Altered expression of glymphatic system-related proteins in prion diseases: Implications for the role of the glymphatic system in prion diseases

作     者：Yong-Chan Kim Sae-Young Won Byung-Hoon Jeong 

作者机构：Korea Zoonosis Research InstituteJeonbuk National UniversityIksanJeonbukRepublic of Korea Department of Bioactive Material Sciences and Institute for Molecular Biology and GeneticsJeonbuk National UniversityJeonjuJeonbukRepublic of Korea 

出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)

年 卷 期：2021年第18卷第9期

页      面：2281-2283页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 1001[医学-基础医学(可授医学、理学学位)] 100103[医学-病原生物学] 10[医学] 

基　　金：This work was supported by a National Research Foundation of Korea(NRF)grant funded by the Korean government(MSIT)(2021R1A2C1013213) This research was supported by the Basic Science Research Program through the National Research Foundation(NRF)of Korea funded by the Ministry of Education(2017R1A6A1A03015876) This work was supported by an NRF(National Research Foundation of Korea)Grant funded by the Korean Government(NRF-2019-Fostering Core Leaders of the Future Basic Science Program/Global Ph.D.Fellowship Program) SYW and YCK were supported by the BK21 Plus Program in the Department of Bioactive Material Sciences 

主　　题：AQP4 diseases lymphatic 

摘      要：TO THE EDITOR Prion diseases are fatal and in curable n eurodegenerative diseases caused by a pathogenic form of prion protein(PrP^(Sc))derived from a cellular form of prion protein(PrP^(C)).Recent studies have reported that aquaporin 4(AQP4)expression is dramatically upregulated in the brains of individuals with several different prion *** AQP4 is a key protein of the glymphatic system,which is the perivascular waste clearing system of the brain,and since altered expression of AQP4 has been observed in prion diseases,the glymphatic system may be associated with prion diseases.