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A Study of Microstructure and Mechanical Properties for the Autogenous Single-Pass Butt Weldment of a Ferritic/Martensitic Steel Using Gas Tungsten Arc Welding

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Acta Metallurgica Sinica(English Letters) 2021年第5期34卷 628-638页

作者： Dong Wu Shitong Wei Shanping Lu CAS Key Laboratory of Nuclear Materials and Safety Assessment Institute of Metal ResearchChinese Academy of SciencesShenyang110016China Shenyang national Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang110016China

A 12%Cr ferritic/martensitic steel,HT-9,has been used as a primary core material for nuclear *** microstructure and mechanical properties of gas tungsten arc butt welded joints of HT-9 in as-welded,and as-tempered conditions have been *** as-welded condition,the fusion zone(FZ)contained a fresh martensite matrix with delta(δ)-***δ-ferrite was rich in Cr and depleted in C compared with the *** heat-aff ected zone(HAZ)could be divided into three areas as the distance from the fusion line increased:δ-ferrite/martensite duplex zone,fully recrystallized zone,and partly recrystallized *** austenitic grains did not coarsen in theδ-ferrite/martensite duplex zone due to the newly nucleatedδ-ferrite grains and incompletely ferritizing(δ-ferrite)during the welding thermal *** weldment microhardness distributed heterogeneously with values above 600 HV_(1.0)in the HAZ and FZ and 250 HV_(1.0)in the base metal(BM).Solute C in the matrix,induced by the dissolution of carbide during the welding process,dominated the microhardness *** toughness was observed in the FZ with a quasi-cleavage fracture tested from-80 to 20℃.The tensile fracture occurred in the relatively soft BM tested from 20 to 600℃.In as-tempered condition(760℃for 1 h),M_(23)C_6-type carbides precipitated within the martensitic laths,the lath boundaries,and theδ-ferrite/martensite ***,V,Cr,Mo-rich nitrides with very small size also precipitated in theδ-ferrite/martensite *** tempering treatment improved the homogenous distribution of weldment hardness *** fracture still occurred in the BM of the weldment specimens tested from 20 to 600℃.The impact toughness improved significantly,but the ductile–brittle transaction temperature was-12℃which was higher than that of the normalized and tempered(N&T)BM.δ-ferrite was considered to be one of the major factors aggravating the impact toughness in the FZ.

关键词： Martensitic stainless steel Gas tungsten arc welding(GTAW) Post-weld heat treatment Microstructure Mechanical properties

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New Agri-Silvo-Pastoral Model Utilizing Terrace RiserEnhancing Crop and Livestock Production Developed inNepal

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Journal of Agricultural Science and Technology(A) 2019年第6期9卷 371-389页

作者： Barakoti Tanka Prasad Sah Raj Kumar Agricultural research Station Nepal Agricultural Research CouncilDhankuta 56800PakhribasNepal

Twelve fodder species with maize (Zea mays) and millet (Eleusine coracana) were evaluated under agri-silvo-pastoral system along the Terrace risers (T-risers) of cropping land in the Agricultural research Station Pakhribas, Nepal. Major aim of innovative agroforestry experiment designed and tested first time in Nepal was to utilize one-third land in risers of cropping terraces due to limited lands of smallholders to produce green fodders needed for livestock. Trees were planted at 1.5 m on the terrace edges and ground fodders at 30-50 cm on the risers. Trees were not allowed to grow tall to avoid shade effect on crops grown in terraces. They were felled at breast height in second year growing coppices for fodder. The results showed higher survival (76% to 100%), growth (1-3 m high) and yield of improved forages and fodder trees indicating potential for cultivation on T-risers. Dry matter (DM) of tree fodders varied 31%-49%, and ground fodders 19%-32%. DM yields ranged 3.0 t/ha (Stylosanthes guanensis) to 26.5 t/ha (Pennisetum purpureum). Combined effects of fodder species on major hill crops, maize and finger millet growth, yield and other attributes were monitored in the terraces. Most mean data were significant and at par between the treatments. Better combinations of tree and ground fodders for higher grain and stover yields (3.1 t/ha and 3.4 t/ha, respectively) of maize were Grewia optiva/Thysalonaema maxima, Desmodium intortum, Ficus auriculata/Setaria anceps, D. intortum (2.7 t/ha and 3.3 t/ha, respectively). Promising combinations for finger millet growth and yields (2-3 t/ha) were G. optiva/T. maxima, Bauhinia purpurea/S. anceps, F. semicordata/P. cetaceum. Soil analysis result showed positive impact of fodders on the risers where organic matter was highly increased after three years. Farmers and stakeholders also evaluated this technology that has been successful and recommended for similar ecological regions.

关键词： Terrace riser fodder trees forage species maize and millet agri-silvo-pastoral system new model.

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Different fundus imaging modalities and technical factors in AI screening for diabetic retinopathy:a review

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Eye and Vision 2020年第1期7卷 201-213页

作者： Gilbert Lim Valentina Bellemo Yuchen Xie Xin Q.Lee Michelle Y.T.Yip Daniel S.W.Ting School of Computing National University of SingaporeSingaporeSingapore Singapore Eye research Institute Singapore National Eye CentreSingaporeSingapore Duke-NUS Medical School National University of Singapore11 Third Hospital Road AvenueSingapore 168751Singapore Vitreo-Retinal Service Singapore National Eye Center11 Third Hospital Road AvenueSingapore 168751Singapore Artificial Intelligence in Ophthalmology Singapore Eye Research Institute11 Third Hospital Road AvenueSingapore 168751Singapore

Background:Effective screening is a desirable method for the early detection and successful treatment for diabetic retinopathy,and fundus photography is currently the dominant medium for retinal imaging due to its convenience and *** screening using fundus photographs has however involved considerable costs for patients,clinicians and national health systems,which has limited its application particularly in less-developed *** advent of artificial intelligence,and in particular deep learning techniques,has however raised the possibility of widespread automated *** text:In this review,we first briefly survey major published advances in retinal analysis using artificial *** take care to separately describe standard multiple-field fundus photography,and the newer modalities of ultrawide field photography and smartphone-based ***,we consider several machine learning concepts that have been particularly relevant to the domain and illustrate their usage with extant ***:In the ophthalmology field,it was demonstrated that deep learning tools for diabetic retinopathy show clinically acceptable diagnostic performance when using colour retinal fundus *** intelligence models are among the most promising solutions to tackle the burden of diabetic retinopathy management in a comprehensive ***,future research is crucial to assess the potential clinical deployment,evaluate the cost-effectiveness of different DL systems in clinical practice and improve clinical acceptance.

关键词： Artificial intelligence Deep learning Diabetic retinopathy Fundus photographs Retinal imaging modalities Survey

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Hydrodynamic Behavior of Gap Resonance in Multiple-Box Systems with Sharp and Round Inlet Configurations

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China Ocean Engineering 2023年第5期37卷 849-862页

作者： RAN Ya-qing JIANG Sheng-chao GENG Bao-lei JIN Rui-jia Faculty of Vehicle Engineering and Mechanics Dalian University of TechnologyDalian 116024China national Engineering research Center for Port Hydraulic Construction Tianjin Research Institute for Water Transport EngineeringM.O.T.Tianjin 300456China

Fluid resonance within narrow gaps in multiple-box systems with sharp and round inlet configurations are investigated by using the potential flow and viscous fluid flow models in the OpenFOAM^(■)*** discrepancy between two numerical models can be observed for sharp inlet *** addition to the dramatical decrease of resonant amplitude in narrow gaps,some peak values at the higher resonant frequencies predicted by the potential flow model even disappear in the viscous fluid flow *** decreased normalized resonant amplitudes with the increase of incident wave amplitude can be observed for sharp inlet ***,the hydrodynamic behaviors of multiple-box system with round inlet configurations between potential flow and viscous fluid flow models are quite similar with each *** normalized resonant amplitudes are nearly independent of incident wave amplitudes for multiple-box systems with round inlet *** implies that the energy dissipation associated with fluid viscosity and flow rotation plays an important role in the gap resonance for sharp inlet configurations;while it is insignificant for round inlet configurations.

关键词： fluid resonance multiple boxes sharp edge round edge OpenFOAM

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The molecular tumor burden index as a response evaluation criterion in breast cancer

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Signal Transduction and Targeted Therapy 2021年第8期6卷 2494-2501页

作者： Zongbi Yi Fei Ma Guohua Rong Binliang Liu Yanfang Guan Jin Li Xiaoying Sun Wenna Wang Xiuwen Guan Hongnan Mo Jiani Wang Haili Qian Binghe Xu Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Geneplus-Beijing Institute BeijingChina Department of Medical Oncology Huanxing Cancer HospitalBeijingChina State Key Laboratory of Molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Circulating tumor DNA(ctDNA)is a potential biomarker of prognosis and therapeutic *** conducted this study to explore the role of the molecular tumor burden index(mTBI)in ctDNA as a therapeutic response and prognostic biomarker in a larger cohort prospective phase III randomized multicenter *** collected 291 plasma samples from 125 metastatic breast cancer patients from the CAMELLIA study(NCT01917279).Target-capture deep sequencing of 1021 genes was performed to detect somatic variants in ctDNA from the plasma *** pretreatment mTBI value was correlated with tumor burden(P=0.025).Patients with high-level pretreatment mTBI had shorter overall survival than patients with low-level pretreatment mTBI,and the median overall survival was 40.9 months and 68.4 months,respectively(P=0.011).Patients with mTBI decrease to less than 0.02%at the first tumor evaluation had longer progression-free survival and overall survival(P<0.001 and P=0.007,respectively).The mTBI has good sensitivity to identify complete response/partial response and progressive disease based on computed tomography scans(88.5%and 87.5%,respectively).The patients classified as molecular responders had longer progression-free survival and overall survival than the nonmolecular responders in the overall cohort(P<0.001 and P=0.036,respectively),as well as in the cohort in which computed tomography scans were defined as representing stable disease(P=0.027 and P=0.015,respectively).The mTBI in ctDNA detected in liquid biopsies is a potential biomarker of therapeutic response and prognosis in patients with metastatic breast cancer.

关键词： breast cancer index

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Cotton genome: challenge into the polyploidy

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Science Bulletin 2017年第24期62卷 1622-1623页

作者： Zhi-Wen Chen Jun-Feng Cao Xiu-Fang Zhang Xiao-Xia Shangguan Ying-Bo Mao Ling-Jian Wang Xiao-Ya Chen national Key Laboratory of Plant Molecular Genetics and national Center for Plant Gene research Institute of Plant Physiology and Ecology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Plant Science research Center Shanghai Chenshan Botanical Garden Shanghai Key Laboratory of Plant Functional Genomics and Resources

Cottons are the most important fiber crops in the *** cotton genus Gossypium has 52 species,including seven allotetraploid species and 45 *** species were domesticated and remain as crops under cultivation today:the New World allopolyploid species *** and ***(2n=52),and the Old World diploid species *** and ***(2n=26).The primary cultivated species is Upland cotton(*** L.),which accounts for more than 90%of global cotton fiber production.

关键词： Cotton genome challenge into the polyploidy

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Changes in human hepatic metabolism in steatosis and cirrhosis

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World Journal of Gastroenterology 2017年第15期23卷 2685-2695页

作者： Zoe Schofield Michelle AC Reed Philip N Newsome David H Adams Ulrich L Günther Patricia F Lalor Sci-Phy-4-Health EPSRC Research and Training Centre in Physical Sciences for HealthCollege of Engineering and Physical Sciences School of Cancer Sciences at the University of Birmingham Centre for Liver research and national Institute for Health research(NIHR)Birmingham Liver Biomedical research Unit 不详

AIMTo understand the underlying metabolic changes in human liver disease we have applied nuclear magnetic resonance (NMR) metabolomics analysis to human liver *** have carried out pilot study using 1H-NMR to derive metabolomic signatures from human liver from patients with steatosis, nonalcoholic steatohepatitis (NASH) or alcohol-related liver damage (ARLD) to identify species that can predict outcome and discriminate between alcohol and metabolic-induced liver *** in branched chain amino acid homeostasis, tricarboxylic acid cycle and purine biosynthesis intermediates along with betaine were associated with the development of cirrhosis in both ARLD and nonalcoholic fatty liver disease. Species such as propylene glycol and as yet unidentified moieties that allowed discrimination between NASH and ARLD samples were also detected using our *** high throughput, non-destructive technique for multiple analyte quantification in human liver specimens has potential for identification of biomarkers with prognostic and diagnostic significance.

关键词： Human Liver Metabolomics Steatosis Nuclear magnetic resonance Alcohol

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Buffeting numerical simulation coupled with aerodynamics and structure based on MDDES

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Science China(Technological Sciences) 2013年第10期56卷 1550-1560页

作者： HUANG JiangTao GAO ZhengHong national Key Laboratory of Aerodynamic Design and research Northwestern Polytechnical University

Unsteady effect of seriously separated flow is the main factor of modern aircraft buffeting. So accurate simulation of this complex flow becomes the basis associated with the research of aircraft buffeting. This paper constructs an unsteady numerical simulation method for separation flow based on modified delayed detached eddy simulation (MDDES) method by considering both modern computer resources and the credibility of simulating separation flow. The proposed method is also verified through the simulation of the separated flow by a typical fighter at high angle of attack. And then a robust and efficient technology for deforming mesh is established using radial basis function (RBF) and infinite interpolation method. Moreover, the platform for numerical simulation of buffeting is set up in combination with the structural dynamics equations in the modal space, by which the research of vertical tail buffeting caused by edge vortex is carried out on a fighter at large angle of attack. Through spectrum analysis of time-domain response of pressure pulsation on the location of vortex rupture, the results show that the pulsation frequency of vortex structure with different scales covers the inherent modal frequency of vertical tail structure. Compared to the Reynolds-averaged Navier-Stokes equations, the MDDES method can distinguish the more detailed and higher frequency small-scale vortex structure. Unlike flutter, displacement acceleration response of each mode in buffeting is dominated by its own mode. There exists strong coupling between the first bending mode and first torsion mode, and it leads to acceleration and large inertia impact of structure, which is the main factor causing structural fatigue. In sum, the obtained results verify the validity of the numerical means and the corresponding methods in the paper.

关键词： aircraft buffeting modified delayed detached eddy simulation (MDDES) modal super-position grid deformation

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Altered expression of glymphatic system-related proteins in prion diseases: Implications for the role of the glymphatic system in prion diseases

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Cellular & Molecular Immunology 2021年第9期18卷 2281-2283页

作者： Yong-Chan Kim Sae-Young Won Byung-Hoon Jeong Korea Zoonosis research Institute Jeonbuk National UniversityIksanJeonbukRepublic of Korea Department of Bioactive Material Sciences and Institute for Molecular Biology and Genetics Jeonbuk National UniversityJeonjuJeonbukRepublic of Korea

TO THE EDITOR Prion diseases are fatal and in curable n eurodegenerative diseases caused by a pathogenic form of prion protein(PrP^(Sc))derived from a cellular form of prion protein(PrP^(C)).Recent studies have reported that aquaporin 4(AQP4)expression is dramatically upregulated in the brains of individuals with several different prion *** AQP4 is a key protein of the glymphatic system,which is the perivascular waste clearing system of the brain,and since altered expression of AQP4 has been observed in prion diseases,the glymphatic system may be associated with prion diseases.

关键词： AQP4 diseases lymphatic

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Nanovesicles Are Secreted during Pollen Germination and Pollen Tube Growth： A Possible Role in Fertilization

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Molecular Plant 2014年第3期7卷 573-577页

作者： Noela Prado Juan de Dios Alche Juan Casado-Vela Salvador Mas Mayte Villalba Rosalia Rodriguez Eva Batanero Departamento de Bioquimica y Biologia Molecular Facultad de Qu[mica Universidad Complutense de Madrid 28040 Madrid Spain Departamento de Bioquimica Biologia Celular y Molecular de Plantas Estacion Experimental de1Zaidin (CSIC) E-18080 Granada Spain Spanish national research council (CSIC) Spanish National Centre for Biotechnoiogy (CNB) Darwin 3 Cantoblanco 28049 Madrid Spain

Dear Editor, During recent decades, a novel mechanism of secretion has been identified in a wide range of mammalian cells. It involves the release of bioactive membrane nanovesicles （30-100 nm）, termed exosomes, upon the fusion of multivesicular bodies with the plasma membrane （Thery et al., 2009）. Exosomes are implicated in diverse functions, such as scavenging of archaic proteins, intercellular messengers delivering cell-specific signals, and vehicles for transmissible pathogens. Exosomes have also been described in other organisms such as bacte- ria, Drosophila, and fungi.

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