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Prognostic and predictive role of immune microenvironment in colorectal cancer

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World Journal of Gastrointestinal oncology 2024年第3期16卷 643-652页

作者： Olesya Kuznetsova Mikhail Fedyan.n.Larisa Zavalishina Larisa Moskvina Olga Kuznetsova Alexandra Lebedeva Alexey Tryakin Galina Kireeva Gleb Borshchev Sergei Tjulandin Ekaterina Ignatova Department of Chemotherapy Federal State Budgetary Institution(N.N.Blokhin National Medical Research Center of Oncology)of the Ministry of Health of the Russian FederationMoscow 115478Russia Department of Pathology Russian Medical Academy of Continuous Professional EducationMoscow 123242Russia OncoAtlas LCC Moscow 115478Russia Federal State Budgetary Institution“national medical and Surgical center named after n.I.Pirogov”of the Ministry of Health of the Russian Federation Moscow 105203Russia STOOnCO:Science and Technology in oncology Moscow 115478Russia

Colorectal cancer(CRC)represents a molecularly heterogeneous disease and one of the most frequent causes of cancer-related death *** traditional classification of CRC is based on pathomorphological and molecular character-istics of tumor cells(mucinous,ring-cell carcinomas,etc.),analysis of mechanisms of carcinogenesis involved(chromosomal instability,microsatellite instability,CpG island methylator phenotype)and mutational statuses of commonly altered genes(KRAS,nRAS,BRAF,APC,etc.),as well as expression signatures(CMS 1-4).It is also suggested that the tumor microenvironment is a key player in tumor progression and metastasis in *** to the latest data,the immune microenvironment can also be predictive of the response to immune checkpoint *** this review,we highlight how the immune environment influences CRC prognosis and sensitivity to systemic therapy.

关键词： Immunoscore Immune microenvironment Colorectal cancer Gastrointestinal cancers Predictive biomarkers Digital pathology

Targeting hormone-resistant breast cancer cells with docetaxel:a look inside the resistance

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Cancer Drug Resistance 2023年第1期6卷 103-115页

作者： Alexander M.Scherbakov Anna A.Basharina Danila V.Sorokin Ekaterina I.Mikhaevich Iman E.Mizaeva Alexandra L.Mikhaylova Tatiana A.Bogush Mikhail A.Krasil’nikov Department of Experimental Tumor Biology Blokhin N.N.National Medical Research Center of OncologyMoscow 115522Russian Federation Group of Molecular Tumor Markers Blokhin N.N.National Medical Research Center of OncologyMoscow 115522Russian Federation

Aim:The study aims to analyze the effect of long-term incubation of ERα-positive MCF7 breast cancer cells with 4-hydroxytamoxifen(HT)on their sensitivity to tubulin polymerization inhibitor ***:The analysis of cell viability was performed by the MTT *** expression of signaling proteins was analyzed by immunoblotting and flow ***αactivity was evaluated by gene reporter *** establish hormone-resistant subline MCF7,breast cancer cells were treated with 4-hydroxytamoxifen for 12 ***:The developed MCF7/HT subline has lost sensitivity to 4-hydroxytamoxifen,and the resistance index was *** Akt activity(2.2-fold)and decreased ERαexpression(1.5-fold)were revealed in MCF7/HT *** activity of the estrogen receptorαwas reduced(1.5-fold)in MCF7/*** of class Ⅲβ-tubulin expression(TUBB3),a marker associated with metastasis,revealed the following trends:higher expression of TUBB3 was detected in triple-negative breast cancer MDA-MB-231 cells compared to hormone-responsive MCF7 cells(Pn of TUBB3 was found in hormone-resistant MCF7/HT cells(MCF7/HTn strongly correlated with docetaxel resistance:IC_(50)value of docetaxel for MDA-MB-231 cells was greater than that for MCF7 cells,whereas resistant MCF7/HT cells were the most sensitive to the *** accumulation of cleaved PARP(a 1.6-fold increase)and Bcl-2 downregulation(1.8-fold)were more pronounced in docetaxel-treated resistant cells(Pn of cyclin D1 decreased(2.8-fold)only in resistant cells after 4 nM docetaxel treatment,while this marker was unchanged in parental MCF7 breast cancer ***:Further development of taxane-based chemotherapy for hormone-resistant cancer looks highly promising,especially for cancers with low TUBB3 expression.

关键词： Cancer docetaxel 4-hydroxytamoxifen classⅢβ-tubulin resistance breast cancer estrogen receptors alpha

Study of Biological Activity and Toxicity of Thiosemicarbazides Carbohydrate Derivatives by in Silico, in Vitro and in Vivo Methods

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Journal of Agricultural Chemistry and Environment 2022年第1期11卷 15-23页

作者： Baktygul Ernazarova Taitokur Zhusubaliev Zarylkan Asilbek kyzy Aida Bakirova Gulsara Zhusupbaeva Orozby Akparalieva Zhypargul Abdullaeva nasibakhon Razykova Asilkan Dzhumanazarova Galina Apryshko Alina Orozmatova Department of Pharmacy and medical-Biological Disciplines Zhalal-Abad State University Zhalal-Abad Kyrgyzstan Zhalal-Abad Scientific center South Department Academy of Sciences Zhalal-Abad Kyrgyzstan Science and research Department Osh State University Osh Kyrgyzstan Institute of Chemistry and Phytotechnology National Academy of Sciences Bishkek Kyrgyzstan national medical research center of oncology named after n.n. blokhin Moscow Russia

Computer analysis of n-(β-D-galactopyranosyl)-thiosemicarbazide compounds by in silico method revealed high probability of antibacterial (antimycobacterial), anti-tuberculosis (antituberculosic), antiviral (Influenza), antitumor (antineoplastic) 9 > Pa > 0.5 and with a low probability of cytotoxic/cytostatic (cytostatic/cytotoxic) activities. An experimental study by in vitro and in vivo methods allowed us to conclude that studied new synthetic compound n-(β-D-galactopyranosyl)-thiosemicarbazide in the studied concentrations has a pronounced bactericidal and bacteriostatic effects.

关键词： Biological Activity Synthesis Urea Carbohydrate Compounds Hyperurcemia Ototoxicity Testing Toxicity Anti Tuberculosis Antitumor

Correlation of Quantitative Changes in Bone Marrow Lymphocyte Subpopulations with Some Rhabdomyosarcoma Prognosis Factors in Children

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Advances in Biological Chemistry 2021年第5期11卷 234-250页

作者： Olga P. Kolbatskaya Tatiana V. Gorbunova Svetlana V. Chulkova Anna A. Khachatryan.n.kolai n. Tupitsyn Vladimir G. Polyakov national medical research center of oncology named after n.n. blokhin Ministry of Health of Russia Moscow Russia medical Faculty of the oncology and Radiotherapy Pirogov Russian National Research Medical University Ministry of Health of Russia Moscow Russia Russian medical Academy of Continuing Professional Education Ministry of Health of Russia Moscow Russia

Rationale: The known prognosis factors for rhabdomyosarcoma (RMS) in children do not always explain the unsatisfactory outcome of treatment. Changes in the subpopulation composition of Bone Marrow (BM) effector cells during the development of RMS may indicate new directions for the search for prognostic factors and points for the impact of targeted therapy. Purposen>n>: To identify correlations between quantitative changes in the levels of subpopulations of T, B and NK-lymphocytes of BM and known risk factors for RMS in children. Objectsn>n>: The study included 31 patients. The main group included 16 patients with RMS, average age—6.8 ± 1.0 years, while children 1 - 10 years old—13 (81.3%), over 10 years old—3 (18.8%) people, girls and boys were 8 people each. The embryonic variant of RMS was established in 10 (62.5%) cases, the alveolar variant—in 4 (25%) cases, in two patients (12n>.n style="font-family:;" "="">n style="font-family:Verdana;">5%), t

关键词： Rhabdomyosarcoma Bone Marrow Children Lymphocyte Subpopulations

Structure,mechanical characteristics,biodegradation,and in vitro cytotoxicity of magnesium alloy ZX11 processed by rotary swaging

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Journal of Magnesium and Alloys 2020年第4期8卷 1038-1046页

作者： natalia Martyn.n.o natalia Anisimova Mikhail Kiselevskiy natalia Tabachkova Diana Temralieva Dmitry Prosvirn.n. Vladimir Terentiev Andrey Koltygina Vladimir Belov Mikhail Morosov Vladimir Yusupov Sergey Dobatkina national University of Science and Technology"M1SIS" Leninsky prospect4119049 MoscowRussia A.A.Baikov Institute of Metallurgy and Materials Science of the RAS Leninsky prospect49119334 MoscowRussia ≪n.n.blokhin national medical research center of oncology≫of the Ministry of Health of the Russian Federation Kashirskoye Highway23115478 MoscowRussia A.M.Prokhorov General Physics Institute of the RAS Vavilova st.3&Moscow 119991、Russia 5.Department of Materials Science and EngineeringMonash UniversityClaytonMelbourne VIC 3800Australia 6.Department of Mechanical EngineeringThe University of Western AustraliaCrawleyPerth WA 6009Australia

Rotary swaging(RS)of alloy Mg-1.03Zn-0.66Ca(ZX11)was shown to refine the average grain size to 4.5±1.2μm in a longitudinal section and 4.8±0.9μm in a transverse *** addition,a small amount of Mg2Ca particles about 300nm in size and Mg6Zn3Ca2 particles with a size of about lOOnm was *** resulted in pronounced strengthen.n.:the yield strength and the ultimate tensile strength rose to 210±8 MPa and 276±6 MPa,respectively,while the elongation hardly decreased(22.0±1.8% and 18.3±2.9% before and after RS).Furthermore,RS led to an increase in the fatigue limit of the alloy from 120 MPa to 135 MPa and did not impair its resistance to chemical *** studies in vitro showed that ZX11 induces hemolysis without inhibiting the viability of peripheral blood mon.n.clear cells and has a more pronounced cytotoxic effect on tumor cells in comparison with n.n.transformed *** significant difference of the latter effect between the initial and the deformed states was observed.

关键词： Magnesium alloy Rotary swaging Mechanical characteristics Hemolysis Cell viability Cytotoxicity