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Blautia producta displays potential probiotic properties against dextran sulfate sodium-induced colitis in mice

food Science and Human Wellness 2024年第2期13卷 709-720页

作者： Bingyong Mao Weiling Guo Shumao Cui Qiuxiang Zhang Jianxin Zhao Xin Tang Hao Zhang State Key Laboratory of food Science and Resources Jiangnan UniversityWuxi 214122China School of food Science and Technology Jiangnan UniversityWuxi 214122China national engineering research center for functional food Jiangnan UniversityWuxi 214122China

Blautia has attracted attention because of its potential efficacy in ameliorating host energy metabolism and *** study aims to investigate the influences of Blautia producta D4 on colitis induced by dextran sulfate sodium(DSS)and to reveal the underlying *** showed that *** D4 intervention significantly relieved body weight loss,and suppressed the elevation of pro-inflammatory cytokines(including interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),and interleukin-1β(IL-1β))and excessive oxidative stress(myeloperoxidease(MPO)activity,superoxide dismutase(SOD)activity,glutathione peroxidase(GSH-Px)activity,and malondialdehyde(MDA)level)in colitis ***,the concentrations of tight junction proteins(occludin,claudin-1,and ZO-1)related to the intestinal barrier were obviously elevated,and colitis-related TLR4/NF-κB pathway activation was remarkably inhibited after *** D4 *** intestinal microbial disorder was evidently ameliorated by increasing the relative abundance of Clostridium sensu stricto 1,Bifidobacterium,GCA-900066225,Enterorhabdus,and reducing the relative abundance of Lachnospiraceae NK4A136 *** conclusion,oral administration of *** D4 could ameliorate DSS-induced colitis by suppressing inflammatory responses,maintaining the intestinal barrier,inhibiting TLR4/NF-κB pathway,and regulating intestinal microbiota *** results are conducive to accelerate the development of *** D4 as a functional probiotic for colitis.

关键词： Blautia producta D4 Colitis Intestinal mechanical barrier TLR4/NF-κB pathway Intestinal microbiot

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Akkermansia muciniphila-directed polyphenol chlorogenic acid intervention for obesity in mice

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food Science and Human Wellness 2024年第1期13卷 90-100页

作者： Xiaoxiang Gao Chenbo Yue Ruocen Tian Leilei Yu Fengwei Tian Jianxin Zhao Wei Chen Qixiao Zhai State Key Laboratory of food Science and Technology Jiangnan UniversityWuxi 214122China School of food Science and Technology Jiangnan UniversityWuxi 214122China national engineering research center for functional food Jiangnan UniversityWuxi 214122China

Akkermansia muciniphila play an important in ameliorating obesity but is not allowed for direct consumption in most *** date,microbiota-directed foods selectively promote the targeted human gut microbes,providing a strategy for *** *** studies have indicated the potential regulation of the polyphenol on ***,a polyphenol screening based on *** upregulation was performed in *** acid(CGA)exhibited a greater response to *** ***,we found that CGA did not directly promote *** growth or mucin *** and metabolomics revealed that the increased abundance of *** resulted from the inhibition of CGA on Desulfovibrio and Alistipes and the influence of docosahexaenoic acid,β-hydroxybutyrate,and ***,to confirm the regulation of CGA on *** under disease conditions,high-fat diet-fed mice were *** results showed CGA promoted *** growth,and we expectedly found that CGA suppressed the augment in body weight of mice,significantly attenuated adipose tissue abnormality,provided liver protection and improved gut barrier *** results suggest that CGA inhibits the development of ***,our results indicate that microbiota-directed food is a promising approach for the treatment of obesity.

关键词： Akkermansia muciniphila polyphenol chlorogenic acid obesity

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Probiotics administration alleviates cognitive impairment and circadian rhythm disturbance induced by sleep deprivation

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food Science and Human Wellness 2024年第4期13卷 1951-1961页

作者： Peijun Tian Yunfei Hou Zheng Wang Jiaona Jiang Xin Qian Zhihao Qu Jianxin Zhao Gang Wang Wei Chen State Key Laboratory of food Science and Resources Jiangnan UniversityWuxi 214122China School of food Science and Technology Jiangnan UniversityWuxi 214122China national engineering research center for functional food Jiangnan UniversityWuxi 214122China Institute of food Biotechnology(Yangzhou) Jiangnan UniversityYangzhou 225004China

Gut microbiome is indispensable for maintaining normal brain ***,gut microbiota plays a causal role in sleep deprivation(SD)-induced cognitive *** this study,neurobehavioral effects of the Bifidobacterium breve strain(CCFM1025)were assessed in sleep-deprived ***1025 improved the body weight and food and water intake of the *** also alleviated SD-induced cognitive behavioural abnormalities(in the novel object recognition test),but did not show beneficial effects on mood-and spatial memory-related ***1025 significantly altered the gut microbial composition and genome *** microbial metabolites that may regulate sleep function were also identified,such as isovaleric acid andγ-aminobutyric acid in the gut and purine metabolites in the *** metabolites may participate in gutbrain communication by acting on the striatal melatonin system,for example to increase melatonin levels,and by regulating the expression of circadian clock genes such as those encoding the adenosine A2A receptor and period circadian regulator ***,administration of probiotics alleviated cognitive impairment and circadian rhythm disturbance induced by SD via modulation of gut microbiome and its *** findings may help guide the treatment of insomnia or other sleep disorders via dietary strategies.

关键词： Bifidobacterium Sleep Circadian rhythm Purine Gut microbiome

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Environmental enrichment in combination with Bifidobacterium breve HNXY26M4 intervention amplifies neuroprotective benefits in a mouse model of Alzheimer's disease by modulating glutamine metabolism of the gut microbiome

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food Science and Human Wellness 2024年第2期13卷 982-992页

作者： Guangsu Zhu Min Guo Jianxin Zhao Hao Zhang Gang Wang Wei Chen State Key Laboratory of food Science and Resources Jiangnan UniversityWuxi 214122China School of food Science and Technology Jiangnan UniversityWuxi 214122China (Yangzhou)Institute of food Biotechnology Jiangnan UniversityYangzhou 225004China national engineering center of functional food Jiangnan UniversityWuxi 214122China

The gut microbiota-brain axis has emerged as a novel target for Alzheimer's disease(AD),a neurodegenerative disease characterised by behavioural and cognitive ***,most previous microbiome-based intervention studies have focused on single factors and yielded only modest cognitive ***,we proposed a multidomain intervention strategy that combined Bifidobacterium breve treatment with environmental enrichment(EE)*** this study,we found that compared with EE or *** treatment alone,*** intervention combined with EE amplified its neuroprotective effects on AD mice,as reflected by improved cognition,inhibited neuroinflammation and enhanced synaptic ***,using microbiome and metabolome profiling,we found that the combination of *** and EE treatment restored AD-related gut microbiota dysbiosis and reversed microbial metabolite ***,by integrating behavioural and neurological data with metabolomic profiles,we revealed that the underlying mechanism may involve the modulation of microbiota-derived glutamine metabolism via gut-brain ***,combined *** intervention with EE treatment can alleviate AD-related cognitive impairment and improve brain function by regulating glutamine metabolism of the gut *** findings provide a promising multidomain intervention strategy,with a combination of dietary microbiome-based and lifestyle-targeted interventions,to promote brain function and delay the progression of AD.

关键词： Alzheimer’s disease Bifidobacterium breve Environmental enrichment Glutamine metabolism Microbiota-gut-brain axis

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Differences in the effects and action modes of gut commensals against dextran sulfate sodium-induced intestinal inflammation

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food Science and Human Wellness 2024年第3期13卷 1201-1211页

作者： Dingwu Qu Zhennan Gu Saisai Feng Leilei Yu Fengwei Tian Hao Zhang Wei Chen Qixiao Zhai State Key Laboratory of food Science and Technology Jiangnan UniversityWuxi 214122China School of food Science and Technology Jiangnan UniversityWuxi 214122China national engineering research center for functional food Jiangnan UniversityWuxi 214122China Wuxi Translational Medicine research center and Jiangsu Translational Medicine research Institute Wuxi Branch Wuxi 214122China

Inflammatory bowel disease(IBD)is a complex relapsing inflammatory disease in the gut and is driven by complicated host-gut microbiome *** commensals have shown different functions in IBD prevention and *** gain a mechanistic understanding of how different commensals affect intestinal inflammation,we compared the protective effects of 6 probiotics(belonging to the genera Akkermansia,Bifidobacterium,Clostridium,and Enterococcus)on dextran sulfate sodium(DSS)-induced colitis in mice with or without gut ***-inflammatory properties(ratio of interleukin(IL)-10 and IL-12)of these strains were also evaluated in an in vitro mesenteric lymph nodes(MLN)co-culture *** showed that 4 probiotics(belonging to the species Bifidobacterium breve,Bifidobacterium bifidum,and Enterococcus faecalis)can alleviate colitis in normal *** probiotic strains differed in regulating the intestinal microbiota,cytokines(IL-10,IL-1βand interferon(IFN)-γ),and tight junction function(Zonulin-1 and Occludin).By constrast,Akkermansia muciniphila AH39 and Clostridium butyricum FHuNHHMY49T1 were not ***,*** JSNJJNM2 with high anti-inflammatory potential in the MLN model could relieve colitis symptoms in antibiotic cocktail(Abx)-treated ***,*** FJSWX25M1induced low levels of cytokines in vitro and showed no beneficial ***,we provided insight into the clinical application of probiotics in IBD treatment.

关键词： Gut commensals Dextran sulfate sodium(DSS)colitis Intestinal barrier Immunoregulation

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Alleviative effects of Bacillus coagulans strains on irritable bowel syndrome-unraveling strain specificity through physiological and genomic analysis

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food Science and Human Wellness 2024年第4期13卷 1845-1855页

作者： Jiang Cao Leilei Yu Jianxin Zhao Hao Zhang Wei Chen Yuzheng Xue Qixiao Zhai State Key Laboratory of food Science and Technology Jiangnan UniversityWuxi 214122China School of food Science and Technology Jiangnan UniversityWuxi 214122China national engineering research center for functional food Jiangnan UniversityWuxi 214122China Wuxi Translational Medicine research center and Jiangsu Translational Medicine research Institute Wuxi Branch Wuxi 214122China Department of Gastroenterology Affiliated Hospital of Jiangnan UniversityWuxi 214122China

The high intraspecies heterogeneity of Baciillus coagulans leads to significant phenotypic differences among different ***,6 *** strains were tested in the present study using an irritable bowel syndrome(IBS)animal model to determine whether the IBS-alleviating effects of *** strains are *** results of this study showed that the ingestion of *** GBI-30,6086,and *** CCFM1041 significantly alleviated IBS symptoms in *** contrast,other *** strains showed no or limited alleviating effects on IBS *** to our experimental results,the two main common features of these strains were as follows:1)The resistance of vegetative cells to bile salts,and 2)ability to synthesize specific lipids and secondary *** strains based on these two indicators may greatly reduce costs and provide a basis for mining new functional *** *** results also suggest that administration of *** could significantly regulate microbiota dysbiosis in animal ***,the close relationships between the gut microbiota,gut microbiota metabolites,and IBS were further confirmed in this study.

关键词： Baciillus coagulans Irritable bowel syndrome Resistance to bile salts Comparative genomic analysis Gut microbiota

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Lactobacillus plantarum CCFM1180 attenuates obesity induced by estrogen deficiency by activating estrogen receptor alpha in abdominal adipose tissue and regulating gut microbiota-derived metabolites

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food Science and Human Wellness 2024年第2期13卷 765-777页

作者： Qian Chen Chunxia Mei Min Guo Botao Wang Haiqin Chen Jianxin Zhao Gang Wang Wei Chen State Key Laboratory of food Science and Resources Jiangnan UniversityWuxi 214122China School of food Science and Technology Jiangnan UniversityWuxi 214122China national engineering research center for functional food Jiangnan UniversityWuxi 214122China (Yangzhou)Institute of food Biotechnology Jiangnan UniversityYangzhou 225004China Bloomage Biotechnology Co. Ltd.Jinan 250000China

Lipid metabolism disorders commonly occur during *** deficiency has been shown to lead to excessive energy intake and abnormal lipid metabolism in ovariectomized rats,resulting in *** exhibit anti-obesity properties,and their underlying mechanism has been widely *** this study,we demonstrated the metabolic benefits of Lactobacillus plantarum CCFM1180 in suppressing appetite,controlling body weight,correcting obesity-induced abnormalities,enhancing liver lipid metabolism,and protecting liver function in estrogen-deficient *** mechanisms associated with the anti-obesity and anti-dyslipidemia effects of CCFM1180 on estrogen-deficient rats were *** results showed that CCFM1180 dramatically reduced food intake by activating the expression of estrogen receptor alpha(ERα)and increasing the level of leptin in abdominal adipose *** changes,combined with the increased butyrate concentration and recovered bile acid structure,helped enhance lipid ***,CCFM1180 treatment was found to be safer than exogenous estrogen ***,*** CCFM1180 could be considered a new therapeutic strategy for preventing and alleviating menopausal lipid abnormalities.

关键词： Bile acid Gut microbiota Menopause Ovariectomy Short chain fatty acid

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2’-Fucosyllactose alleviate immune checkpoint blockade-associated colitis by reshaping gut microbiota and activating AHR pathway

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food Science and Human Wellness 2024年第5期13卷 2543-2561页

作者： Shikai Yan Leilei Yu Fengwei Tian Jianxin Zhao Wei Chen Qixiao Zhai State Key Laboratory of food Science and Technology Jiangnan UniversityWuxi 214122China School of food Science and Technology Jiangnan UniversityWuxi 214122China national engineering research center for functional food Jiangnan UniversityWuxi 214122China

Immune checkpoint blockade(ICB)therapeutics are highly effective in cancer immunotherapy,but gastrointestinal toxicity limited the *** microbiota plays a crucial role in ICB-associated colitis.2’-Fucosyllactose(2’FL)is most abundance prebiotic in human milk that can reshape gut microbiota and exert immune regulatory *** study aimed to determine the effects of 2’FL on ICB-associated colitis and to uncover the mediating ***-associated colitis was induced by the ipilimumab and dextran sulfate *** administration of 2’FL(0.6 g/(kg∙day))ameliorated ICB-induced colitis by enhancing regulatory T cells(Treg)and the M2/M1 ratio of macrophages in colon.2’FL treatment also increased the expression of tight junction proteins(zonula occludens-1(ZO-1)and mucin 2(MUC2))and antioxidant stress indicators(superoxide dismutase(SOD)and catalase(CAT)).In addition,administration of 2’FL increased the abundance of Bifidobacterium and Lactobacillus,and elevated the levels of microbial metabolites,such as indole-3-lactic acid(ILA),which activated the aryl hydrocarbon receptor ligands(AHR)*** protective effect of 2’FL was abolished upon depletion of gut microbiota,and ILA treatment partially simulated the protective effect of 2’***,2’FL did not exhibit inhibition of antitumor *** findings suggest that 2’FL could serve as a potential protective strategy for ICB-associated colitis by modulating the intestinal microbiota and bacterial metabolites.

关键词： 2’-Fucosyllactose Immune checkpoint blockade-associated colitis Gut microbiota Metabolomics Regulatory T cells(Treg)

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Diet mediates the gut microbiome composition and assembly processes in infant and toddler populations

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food Science and Human Wellness 2024年

作者： Shumin Wang Leilei Yu Fengwei Tian Wei Chen Qixiao Zhai State Key Laboratory of food Science and Resources， jiangnan university School of food Science and Technology， jiangnan university national engineering research center for functional food， jiangnan university

Infancy and toddlerhood are critical phases of life， as the gut microbiota is established here， which influences current and future health. During this period， the microbiota was relatively less stable and highly responsive to environmental factors. Therefore， it is important to understand how dietary factors affect this complex stage of microbial assembly. The effect of feeding practices (breast milk/formula) on microbial colonization in early infancy has been actively studied; however， studies on the effect of diet on the gut microbiota during the complementary feeding period are sparse. The introduction of complementary foods provides abundant new dietary compounds for the gut microbiota， which induces a shift in gut microbiota and metabolism from milk-adapted toward a more mature and diverse adult-like community. Herein， we discuss the impact of dietary nutrients (carbohydrates， proteins， fats， vitamins， and minerals) on microbiome of infants and toddlers. Furthermore， this review summarizes the effects of complementary feeding patterns， specific foods (such as cereals; legumes and nuts; vegetables and fruits; meats; dairy products)， food additives， and malnutrition (undernutrition or overnutrition) on gut microbiota of this populations. These findings might deepen our comprehension of the complex interactions between diets and the development and establishment of the gut microbiota. This may facilitate the tailoring of interventions aimed at promoting beneficial modifications within the gut microbial community. Furthermore， the insights gained could inform the design and implementation of safe and efficacious complementary feeding practices.

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Lactobacillus acidophilus FCQHC4L1 strengthens the intestinal mucus barrier and inhibits endoplasmic reticulum stress

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food Science and Human Wellness 2024年

作者： Yuli Qi Leilei Yu Fengwei Tian Wei Chen Xiaoming Liu Qixiao Zhai State Key Laboratory of food Science and Technology， jiangnan university national engineering research center for functional food， jiangnan university School of food Science and Technology， jiangnan university

Mucin 2 (MUC2) is a critical component of the intestinal mucus barrier. Lactic acid bacteria (LAB) strains can improve mucosal homeostasis. In this study， we determined the expression of Muc2 induced by dead bacteria and cell-free conditioned medium (CM) of 50 LAB strains in the human goblet cell line， LS174T. Dead bacteria or CM of LAB affected the Muc2 expression in a species- and strain-specific manner under homeostasis. Next， LAB strains with different regulatory abilities were selected， gavaged into mice， and exposed to dextran sodium sulfate (DSS) after 1 week. Different LAB strains inhibited intestinal injury to different degrees， with Lactobacillus acidophilus FCQHC4L1 exerting the most potent effect. FCQHC4L1 significantly decreased the secretion of pro-inflammatory factors， promoted the expression and secretion of mucin， and inhibited colitis development. This strain also regulated the gut microbiota and increased the secretion of butyric acid. Moreover， CM of FCQHC4L1 inhibited endoplasmic reticulum (ER) stress and ameliorated the abnormal expression of MUC2 by suppressing the activation of the GRP78/ATF6 and GRP78/IRE1/XBP1 signaling pathways. Our results highlight the potential of FCQHC4L1 as a therapeutic agent for strengthening the mucus barrier and improving the gut health.

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