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Semiconductor Science and Information Devices 2019年第2期1卷 11-18页

作者： Ashish Kumar Wen-Hsi Lee Department of Electrical Engineering National Cheng Kung UniversityTaiwan

In this study,we fabricate Si/SiGe core-shell Junctionless accumulation mode(JAM)FinFET devices through a rapid and novel process with four main steps,i.e.e-beam lithography definition,sputter deposition,alloy combination annealing,and chemical solution *** height of Si core is 30 nm and the thickness of Si/SiGe core-shell is about 2 *** finishing the fabrication of devices,we widely studied the electrical characteristics of poly Si/SiGe core-shell JAM FinFET transistors from a view of different Lg and Wch.A poly-Si/SiGe core-shell JAMFETs was successfully demonstrated and it also exhibits a superior subthreshold swing of 81mV/dec and high on/off ratio>10^5 when annealing for 1hr at 600℃.The thermal diffusion process condition for this study are 1hr at 600℃ and 6hr at 700℃ for *** annealing condition at 700oC for 6 hours shows undesired electrical characteristics against the *** suggests that from over thermal budget causes a plenty of Ge to precipitate against to form SiGe thin *** JAMFETs at low temperature shows outstanding Subthreshold swing and better swing condition when compared to its counterpart *** higher *** new process can still fabricate a comparable performance to classical planar FinFET in driving current.

关键词： Junctionless-accumulation(JAM)FET Junctionless(JL)FET SiGe core-shell Rapid thermal anneal Subthreshold swing(SS)

Interleukin-1β is a potential therapeutic target for periodontitis: a narrative review

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International Journal of Oral Science 2020年第1期12卷 1-9页

作者： Ran cheng Zhiwu Wu Mingming Li Meiying Shao Tao Hu State Key Laboratory of Oral Diseases&national Clinical Research Center for Oral Diseases&West China Hospital of Stomatology Sichuan UniversityChengduChina West China School of Public Health and West China Fourth Hospital Sichuan UniversityChengduChina

Interleukin(IL)-1β, a pro-inflammatory cytokine, was elevated and participates in periodontitis. Not only the link between IL-1β and periodontitis was proved by clinical evidence, but also the increased IL-1β triggers a series of inflammatory reactions and promotes bone resorption. Currently, IL-1β blockage has been therapeutic strategies for autoimmune and autoinflammatory diseases such as rheumatoid arthritis, cryopyrin-associated periodic syndromes, gout and type II diabetes mellitus. It is speculated that IL-1β be a potential therapeutic target for periodontitis. The review focuses on the production, mechanism, present treatments and future potential strategies for IL-1β in periodontitis.

关键词： Interleukin therapeutic period

Stable classi?cation with limited sample: transferring a 30-m resolution sample set collected in 2015 to mapping 10-m resolution global land cover in 2017

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Science Bulletin 2019年第6期64卷 370-373页

作者： Peng Gong Han Liu Meinan Zhang Congcong Li Jie Wang Huabing Huang Nicholas Clinton Luyan Ji Wenyu Li Yuqi Bai Bin Chen Bing Xu Zhiliang Zhu Cui Yuan Hoi Ping Suen Jing Guo Nan Xu Weijia Li Yuanyuan Zhao Jun Yang Chaoqing Yu Xi Wang Haohuan Fu Le Yu Iryna Dronova Fengming Hui Xiao cheng Xueli Shi Fengjin Xiao Qiufeng Liu Lianchun Song Ministry of Education Key Laboratory for Earth System Modeling Department of Earth System Science Tsinghua University AI for Earth Lab Cross-Strait Institute Tsinghua University Department of Environmental Science Policy and Management University of CaliforniaBerkeley State Key Laboratory of Remote Sensing Science Institute of Remote Sensing and Digital Earth Chinese Academy of Sciences Google LLC Institute of Electronics Chinese Academy of Sciences United States Geological Survey national Supercomputing Center in Wuxi Department of Landscape Architecture University of CaliforniaBerkeley State Key Laboratory of Remote Sensing Science College of Global Change and Earth System Science Beijing Normal University national Climate Center China Meteorological Administration

As the world strives to reduce the impact of population growth, urbanization, agricultural expansion, and climate change on food security, energy and water shortage, resource over-exploration, biodiversity loss, environmental pollution, and ultimately human health, timely and higher resolution land cover information is urgently needed to achieve the sustainable development goals of the United Nations.

关键词： the world strives to reduce timely and higher resolution information is urgently needed

A novel gene-activated matrix composed of PEI/plasmid-BMP2 complexes and hydroxyapatite/chitosan-microspheres promotes bone regeneration

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Nano Research 2022年第7期15卷 6348-6360页

作者： Ruyuan Ding Yajun Liu Dawei cheng Gang Yang Wenjing Wu Haoran Du Xin Jin Yihan Chen Yuanyin Wang Boon Chin HENG Qing Yang Jianguang XU Key Lab.of Oral Diseases Research of Anhui Province College&Hospital of StomatologyAnhui Medical UniversityHefei 230032China Central Laboratory Peking University School and Hospital of StomatologyBeijing 100081China School of Medical and Life Sciences Sunway UniversitySelangor Darul EhsanMalaysia Department of Orthopaedics The First Affiliated Hospital of Anhui Medical UniversityAnhui Medical UniversityHefei 230032China Department of Chemistry and Laboratory of Nanomaterials for Energy Conversion(LNEC)University of Science and Technology of China(USTC)Hefei 230026China

The incorporation of pro-osteogenic growth factors into bone graft materials to enhance bone regeneration is a key research area within the field of bone tissue engineering and regenerative ***,growth factors directly incorporated in protein form are easily degraded,and have a limited active half-life,which cannot exert long-term and stable osteoinductive and oteoconductive *** combination of gene therapy and tissue engineering through gene-activated matrix(GAM)may provide a good alternative solution to overcome such *** materials can be combined together with plasmid DNA and a chemical-based transfection agent to form GAM,through which transfected cells could secrete growth factors in a sustained manner over a longer time duration;thereby enabling bone graft materials to act as a repository of therapeutic genes,while providing structural support and a scaffold matrix for new bone tissue *** this study,we prepared hydroxyapatite/chitosan-microspheres(HA/CS-MS)with microfabrication technology and emulsification method,and loaded the polyethylene imine/bone morphogenetic protein 2 plasmid(PEI/pBMP2)complexes with high transfection capacity(transfection efficiency up to 54.79%±4.95%),thus forming a novel GAM system with superior bone regeneration capacity—PEI/pBMP2-HA/*** in vitro experiments in this study demonstrated that our GAM had excellent biocompatibility(with cell viability over 95%),and that the as-fabricated microsphere material possessed a nano-network fibrous structure similar to natural extracellular matrix(ECM),together with a higher surface area that can provide more cell adhesion *** sizes of the prepared microspheres were mainly distributed in the 160–180μm range,while the maximal loading rate of PEI-pBMP2 complexes was 59.79%±1.85%.As a loaded complexes system,the GAM can release plasmids in a slow controlled manner,effectively transfecting surrounding target cells(release effect for up to 21 d

关键词： BMP2 chitosan gene therapy nanoparticle regeneration microsphere

Histone deacetylase inhibitor promotes differentiation of embryonic stem cells into neural cells in adherent monoculture

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Chinese Medical Journal 2010年第6期123卷 734-738页

作者： YAO Xing ZHANG Jia-rong HUANG Hua-rong DAI Li-cheng LIU Qing-jun ZHANG Ming Department of Hepatopancreatobilary Surgery Huzhon Central Hospital Huzhou Zhejiang 313000 China College of Life Science Zhejiang University Hangzhou Zhejiang 310058 China Biosensor national Special Laboratory Department of Biomedical Engineering Zhejiang University Hangzhou Zhejiang 310027 China

Background Embryonic stem （ES） cells poss unlimited self-renewal capacity and the ability to differentiate into cell of all three germ layers in vitro. Induced differentiation of ES cells to neural lineage cells has great potential in basic study of neurogenesis and regeneration therapy of neurodegenerative diseases. Histone deacetylase （HDAC） inhibitors enhance histone acetylation so that globularly activate gene expression and may initiate multilineage differentiation. In this study,we aimed to develop a method to induce the differentiation of ES cells to neural cells combining HDAC inhibition and neural *** In this study, we used HDAC inhibitor sodium butyrate （NAB） to induce the differentiation of mouse embryonic stem cells to neural cells through monolayer culture. After differentiation initiation by histone deacetylase inhibitor sodium butyrate, neural cells were induced and selected with a serum free culture system. Results Homogeneous neurons without glial cells demonstrated by molecular marker expression were differentiated with the method. The resultant neurons were excitable. Conclusion The method combined differentiation induction effect of HDAC inhibitors and selective culture system to derive neural cells from ES cells, and implied the involvement of epigenetic regulation in neural differentiation.

关键词： embryonic stem cells histone deacetylase inhibitor neural differentiation adherent monoculture

A Comparison of Methods to Verify Energy-Saving Benefits for Chillers

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Open Journal of Applied Sciences 2013年第1期3卷 44-49页

作者： Yung-chung Chang Chao-Yuan Chen Jyun-Ting Lu Tien-Shun Chan Ching-Liang Chen Jin-Kwei Lee national Taipei university of Technology Taipei China

The simulation model for performance of chiller (ASHRAE model in this study) disclosed in ASHRAE Guideline 14 in 2002 is implemented in Taiwan to verify the efficiency of energy-saving methods adopted by energy service companies (ESCO). Since the accuracy of the simulation model for performance of chillers has influenced on the promotion of the ESCO business, the author used practical measurement data to compare the accuracy between the ASHRAE model and the commonly used energy consumption model of chillers (XY model in this study) and concluded that the XY model had much higher accuracy than the ASHRAE model.

关键词： Chiller ESCO COP Regression Analysis

A measurement error model for microarray data analysis

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Progress in Natural Science:Materials International 2005年第7期15卷 614-620页

作者： ZHOU Yiming and cheng Jing ( Department of Biological Sciences and Biotechnology, Tsinghua university, Beijing 100084, China State Key Laboratory of Biomembrane and Membrane Biotechnology, Tsinghua university, Beijing 100084, China national Engineering Research Center for Beijing Biochip Technology, 18 Life Science Parkway, Beijing 102206, China) Department of Biological Sciences and Biotechnology Tsinghua University Beijing 100084 China State Key Laboratory of Biomembrane and Membrane Biotechnology Tsinghua University Beijing 100084 China national Engineering Research Center for Beijing Biochip Technology 18 Life Science Parkway Beijing 102206 China

Microarray technology has been widely used to analyze the gene expression levels by detecting fluorescence intensity in a high throughput fashion. However, since the measurement error produced from various sources in microarray experiments is heterogeneous and too large to be ignored, we propose here a measurement error model for microarray data processing, by which the standard deviation of the measurement error is demonstrated to be linearly increased with fluorescence intensity. A robust algorithm, which estimates the parameters of the measurement error model from a single microarray without replicated spots, is provided. The model and algorithm for estimating of the parameters from a given data set are tested on both the real data set and the simulated data set, and the result has been proven satisfactory. And, combining the measurement error model with traditional Z-test method, a full statistical model has been developed It can significantly improve the statistical inference for identifying differentially expressed genes.

关键词： microarray measurement error model parameter estimation differentially expressed genes.

In-situ chemical conversion film for stabilizing zinc metal anodes

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Journal of Energy Chemistry 2022年第10期31卷 387-393,I0009页

作者： Hao Fu Qing Wen Pei-Yao Li Zhen-yu Wang Zhen-jiang He cheng Yan Jing Mao Kehua Dai Xia-hui Zhang Jun-chao Zheng School of Metallurgy and Environment Central South UniversityChangsha 410083HunanChina Engineering Research Center of the Ministry of Education for Advanced Battery Materials Central South UniversityChangsha 410083HunanChina School of Mechanical Medical and Process EngineeringQueensland University of TechnologyBrisbaneQueensland 4001Australia School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450001HenanChina College of Chemistry Tianjin Normal UniversityTianjin 300387China School of Mechanical and Materials Engineering Washington State UniversityPullmanWashington 99164United States

Zinc metal anodes face several challenges,including the uncontrolled formation of dendrites,hydrogen evolution,and corrosion,which seriously hinder their application in *** address the above problems such as dendrite formation and corrosion,we present a simple and applicable immersion method that enables in situ formation of a zinc phytate(PAZ)coating on the surface of commercial Zn flakes via a substitution *** protective coating mitigates corrosion of zinc flakes by the electrolyte,reduces the interfacial impedance,and accelerates the migration kinetics of zinc ***,this method can preferentially expose the(002)crystal plane with strong atomic bonding,which not only improves the corrosion resistance of the zinc flake,but can also guide the parallel deposition of zinc ions along the(002)crystal plane and reduce the formation of *** from the above advantages,the PAZ@Zn‖Cu half-cell has shown over 900 cycles with average coulombic efficiency(CE)of99.81%at 4 mA cm^(-2).Besides,the PAZ@Zn‖PAZ@Zn symmetric cell operate stably for>1000 h at5 mA cm^(-2)and>340 h at 10 mA cm^(-2).Furthermore,we demonstrated that this in situ chemical treatment enables the formation of a robust,well-bound protective *** method provides insights for advancing the commercialization of zinc anodes and other metal anodes.

关键词： Zinc anode Phytic acid Protective coating Dendrites Surface modification Corrosion resistance

Landau–Zener–Stückelberg Interference in Nonlinear Regime

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Chinese Physics Letters 2019年第12期36卷 36-39页

作者：吴桐周宇轩徐源刘松李剑 Department of Physics Harbin Institute of Technology Institute for Quantum Science and Engineering and Department of Physics Southern university of Science and Technology Shenzhen Key Laboratory of Quantum Science and Engineering Southern university of Science and Technology Center for Quantum Computing Peng cheng Laboratory

Landau-Zener-Stückelberg(LZS)interference has drawn renewed attention to quantum information processing research because it is not only an effective tool for characterizing two-level quantum systems but also a powerful approach to manipulate quantum *** quantum circuits,due to their versatile tunability and degrees of control,are ideal platforms for studying LZS interference *** use a superconducting Xmon qubit to study LZS interference by parametrically modulating the qubit transition frequency *** dc flux biasing of the qubit slightly far away from the optimal flux point,the qubit excited state population shows an interference pattern that is very similar to the standard LZS interference in linear regime,except that all bands shift towards lower frequencies when increasing the rf modulation *** dc flux biasing close to the optimal flux point,the negative sidebands and the positive sidebands behave differently,resulting in an asymmetric interference *** experimental results are also in good agreement with our analytical and numerical simulations.

关键词： bands quantum Landau

Microbial Gas in the Mohe Permafrost, Northeast China and its Significance to Gas Hydrate Accumulation in Permafrost across China

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Acta Geologica Sinica(English Edition) 2018年第6期92卷 2251-2266页

作者： ZHAO Xingmin SUN Youhong DENG Jian RAO Zhu Lü cheng SONG Jian Li Lixia Oil & Gas Survey China Geological SurveyBeijing 100029China Jilin university Changchun 130012China national Research Center of Geoanalysis Beijing 100037China China university of Petroleum-Bejing Beijing 102249China CNOOC Research Institute Beijing 100028China

The Mohe permafrost in northeast China possesses favorable subsurface ambient temperature, salinity, Eh values and pH levels of groundwater for the formation of microbial gas, and the Mohe Basin contains rich organic matter in the Middle Jurassic dark mudstones. This work conducted gas chromatography and isotope mass spectrometry analyses of nearly 90 core gas samples from the Mk-2 well in the Mohe Basin. The results show that the dryness coefficient(C1/C1–5) of core hydrocarbon gas from approximately 900 m intervals below the surface is larger than 98%, over 70% of the δ13 C values of methane are smaller than-55‰, and almost all δD values of methane are smaller than-250‰, indicative of a microbial origin of the gas from almost 900 m of the upper intervals in the Mohe permafrost. Moreover, the biomarker analyses of 72 mudstone samples from the Mohe area indicate that all of them contain 25-norhopane series compounds, thereby suggesting widely distributed microbial activities in the permafrost. This work has confirmed the prevailing existence of microbial gas in the Mohe area, which may be a potential gas source of gas hydrate formation in the Mohe permafrost. This result is of great significance to gas hydrate accumulation in the permafrost across China.

关键词： microbial gas gas hydrate accumulation permafrost oil and gas Mohe northeast China