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Coiled-coil domain-containing 38 is required for acrosome biogenesis and fibrous sheath assembly in mice

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Journal of Genetics and Genomics 2024年第4期51卷 407-418页

作者： Yaling Wang Xueying Huang Guoying Sun Jingwen Chen Bangguo Wu Jiahui Luo Shuyan Tang Peng Dai Feng Zhang Jinsong Li Lingbo Wang Shanghai Key Laboratory of Metabolic Remodeling and Health Institute of Metabolism and Integrative BiologyFudan UniversityShanghai 200438China Institute of Reproduction and Development Obstetrics and Gynecology HospitalFudan UniversityShanghai 200011China Shanghai Key Laboratory of Maternal and Fetal Medicine Clinical and Translational Research Center of Shanghai First Maternity and Infant HospitalFrontier Science Center for Stem Cell ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China State Key Laboratory of cell Biology CAS Center for Excellence in Molecular Cell ScienceShanghai Institute of Biochemistry and Cell BiologyChinese Academy of SciencesShanghai 200031China

During spermiogenesis,haploid spermatids undergo dramatic morphological changes to form slender sperm flagella and cap-like acrosomes,which are required for successful *** deformities in flagella cause a male infertility syndrome,multiple morphological abnormalities of the flagella(MMAF),while acrosomal hypoplasia in some cases leads to sub-optimal embryonic developmental ***,evidence regarding the occurrence of acrosomal hypoplasia in MMAF is ***,we report the generation of base-edited mice knocked out for coiled-coil domain-containing 38(Ccdc38)via inducing a nonsense mutation and find that the males are *** Ccdc38-KO sperm display acrosomal hypoplasia and typical MMAF *** find that the acrosomal membrane is loosely anchored to the nucleus and fibrous sheaths are disorganized in Ccdc38-KO *** analyses reveal that Ccdc38 knockout causes a decreased level of TEKT3,a protein associated with acrosome biogenesis,in testes and an aberrant distribution of TEKT3 in *** finally show that intracytoplasmic sperm injection overcomes Ccdc38-related *** study thus reveals a previously unknown role for CCDC38 in acrosome biogenesis and provides additional evidence for the occurrence of acrosomal hypoplasia in MMAF.

关键词： Acrosomal hypoplasia Multiple morphological abnormalities of the flagella(MMAF) Infertility Sperm motility Asthenoteratozoospermia Disease modeling

Microstructure evolution and strengthening mechanism of high -performance powder metallurgy TA15 titanium alloy by hot rolling

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International Journal of Minerals,Metallurgy and Materials 2024年第6期31卷 1426-1436页

作者： Ying Gao Ce Zhang Jiazhen Zhang Xin Lu Beijing Advanced Innovation center for Materials Genome Engineering State Key Laboratory for Advanced Metals and MaterialsInstitute for Advanced Ma-terials and TechnologyUniversity of Science and Technology BeijingBeijing 100083China national Engineering Research center for Advanced Rolling Technology National Engineering Research Center for Flat Rolling EquipmentInstitute of Engin-eering TechnologyUniversity of Science and Technology BeijingBeijing 100083China

Hot deformation of sintered billets by powder metallurgy(PM)is an effective preparation technique for titanium alloys,which is more significant for high-alloying *** this study,Ti–6.5Al–2Zr–Mo–V(TA15)titanium alloy plates were prepared by cold press-ing sintering combined with high-temperature hot *** microstructure and mechanical properties under different process paramet-ers were *** microscope,electron backscatter diffraction,and others were applied to characterize the microstructure evolution and mechanical properties strengthening *** results showed that the chemical compositions were uniformly dif-fused without segregation during sintering,and the closing of the matrix craters was accelerated by increasing the sintering *** block was hot rolled at 1200℃ with an 80%reduction under only two passes without *** strength and elongation of the plate at 20–25℃ after solution and aging were 1247 MPa and 14.0%,respectively,which were increased by 24.5%and 40.0%,respect-ively,compared with the as-sintered alloy at 1300℃.The microstructure was significantly refined by continuous dynamic recrystalliza-tion,which was completed by the rotation and dislocation absorption of the substructure surrounded by low-angle grain *** hot rolling combined with heat treatment,the strength and plasticity of PM-TA15 were significantly improved,which resulted from the dense,uniform,and fine recrystallization structure and the synergistic effect of multiple slip systems.

关键词： elemental powder powder metallurgy titanium alloy hot rolling strength and plasticity

Monophase-homointerface electrodes intrinsically stabilize high-voltage all-solid-state batteries

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science China Chemistry 2024年第5期67卷 1729-1739页

作者： Xiaolin Xiong Xianguo Ma Tianshi Lv Liquan Chen Liumin Suo Beijing national Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of ScienceBeijing 100190China center of Materials science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China

The electrochemical stability and contact reliability of heterointerfaces between the solid electrolyte(SE) and electrode are critical for all-solid-state batteries(ASSBs), particularly much more challenging for high-voltage ASSBs, owing to the limited thermodynamically electrochemical window and mechanical inflexibility of SE, aggravating interfacial side reactions and contact failure. Considering all those issues originating from intrinsic heterogeneity in physicochemical features between the cathode material and SE, we are thinking about simplifying the heterointerfaces into a homointerface as a permanent cure to solve all electrochemical-mechanical interfacial failure. Herein, we propose monophase cathodes to construct thermodynamically stable all-in-one homointerfaces in ASS electrodes, removing unstable heterointerfaces by excluding SEs and intrinsically eliminating the Li chemical potential gap to avoid the formation of lithium-depleted space-charge layer and highly resistive mixed ion–electron conductor interphase. Our conception is successfully validated in the layered transition-metal oxide cathodes, which display outstanding stability no matter the MH-LiCoO_(2) cathode charging to 4.7 V or MH-Li_(1.2)Mn_(0.54)Ni_(0.13)-Co_(0.13)O_(2) cathode charging to 5.3 V. It is undeniable that our current version of above-illustrated MH-cathodes would bring out some new challenges for the practical application due to abandoning the SE. However, we believe our work also offers a brandnew direction to ultimately address the electrochemical–mechanical interfacial issues that would be promising for high-energy ASSBs with more discoveries of advanced monophase cathodes in the future.

关键词： monophase-homointerface electrode high-voltage all-solid-state batteries electrochemical-mechanical interfacial issue

Study of factors influencing the occurrence rate of 60 Hz power line radiation in the topside ionosphere:A systematic survey using the CSES satellite

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science China(Technological sciences) 2024年第6期67卷 1879-1892页

作者： MA ZhenHui ZHAO ShuFan LIAO Li SHEN XuHui LU HengXin School of Emergency Management science and Engineering University of Chinese Academy of SciencesBeijing100049China State Key Laboratory of Space Weather National Space Science CenterChinese Academy of SciencesBeijing100190China Key Laboratory of Solar Activity and Space Weather National Space Science CenterChinese Academy of SciencesBeijing100190China national Institute of Natural Hazards Ministry of Emergency Management of ChinaBeijing100085China Institute of Geophysics China Earthquake AdministrationBeijing100081China

We analyze the topside ionosphere power line radiation(PLR)at 60 Hz over the US using electric field data collected by CSES satellite between January 2019 and December *** study aimed to further investigate the month-to-month variation characteristic of PLR occurrence rate observed by satellite and its several influencing factors,including solar radiation,lightning activity,and try to clarify the influence of electricity *** results show that the solar radiation(solar zenith angle and F10.7)plays a major role in the variation of the PLR occurrence rate,and that there is no direct connection with the number of *** the relationship between PLR occurrence rate and electricity consumption,the low occurrence rate associated with decreased weekend electricity consumption was not observed in the ***,there is a significant difference in PLR occurrence rate between the East and West Coasts of the US at the same latitude during the same time period,suggesting that the significant difference in PLR occurrence rate is caused by the significant difference in electricity consumption between the two *** excluding the effect of solar radiation on PLR occurrence rate,we concluded that only a significant difference in regional electricity consumption could lead to a corresponding change in PLR occurrence rate detected by the Low-Earth-Orbit ***,we also found there is seasonal variation in the diurnal differences of the PLR occurrence rate caused by seasonal variation of the lower ionosphere.

关键词： CSES satellite power line radiation occurrence rate solar radiation lightning activity electricity consumption

Advances in neuromorphic computing:Expanding horizons for AI development through novel artificial neurons and in-sensor computing

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Chinese Physics B 2024年第3期33卷 1-23页

作者：杨玉波赵吉哲刘胤洁华夏扬王天睿郑纪元郝智彪熊兵孙长征韩彦军王健李洪涛汪莱罗毅 Department of Electronic Engineering Tsinghua UniversityBeijing 100084China Beijing national Research center for Information science and Technology Tsinghua UniversityBeijing 100084China

AI development has brought great success to upgrading the information *** the same time,the large-scale artificial neural network for building AI systems is thirsty for computing power,which is barely satisfied by the conventional computing *** the post-Moore era,the increase in computing power brought about by the size reduction of CMOS in very large-scale integrated circuits(VLSIC)is challenging to meet the growing demand for AI computing *** address the issue,technical approaches like neuromorphic computing attract great attention because of their feature of breaking Von-Neumann architecture,and dealing with AI algorithms much more parallelly and energy *** by the human neural network architecture,neuromorphic computing hardware is brought to life based on novel artificial neurons constructed by new materials or *** it is relatively difficult to deploy a training process in the neuromorphic architecture like spiking neural network(SNN),the development in this field has incubated promising technologies like in-sensor computing,which brings new opportunities for multidisciplinary research,including the field of optoelectronic materials and devices,artificial neural networks,and microelectronics integration *** vision chips based on the architectures could reduce unnecessary data transfer and realize fast and energy-efficient visual cognitive *** paper reviews firstly the architectures and algorithms of SNN,and artificial neuron devices supporting neuromorphic computing,then the recent progress of in-sensor computing vision chips,which all will promote the development of AI.

关键词： neuromorphic computing spiking neural network(SNN) in-sensor computing artificial intelligence

Current progress of research on heat -resistant Mg alloys: A review

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International Journal of Minerals,Metallurgy and Materials 2024年第6期31卷 1406-1425页

作者： Hong Yang Wenlong Xie Jiangfeng Song Zhihua Dong Yuyang Gao Bin Jiang Fusheng Pan national Engineering Research center for Magnesium Alloys Chongqing UniversityChongqing 400044China College of Materials science and Engineering Chongqing UniversityChongqing 400044China

With the increasing attention received by lightweight metals,numerous essential fields have increased requirements for mag-nesium(Mg)alloys with good room-temperature and high-temperature mechanical ***,the high-temperature mechanic-al properties of commonly used commercial Mg alloys,such as AZ91D,deteriorate considerably with increasing *** the past several decades,extensive efforts have been devoted to developing heat-resistant Mg *** approaches either inhibit the gen-eration of thermally unstable phases or promote the formation of thermally stable precipitates/phases in matrices through solid solution or precipitation *** this review,numerous studies are systematically introduced and *** alloy systems,includ-ing those based on Mg–Al,Mg–Zn,and Mg–rare earth,are carefully classified and compared to reveal their mechanical properties and strengthening *** emphasis,limitations,and future prospects of these heat-resistant Mg alloys are also pointed out and dis-cussed to develop heat-resistant Mg alloys and broaden their potential application areas in the future.

关键词： magnesium alloys mechanical properties heat resistance microstructures high temperatures strengthening mechanisms

Cyclohexanol optimizes Pt/ionomer interface in fuel cell cathodes

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science China Chemistry 2024年第2期67卷 417-419页

作者： Lei Tong Hai-Wei Liang Hefei national Research center for Physical sciences at the Microscale Department of ChemistryUniversity of Science and Technology of ChinaHefei230026China

This highlight is based on a recent article published in Nature Catalysis, in which Wei's group [1] from Chongqing University proposes a novel approach to enhance the performance of proton exchange membrane fuel cells(PEMFCs)by adjusting the interface between Pt and ionomer in the cathode catalyst layer. Their strategy involves adding cyclohexanol to the cathode catalyst ink to impede the adsorption of sulfonate groups from the ionomer onto Pt nanoparticles, which results in the release of Pt activity sites and a significant improvement in the mass transport efficiency.

关键词： interface catalyst adding

Interpretation of Chinese Expert Consensus on the Diagnosis and Management Strategy of Patients with Statin Intolerance: A guiding file for helping to lipid management for Chinese population

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Journal of Geriatric Cardiology 2024年第7期21卷 713-715页

作者： Jian-Jun LI Cardiometabolic center National Center for Cardiovascular DiseaseChinese Academy of Medical ScienceFuwai Hos-pitalBeijingChina

It is well-known that elevated low-density lipoprotein cholesterol(LDL-C)is a causal risk factor for atheroscler-otic cardiovascular disease(ASCVD),statins are cornerstone drugs for the cause-based treatment of ASCVD,which has created a new era for ASCVD ***,statin intolerance is not clinically uncommon,which there are several issues with confu-sion and ***,a file named Chinese Expert Consensus on the Diagnosis and Management Strategy of Pa-tients With Statin Intolerance,like a navigator,has recently been published written by a team of experts from the Cardiovascular Metabolic Medicine Professional Committee,Expert Committee of the national center for Cardiovascular Diseases aiming to en-hance the standardized clinical application of statins and improve the prevention and clinical *** this article,author briefly summarized the key points of above consensus in order to helping to comprehending the content of the consensus sugges-tions.

关键词： Expert Strategy corners

A FAS approach for stabilization of generalized chained forms: part 1. Discontinuous control laws

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science China(Information sciences) 2024年第2期67卷 118-143页

作者： Guang-Ren DUAN center for Control Theory and Guidance Technology Harbin Institute of Technology center for Control science and Technology Southern University of Science and Technology

In this paper, a type of general nonholonomic systems is proposed, which contains both the Brockett’s two example systems, and their extended n-dimensional chained forms, as special cases. For the stabilization of such systems, a stabilizing controller is proposed based on the fully actuated system(FAS)approach, which is discontinuous at the origin but time-invariant when the open-loop system is time-invariant,and drives the feasible trajectories of the system to the origin exponentially. Furthermore, the proposed FAS approach is also extended to the sub-normal system case and the time-delay system case.

关键词： nonholonomic systems feedback stabilization exponential convergence sub-fully actuated systems time-delay systems