2024年第1期3卷 1-16页

作者： Cheng Zheng Li Yang Yunbing Wang national engineering research Center for biomaterials Sichuan UniversityChengdu 610064China

Valvular heart disease(VHD),clinically manifested as stenosis and regurgitation of native heart valve,is one of the most prevalent cardiovascular diseases with high *** valve replacement surgery has been recognized as golden standard for the treatment of *** to the clinical application of transcatheter heart valve replacement technic and the excellent hemodynamic performance of bioprosthetic heart valves(BHVs),implantation of BHVs has been increasing over recent years and gradually became the preferred choice for the treatment of ***,BHVs might fail within 10-15 years due to structural valvular degeneration(SVD),which was greatly associated with drawbacks of glutaraldehyde crosslinked BHVs,including cytotoxicity,calcification,component degradation,mechanical failure,thrombosis and immune *** prolong the service life of BHVs,much effort has been devoted to overcoming the drawbacks of BHVs and reducing the risk of *** this review,we summarized and analyzed the research and progress on:(i)modification strategies based on glutaraldehyde crosslinked BHVs and(ii)nonglutaraldehyde crosslinking strategies for BHVs.

关键词： bioprosthetic heart valves modification crosslinking anticalcification antithrombosis