Correlation of Quantitative Changes in Bone Marrow Lymphocyte Subpopulations with Some Rhabdomyosarcoma Prognosis Factors in Children

作     者：Olga P. Kolbatskaya Tatiana V. Gorbunova Svetlana V. Chulkova Anna A. Khachatryan Nikolai N. Tupitsyn Vladimir G. Polyakov Olga P. Kolbatskaya;Tatiana V. Gorbunova;Svetlana V. Chulkova;Anna A. Khachatryan;Nikolai N. Tupitsyn;Vladimir G. Polyakov

作者机构：National Medical Research Center of Oncology Named after N.N. Blokhin Ministry of Health of Russia Moscow Russia Medical Faculty of the Oncology and Radiotherapy Pirogov Russian National Research Medical University Ministry of Health of Russia Moscow Russia Russian Medical Academy of Continuing Professional Education Ministry of Health of Russia Moscow Russia 

出 版 物：《Advances in Biological Chemistry》 (生物化学进展（英文）)

年 卷 期：2021年第11卷第5期

页      面：234-250页

学科分类：07[理学] 0701[理学-数学] 070101[理学-基础数学] 

主　　题：Rhabdomyosarcoma Bone Marrow Children Lymphocyte Subpopulations 

摘      要：Rationale: The known prognosis factors for rhabdomyosarcoma (RMS) inchildren do not always explain the unsatisfactory outcome of treatment. Changes in the subpopulation composition of Bone Marrow (BM) effector cells during the development of RMS may indicate new directions for the search for prognostic factors and points for the impact of targeted therapy. Purpose: To identify correlations between quantitative changes in the levels of subpopulations of T, B and NK-lymphocytes of BM and known risk factors for RMS in children. Objects: The study included 31 patients. The main group included 16 patients with RMS, average age—6.8 ± 1.0 years, while children 1 - 10 years old—13 (81.3%), over 10 years old—3 (18.8%) people, girls and boys were 8 people each. The embryonic variant of RMS was established in 10 (62.5%) cases, the alveolar variant—in 4 (25%) cases, in two patients (12.5%), t