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Application of Newcastle disease virus in the treatment of colorectal cancer

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World Journal of Clinical Cases 2019年第16期7卷 2143-2154页

作者： Hui Song Li-Ping Zhong Jian He Yong Huang Yong-Xiang Zhao national center for international research of Bio-targeting theranostics Guangxi Key Laboratory of Biotargeting Theranostics Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy Guangxi Medical University

Colorectal cancer (CRC) is one of the main reasons of tumor-related deaths *** present,the main treatment is surgery,but the results are unsatisfactory,and the prognosis is *** majority of patients die due to liver or lung metastasis or *** recent years,great progress has been made in the field of tumor gene therapy,providing a new treatment for combating *** oncolytic viruses selectively replicate almost exclusively in the cytoplasm of tumor cells and do not require integration into the host genome,they are safer,more effective and more attractive as oncolytic *** disease virus (NDV) is a natural RNA oncolytic *** NDV selectively infects tumor cells,the immune response induced by NDV’s envelope protein and intracellular factors can effectively kill the tumor without affecting normal *** genetic techniques make NDV a vector for gene *** the virus by inserting various exogenous genes or using NDV in combination with immunotherapy can also improve the anti-CRC capacity of NDV,and good results have been achieved in animal models and clinical treatment *** article reviews the molecular biological characteristics and oncolytic mechanism of NDV and discusses in vitro and in vivo experiments on NDV anti-CRC capacity and clinical *** conclusion,NDV is an excellent candidate for cancer treatment,but more preclinical studies and clinical trials are needed to ensure its safety and efficacy.

关键词： Newcastle disease virus Exogenous gene Armed virus Oncolytic therapy Colorectal cancer

Review:Development of SARS-CoV-2 immuno-enhanced COVID-19 vaccines with nano-platform

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Nano research 2022年第3期15卷 2196-2225页

作者： Nawamin Sa-nguanmoo Katawut Namdee Mattaka Khongkow Uracha Ruktanonchai YongXiang Zhao Xing-Jie Liang CAS center for Excellence in Nanoscience CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyNational Center for Nanoscience and Technology of ChinaBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China national Nanotechnology center(NANOTEC) National Science and Technology Development AgencyPathum Thani 12120Thailand national center for international research of biotargeting theranostics Guangxi Key Laboratory of Biotargeting TheranosticsCollaborative Innovation Center for Targeting Tumour Theranostics and TherapyGuangxi Medical UniversityNanning 530021China

Vaccination is the most effective way to prevent coronavirus disease 2019(COVID-19).Vaccine development approaches consist of viral vector vaccines,DNA vaccine,RNA vaccine,live attenuated virus,and recombinant proteins,which elicit a specific immune *** use of nanoparticles displaying antigen is one of the alternative approaches to conventional *** is due to the fact that nano-based vaccines are stable,able to target,form images,and offer an opportunity to enhance the immune *** diameters of ultrafine nanoparticles are in the range of 1–100 *** application of nanotechnology on vaccine design provides precise fabrication of nanomaterials with desirable properties and ability to eliminate undesirable *** be successful,nanomaterials must be uptaken into the cell,especially into the target and able to modulate cellular functions at the subcellular *** advantages of nano-based vaccines are the ability to protect a cargo such as RNA,DNA,protein,or synthesis substance and have enhanced stability in a broad range of pH,ambient temperatures,and humidity for long-term ***,nano-based vaccines can be engineered to overcome biological barriers such as nonspecific distribution in order to elicit functions in antigen presenting *** this review,we will summarize on the developing COVID-19 vaccine strategies and how the nanotechnology can enhance antigen presentation and strong immunogenicity using advanced technology in nanocarrier to deliver *** discussion about their safe,effective,and affordable vaccines to immunize against COVID-19 will be highlighted.

关键词： COVID-19 SARS-CoV-2 vaccine nanotechnology antigen presenting cells(APCs)

Averrhoa carambola extractive inhibits breast cancer via regulating CEPT1 and LYPLA1

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Chinese Chemical Letters 2023年第3期34卷 372-377页

作者： Xiaolin Zhang Xiuli Liu Luhui Qin Chao Tang Yu Huo Jinbin Wei Ming Chen Yutong Gao Xiaoping Zhang Yani Wu Yongxiang Zhao Renbin Huang Liping Zhong Bing Wang Pharmaceutical College Guangxi Medical UniversityNanning 530021China national center for international biotargeting theranostics Guangxi Key Laboratory of Biotargeting TheranosticsCollaborative Innovation Center for Targeting Tumor TheranosticsGuangxi Medical UniversityNanning 530021China Department of Spine Surgery The Second Xiangya Hospital of Central South UniversityChangsha 410011China

Liposomes have been widely exploited as a drug delivery system in treating tumors because of their advantage to enhance anti-tumor efficacy and reduce side effects. In this study, the tumor-targeted 2-dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione(DMDD, i.e., Averrhoa carambola extractive) liposomes(HA/TN-DLP) were conducted and assessed. HA/TN-DLP showed controllable drug loading(up to 83%)with high stability. In vitro and in vivo studies showed good cell uptake behavior and high inhibition rate of breast cancer compared to free DMDD. HA/TN-DLP might be the suitable for DMDD due to its better advantages in delivery, penetrability, and targeting-tumor capability. For in vivo mouse model tests,HA/TN-DLP effectively inhibited tumor growth compared to free DMDD. Further analyses indicated that HA/TN-DLP inhibited the glycerophospholipid metabolism pathway by reducing the biosynthesis of phosphatidylcholine and 1-acyl-sn-glycero-3-phosphocholine through regulating the expressions of CEPT1 and LYPLA1, and inhibited tumor cell growth by regulating the PI3K/Akt and NF-κ B signaling pathways. In conclusion, the obviously enhanced antitumor effect further demonstrated that HA/TN-DLP may be a promising tumor-targeting agent.

关键词： DMDD Breast cancer Transcriptomics Metabolomics PI3K/Akt pathway Glycerophospholipid metabolism pathway

Generation ofαGal-enhanced bifunctional tumor vaccine

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Acta Pharmaceutica Sinica B 2022年第7期12卷 3177-3186页

作者： Jian He Yu Huo Zhikun Zhang Yiqun Luo Xiuli Liu Qiaoying Chen Pan Wu Wei Shi Tao Wu Chao Tang Huixue Wang Lan Li Xiyu Liu Yong Huang Yongxiang Zhao Lu Gan Bing Wang Liping Zhong national center for international research of biotargeting theranostics Guangxi Key Laboratory of Biotargeting TheranosticsCollaborative Innovation Center for Targeting Tumor Diagnosis and TherapyGuangxi Talent Highland of Biotargeting TheranosticsGuangxi Medical UniversityNanning 530021China The First Affiliated Hospital Guangxi University of Chinese MedicineNanning 530023China The First People’s Hospital of Changde City Changde 415003China Department of Spine Surgery the Second Xiangya Hospital of Central South UniversityChangsha 410011China

Hepatocellular carcinoma(HCC)is a common malignant tumor with poor prognosis and high *** this study,we demonstrated a novel vaccine targeting HCC and tumor neovascular endothelial cells by fusing recombinant MHCC97H cells expressing porcine a-1,3-galactose epitopes(a Gal)and endorphin extracellular domains(END)with dendritic cells(DCs)from healthy ***^(+)/Gal^(+)-MHCC97H/DC fusion cells induced cytotoxic T lymphocytes(CTLs)and secretion of interferon-gamma(IFN-γ).CTLs targeted cells expressing a Gal and END and tumor *** fused cell vaccine can effectively inhibit tumor growth and prolong the survival time of human hepatoma mice,indicating the high clinical potential of this new cell based vaccine.

关键词： aGal Endoglin Dendritic cells Fusion cells Hepatocellular carcinoma Tumor neovascular endothelial cells Cytotoxic T lymphocytes Immunotherapy

Boron difluoride formazanate dye for high-efficiency NIR-Ⅱ fluorescence imaging-guided cancer photothermal therapy

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Chinese Chemical Letters 2022年第5期33卷 2501-2506页

作者： Hanming Dai Zijin Cheng Tian Zhang Weili Wang Jinjun Shao Wenjun Wang Yongxiang Zhao Xiaochen Dong Liping Zhong Key Laboratory of Flexible Electronics(KLOFE)&Institute of Advanced Materials(IAM) Nanjing Tech University(NanjingTech)Nanjing 211800China School of Physical Science and Information Technology Liaocheng UniversityLiaocheng 252059China national center for international biotargeting theranostics Guangxi Key Laboratory of Biotargeting TheranosticsCollaborative Innovation Center for Targeting Tumor TheranosticsGuangxi Medical UniversityNanning 530021China

The small molecular second near-infrared(NIR-Ⅱ, 1000–1700 nm) dye-based nanotheranostics can concurrently combine deep-tissue photodiagnosis with in situ phototherapy, which occupies a vital position in the early detection and precise treatment of tumors. However, the development of small molecular NIR-Ⅱ dyes is still challenging due to the limited electron acceptors and cumbersome synthetic ***, we report a novel molecular electron acceptor, boron difluoride formazanate(BDF). Based on BDF, a new small molecular NIR-Ⅱ dye BDF1005 is designed and synthesized with strong NIR-I absorption at 768 nm and bright NIR-Ⅱ peak emission at 1034 nm. In vitro and in vivo experiments demonstrate that BDF1005-based nanotheranostics can be applied for NIR-Ⅱ fluorescence imaging-guided photothermal therapy of 4T1 tumor-bearing mice. Under 808 nm laser irradiation, tumor growth can be effectively inhibited. This work opens up a new road for the exploitation of NIR-Ⅱ small molecular dyes for cancer phototheranostics.

关键词： NIR-II nanotheranostics Boron difluoride formazanate Fluorescence imaging Photothermal therapy Phototheranostics

Bamboo‑Inspired Gasotransmitter Microfibres for Wound Healing

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Advanced Fiber Materials 2023年第1期5卷 388-399页

作者： Cheng Zhao Jiahui Guo Han Zhang Min Nie Caihong Yang Yujuan Zhu Yuanjin Zhao Liping Zhong Department of Rheumatology and Immunology Institute of Translational MedicineThe Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210002China national center for international biotargeting theranostics Guangxi Key Laboratory of Biotargeting TheranosticsCollaborative Innovation Center for Targeting Tumour TheranosticsGuangxi Medical UniversityGuangxi 530021China State Key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China

Diabetic wounds have become a major clinical problem that cannot be ***,such as hydrogen sulphide(H_(2)S),have demonstrated value in inducing angiogenesis and accelerating wound healing,while their effective delivery is still ***,inspired by the continuous-independent hollow structure of bamboo,we propose novel gasotransmitter microfibres with septal H_(2)S bubbles using microfluidic spinning for diabetic wound *** from the exact control of microfluidics,gasotransmitter microfibres with different bubble sizes and morphologies could be generated successfully and *** the dual effects of drugs in the shell and gas in the core,the wound healing process could be ***,the controllable release of drugs could be achieved by adding responsive materials into the microfiber shell,which would promote continuous effects of contents on *** on in vitro and in vivo stud-ies,we have proven that these gasotransmitter microfibres have a positive impact on inducing angiogenesis and promoting cell proliferation during wound ***,it is believed that the bamboo-inspired gasotransmitter microfibres will have important value in gasotransmitter research and clinical applications.

关键词： Microfluidics Hydrogel Wound healing Bioinspired Gasotransmitter

POD Nanozyme optimized by charge separation engineering for light/pH activated bacteria catalytic/photodynamic therapy

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Signal Transduction and Targeted Therapy 2022年第4期7卷 1334-1342页

作者： Changyu Cao Tingbo Zhang Nan Yang Xianghong Niu Zhaobo Zhou Jinlan Wang Dongliang Yang Peng Chen Liping Zhong Xiaochen Dong Yongxiang Zhao Key Laboratory of Flexible Electronics(KLOFE)and Institute of Advanced Materials(IAM) School of Physical and Mathematical SciencesNanjing Tech University(NanjingTech)Nanjing 211816China School of Physics Southeast UniversityNanjing 211189China School of Chemical and Biomedical Engineering Nanyang Technological University62 Nanyang DriveSingapore 637459Singapore national center for international biotargeting theranostics Guangxi Key Laboratory of Biotargeting TheranosticsCollaborative Innovation Center for Targeting Tumor TheranosticsGuangxi Medical UniversityNanningGuangxi 530021China

The current feasibility of nanocatalysts in clinical anti-infection therapy,especially for drug-resistant bacteria infection is extremely restrained because of the insufficient reactive oxygen ***,a novel Ag/Bi2MoO6(Ag/BMO)nanozyme optimized by charge separation engineering with photoactivated sustainable peroxidase-mimicking activities and NIR-II photodynamic performance was synthesized by solvothermal reaction and *** Ag/BMO nanozyme held satisfactory bactericidal performance against methicillin-resistant Staphylococcus aureus(MRSA)(~99.9%).The excellent antibacterial performance of Ag/BMO NPs was ascribed to the corporation of peroxidase-like activity,NIR-II photodynamic behavior,and acidity-enhanced release of Ag^(+).As revealed by theoretical calculations,the introduction of Ag to BMO made it easier to separate photo-triggered electronhole pairs for ROS *** the conduction and valence band potentials of Ag/BMO NPs were favorable for the reduction of O_(2) to·O_(2)^(−).Under 1064 nm laser irradiation,the electron transfer to BMO was beneficial to the reversible change of Mo^(5+)/Mo^(6+),further improving the peroxidase-like catalytic activity and NIR-II photodynamic performance based on the Russell *** vivo,the Ag/BMO NPs exhibited promising therapeutic effects towards MRSA-infected *** study enriches the nanozyme research and proves that nanozymes can be rationally optimized by charge separation engineering strategy.

关键词： mechanism. separation charge

MyD88 in macrophages protects against colitis via inhibiting the activation of NLRP3 inflammasome in epithelial cells

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Genes & Diseases 2023年第2期10卷 344-347页

作者： Shi Liu Yanmin Wu Haiqiang Chen Qi Yuan Shuang Ge Lishu Zhang Lingling Hou Tian Tian Jinhua Zhang College of Life Science and Bioengineering Beijing Jiaotong UniversityBeijing 100044China national center for international research of Bio-targeting theranostics Guangxi Key Laboratory of Bio-targeting TheranosticsCollaborative Innovation Center for Targeting Tumor Diagnosis and TherapyGuangxi Talent Highland of Bio-targeting TheranosticsGuangxi Medical UniversityNanningGuangxi 530021China

The signal adaptor myeloid differentiation primary response 88(MyD88)of Toll-like receptor(TLR)signaling is universally expressed in immune cells and non-immune cells,and myeloid cells play a significant role in modulating *** are myeloid lineage cells which is important for maintaining intestinal homeostasis in inflammation.1 And macrophages can recognize invading pathogens through pattern recognition receptors(PRRs),such as TLRs and the nucleotide oligomerization domain(NOD)-like receptor family,pyrin domain-containing 3(NLRP3),and quickly infiltrate the injured site leading to inflammation.2 MyD88 expression in myeloid cells can rescue the intestinal injury induced by dextran sulfate sodium(DSS)in murine ***,the mechanism whereby MyD88 works in myeloid cells and influence the progress of the disease remain *** this study,we used DSS induced colitis mouse model and found Lysm-cre-MyD88fl/fl(MyD88ΔМΦ)mice were more susceptible to *** deficiency of MyD88 leads to up-regulation of S100A8,which activate NLRP3 inflammasome and their associated pyroptosis in intestinal epithelial cells in a RAGE dependent ***,MyD88 signaling in macrophages,which is necessary to maintain intestinal homeostasis,crucially prevents the development of *** results may shed new lights on potential targets that can be applied in colitis therapy.

关键词： NLRP3 colitis homeostasis

Aptamers targeting SARS-CoV-2 nucleocapsid protein exhibit potential ant1ip1 an-coronavirus activity

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Signal Transduction and Targeted Therapy 2024年第3期9卷 1186-1198页

作者： Minghui Yang Chunhui Li Guoguo Ye Chenguang Shen Huiping Shi Liping Zhong Yuxin Tian Mengyuan Zhao Pengfei Wu Abid Hussain Tian Zhang Haiyin Yang Jun Yang Yuhua Weng Xinyue Liu Zhimin Wang Lu Gan Qianyu Zhang Yingxia Liu Ge Yang Yuanyu Huang Yongxiang Zhao School of Life Science Advanced Research Institute of Multidisciplinary ScienceKey Laboratory of Molecular Medicine and BiotherapyBeijing Institute of TechnologyBeijing 100081China national Clinical research center for infectious disease Shenzhen Third People’s HospitalSecond Hospital Affiliated to Southern University of Science and TechnologyShenzhen 518112China Guangdong Provincial Key Laboratory of Tropical Disease research School of Public HealthSouthern Medical UniversityGuangzhou 510515China State Key Laboratory of Targeting Oncology National Center for International Research of Biotargeting TheranosticsGuangxi Key Laboratory of Biotargeting TheranosticsCollaborative Innovation Center for Targeting Tumor Diagnosis and TherapyGuangxi Medical UniversityNanning 530021China CAMS Key Laboratory of Antiviral Drug research Beijing Key Laboratory of Antimicrobial AgentsInstitute of Medicinal BiotechnologyChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China

Emerging and recurrent infectious diseases caused by human coronaviruses(HCoVs)continue to pose a significant threat to global public health *** light of this ongoing threat,the development of a broad-spectrum drug to combat HCoVs is an urgently ***,we report a series of anti-pan-coronavirus ssDNA aptamers screened using Systematic Evolution of Ligands by Exponential Enrichment(SELEX).These aptamers have nanomolar affinity with the nucleocapsid protein(NP)of Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and also show excellent binding efficiency to the N proteins of both SARS,MERS,HCoV-OC43 and-NL63 with affinity KD values of 1.31 to 135.36 *** aptamer-based therapeutics exhibited potent antiviral activity against both the authentic SARS-CoV-2 prototype strain and the Omicron variant(BA.5)with EC50 values at 2.00 nM and 41.08 nM,*** protein docking analysis also evidenced that these aptamers exhibit strong affinities for N proteins of pan-coronavirus and other HCoVs(−229E and-HKU1).In conclusion,we have identified six aptamers with a high pan-coronavirus antiviral activity,which could potentially serve as an effective strategy for preventing infections by unknown coronaviruses and addressing the ongoing global health threat.

关键词： acute threat conclusion